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https://www.readbyqxmd.com/read/30516483/variants-of-endovascular-revascularization-of-lower-limbs-with-critical-is%C3%B0-hemia-doe-extensive-aterosclerosis-and-assessment-of-their-effectiveness
#1
V Goshchynsky, O Lugoviy, P Goshchynsky, S Lugoviy, U Lugoviy
A retrospective analysis of the results of endovascular operations on the arteries of the lower extremities was performed in 209 patients, of which 45 (21.5%) were patients with chronic ischemia of the 2nd stage, category 4, 138 (66.1%) of patients with ischemia of the lower extremities of the third stag, category 5 and 26 (12.4%) of patients with IV stage, category 6 (by classification Rutherford et al., 1997) 17, 187 men, 22 women. The average age of patients was 63.7±9.3 years. Based on clinical and angiographic data, several variants of endovascular revascularization of the lower extremities were used: the vasoballoone segmentation followed by its stenting with a self-expanding stent of Terumo Misago (Japan) or a stent of Palmas Cordis (USA), one stent or two end-to-end stents (the stenting of the artery was supplemented by vasoballoone dilatation of the segment over the stents, between stents or under stents), sub intimal angioplasty was performed under the condition of Re-Entry Outback (Cordis, USA), balloon angioplasty was used using IN cylinders...
October 2018: Georgian Medical News
https://www.readbyqxmd.com/read/30510636/revisiting-endovascular-treatment-in-below-the-knee-disease-are-drug-eluting-stents-the-best-option
#2
EDITORIAL
Stavros Spiliopoulos, Panagiotis M Kitrou, Elias N Brountzos
Patients with below-the-knee arterial disease are primarily individuals suffering from critical limb ischemia (CLI), while a large percentage of these patients are also suffering from diabetes or chronic renal failure or both. Available data from randomized controlled trials and their meta-analysis demonstrated that the use of infrapopliteal drug-eluting stents (DES), in short- to medium- length lesions, obtains significantly better results compared to plain balloon angioplasty and bare metal stenting with regards to vascular restenosis, target lesion revascularization, wound healing and amputations...
November 26, 2018: World Journal of Cardiology
https://www.readbyqxmd.com/read/30497486/fufang-zhenzhu-tiaozhi-capsule-reduces-restenosis-via-the-downregulation-of-nf-kappab-and-inflammatory-factors-in-rabbits
#3
Rendan Zhang, Tudi Li, Jiao Guo, Yanqun Zhao, Yuhong Liu, Yusi Yao, Zhihuan Zeng
BACKGROUND: To investigate the effects of a Chinese herbal medicine Fufang-Zhenzhu Tiaozhi Capsule (FTZ) on restenosis and elucidate the mechanism of action. METHODS: A restenosis model was established by balloon rubbing the endothelium of the abdominal aorta followed by high fat diet. Rabbits were divided into blank control group, restenosis group, FTZ group (0.66 mg/kg/day), atorvastatin group (5 mg/kg/day) and FTZ + atorvastatin group (n = 8). Vascular stenosis was analyzed by X-ray...
November 30, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30485667/biofunctionalized-electrospun-pcl-pibmd-sf-vascular-grafts-with-peg-and-cell-adhesive-peptides-for-endothelialization
#4
Lingchuang Bai, Jing Zhao, Qian Li, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Yakai Feng
Artificial small-caliber vascular grafts are still limited in clinical application because of thrombosis, restenosis, and occlusion. Herein, a small-caliber vascular graft (diameter 2 mm) is fabricated from poly(ε-caprolactone)-b-poly(isobutyl-morpholine-2,5-dione) (PCL-PIBMD) and silk fibroin (SF) by electrospinning technology and then biofunctionalized with low-fouling poly(ethylene glycol) (PEG) and two cell-adhesive peptide sequences (CREDVW and CAGW) with the purpose of enhancing antithrombogenic activity and endothelialization...
