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Autologous Fat Transplantation

Danijela Dejanovic, Annemarie Amtoft, Annika Loft
Graft-versus-host-disease (GVHD) following stem cell transplantation (SCT) is a common complication in patients that have undergone allogenic SCT but rare in recipients of autologous SCT. Gastro-intestinal tract (GIT)-GVHD can be difficult to diagnose due to non-specific symptoms such as fever, nausea, diarrhea, and vomiting; a histological confirmation is therefore required. Here, we present the findings of a whole-body 18 FDG PET/CT with extensive and multifocal involvement of the GIT in a patient that developed severe acute GVHD 93 days post autologous SCT for Hodgkin's lymphoma...
October 15, 2018: Diagnostics
Ken-Ichi Inoue, Satoko Kishimoto, Kanya Kaga, Miki Fuse, Akira Furuta, Tomonori Yamanishi
Introduction: Autologous transplantation of adipose stromal vascular fraction (SVF) is a cost-effective and technically accessible option for cell therapy. Clinical study of SVF transplantation for male stress urinary incontinence (SUI) is underway, but the effectiveness remains unknown for female SUI, majority of which is caused by childbirth trauma. Methods: Vaginal Distension (VD) rats were generated as in vivo model for female SUI. To quantitate the severity of SUI, leak point pressure (LPP) was measured by placing a bladder catheter...
June 2018: Regenerative Therapy
Yasuhiro Maruya, Nobuo Kanai, Shinichiro Kobayashi, Kurodo Koshino, Teruo Okano, Susumu Eguchi, Masayuki Yamato
Objective: Adipose-derived stem cells (ASCs) are capable of multiple differentiation pathways, imparting immunomodulatory effects, and secreting factors that are important for wound healing. These characteristics can be exploited to decrease the incidence of anastomotic leakage. Methods: In order to delay local wound healing at the anastomotic site, we induced ischemia in a portion of porcine small intestine by ligating vessels. Then, we injected mitomycin C into the serosa of the small intestine above the ligated vessels...
December 2017: Regenerative Therapy
Anna Jablonka, Jan Scheich, Frank Jacobsen, Tobias Hirsch, Mazen Hagouan, Marcus Lehnhardt, Clemens B Tempfer, Günther A Rezniczek
PURPOSE: Autologous transplantation of adipose tissue into the breast is commonly performed in clinical practice, but its oncological safety has not been established. METHODS: We conducted an in vitro study to assess the influence of factors released by adipose-derived stem cells (ASCs), from multiple source tissues and harvested using different techniques, on proliferation and invasiveness of two breast cancer cell lines. RESULTS: Fat specimens of 66 donors (57 female, 9 male) were collected and 44 ASC cultures were established...
September 24, 2018: Archives of Gynecology and Obstetrics
Yucang He, Xiaofang Yu, Zhuojie Chen, Liqun Li
Autologous fat transplantation is increasingly applied in plastic and reconstructive surgery. Stromal vascular fraction cells (SVFs) combined with angiogenic factors, such as VEGF (vascular endothelial growth factor A) and Ang-1 (angiogenin-1), can improve angiogenesis, which is a critical factor for graft survival. However, direct transplant with such a mixture is insufficient owing to the short half-life of angiogenic factors. In this study, we evaluated whether a double sustained release system of VEGF/ANG-1-PLGA (poly (lactic-co-glycolic acid)) microspheres plus SVFs can improve angiogenesis and graft survival after autologous fat transplantation...
September 21, 2018: Journal of Cellular Physiology
Christian Herold, Hans-Oliver Rennekampff, Sixtus Allert
No abstract text is available yet for this article.
