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Autologous Fat Transplantation

Adriana L Carvalho, Bianca Massaro, Luciana T P E Silva, Carlos E G Salmon, Sandra Y Fukada, Marcello H Nogueira-Barbosa, Jorge Elias, Maria C F Freitas, Carlos E B Couri, Maria C Oliveira, Belinda P Simões, Clifford J Rosen, Francisco J A de Paula
Anthropomorphic measures among type 1 diabetic patients are changing as the obesity epidemic continues. Excess fat mass may impact bone density and ultimately fracture risk. We studied the interaction between bone and adipose tissue in type 1 diabetes subjects submitted to two different clinical managements: (I) conventional insulin therapy or (II) autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST). The study comprised 3 groups matched by age, gender, height and weight: control (C = 24), type 1 diabetes (T1D = 23) and type 1 diabetes treated with AHST (T1D-AHST = 9)...
July 5, 2018: Journal of Clinical Densitometry
Sven Holger Baum, Christopher Mohr
PURPOSE: The aim of this study was to examine the indications and results of autologous dermis-fat grafts in the reconstruction of maxillofacial soft-tissue defects. MATERIALS AND METHODS: A total of 93 patients with dermis-fat graft reconstruction due to a soft tissue defect in the head and neck region were enrolled in this retrospective clinical study between March 2002 and January 2017. They were classified into the subgroups 'parotid surgery', 'orbital surgery', and 'facial surgery'...
July 24, 2018: Journal of Cranio-maxillo-facial Surgery
Michael K Cerny, Philipp Moog, Anna-Theresa Bauer, Daniel Schmauss, Laszlo Varga, Matthias M Aitzetmueller, Hans-Günther Machens, Dominik Duscher, Holger Erne
INTRODUCTION: Regardless of the good outcomes of conservatively treated fingertip injuries, many patients complain about volume defects and hypoesthesia. Injection of autologous fat into the defect zone may resolve the volume problem and stimulate digital nerve regeneration by adipose derived stem cell transplantation. METHODS: We analyzed 5 volume defects resulting from conservatively treated fingertip injuries in 4 patients (male to female ratio, 2:2), 6 months after the injection of autologous abdominal fat into the defect zone retrospectively...
July 31, 2018: Annals of Plastic Surgery
Alok Kumar Sahoo, Savita Yadav, Vinod K Sharma, Anita Singh Parihar, Surabhi Vyas, Somesh Gupta
Background: Available options for correction of facial volume loss, such as synthetic fillers, autologous fat and cultured fibroblasts, have limitations viz. temporary effect and high cost. Aim: To assess the use of a novel technique, autologous non-cultured dermal cell suspension transplantation, for correction of localized facial volume loss due to inflammatory pathologies. Methods: It was a pilot study conducted in the Dermatology Outpatient Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India...
July 30, 2018: Indian Journal of Dermatology, Venereology and Leprology
Agata Gorecka, Souzan Salemi, Deana Haralampieva, Federica Moalli, Deborah Stroka, Daniel Candinas, Daniel Eberli, Lukas Brügger
BACKGROUND: Skeletal muscle has a remarkable regenerative capacity. However, extensive damage that exceeds the self-regenerative ability of the muscle can lead to irreversible fibrosis, scarring, and significant loss of function. Adipose-derived stem cells (ADSC) are a highly abundant source of progenitor cells that have been previously reported to support the regeneration of various muscle tissues, including striated muscles. The aim of this study was to evaluate the effect of ADSC transplantation on functional skeletal muscle regeneration in an acute injury model...
July 17, 2018: Stem Cell Research & Therapy
Sławomir Mazur, Aleksandra Zołocińska, Katarzyna Siennicka, Karolina Janik-Kosacka, Anna Chrapusta, Zygmunt Pojda
BACKGROUND: Progress in breast cancer surgery results in a decreased frequency of mastectomy, in the early phases of cancer replaced by breast conserving therapy (lumpectomy). Increased popularity of breast reconstruction by fat or adipose stem cells (ASC)-enriched fat transfer raised uncertainty about the possible risk of increased cancer recurrence. In vitro studies suggest that locally secreted cytokines and reconstructed local blood vessels may stimulate cancer expansion or cancer de novo induction from glandular tissue remaining after lumpectomy...