November 28, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/30453089/detoxification-and-activating-blood-circulation-decoction-reduces-restenosis-involving-the-tlr4-nf-%C3%AE%C2%BAb-pathway-after-balloon-injury
#5
Guohui Zou, Jinhua Zhu, Zhongyong Liu, Lu Wu, Ri Xu, Hongtao Chen, Peng Deng, Changqing Deng
Restenosis is a major problem after percutaneous coronary intervention (PCI) treatment. Inflammation is one of the major core mechanisms involved in the occurrence of restenosis, and plays an important role in intimal hyperplasia. Detoxification and activating blood circulation decoction (DABCD) is a traditional Chinese medicine that is used in the treatment and prevention of atherosclerotic and inflammatory diseases. Our previous studies demonstrated that DABCD-mediated cardioprotection involves anti-inflammatory mechanisms and could be developed as a novel drug for the treatment of vascular smooth muscle cell (VSMC) proliferation and aortic restenosis...
November 16, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/30410117/a-rapamycin-derivative-biolimus-preferentially-activates-autophagy-in-vascular-smooth-muscle-cells
#6
Yerin Kim, Jun Kyu Park, Jun-Hyuk Seo, Hyun-Seung Ryu, Kyung Seob Lim, Myung Ho Jeong, Dong Hoon Kang, Sang Won Kang
Although rapamycin is a well-known conformational inhibitor of mTORC1, it is now widely used for treating arterial restenosis. Various rapamycin analogues (rapalogue) have been made for applying to drug-eluting stents. Here we show that two major rapalogues, everolimus and biolimus, exert a differential effect on the mTORC1-mediated signaling pathways in vascular smooth muscle cells. In balloon-injured carotid arteries, both rapalogues strongly inhibit neointimal hyperplasia. Signaling pathway analyses reveal that everolimus exert cytotoxicity by increasing cellular reactive oxygen species and consequently reduce energy metabolism...
November 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30407362/coronary-artery-aneurysm-formation-after-drug-coated-balloon-treatment-of-de-novo-lesions-two-case-reports
#7
Hui-Ping Zhang, Xue Yu, Fu-Sui Ji, Fu-Cheng Sun
RATIONALE: The safety and efficacy of drug-coated balloon (DCB) technology have primarily been proven in the treatment of coronary in-stent restenosis. Whereas increasing evidences show that DCB use was feasible in certain de novo coronary lesions. In 2012, Vassilev reported the 1st case in which a coronary aneurysm formed after a DCB was used to treat drug-eluting stent (DES) restenosis. To date, limited information has been reported on coronary artery aneurysm (CAA) development following DCB treatment of de novo lesions...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30405738/plant-derived-products-for-treatment-of-vascular-intima-hyperplasia-selectively-inhibit-vascular-smooth-muscle-cell-functions
#8
REVIEW
Kang Xu, Mohanad Kh Al-Ani, Xin Pan, Qingjia Chi, Nianguo Dong, Xuefeng Qiu
Natural products are used widely for preventing intimal hyperplasia (IH), a common cardiovascular disease. Four different cells initiate and progress IH, namely, vascular smooth muscle, adventitial and endothelial cells, and circulation or bone marrow-derived cells. Vascular smooth muscle cells (VSMCs) play a critical role in initiation and development of intimal thickening and formation of neointimal hyperplasia. In this review, we describe the different originating cells involved in vascular IH and emphasize the effect of different natural products on inhibiting abnormal cellular functions, such as VSMC proliferation and migration...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30371217/cytochrome-p450-1b1-is-critical-for-neointimal-growth-in-wire-injured-carotid-artery-of-male-mice
#9
Kamalika Mukherjee, Chi Young Song, Anne M Estes, Ahmad N Dhodi, Benjamin H Ormseth, Ji Soo Shin, Frank J Gonzalez, Kafait U Malik
Background We have reported that cytochrome P450 1B1 ( CYP 1B1), expressed in cardiovascular tissues, contributes to angiotensin II -induced vascular smooth muscle cell ( VSMC ) migration and proliferation and development of hypertension in various experimental animal models via generation of reactive oxygen species. This study was conducted to determine the contribution of CYP 1B1 to platelet-derived growth factor-BB-induced VSMC migration and proliferation in vitro and to neointimal growth in vivo. Methods and Results VSMC s isolated from aortas of male Cyp1b1 +/+ and Cyp1b1 -/- mice were used for in vitro experiments...
