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Petra Anheuser, Sandra Mühlstädt, Jennifer Kranz, Laila Schneidewind, Joachim Steffens, Paolo Fornara
INTRODUCTION: Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems to be a key treatment point for Fournier's gangrene. The aim of this study was to investigate the influence of HBO therapy on the outcome and prognosis of Fournier's gangrene. PATIENTS AND METHODS: In the present multicenter, retrospective observational study, we evaluated the data of approximately 62 patients diagnosed with Fournier's gangrene between 2007 and 2017...
October 16, 2018: Urologia Internationalis
Yasuyuki Okumura, Naoya Sugiyama, Toshie Noda
The study objective was to investigate the association between timely follow-up visits after psychiatric hospitalization and the risk of readmission in patients with schizophrenia or bipolar disorder. A retrospective cohort study was conducted using a nationwide claims database in Japan. Between April 2014 and March 2015, all psychiatric hospitalization data were obtained and patients with a principal diagnosis of schizophrenia or bipolar disorder were followed up from 180 days before admission to 210 days after discharge...
October 9, 2018: Psychiatry Research
Zhen Liang, Chen Xu, Yi Cao, Hai-Dong Kan, Ren-Jie Chen, Chun-Yan Yao, Xiao-Ling Liu, Ying Xiang, Na Wu, Long Wu, Ya-Fei Li, Ai-Ling Ji, Tong-Jian Cai
Schizophrenia is a devastating neuropsychiatric disorder with increasing concern. Limited studies have been conducted to assess the relationship between short-term exposure to ambient air pollution and schizophrenia attacks. This study aimed to investigate the associations between short-term air pollution exposure and schizophrenia outpatient visits based on a time-series study performed in China. Daily data of schizophrenia outpatient admissions and air pollution from 1 October 2010 to 31 December 2013 were collected in Xi'an, a heavily-polluted city in China...
October 3, 2018: Environmental Pollution
Ashley N Selner, Clayton L Rosinski, Ryan G Chiu, David Rosenberg, Anisse N Chaker, Hamidou Drammeh, Darian R Esfahani, Ankit I Mehta
BACKGROUND: Epilepsy is one of the most common neurologic disorders, and often remains refractory despite pharmacologic treatment. In patients unamenable to surgical resection of seizure foci, vagal nerve stimulation (VNS) may provide benefit. Multiple case series have attempted to construct a risk profile for VNS, yet are largely confined to pediatric or single-center populations. OBJECTIVE: To compile a risk profile for adults undergoing VNS, utilizing multi-center patient data from an international database...
October 13, 2018: World Neurosurgery
Wendy C King, Amanda S Hinerman, Steven H Belle, Abdus S Wahed, Anita P Courcoulas
Importance: Estimates of weight regain following bariatric surgery vary widely. Objective: To describe weight regain after reaching nadir weight following Roux-en-Y gastric bypass (RYGB) surgery and compare weight regain measures for association with outcomes. Design, Setting, and Participants: Prospective cohort study of 2458 adults who underwent bariatric surgery at 10 hospitals in 6 US cities between March 2006 and April 2009. Assessments were conducted within 30 days' presurgery, at 6 months' postsurgery, and then annually until January 2015...
October 16, 2018: JAMA: the Journal of the American Medical Association
Elizabeth D Stephenson, Saangyoung Eric Lee, Katherine Adams, Douglas R Farquhar, Zainab Farzal, Charles S Ebert, Matthew Ewend, Deanna Sasaki-Adams, Brian D Thorp, Adam M Zanation
Importance: The use of skull base surgery in patients 70 years or older is increasing, but its safety in this age group has not been evaluated to date. Objectives: To describe outcomes in a cohort of patients 70 years or older undergoing skull base surgery and to evaluate whether age, type of disease process, and approach (endoscopic vs traditional open surgery) are associated with increased intraoperative and postoperative complications in this population. Design, Setting, and Participants: This retrospective cohort study analyzed a population-based sample of 219 patients 70 years or older from a database of 1720 patients who underwent skull base surgery at University of North Carolina Hospitals, Chapel Hill, a tertiary referral center, between October 2007 and June 2017...
September 20, 2018: JAMA Otolaryngology—Head & Neck Surgery
Kelvin Robertson, Laurence A G Marshman, David Plummer, Elena Downs
Importance: Optimal pharmacologic treatment for chronic sciatica (CS) is currently unclear. While gabapentin (GBP) and pregabalin (PGB) are both used to treat CS, equipoise exists. Nevertheless, pharmaceutical regulation authorities typically subsidize one drug over the other. This hinders interchange wherever the favored drug is either ineffective or ill-tolerated. Objective: To assess GBP vs PGB head to head for the treatment of CS. Design, Setting, and Participants: A preplanned interim analysis of a randomized, double-blind, double-dummy crossover trial of PGB vs GBP for management of CS at half the estimated final sample size was performed in a single-center, tertiary referral public hospital...