July 10, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mario Polo
No abstract text is available yet for this article.
July 4, 2018: Aesthetic Surgery Journal
Daphne L Mourits, Maarten P Mourits, Roel J H M Kloos, H Stevie Tan, Annette C Moll, Dyonne T Hartong
BACKGROUND: Cosmetic dissatisfaction, pain, and chronic discharge may present months till years after enucleation in patients operated because of retinoblastoma. If noninvasive treatment modalities are insufficient, socket reconstruction can be considered. In this study, we discuss the results of dermis-fat exchange to treat these problems. METHOD: Four patients with late onset post enucleation socket problems with a request for treatment were included in this prospective study...
June 25, 2018: Ophthalmic Genetics
Yanna Sun, Rongming Zhang, Xu Mao, Mengshu Zhang
Objective: To investigate the early effects of acellular xenogeneic nerve combined with adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) in repairing facial nerve injury in rabbits. Methods: The bilateral sciatic nerves of 15 3-month-old male Sprague-Dawley rats were harvested and decellularized as xenografts. The allogeneic ADSCs were extracted from the neck and back fat pad of healthy adult New Zealand rabbits with a method of digestion by collagenase type Ⅰ and the autologous PRP was prepared by two step centrifugation...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Hong-Yu Yin, Chuan Wang, Zhi-Yong Zhang, Lei Shi, Lin Yin, Wei Liu, Shi Feng, Yi-Lin Cao, Xiao-Jun Tang
BACKGROUND: The relapse of hemifacial microsomia was thought to be highly related to the soft tissue envelope around the mandible angle mainly composed by masseter and medial pterygoid. According to the reason, we tried to apply masseter injection of type A botulinum toxin to weaken the soft envelope tension on the early stage post mandible distraction in adult HFM patients. METHODS: Eight patients diagnosed with HFM were studied and randomly assigned to an experimental or control group...
June 11, 2018: Journal of Craniofacial Surgery
William M Harris, Michael Plastini, Nikolas Kappy, Telisha Ortiz, Shaohua Chang, Spencer Brown, Jeffrey P Carpenter, Ping Zhang
Background: Adipose-derived stem cells (ASCs) assisted lipotransfer have been considered to facilitate the survival of fat grafts. However, emerging evidence of insufficient vascularization is another obstacle for fat graft survival in cell-assisted lipotransfer. Objectives: This study evaluated whether supplementation of differentiated toward an endothelial phenotype ASCs with fat lipoaspirate improves survival and neovascularization in fat transplantation. Methods: ASCs were isolated from human periumbilical fat tissue and cultured in Endothelial Growth Medium for 2wk...
May 28, 2018: Aesthetic Surgery Journal
Bo Zhou, Xiao Zhou, Zan Li, Xiaowei Peng, Lichang Yang, Chunliu Lü, Dajiang Song, Peng Wu, Cuie Peng
Objective: To investigate the effect of indocyanine green (ICG)-based fluorescent angiography in autologous tissue breast reconstruction. Methods: Between June 2016 and June 2017, 14 female patients were treated with the autologous tissue breast reconstruction. The age ranged from 27 to 64 years with the median age of 46.5 years. There were 11 patients of one-stage reconstruction, including 9 with invasive ductal carcinoma of breast, 1 with recurrence tumor on chest wall, and 1 with angiosatcoma in the breast...
