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vascular restenosis

Jérémie Jayet, Raphaël Coscas, Frédéric Heim, Olivier Goeau Brissoniere, Isabelle Javerliat, Nabil Chakfe, Marc Coggia
OBJECTIVES: In the past decade, excimer laser angioplasty (ELA) has emerged in the field of peripheral atherosclerotic disease (PAD). Laser indications now extend to off-label uses, such as in situ fenestration of aortic endograft. The aim of this study was to review the different therapeutics applications of lasers in arterial disease treatment. REVIEW METHODS: We reviewed the English-language literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines...
August 14, 2018: Annals of Vascular Surgery
Mehmet H Kural, Guohao Dai, Laura E Niklason, Liqiong Gui
OBJECTIVE: Invasive coronary interventions can fail due to intimal hyperplasia and restenosis. Endothelial cell (EC) seeding to the vessel lumen, accelerating re-endothelialization, or local release of mTOR pathway inhibitors have helped reduce intimal hyperplasia after vessel injury. While animal models are powerful tools, they are complex and expensive, and not always reflective of human physiology. Therefore, we developed an in vitro 3D vascular model validating previous in vivo animal models and utilizing isolated human arteries to study vascular remodeling after injury...
August 10, 2018: Cell Transplantation
Marc Garbey, Stefano Casarin, Scott A Berceli
Peripheral arterial occlusive disease is a chronic pathology affecting at least 8-12 million people in the USA, typically treated with a vein graft bypass or through the deployment of a stent in order to restore the physiological circulation. Failure of peripheral endovascular interventions occurs at the intersection of vascular biology, biomechanics, and clinical decision making. It is our hypothesis that the majority of endovascular treatment approaches share the same driving mechanisms and that a deep understanding of the adaptation process is pivotal in order to improve the current outcome of the procedure...
August 9, 2018: Biomechanics and Modeling in Mechanobiology
Tammy R Dugas, Gabrielle Brewer, Madison Longwell, Taylor Fradella, Jacob Braun, Carlos E Astete, Merilyn H Jennings, Cristina M Sabliov
Peripheral artery disease is a cardiovascular disease characterized by a narrowing of arteries that supply blood to the extremities, particularly, the legs. When surgical intervention is warranted, the primary approach is balloon angioplasty. Drug coated balloons (DCB) designed to release antimitogenic agents to the site of the blockage are a relatively new product aimed at reducing artery re-narrowing, or restenosis, after intervention. However, first generation DCB utilize mainly direct application of the chemotherapy drug paclitaxel, along with hydrophilic excipients to facilitate uptake into the tissue, and the majority of drug is released from the DCB systemically...
August 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa
Vascular smooth muscle cell (VSMC) migration and the subsequent intimal thickening play roles in vascular restenosis. We previously reported that an exchange protein activated by cAMP 1 (Epac1) promotes platelet-derived growth factor (PDGF)-induced VSMC migration and intimal thickening. Because basic fibroblast growth factor (bFGF) also plays a pivotal role in restenosis, we examined whether Epac1 was involved in bFGF-mediated VSMC migration. bFGF-induced lamellipodia formation and migration were significantly decreased in VSMCs obtained from Epac1-/- mice compared to those in Epac1+/+ -VSMCs...
August 6, 2018: Journal of Physiological Sciences: JPS
Zichao Wu, Ji Zhao, Wenzheng Wu, Peipei Wang, Bofan Wang, Guiwei Li, Shuo Zhang
Biodegradable stents offer the potential to reduce the in-stent restenosis by providing support long enough for the vessel to heal. The polylactic acid (PLA) vascular stents with negative Poisson's ratio (NPR) structure were manufactured by fused deposition modeling (FDM) 3D printing in this study. The effects of stent diameter, wall thickness and geometric parameters of arrowhead NPR structure on radial compressive property of 3D-printed PLA vascular stent were studied. The results showed that the decrease of stent diameter, the increase of wall thickness and the increase of the surface coverage could enhance the radial force (per unit length) of PLA stent...
August 6, 2018: Materials
Chandra S Boosani, Palanikumar Gunasekar, Megan Block, Wanlin Jiang, Zefu Zhang, Mohamed Radwan, Devendra K Agrawal
Increased expression of DNA methyltransferase-1 (DNMT1) associates with the progression of many human diseases. Since DNMT1 induces cell proliferation, drugs that inhibit DNMT1 have been used to treat proliferative diseases. Since these drugs are non-specific inhibitors of DNMT1, subsidiary events or the compensatory mechanisms that are activated in the absence of DNMT1 limit their therapeutic application. Here, we studied the molecular mechanisms that occur during angioplasty-induced restenosis and found that DNMT1 inhibition in both in-vitro and in-vivo approaches resulted in the induction of DNMT3a expression...