September 3, 2018: Deutsches Ärzteblatt International
Adriana L Carvalho, Bianca Massaro, Luciana T P E Silva, Carlos E G Salmon, Sandra Y Fukada, Marcello H Nogueira-Barbosa, Jorge Elias, Maria C F Freitas, Carlos E B Couri, Maria C Oliveira, Belinda P Simões, Clifford J Rosen, Francisco J A de Paula
Anthropomorphic measures among type 1 diabetic patients are changing as the obesity epidemic continues. Excess fat mass may impact bone density and ultimately fracture risk. We studied the interaction between bone and adipose tissue in type 1 diabetes subjects submitted to two different clinical managements: (I) conventional insulin therapy or (II) autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST). The study comprised 3 groups matched by age, gender, height and weight: control (C = 24), type 1 diabetes (T1D = 23) and type 1 diabetes treated with AHST (T1D-AHST = 9)...
July 5, 2018: Journal of Clinical Densitometry
Sven Holger Baum, Christopher Mohr
PURPOSE: The aim of this study was to examine the indications and results of autologous dermis-fat grafts in the reconstruction of maxillofacial soft-tissue defects. MATERIALS AND METHODS: A total of 93 patients with dermis-fat graft reconstruction due to a soft tissue defect in the head and neck region were enrolled in this retrospective clinical study between March 2002 and January 2017. They were classified into the subgroups 'parotid surgery', 'orbital surgery', and 'facial surgery'...
July 24, 2018: Journal of Cranio-maxillo-facial Surgery
Michael K Cerny, Philipp Moog, Anna-Theresa Bauer, Daniel Schmauss, Laszlo Varga, Matthias M Aitzetmueller, Hans-Günther Machens, Dominik Duscher, Holger Erne
INTRODUCTION: Regardless of the good outcomes of conservatively treated fingertip injuries, many patients complain about volume defects and hypoesthesia. Injection of autologous fat into the defect zone may resolve the volume problem and stimulate digital nerve regeneration by adipose derived stem cell transplantation. METHODS: We analyzed 5 volume defects resulting from conservatively treated fingertip injuries in 4 patients (male to female ratio, 2:2), 6 months after the injection of autologous abdominal fat into the defect zone retrospectively...
July 31, 2018: Annals of Plastic Surgery
Alok Kumar Sahoo, Savita Yadav, Vinod K Sharma, Anita Singh Parihar, Surabhi Vyas, Somesh Gupta
Background: Available options for correction of facial volume loss, such as synthetic fillers, autologous fat and cultured fibroblasts, have limitations viz. temporary effect and high cost. Aim: To assess the use of a novel technique, autologous non-cultured dermal cell suspension transplantation, for correction of localized facial volume loss due to inflammatory pathologies. Methods: It was a pilot study conducted in the Dermatology Outpatient Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India...
July 30, 2018: Indian Journal of Dermatology, Venereology and Leprology
Agata Gorecka, Souzan Salemi, Deana Haralampieva, Federica Moalli, Deborah Stroka, Daniel Candinas, Daniel Eberli, Lukas Brügger
BACKGROUND: Skeletal muscle has a remarkable regenerative capacity. However, extensive damage that exceeds the self-regenerative ability of the muscle can lead to irreversible fibrosis, scarring, and significant loss of function. Adipose-derived stem cells (ADSC) are a highly abundant source of progenitor cells that have been previously reported to support the regeneration of various muscle tissues, including striated muscles. The aim of this study was to evaluate the effect of ADSC transplantation on functional skeletal muscle regeneration in an acute injury model...
July 17, 2018: Stem Cell Research & Therapy
Sławomir Mazur, Aleksandra Zołocińska, Katarzyna Siennicka, Karolina Janik-Kosacka, Anna Chrapusta, Zygmunt Pojda
BACKGROUND: Progress in breast cancer surgery results in a decreased frequency of mastectomy, in the early phases of cancer replaced by breast conserving therapy (lumpectomy). Increased popularity of breast reconstruction by fat or adipose stem cells (ASC)-enriched fat transfer raised uncertainty about the possible risk of increased cancer recurrence. In vitro studies suggest that locally secreted cytokines and reconstructed local blood vessels may stimulate cancer expansion or cancer de novo induction from glandular tissue remaining after lumpectomy...
July 10, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mario Polo
No abstract text is available yet for this article.
