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https://www.readbyqxmd.com/read/30513346/reversibility-of-irreversible-aging
#1
REVIEW
Fedor Galkin, Bohan Zhang, Sergey E Dmitriev, Vadim N Gladyshev
Most multicellular organisms are known to age, due to accumulation of damage and other deleterious changes over time. These changes are often irreversible as organisms, humans included, evolved fully differentiated, irreplaceable cells (e.g. neurons) and structures (e.g. skeleton). Hence, deterioration or loss of at least some cells and structures should lead to inevitable aging of these organisms. Yet, some cells may escape this fate: adult somatic cells may be converted to partially reprogrammed cells or induced pluripotent stem cells (iPSCs)...
December 1, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/30349344/evaluating-the-role-of-small-particle-hyaluronic-acid-fillers-using-micro-droplet-technique-in-the-face-neck-and-hands-a-retrospective-chart-review
#2
Andreas Nikolis, Kaitlyn M Enright
Background: Loss of the viscoelastic properties of the skin is a primary sign of aging and contributes to the appearance of wrinkles. Hyaluronic acid (HA) fillers are one of the most commonly used treatments for age-related soft-tissue reduction and volume loss. Evidence is also emerging that HA fillers rejuvenate the skin. Methods: A retrospective chart review was completed on 20 subjects treated with small particle HA (SP-HA), to investigate its effects on skin properties...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29897518/calcium-hydroxyapatite-caha-indication-for-hand-rejuvenation
#3
Miles H Graivier, Z Paul Lorenc, Lawrence M Bass, Rebecca Fitzgerald, David J Goldberg
The recent approval in 2015 of Radiesse for injection into the hand by the FDA has spurred an increase in interest among patients and clinicians in nonsurgical hand rejuvenation using fillers. Application of the same techniques used to treat the face to the dorsum of the hands does not account for the unique nature of the skin and underlying anatomy, and can lead to suboptimal outcomes and an increased risk of adverse events such as the formation of nodules. Here, the authors discuss dilution strategies and injection techniques for hand rejuvenation using Radiesse for optimal patient safety and aesthetic outcomes...
April 6, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29755986/implications-of-cellular-aging-in-cardiac-reprogramming
#4
Fabiana Passaro, Gianluca Testa
Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfunction over time, representing a risk factor for diseases development, including cardiovascular. The aging process occurring in the cardiovascular system involves heart and vessels at molecular and cellular level, with subsequent structural modifications and functional impairment. Several modifications involved in the aging process can be ascribed to cellular senescence, a biological response that limits the proliferation of damaged cells...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29710230/long-term-outcomes-of-temporal-hollowing-augmentation-by-targeted-volume-restoration-of-fat-compartments-in-chinese-adults
#5
Ru-Lin Huang, Yun Xie, Wenjin Wang, Pohching Tan, Qingfeng Li
Importance: Previous anatomical and clinical studies have suggested that targeted restoration of the volume and distribution of fat compartments using appropriate cannula entry sites and injection planes is an excellent fat-grafting technique for facial contouring and hand rejuvenation. Objective: To perform subjective and objective evaluations of the safe and effective profile of the targeted fat-grafting technique for temporal hollowing augmentation. Design, Setting, and Participations: In a retrospective cohort study, a total of 96 consecutive patients with temporal hollowing were treated at the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai, China, with the targeted fat-grafting technique from January 1, 2009, to January 1, 2017...
September 1, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29697606/the-anatomy-behind-adverse-events-in-hand-volumizing-procedures-retrospective-evaluations-of-11-years-of-experience
#6
COMPARATIVE STUDY
Konstantin Frank, Konstantin Koban, Stefan Targosinski, Katharina Erlbacher, Thilo L Schenck, Gabriela Casabona, Andre V Braz, Tatjana Pavicic, Sebastian Cotofana
BACKGROUND: To retrospectively evaluate the rate of adverse events after hand volumizing procedures using a calcium hydroxylapatite product and to investigate the relationship between injector used (i.e., needle versus cannula) and technique applied (i.e., bolus, tenting, proximal-to-distal fanning, distal-to-proximal single line). METHODS: Two hundred twenty individuals, including 214 women (97.3 percent) aged 52.3 ± 11.4 years, treated bilaterally for hand rejuvenation were investigated between the years 2006 and 2017...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29353456/in-vivo-transient-and-partial-cell-reprogramming-to-pluripotency-as-a-therapeutic-tool-for-neurodegenerative-diseases
#7
REVIEW
S Tamanini, G P Comi, S Corti
In theory, human diseases in which a specific cell type degenerates, such as neurodegenerative diseases, can be therapeutically addressed by replacement of the lost cells. The classical strategy for cell replacement is exogenous cell transplantation, but now, cell replacement can also be achieved with in situ reprogramming. Indeed, many of these disorders are age-dependent, and "rejuvenating" strategies based on cell epigenetic modifications are a possible approach to counteract disease progression...