September 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30369549/linagliptin-protects-rat-carotid-artery-from-balloon-injury-and-activates-the-nrf2-antioxidant-pathway
#10
Jiyuan Si, Ranran Meng, Peng Gao, Feifei Hui, Yu Li, Xianhu Liu, Bin Yang
Percutaneous coronary intervention (PCI) is main treatment for acute coronary syndrome (ACS). However, restenosis caused by PCI-induced injury influences the outcome of patients. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, has been reported to ameliorate intimal hyperplasia post vascular injury. The underlying mechanisms by which linagliptin protects against balloon injury are unclear and require to be explored. Herein, Wistar rats with carotid artery balloon injury were given 1, 2 or 3 mg/kg/day linagliprin for 6 weeks...
October 23, 2018: Experimental Animals
https://www.readbyqxmd.com/read/30368024/non-coding-rnas-in-vascular-remodeling-and-restenosis
#11
REVIEW
Ciro Indolfi, Claudio Iaconetti, Clarice Gareri, Alberto Polimeni, Salvatore De Rosa
Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) are crucial in vascular remodeling. They exert pivotal roles in the development and progression of atherosclerosis, vascular response to injury, and restenosis after transcatheter angioplasty. As a witness of their importance in the cardiovascular system, a large body of evidence has accumulated about the role played by micro RNAs (miRNA) in modulating both VSMCs and ECs. More recently, a growing number of long noncoding RNA (lncRNAs) came beneath the spotlights in this research field...
October 24, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/30367355/bioresorbable-scaffold-based-controlled-drug-delivery-for-restenosis
#12
REVIEW
Belay Tesfamariam
Bioresorbable scaffolds have emerged as a potential alternative to non-erodible metal implants to alleviate the long-term risk of permanent device vascular implant-related adverse events. Bioresorbable scaffolds provide a temporary mechanical support function until the vessel reaches complete healing, and the implant progressively disappears and vasomotion resumes. A polymer matrix with embedded drugs coated onto the scaffold surface degrades slowly, reducing the size from the exterior toward the interior, and this allows controlled drug release to a local vascular segment...
October 26, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30364175/weighing-in-on-the-off-label-use-initial-experience-of-neuroform-ez-stenting-for-intracranial-arterial-stenosis-in-45-patients
#13
Zhihua Du, Jing Mang, Shengyuan Yu, Chenglin Tian, Xiangyu Cao, Xinfeng Liu, Renzheng Ma, Rongju Zhang, Bin Lv, Jun Wang
Background: The role of stenting for intracranial arterial stenosis (ICAS) has been increasingly debated due to negative results of randomized trials. Thus, exploration of more appropriate devices may hopefully shed light on the endovascular approach, especially for patients with recalcitrant ICAS related to a high risk of stroke. We sought to present and analyze the data of Neuroform EZ stenting for medically refractory ICAS in a single-center series. Materials and methods: Between November 2016 and January 2018, 45 consecutive patients treated with the Neuroform EZ stent were included in our retrospective study...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30353645/the-effects-of-stenting-on-coronary-endothelium-from-a-molecular-biological-view-time-for-improvement
#14
REVIEW
Anne Cornelissen, Felix Jan Vogt
Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of vascular endothelium. The damaged endothelium is intrinsically repaired by locally derived endothelial cells and by circulating endothelial progenitor cells from the blood, leading to re-population of the denuded regions within several weeks to months. However, the process of re-endothelialization is often incomplete or dysfunctional, promoting in-stent thrombosis and restenosis...
October 23, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30350271/refractory-in-stent-restenosis-improving-outcomes-by-standardizing-our-approach
#15
REVIEW
Ron Waksman, Micaela Iantorno
PURPOSE OF REVIEW: This review will focus on our approach for the treatment of refractory in-stent restenosis. RECENT FINDINGS: The discovery of bare metal stents over three decades ago set a milestone in the evolution of percutaneous coronary intervention, which is currently the most widely performed procedure for the treatment of symptomatic coronary disease. However, the broad utilization of stents resulted in the new phenomenon of in-stent restenosis (ISR). Over the years, there has been an increase of the incidence of ISR despite continued improvement of drug-eluting stent (DES) technology...