August 1, 2018: Canadian Journal of Physiology and Pharmacology
Shougang Sun, Quan Zhang, Qiongying Wang, Qiang Wu, Guangli Xu, Peng Chang, Hao Hu, Feng Bai
OBJECTIVE: To observe the effect of local administration of thalidomide on neointimal formation after balloon-induced carotid artery injury in rats. METHODS: Forty-eight male Sprague-Dawley rats were randomly divided into 3 groups (n = 16): Sham operation group (group A), alone operation group (group B) and Thalidomide group (group C). The carotid arteries of group B and group C were injured by a conventional percutaneous transluminal coronary angioplasty (PTCA) balloon catheter...
February 21, 2018: Pathology, Research and Practice
Masatomo Miura, Kiyofumi Yamada, Seigo Shindo, Kazuma Matsumoto, Kazutaka Uchida, Manabu Shirakawa, Youji Kuramoto, Shinichi Yoshimura
BACKGROUND: Neovascularization (NV) plays an important role in plaque progression and plaque vulnerability. However, visualization of NV is difficult using by standard imaging tools. Recently, optical frequency domain imaging (OFDI) has provided intra-plaque microstructure that could not be visualized by previous imaging modalities. Here, we report a rare case that NV in the carotid plaque was detected both prior to carotid artery stenting (CAS) and in-stent restenotic lesion using OFDI...
July 11, 2018: World Neurosurgery
Ieva Briede, Inga Narbute, Indulis Kumsars, Dace Sondore, Karlis Trushinskis, Sanda Jegere, Gustavs Latkovskis, Karlis Strenge, Ainars Rudzitis, Andrejs Erglis
Aim: The aim of this long-term registry data was to evaluate 2-year clinical and angiographic outcomes after implantation of everolimus-eluting bioresorbable scaffolds (Absorb) from the Latvian Centre of Cardiology Real-life Registry. Material and methods: Between November 2012 and December 2014 in the Centre of Cardiology Real-life Bioresorbable Vascular Scaffold Registry, 187 patients with stable angina or acute coronary syndrome and available 2-year follow-up were selected...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Shasha Yu, Yintao Chen, Shuang Chen, Ning Ye, Yan Li, Yingxian Sun
BACKGROUND It has been proven that phenotype shifting, from the contractile phenotype to the synthetic phenotype, of vascular smooth muscle cells (VSMCs), plays an important role in vascular diseases such as atherosclerosis, restenosis, and hypertension. Recently, accumulating evidence suggests that Klotho is associated with many cardiovascular diseases or damage. Through the estimation of the proliferation and migration of Ang II-induced VSMCs and the related intracellular signal transduction pathways, we researched the effects of Klotho on phenotype modulation in this study...
July 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sandra L Arias, Akshath Shetty, Joshua Devorkin, Jean-Paul Allain
Tissue-engineered vascular grafts (TEVG) use biologically-active cells with or without supporting scaffolds to achieve tissue remodeling and regrowth of injured blood vessels. However, this process may take several weeks because the high hemodynamic shear stress at the damaged site causes cellular denudation and impairs tissue regrowth. We hypothesize that a material with magnetic properties can provide the force required to speed up re-endothelization at the vascular defect by facilitating high cell density coverage, especially during the first 24 h after implantation...
July 10, 2018: Acta Biomaterialia
Jarkko P Hytönen, Jouni Taavitsainen, Johannes T T Laitinen, Anna Partanen, Kari Alitalo, Olli Leppänen, Seppo Ylä-Herttuala
BACKGROUND: Antiproliferative drugs in drug eluting stents (DES) are associated with complications due to impaired re-endothelialization. Additionally, adventitial neovascularization has been suggested to contribute to in-stent restenosis (ISR). Since Vascular Endothelial Growth Factors (VEGFs) are the key mediators of angiogenesis, we investigated feasibility and efficacy of local gene therapy for ISR utilizing soluble decoy VEGF receptors to reduce biological activity of adventitial VEGFs...