August 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29320593/injection-depth-in-intradermal-therapy-update-and-correction-of-published-data
#8
REVIEW
Patrick Micheels, Lisa Goodman
BACKGROUND: This paper sought to compare calculated injection depth data with published report claims concerning intradermal therapy and skin rejuvenation of the face, hands, neck, and décolleté. OBJECTIVE: A mathematical formula was employed to assess the injection depth, and data from literature were retrieved and compared with the calculated figures to determine whether the claims about the injection depth proved correct. METHODS: Based on a study by Della Volpe et al...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29184426/recommendations-for-volume-augmentation-and-rejuvenation-of-the-face-and-hands-with-the-new-generation-polycaprolactone-based-collagen-stimulator-ellans%C3%A3-%C3%A2
#9
REVIEW
Francisco de Melo, Pierre Nicolau, Luca Piovano, Shang-Li Lin, Tiago Baptista-Fernandes, Martyn I King, Alessandra Camporese, Kyungkook Hong, Maria M Khattar, Marie-Odile Christen
Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé® ) that demonstrates properties as yet unseen in soft-tissue fillers. It is composed of polycaprolactone (PCL) microspheres in an aqueous carboxymethylcellulose gel carrier...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29122499/micro-autologous-fat-transplantation-for-rejuvenation-of-the-dorsal-surface-of-the-aging-hand
#10
Lin Yun-Nan, Huang Shu-Hung, Lin Tsung-Ying, Chou Chih-Kang, Huang Yu-Hao, Takahashi Hidenobu, Lai Chung-Sheng, Lin Sin-Daw, Lin Tsai-Ming
BACKGROUND: Rejuvenation of the dorsal surface of the hand for various conditions, such as cutaneous dyschromia, fine wrinkling, skin laxity, visible extensor tendons, and varicosities appear vital to prevent wrist and digit flexion resulting from hiding of the aged appearance of the hand. Numerous fillers have been applied to re-contour the aging dorsal surface of the hand and the results were variable. The micro-autologous fat transplantation (MAFT) technique, proposed by Lin et al...
October 6, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29117295/hand-rejuvenation-by-targeted-volume-restoration-of-the-dorsal-fat-compartments
#11
Jia Zhou, Yun Xie, Wen-Jin Wang, Tanja Herrler, Ru-Lin Hang, Pei-Juan Zhao, Si-Zheng Zhou, Qing-Feng Li
Background: Recent anatomic findings suggest aging-related changes of the complex fat distribution in the hand. Objectives: To rejuvenate the aging hand, we developed a targeted fat grafting technique based on the physiologic fat distribution of the hand. Methods: The dorsum of both hands was examined in 30 healthy volunteers of different age utilizing B-mode ultrasound to determine physiological changes of the aging hand. Additional anatomic dissection was performed in 10 hands of five fresh cadavers to establish the anatomic basis for the targeted restoration technique...
December 13, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28990118/efficacy-of-long-pulse-nd-yag-laser-versus-fractional-er-yag-laser-in-the-treatment-of-hand-wrinkles
#12
RANDOMIZED CONTROLLED TRIAL
Reza M Robati, Elmira Asadi, Anoosh Shafiee, Nastaran Namazi, Atefeh Talebi
There are different modalities for hand rejuvenation. Fractional Er:YAG laser and long pulse Nd:YAG laser were introduced for treating hand wrinkles. We plan to compare fractional Er:YAG laser and long pulse Nd:YAG laser in a randomized controlled double-blind design with multiple sessions and larger sample size in comparison with previous studies. Thirty-three participants with hand wrinkles entered this study. They were randomly allocated to undergo three monthly laser treatments on each hand, one with a fractional Er:YAG laser and the other with a long pulse Nd:YAG laser...
April 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/28989238/hand-rejuvenation-with-fat-grafting-a-12-year-single-surgeon-experience
#13
Fabio Fantozzi
BACKGROUND: Fat grafting has been successfully used for reconstructive and esthetic surgery of the breast, face, and other body parts. In this article, we present our protocol for hand fat grafting and over a decade of clinical experience. METHODS: Fat tissue is obtained from the flanks, peri-umbilical region, or internal side of the thigh or knee. No centrifuge machine is used to prevent fat damage. After decantation, fat is injected into the dorsum of the hand using a cannula from the wrist and not from the fingers...
