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degradable magnesium

Oscar van Mastrigt, Elisa Di Stefano, Sylviani Hartono, Tjakko Abee, Eddy J Smid
BACKGROUND: Important industrial traits have been linked to plasmids in Lactococcus lactis. RESULTS: The dairy isolate L. lactis subsp. lactis biovar diacetylactis FM03P was sequenced revealing the biggest plasmidome of all completely sequenced and published L. lactis strains up till now. The 12 plasmids that were identified are: pLd1 (8277 bp), pLd2 (15,218 bp), pLd3 (4242 bp), pLd4 (12,005 bp), pLd5 (7521 bp), pLd6 (3363 bp), pLd7 (30,274 bp), pLd8 (47,015 bp), pLd9 (15,313 bp), pLd10 (39,563 bp), pLd11 (9833 bp) and pLd12 (3321 bp)...
August 17, 2018: BMC Genomics
Paridhi Gulati, Devin J Rose
Great Northern beans (GNB) contain appreciable magnesium (Mg), potassium (K), phosphorus (P), and iron (Fe), together with the heat-labile vitamin, folate, and the anti-nutritional compound phytate. Thus, the objective was to increase dialyzability of essential mineral elements while degrading phytate and minimizing destruction of folate through extrusion of GNB. Extrusion resulted in significant (p < 0.05) increases in dialyzability of Mg, P, K, and Fe by as much as 50%, 30%, 5%, and 79%, respectively, while decreasing cadmium (Cd) dialyzability...
December 15, 2018: Food Chemistry
N G Grün, P Holweg, S Tangl, J Eichler, L Berger, J J J P van den Beucken, J F Löffler, T Klestil, A M Weinberg
Fracture treatment in children needs new implant materials to overcome disadvantages associated with removal surgery. Magnesium-based implants constitute a biocompatible and bioresorbable alternative. In adults and especially in children, implant safety needs to be evaluated. In children the bone turnover rate is higher and implant material might influence growth capacity, and the long-term effect of accumulated particles or ions is more critical due to the host's prolonged post-surgery lifespan. In this study we aimed to investigate the degradation behavior of ZX00 (Mg-0...
July 29, 2018: Acta Biomaterialia
Sang-Ho Ye, Yingqi Chen, Zhongwei Mao, Xinzhu Gu, Venkat Shankarraman, Yi Hong, Vesselin Shanov, William R Wagner
Degradable metallic stents, most commonly composed of Mg-based alloys, are of interest as an alternative to traditional metallic stents for application in cardiac and peripheral vasculature. Two major design challenges with such stents are control of the corrosion rate and acute presentation of a nonthrombogenic surface to passing blood. In this study, several types of sulfobetaine (SB)-bearing biodegradable polyurethanes were developed and assessed as physical, chemical, and combination-type coatings for a model degradable Mg alloy, AZ31...
August 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Mazin Alqhazo, Ayat Bani Rashaid
OBJECTIVES: This study investigates the levels of 15 bioelements (calcium, copper, chromium, sodium, iron, magnesium, manganese, zinc, cobalt, selenium, molybdenum, vanadium, potassium, boron, and lithium) in the hair species of Jordanian stutterer. METHODS: The subjects of the study included 25 cases of stuttering, and 25 normal children (age and sex matched). The severity of stuttering (low, moderate, and severe) were assessed using Stuttering Severity Instrument, Fourth edition (SSI-4)...
September 2018: International Journal of Pediatric Otorhinolaryngology
Manzoor Qadir, Sven Schubert, James D Oster, Garrison Sposito, Paramjit S Minhas, Seyed A M Cheraghi, Ghulam Murtaza, Alisher Mirzabaev, Muhammad Saqib
Food insecurity and declining availability of freshwater and new productive land in water-scarce areas and countries necessitate effective use of marginal-quality waters and underperforming soils. High‑magnesium waters and soils are emerging examples of water quality deterioration and land degradation leading to environmental and food security constraints in several irrigation schemes. A ratio of magnesium-to-calcium > 1 in irrigation waters and an exchangeable magnesium percentage > 25% in soils are considered high enough to result in soil degradation and impact crop yields negatively...
November 15, 2018: Science of the Total Environment
Li Tian, Yifeng Sheng, Le Huang, Dick Ho-Kiu Chow, Wing Ho Chau, Ning Tang, To Ngai, Chi Wu, Jian Lu, Ling Qin
Magnesium (Mg) is a potential biomaterial suitable for developing biodegradable orthopaedic implants, especially as internal fixators for fracture fixation at non-load bearing skeletal sites. However, Mg alone cannot provide sufficient mechanical support for stable fracture fixation at load bearing sites due to its rapid degradation in the early stage after implantation. In consideration of the strengths and weaknesses of Mg, we developed an innovative magnesium/titanium (Mg/Ti) hybrid fixation system for long bone fracture fixation and investigated the fixation efficacy...