April 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Lihong Qiu, Zhaoxiang Zhang, Hui Zheng, Shaoheng Xiong, Yingjun Su, Xianjie Ma, Chenggang Yi
BACKGROUND: The clinical unpredictability of autologous fat grafting originates partially from the unique characteristics of adipose tissue. Evidence of adipose remodeling toward browning (developing of brown-like adipocytes in white adipose tissue) in response to trauma has been emerging. With regard to fat grafting surgery by which adipose tissue depots are directly and ubiquitously traumatized, whether it affects adipose phenotype change toward browning has not been previously reported...
August 2018: Plastic and Reconstructive Surgery
Rami Anderi, Nehman Makdissy, Albert Azar, Francine Rizk, Aline Hamade
BACKGROUND: Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. The potential use of stem cell-based therapies (SCBT) for the repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions, which can be applied to prevent hair loss...
May 15, 2018: Stem Cell Research & Therapy
Ru-Lin Huang, Yun Xie, Wenjin Wang, Pohching Tan, Qingfeng Li
Importance: Previous anatomical and clinical studies have suggested that targeted restoration of the volume and distribution of fat compartments using appropriate cannula entry sites and injection planes is an excellent fat-grafting technique for facial contouring and hand rejuvenation. Objective: To perform subjective and objective evaluations of the safe and effective profile of the targeted fat-grafting technique for temporal hollowing augmentation. Design, Setting, and Participations: In a retrospective cohort study, a total of 96 consecutive patients with temporal hollowing were treated at the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai, China, with the targeted fat-grafting technique from January 1, 2009, to January 1, 2017...
April 19, 2018: JAMA Facial Plastic Surgery
Francesco Egro, Kacey G Marra
Autologous fat transplantation has revolutionized soft tissue reconstruction, but conventional methods remain unpredictable as graft resorption rates are high due to lack of vascularization. The advent of adipose-derived stem cells (ASCs) has led to improvement of fat grafting outcomes, in part to their ability to undergo facile differentiation into adipose tissue, their angiogenic properties, and their ability to express and secrete multiple growth factors. This chapter discusses the isolation and characterization of human ASCs, its expansion in vitro, and relevant in vivo models for adipose tissue engineering...
2018: Methods in Molecular Biology
E López-Ruiz, G Jiménez, W Kwiatkowski, E Montañez, F Arrebola, E Carrillo, S Choe, J A Marchal, M Perán
The success of cell-based approaches for the treatment of cartilage defects requires an optimal autologous cell source with chondrogenic differentiation ability that maintains its differentiated properties and stability following implantation. The objective of this study was to compare the chondrogenic capacity of mesenchymal stem cells (MSCs) isolated from lipoaspirates (ASCs) and the infrapatellar fat pad (IFPSCs) of osteoarthritic patients and treated with transforming growth factor (TGF)-β family-related growth factors...
April 13, 2018: European Cells & Materials
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Shu-Hung Huang, Yu-Hao Huang, Yun-Nan Lin, Su-Shin Lee, Chih-Kang Chou, Tsung-Ying Lin, Hidenobu Takahashi, Yur-Ren Kuo, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
Background: A gummy smile is treated using a number of techniques, including botulinum toxin injection and various surgical interventions. Micro-autologous fat transplantation (MAFT) is a potentially advantageous alternative approach that has not been previously evaluated. Objective: This study sought to determine the long-term results of MAFT in patients with a gummy smile. Methods: Seven patients with gummy smiles were evaluated for MAFT treatment between October 2015 and April 2017...
March 16, 2018: Aesthetic Surgery Journal
Ji Sun Baek, Kun Hae Kim, Jung Hye Lee, Hye Sun Choi
PURPOSE: To assess the ophthalmologic complications after oculofacial plastic and esthetic surgeries, including their incidence and management. METHODS: A retrospective study was performed on 110 patients who presented with ocular complications followed by oculofacial plastic and esthetic surgeries from January 2014 to December 2015. The incidence and management of complications after each surgery or procedure were analyzed. RESULTS: For lower eyelid blepharoplasty, the common complications were chemosis and lower eyelid ectropion...
July 2018: Journal of Craniofacial Surgery
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