2017: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28979662/topical-treatment-of-aging-hands-brief-report
#14
Wendy E Roberts, Lora Colvan, Vincent Gotz
Rejuvenation of aging hands is becoming increasingly important to physicians and their patients. While a variety of invasive treatments are available, topical products that improve manifestations of aging hands are needed. In this brief report, the efficacy of a topical product containing urea, lipids, sodium copper chlorophyllin complex, antioxidants, and humectants was assessed in subjects with moderate-to-severe photodamage of the hands.
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28886872/-benefits-of-volumetric-to-facial-rejuvenation-part-1-fat-grafting
#15
P Bui, C Lepage
For a number of years, a volumetric approach using autologous fat injection has been implemented to improve cosmetic outcome in face-lift procedures and to achieve lasting rejuvenation. Autologous fat as filling tissue has been used in plastic surgery since the late 19th century, but has only recently been associated to face lift procedures. The interest of the association lies on the one hand in the pathophysiology of facial aging, involving skin sag and loss of volume, and on the other hand in the tissue induction properties of grafted fat, "rejuvenating" the injected area...
October 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28856396/objective-evaluation-of-eyebrow-position-after-autologous-fat-grafting-to-the-temple-and-forehead
#16
Cheng-Hung Chiu
BACKGROUND: Fat grafting can be used to correct age-related volume loss in the face. However, the degree of rejuvenation is difficult to be evaluated. OBJECTIVES: The author sought to objectively verify the change in patients' eyebrow position after fat grafting to the upper face. METHODS: The charts of 175 consecutive patients who underwent autologous fat grafting to the forehead and temple were reviewed. Perioperative changes in the heights of medial, middle, and lateral segments of the eyebrow and the eyebrow slant were recorded and compared...
December 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28628686/off-face-usage-of-poly-l-lactic-acid-for-body-rejuvenation
#17
REVIEW
Ahmad Jabbar, Suleima Arruda, Neil Sadick
<p>Injectable soft-tissue augmentation agents have become popular alternatives to surgical procedures for the aging face and body. In contrast to temporary, space-occupying replacement fillers such as collagen-based and hyaluronic acid products, poly-l-lactic acid (PLLA) has been demonstrated to gradually promotes deposition of collagen via a biostimulatory response, with therapeutic effects lasting approximately two years. In 2004, the FDA approved its use for rejuvenation of facial contours secondary to lipoatrophy associated with antiretroviral therapy for HIV infection...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28215619/the-effect-of-aging-on-the-three-dimensional-aspect-of-the-hand-a-pilot-study
#18
I A Hoevenaren, T S Wesselius, J W Meulstee, R D Vreeken, T J J Maal, D J O Ulrich
BACKGROUND: With the increasing popularity of rejuvenation treatments of the skin, there has been an increase in patient inquiry for rejuvenation of the hand. Thus far, no imaging tool exists to analyze the aging process of the hand. Three-dimensional (3D) stereophotogrammetry is a reliable technique, which is used for other purposes in soft tissue analysis of the upper extremity. This pilot study aimed to investigate the possibility of visualizing the hand aging process by 3D stereophotogrammetry...
April 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28189337/-correction-of-an-amyotrophic-dorsal-face-of-hands-due-to-neurological-disease-with-autologous-fat-cells-transplant-an-original-case
#19
L Ruffenach, S Gouzou, P Liverneaux, C Bruant Rodier, F Bodin
INTRODUCTION: Autologous fat grafting allows the correction of many volume defects whether natural or post-traumatic. In hand surgery, the most common indication is the rejuvenation of the dorsal aspect of the hands. We present, here, an original case of amyotrophic hands lipofilling due to Charcot-Marie-Tooth disease. PATIENT AND METHODS: The patient had a bilateral and asymmetric amyotrophy of the intermetacarpal spaces responsible of a social handicap. Autologous fat grafting, according to Coleman's procedure, was done at the dorsal aspect of the two hands, three years apart...
June 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27881936/autologous-fat-transfer-to-the-subcutaneous-tissue-in-the-context-of-breast-reconstructive-procedures
#20
REVIEW
Pawel Szychta, Marek Zadrozny, Jan Rykala, Lukasz Banasiak, Henryk Witmanowski
Autologous fat transfer (AFT) is an appropriate technique for aesthetic rejuvenation of the face, aesthetic enhancement of hands, correction of the facial appearance in various disorders and constitutes a surgical alternative of treatment of numerous breast deformities ranging from distorting posttraumatic scars, post-eczema lesions, post-burn deformities to partial or total breast reconstruction. Our work is aimed to familiarize dermatologists with the technique of harvesting and implanting the aspirate of adipose cells in patients consulted for deformities of the breast...
October 2016: Postȩpy Dermatologii i Alergologii
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