October 15, 2018: JAMA Neurology
Russell G Witt, Michael Zobel, Benjamin Padilla, Hanmin Lee, Tippi C MacKenzie, Lan Vu
Importance: Sutureless gastroschisis repair offers an alternative to the traditional sutured method and has been associated with decreased intubation time. Published study results are inconsistent regarding the advantages of sutureless closure. Objective: To compare the clinical outcomes of sutureless and sutured gastroschisis repair. Design, Setting, and Participants: A single-center cohort review was performed of all consecutive patients (n = 97) who underwent gastroschisis repair from February 1, 2007, to April 30, 2017, at the University of California, San Francisco...
September 19, 2018: JAMA Surgery
Feng Mei, Yanfeng Wu, Guibing Ding, Fenghua Pan, Liang Chen, Jin Wu
OBJECTIVE: To investigate the association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with post-stroke depression risk and antidepressant treatment response in Han Chinese. METHODS: This cross-sectional study was conducted at the Department of Neurology and Neurosurgery, the Second Affiliated Hospital of Nanjing Medical University and Nanjing Brain Hospital, China, between February 2010 and December 2014. It comprised patients who had experienced first-episode acute stroke...
June 2018: JPMA. the Journal of the Pakistan Medical Association
Ellen M Soffin, Avani S Vaishnav, Douglas Wetmore, Lauren Barber, Patrick Hill, Catherine Himo Gang, James D Beckman, Todd J Albert, Sheeraz A Qureshi
STUDY DESIGN: A retrospective cohort study of prospectively-collected data. OBJECTIVE: To describe the development of and early experience with an evidence-based ERAS pathway for lumbar decompression. SUMMARY OF BACKGROUND DATA: Enhanced recovery after surgery (ERAS) protocols have been consistently associated with improved patient experience and outcomes, and reduced cost and length of hospital stay (LoS). Despite successes in other orthopedic subspecialties, ERAS has yet to be established in spine surgery...
October 15, 2018: Spine
Ning A Rosenthal, Kirstin H Heinrich, Jessica Chung, Holly Yu
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To assess hospital resource utilization and costs associated with Staphylococcus aureus infection within 180 days post elective posterior instrumented spinal fusion surgeries (index surgery) between 2010-2015. SUMMARY OF BACKGROUND DATA: Surgical site infections (SSIs) and blood stream infections (BSIs) post spinal fusion surgeries are associated with worse clinical outcomes and increased costs...
October 15, 2018: Spine
Michael S Zastrozhin, Anastasiya P Antonenko, Elena V Nesterenko, Leyla I Seyfullaeva, Violetta R Mustafina, Antonina P Esakova, Elena A Grishina, Alexandr S Sorokin, Valentin Yu Skryabin, Ludmila M Savchenko, Evgeny A Bryun, Dmitry A Sychev
Background Bromodihydrochlorophenylbenzodiazepine (Phenazepam®) is used in the therapy of anxiety disorders in patients with alcohol dependence. However, Phenazepam therapy often turns out to be ineffective, and some patients develop dose-related adverse drug reactions (ADR): severe sedation, dizziness, headache, dyspepsia, falling, etc. That ensures the effectiveness of this category of patients. Despite the popularity of Phenazepam® as an anxiolytic drug, there is currently no accurate data on its biotransformation, as well as the effect of polymorphism of a gene on the efficacy and safety of bromodihydrochlorophenylbenzodiazepine in patients...
October 16, 2018: Drug Metabolism and Personalized Therapy
Maribeth Anne P Gelisanga, Edward James R Gorgon
BACKGROUND: Previous studies have distilled the Upright Motor Control Test Knee Extension and Knee Flexion subscales (UMCT-KE and UMCT-KF, respectively) from the original 6-item instrument and examined these as stand-alone rapid tests of voluntary movement control in the standing position. Systematic review evidence suggests that the UMCT-KE and UMCT-KF may have value in predicting walking ability after stroke. OBJECTIVE: To examine the interrater and intrarater reliability, and concurrent validity of the UMCT-KE and UMCT-KF, and associations with walking ability in adults with subacute stroke...