August 16, 2018: Aesthetic Surgery Journal
Daphne L Mourits, Maarten P Mourits, Roel J H M Kloos, H Stevie Tan, Annette C Moll, Dyonne T Hartong
BACKGROUND: Cosmetic dissatisfaction, pain, and chronic discharge may present months till years after enucleation in patients operated because of retinoblastoma. If noninvasive treatment modalities are insufficient, socket reconstruction can be considered. In this study, we discuss the results of dermis-fat exchange to treat these problems. METHOD: Four patients with late onset post enucleation socket problems with a request for treatment were included in this prospective study...
October 2018: Ophthalmic Genetics
Yanna Sun, Rongming Zhang, Xu Mao, Mengshu Zhang
Objective: To investigate the early effects of acellular xenogeneic nerve combined with adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) in repairing facial nerve injury in rabbits. Methods: The bilateral sciatic nerves of 15 3-month-old male Sprague-Dawley rats were harvested and decellularized as xenografts. The allogeneic ADSCs were extracted from the neck and back fat pad of healthy adult New Zealand rabbits with a method of digestion by collagenase type Ⅰ and the autologous PRP was prepared by two step centrifugation...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Hong-Yu Yin, Chuan Wang, Zhi-Yong Zhang, Lei Shi, Lin Yin, Wei Liu, Shi Feng, Yi-Lin Cao, Xiao-Jun Tang
BACKGROUND: The relapse of hemifacial microsomia was thought to be highly related to the soft tissue envelope around the mandible angle mainly composed by masseter and medial pterygoid. According to the reason, we tried to apply masseter injection of type A botulinum toxin to weaken the soft envelope tension on the early stage post mandible distraction in adult HFM patients. METHODS: Eight patients diagnosed with HFM were studied and randomly assigned to an experimental or control group...
October 2018: Journal of Craniofacial Surgery
William M Harris, Michael Plastini, Nikolas Kappy, Telisha Ortiz, Shaohua Chang, Spencer Brown, Jeffrey P Carpenter, Ping Zhang
Background: Adipose-derived stem cells (ASCs) assisted lipotransfer have been considered to facilitate the survival of fat grafts. However, emerging evidence of insufficient vascularization is another obstacle for fat graft survival in cell-assisted lipotransfer. Objectives: This study evaluated whether supplementation of differentiated toward an endothelial phenotype ASCs with fat lipoaspirate improves survival and neovascularization in fat transplantation. Methods: ASCs were isolated from human periumbilical fat tissue and cultured in Endothelial Growth Medium for 2wk...
May 28, 2018: Aesthetic Surgery Journal
Bo Zhou, Xiao Zhou, Zan Li, Xiaowei Peng, Lichang Yang, Chunliu Lü, Dajiang Song, Peng Wu, Cuie Peng
Objective: To investigate the effect of indocyanine green (ICG)-based fluorescent angiography in autologous tissue breast reconstruction. Methods: Between June 2016 and June 2017, 14 female patients were treated with the autologous tissue breast reconstruction. The age ranged from 27 to 64 years with the median age of 46.5 years. There were 11 patients of one-stage reconstruction, including 9 with invasive ductal carcinoma of breast, 1 with recurrence tumor on chest wall, and 1 with angiosatcoma in the breast...
April 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Lihong Qiu, Zhaoxiang Zhang, Hui Zheng, Shaoheng Xiong, Yingjun Su, Xianjie Ma, Chenggang Yi
BACKGROUND: The clinical unpredictability of autologous fat grafting originates partially from the unique characteristics of adipose tissue. Evidence of adipose remodeling toward browning (developing of brown-like adipocytes in white adipose tissue) in response to trauma has been emerging. With regard to fat grafting surgery by which adipose tissue depots are directly and ubiquitously traumatized, whether it affects adipose phenotype change toward browning has not been previously reported...
August 2018: Plastic and Reconstructive Surgery
Rami Anderi, Nehman Makdissy, Albert Azar, Francine Rizk, Aline Hamade
BACKGROUND: Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. The potential use of stem cell-based therapies (SCBT) for the repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions, which can be applied to prevent hair loss...
May 15, 2018: Stem Cell Research & Therapy
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