October 2018: Biomaterials
Song Jiang, Shu Cai, Feiyang Zhang, Peng Xu, Rui Ling, Yue Li, Yangyang Jiang, Guohua Xu
To improve the corrosion resistance and bioactivity of AZ31 magnesium alloy, a crack-free magnesium phytic acid/apatite composite coating was synthesized on AZ31 substrate via chemical conversion deposition and followed a rapid microwave assisted treatment. The influences of pH values of the microwave solution on the morphology, composition and corrosion resistance properties of the composite coating were investigated. An apatite coating with bilayer structure was completely covered the magnesium phytic acid conversion coating after microwave radiation in the solution of pH 6...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Tingzhang Hu, Chun Yang, Song Lin, Qingsong Yu, Guixue Wang
Cardiovascular diseases are one of the major causes of human death in the world. Endovascular stents are the most important implantation devices in cardiovascular intervention, and their efficacy determines the success of cardiovascular disease treatment. In order to reduce the long-term side effects of permanent metallic stents, such as subacute thrombosis and in-stent restenosis, a new generation of endovascular stents so-called "biodegradable stents (BDSs)" is currently being vigorously developed and considered as the most promising candidate...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Y Sasikumar, A Madhan Kumar, R Suresh Babu, Mohammad Mizanur Rahman, Leandro M Samyn, A L F de Barros
Dicalcium phosphate dihydrate (DCPD) brushite coating with flake like crystal structure for the protection of AZX310 and AM50 magnesium (Mg) alloys was prepared through chemical deposition treatment. Chemical deposition treatment was employed using Ca(NO3 )2 ·4H2 O and KH2 PO4 along with subsequent heat treatment. The morphological results revealed that the brushite coating with dense and uniform structures was successfully deposited on the surface of AZX310 and AM50 alloys. The X-ray diffraction (XRD) patterns and Attenuated total reflectance infrared (ATR-IR) spectrum also revealed the confirmation of DCPD layer formation...
July 21, 2018: Journal of Materials Science. Materials in Medicine
Y Li, H Jahr, K Lietaert, P Pavanram, A Yilmaz, L I Fockaert, M A Leeflang, B Pouran, Y Gonzalez-Garcia, H Weinans, J M C Mol, J Zhou, A A Zadpoor
Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most of such biomaterials are, however, based on magnesium and, thus, degrade too fast. Here, we present the first report on topologically ordered porous iron made by Direct Metal Printing (DMP)...
July 6, 2018: Acta Biomaterialia
A Monfared, A Ghaee, S Ebrahimi-Barough
For improving recovery rates and functional outcomes in large nerve defects, a nerve guide conduit, in addition to topographic, physical and chemical cues should provide contact guidance and adequate mechanical support for cell migration and axon outgrowth. Among biomaterials, magnesium (Mg) metal has potential to support nerve regeneration owing to its electrical conductivity, biodegradation and ability to be formed into wires, filaments and ribbons. However, rapid degradation of magnesium can pose a challenge...
June 30, 2018: Colloids and Surfaces. B, Biointerfaces
Fu Yang, Muhammad Akmal Kamarudin, Gaurav Kapil, Daisuke Hirotani, Putao Zhang, Chi Huey Ng, Tingli Ma, Shuzi Hayase
Despite the high efficiency of MAPbI3 perovskite solar cells, the long term stability and degradation in humid atmosphere are issues that still needed to be addressed. In this work, magnesium iodide (MgI2 ) was first successfully used as a dopant into MAPbI3 perovskite prepared in humid air atmosphere. Mg doping decreased the valence band level, which was determined from photoelectron yield spectroscopy. Compared to the pristine MAPbI3 perovskite film, the 1.0% Mg-doped perovskite film showed increased crystal grain size and formation of pinhole-free perovskite film...
July 25, 2018: ACS Applied Materials & Interfaces
R W Lewis, M K LeTourneau, J R Davenport, T S Sullivan
Leaf chlorosis in vineyards is associated with reduced crop yields and quality. While iron (Fe) is understood to play a crucial role in chlorosis, total plant and soil Fe are not always indicative of chlorosis in grapevines. Physiology of chlorosis in vineyards has been well-studied, but the soil microbial consequences of and contributions to chlorosis have received little attention. We used next-generation sequencing (NGS) to examine the bacterial and fungal communities associated with grapevines demonstrating varying degrees of visual chlorosis symptoms...