October 16, 2018: Topics in Stroke Rehabilitation
Alejandra Morales-Cartagena, Mario Fernández-Ruiz, Antonio Lalueza, Jaime Lora-Tamayo, Rafael San Juan, Francisco López-Medrano, Julia Origüen, Fernando Chaves, José María Aguado
BACKGROUND: Recent studies have demonstrated improved survival when the management of Staphylococcus aureus bloodstream infection (BSI) is compliant with evidence-based therapeutic interventions. Whether this effect extends to low-risk sources, such as catheter-related BSI, remains unclear. METHODS: We retrospectively included 225 episodes of methicillin-sensitive S. aureus catheter-related BSI diagnosed in our centre during two non-consecutive periods: 2002-2004 (first period (101 episodes)) and 2009-2013 (second period (124 episodes))...
October 16, 2018: Infectious Diseases
Carlos Roberto Giúdice, Patricio Esteban Lodi, Ana Milena Olivares, Ignacio Pablo Tobia, Gabriel Andrés Favre
PURPOSE: To evaluate safety, efficacy and functional outcomes after open vesicourethral re - anastomosis using different approaches based on previous urinary continence. MATERIALS AND METHODS: Retrospective study of patients treated from 2002 to 2017 due to vesicourethral anastomosis stricture (VUAS) post radical prostatectomy (RP) who failed endoscopic treatment with at least 3 months of follow-up. Continent and incontinent patients post RP were assigned to abdominal (AA) or perineal approach (PA), respectively...
September 20, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Rafael F Coelho, Mauricio D Cordeiro, Guilherme P Padovani, Rafael Localli, Limirio Fonseca, José Pontes, Giuliano B Guglielmetti, Miguel Srougi, William Carlos Nahas
OBJECTIVE: To evaluate the length hospital stay and predictors of prolonged hospitalization after RRP performed in a high-surgical volume teaching institution, and analyze the rate of unplanned visits to the office, emergency care, hospital readmissions and perioperative complications rates. MATERIALS AND METHODS: Retrospective analysis of prospectively collected data in a standardized database for patients with localized prostate cancer undergoing RRP in our institution between January/2010 - January/2012...
September 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Yuika Ikeda, Takekazu Kubo, Eisei Oda, Machiko Abe, Shigeru Tokita
AIMS: This study aimed to describe hospital utilization and examine actual medical costs for severe hypoglycemic events in patients with type 2 diabetes mellitus in Japan. MATERIALS AND METHODS: Medical resource utilization associated with severe hypoglycemia was evaluated using a receipt database of acute-care hospitals in Japan. Patients with type 2 diabetes treated with antihyperglycemic agents were included. Severe hypoglycemic events were identified and divided into 2 groups: with or without hospitalization...
October 16, 2018: Journal of Diabetes Investigation
J F Baekelandt, P A De Mulder, I Le Roy, C Mathieu, A Laenen, P Enzlin, S Weyers, B W J Mol, J J A Bosteels
OBJECTIVE: To compare hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus total laparoscopic hysterectomy (TLH) as a day-care procedure. DESIGN: Parallel group, 1:1 randomised single-centre single -blinded trial, designed as a non- inferiority study with a margin of 15%. SETTING: Belgian teaching hospital. POPULATION: Women aged 18-70 years bound to undergo hysterectomy for benign indication...
October 16, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
S Juujärvi, H Kallankari, P Pätsi, M Leskinen, T Saarela, M Hallman, O Aikio
AIM: We examined the long-term outcomes and safety of early intravenous paracetamol for ductus arteriosus closure at a corrected age of two years. METHODS: This was a follow-up of the 2013-2014 randomised, double-blind Preterm Infant's Paracetamol Study at Oulu University Hospital, Finland, which recruited 48 very preterm infants within 24 hours of birth. They received intravenous paracetamol or a placebo for four days. In 2015-2017 we followed up 44 infants (92%) at two years of corrected age...
October 16, 2018: Acta Paediatrica
Edward C Kuan, Karam W Badran, Frederick Yoo, Naveen D Bhandarkar, Yarah M Haidar, Tjoson Tjoa, William B Armstrong, James N Palmer, Nithin D Adappa, Marilene B Wang, Maie A St John
OBJECTIVES/HYPOTHESIS: To describe rates of complications and mortality within 30 days of open anterior skull base surgery using a large, multi-institutional outcomes database. STUDY DESIGN: Retrospective cohort study. METHODS: The study included patients who underwent open anterior skull base surgery as listed in the American College of Surgeons National Surgical Quality Improvement Project database from 2007 through 2014. RESULTS: A total of 336 open anterior skull base surgeries were identified...
October 16, 2018: Laryngoscope
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