October 22, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/30349543/long-pentraxin-3-modulates-the-angiogenic-activity-of-fibroblast-growth-factor-2
#16
REVIEW
Marco Presta, Eleonora Foglio, Ander Churruca Schuind, Roberto Ronca
Angiogenesis, the process of new blood vessel formation from pre-existing ones, plays a key role in various physiological and pathological conditions. Alteration of the angiogenic balance, consequent to the deranged production of angiogenic growth factors and/or natural angiogenic inhibitors, is responsible for angiogenesis-dependent diseases, including cancer. Fibroblast growth factor-2 (FGF2) represents the prototypic member of the FGF family, able to induce a complex "angiogenic phenotype" in endothelial cells in vitro and a potent neovascular response in vivo as the consequence of a tight cross talk between pro-inflammatory and angiogenic signals...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30346080/one-year-clinical-performance-of-absorb-bioresorbable-vascular-scaffold-in-patients-presenting-with-acute-coronary-syndromes-results-from-the-rai-registry
#17
Elisabetta Moscarella, Alfonso Ielasi, Attilio Varricchio, Bernardo Cortese, Bruno Loi, Giuseppe Tarantini, Francesco Pisano, Alessandro Durante, Giampaolo Pasquetto, Alessandro Colombo, Gabriele Tumminello, Luciano Moretti, Paolo Calabrò, Pietro Mazzarotto, Maurizio Tespili, Pedro Silva Orrego, Donatella Corrado, Giuseppe Steffenino
OBJECTIVES: To report 1-year clinical outcomes of bioresorbable vascular scaffold (BVS) in acute coronary syndromes (ACS) population. BACKGROUND: BVS use has rapidly extended to high-risk patients as those presenting with ACS. To date limited data have been reported on BVS performance in ACS patients. METHODS: RAI is a multicenter, prospective registry that included 1,505 patients treated with at least 1 successful BVS implantation. A subgroup analysis on ACS patients was performed and the 1-year outcomes of this cohort compared to the remaining stable coronary artery disease (SCAD) population are reported here...
October 22, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30341828/bioresorbable-vascular-scaffold-for-the-treatment-of-coronary-in-stent-restenosis-new-dawn-or-frost-on-snow
#18
EDITORIAL
Junbo Ge
BVS might be non-inferiority compared to DES or DEB in ISR treatment in terms of 1-year DOCE. BVS, especially thinner-strut stent may be an attractive alternative in ISR setting. Large prospective randomized trials are needed to provide convince evidences to direct clinical practice in the future.
October 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30338120/preservation-of-vascular-endothelial-repair-in-mice-with-diet-induced-obesity
#19
S T Rashid, N J Haywood, N Y Yuldasheva, J Smith, A Aziz, D J A Scott, M T Kearney, S B Wheatcroft
Introduction: Preservation of structural integrity of the endothelial monolayer and maintenance of endothelial cell function are of critical importance in preventing arterial thrombosis, restenosis and atherosclerosis. Obesity has been intimately linked with endothelial dysfunction, and reports of reduced abundance and functional impairment of circulating progenitor cells in obesity have led to the suggestion that defective endothelial repair contributes to obesity-related cardiovascular disease...
October 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/30337379/arterial-occlusions-increase-the-risk-of-in-stent-restenosis-after-vertebral-artery-ostium-stenting
#20
Jingzhi Li, Yang Hua, Laurence Needleman, Flemming Forsberg, John R Eisenbray, Zhaojun Li, Ran Liu, Xiaojie Tian, Liqun Jiao, Ji-Bin Liu
OBJECTIVE: The study was designed to investigate if vascular occlusion in the internal carotid artery (ICA) or the contralateral vertebral artery (VA) contribute to developing in-stent restenosis (ISR) in patients with vertebral artery ostium stenosis (VAOS). METHODS: 420 consecutive patients treated with VAOS stents (from a population of 8145 patients with VAOS) from January 2013 to December 2014 were analyzed in this retrospective study; 216 with drug eluted stents and 204 with bare metal stents...
October 18, 2018: Journal of Neurointerventional Surgery
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