July 9, 2018: Journal of Molecular and Cellular Cardiology
Sammy San Myint Aung, Htun Latt, Kyaw Kyaw, Chanwit Roongsritong
Coronary interventions are the mainstay of treatment for stenotic coronary vascular lesions. New stent designs are constantly being evaluated to improve stent performances and clinical outcomes. Coronary stent fracture is uncommon; however, it is associated with potential major consequences including acute coronary syndrome and the need for repeated target vessel revascularization due to in-stent restenosis or stent thrombosis. We report a case of a 66-year-old man with an extensive cardiac disease history, who presented with intractable angina and was found to have a fracture of a current generation, platinum chromium everolimus-eluting stent (Synergy, Boston Scientific Inc...
2018: Case Reports in Cardiology
Laura Z Vanags, Nathan Kum Pang Wong, Stephen James Nicholls, Christina A Bursill
Revascularization because of coronary artery disease is commonly achieved by percutaneous coronary intervention with stent deployment. Refinement in interventional techniques, major improvements in stent design (particularly drug-eluting stents), and adjunctive pharmacotherapy with dual antiplatelet regimens have led to marked reductions in the overall rates of stent failure. However, even with the advancements made in the latest generation of drug-eluting stents, unresolved biological problems persist including delayed re-endothelialization and neoatherosclerosis, which can promote late expansion of the neointima and late stent thrombosis...
June 28, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Qian Yang, Jinrong Peng, Chan Chen, Yao Xiao, Liwei Tan, Xingliang Xie, Xiaohong Xu, Zhiyong Qian
Coronary arterial disease (CAD) remains the leading cause of death globally. Although percutaneous coronary interventions (PCI) are most of the important clinical procedure for CAD treating, unfortunately, vascular restenosis is proved as the major drawback of PCI. Because of the complex nature of the restenotic process, the efficacy of drug administration is emphasized. Targeting drug delivery systems become a promising experimental approach for restenosis therapy. Hence, we design and fabricate a thermo/pH-responsive nanogel system with the magnetic inner core as the multifunctional nanocarrier for drug delivery and MRI/fluorescence imaging...
July 1, 2018: Journal of Biomedical Nanotechnology
Jinxuan Wang, Xuepu Jin, Yuhua Huang, Xiaolin Ran, Desha Luo, Dongchuan Yang, Dongyu Jia, Kang Zhang, Jianhua Tong, Xiaoyan Deng, Guixue Wang
Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease. Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis, the mechanisms that cause this initiation are still not fully understood. In this article, we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects: (i) the interaction of the stent with host blood vessel, involve the response of vascular wall, the mechanism of mechanical signal transmission, the process of re-endothelialization and late thrombosis; (ii) the changes of hemodynamics in the lumen of the vascular segment and (iii) the changes of mechanical microenvironment within the vascular segment wall due to stent implantation...
June 2018: Regenerative Biomaterials
Mahmoud B Malas, Hanaa Dakour-Aridi, Grace J Wang, Vikram S Kashyap, Raghu L Motaganahalli, Jens Eldrup-Jorgensen, Jack L Cronenwett, Marc L Schermerhorn
BACKGROUND: Recent evidence from the Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure (ROADSTER) multicenter trial in high-risk patients undergoing transcarotid artery stenting with dynamic flow reversal reported the lowest stroke rate compared with any prospective trial of carotid artery stenting. However, clinical trials have selection criteria that exclude many patients from enrollment and are highly selective of operators performing the procedures, which limit generalizability...
June 13, 2018: Journal of Vascular Surgery
D F Beloiartsev, O L Talybly
BACKGROUND: It is known that namely long-term presence of suture material as the only foreign body in autologous conditions may lead to restenosis in the remote period. Such hypothesis was put forward based on good results of reconstructive cardiovascular operations in case of using absorbable suture material. OBJECTIVE: Our study was aimed at comparative analysis of remote results of using absorbable suture material polydioxanone and non-absorbable suture material polypropylene in eversion carotid endarterectomy...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
K A Kuznetsov, M V Khar'kova, A A Karpenko, P P Laktionov
Using stents for endovascular restoration of blood flow made a revolution in vascular surgery, however, despite numerous variants of stents presented on the pharmacological market, there are no stents which would completely solve the problem of restenosis in the area of stent placement. In order to decrease growth of the neointima of the stented portions of vessels, stents coated with cytostatic and cytotoxic agents were worked out. To optimize the rate of drug release it was suggested to apply them in a mixture with biodegradable or biostable polymers...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
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