June 13, 2018: Plant Physiology and Biochemistry: PPB
T T T Trang, J H Zhang, J H Kim, A Zargaran, J H Hwang, B-C Suh, N J Kim
Although magnesium alloys, as the lightest structural alloys, offer significant potential for automotive applications, their applications remain limited due to their poor formability at room temperature. Since the strategies used for improving formability usually result in a degradation of strength, there are no high strength magnesium alloys showing good formability. Here we report an alloy design concept that can simultaneously provide high strength and good formability. Such designed alloy when subjected to an appropriate processing technique shows a combination of strength and formability that surpasses those of the existing magnesium alloys reported so far...
June 28, 2018: Nature Communications
Mohammad Borhan Uddin, Balakavitha Balaravi Pillai, Kyi Kyi Tha, Maeirah Ashaie, Md Emranul Karim, Ezharul Hoque Chowdhury
Specific gene knockdown facilitated by short interfering RNA (siRNA) is a potential approach for suppressing the expression of ion channels and transporter proteins to kill breast cancer cells. The overexpression of calcium ion channels and transporter genes is seen in the MCF-7 breast cancer cell line. Since naked siRNA is anionic and prone to nuclease-mediated degradation, it has limited permeability across the cationic cell membrane and short systemic half-life, respectively. Carbonate apatite (CA) nanoparticles were formulated, characterized, loaded with a series of siRNAs, and delivered into MCF-7 and 4T1 breast cancer cells to selectively knockdown the respective calcium and magnesium ion channels and transporters...
June 26, 2018: Toxics
Tycho Zimmermann, Ana Ferrandez-Montero, Marcela Lieblich, Begoña Ferrari, José Luis González-Carrasco, Wolf-Dieter Müller, Andreas Dominik Schwitalla
OBJECTIVE: The aim of this study was to assess the degradation behavior by measuring the H2 release of a biodegradable composite consisting of a polylactic acid matrix reinforced with 30% wt. spherical magnesium microparticles (PLA/Mg) as potential bone augmentation material in combination with dental implants of either titanium or polyetheretherketone (PEEK) in order to evaluate the potential influence of the titanium dental implants on the corrosion behavior of the Mg particles within the PLA matrix...
June 22, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Emese Hadnagy, Andrew Mai, Benjamin Smolinski, Washington Braida, Agamemnon Koutsospyros
The manufacturing of insensitive munition 2,4-dinitroanisole (DNAN) generates waste streams that require treatment. DNAN has been treated previously with zero-valent iron (ZVI) and Fe-based bimetals. Use of Mg-based bimetals offers certain advantages including potential higher reactivity and relative insensitivity to pH conditions. This work reports preliminary findings of DNAN degradation by three Mg-based bimetals: Mg/Cu, Mg/Ni, and Mg/Zn. Treatment of DNAN by all three bimetals is highly effective in aqueous solutions (> 89% removal) and wastewater (> 91% removal) in comparison with treatment solely with zero-valent magnesium (ZVMg; 35% removal)...
June 16, 2018: Environmental Science and Pollution Research International
Usman Riaz, Leela Rakesh, Ishraq Shabib, Waseem Haider
The issue of long-term incompatible interactions associated with the permanent implants can be eliminated by using various biodegradable metal implants. The recent research is focusing on the use of degradable stents to restore most of the hindrances of capillaries, and coronary arteries by supplying instant blood flow with constant mechanical and structural support. However, internal endothelialization and infection due to the corrosion of implanted stents are not easy to diagnose in the long run. In the recent past, magnesium (Mg) has been widely investigated for the cardiovascular stent applications...
September 2018: Journal of the Mechanical Behavior of Biomedical Materials
Wei Lu, Lei Guo, Tianlong Jiang, Shenghui Ni, Yuyan Zhao
Magnesium alloys have shown potential as biodegradable metallic materials for orthopaedic applications due to their degradability, and their resemblance to cortical bone and biocompatible degradation/corrosion products. However, the fast corrosion rate and the potential toxicity of their alloying element has limited the clinical application of Mg alloys. In the present study, a novel Mg‑2Zn‑0.5Nd alloy was prepared, and then the effects on the cell biological behaviour of the Mg‑2Zn‑0.5Nd alloy was compared with 317L stainless steel and titanium (Ti‑6Al‑4V) alloys as controls...
August 2018: Molecular Medicine Reports
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