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https://www.readbyqxmd.com/read/28941405/the-effect-of-zoledronate-containing-primer-on-dentin-bonding-of-a-universal-adhesive
#1
Walter Zenobi, Victor Pinheiro Feitosa, Maria Elisa Martins Moura, Camillo D'arcangelo, Lidiany Karla de Azevedo Rodrigues, Salvatore Sauro
OBJECTIVES: To evaluate the bonding ability and nanoleakage of a universal adhesive applied to dentin pre-treated using a zoledronate-containing primer (zol-primer) before and after mechanical load cycling. MATERIALS AND METHODS: Flat dentin surfaces obtained from human molars were assigned to one of the following adhesion procedures (n=6): 1-Single Bond Universal (SBU) applied in etch-and-rinse mode; 2- SBU applied as etch-and-rinse after the application of zol-primer; 3- SBU applied in self-etch strategy; 4- SBU applied as self-etch after the use of zol-primer...
September 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28941391/chlorinated-paraffins-leaking-from-hand-blenders-can-lead-to-significant-human-exposures
#2
Bo Yuan, Anna Strid, Per Ola Darnerud, Cynthia A de Wit, Jessica Nyström, Åke Bergman
BACKGROUND: Chlorinated paraffins (CPs, polychlorinated n-alkanes) are versatile, high-production-volume chemicals. A previous study indicated that hand blenders leak CPs into prepared food. OBJECTIVES: (1) to estimate exposure to CPs from hand blender use compared to background CP exposure from diet; (2) to assess the risk from human dietary exposure to CPs from hand blender use; (3) to investigate how hand blenders leak out CPs. METHODS: CPs were analyzed in food market baskets, in cooking oil/water samples (1g oil/100mL water) mixed using 16 different hand blenders, and in dismantled components of the hand blenders...
September 20, 2017: Environment International
https://www.readbyqxmd.com/read/28938627/prostate-tumor-overexpressed-1-ptov1-promotes-docetaxel-resistance-and-survival-of-castration-resistant-prostate-cancer-cells
#3
Verónica Cánovas, Yolanda Puñal, Valentina Maggio, Enric Redondo, Mercedes Marín, Begoña Mellado, Mireia Olivan, Matilde Lleonart, Jacques Planas, Juan Morote, Rosanna Paciucci
Metastatic prostate cancer is presently incurable. The oncogenic protein PTOV1, first described in prostate cancer, was reported as overexpressed and significantly correlated with poor survival in numerous tumors. Here, we investigated the role of PTOV1 in prostate cancer survival to docetaxel and self-renewal ability. Transduction of PTOV1 in docetaxel-sensitive Du145 and PC3 cells significantly increased cell survival after docetaxel exposure and induced docetaxel-resistance genes expression (ABCB1, CCNG2 and TUBB2B)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938618/beclin-1-and-lc3-as-predictive-biomarkers-for-metastatic-colorectal-carcinoma
#4
Hong Zhao, Maopeng Yang, Bin Zhao
Autophagy is a highly conserved self-destructive process that disassembles dysfunctional or unnecessary cellular components. It plays an important role in cancer metastasis, which is of particular interest considering metastatic disease is the major cause of colorectal carcinoma (CRC) related mortality. Here, we investigated the immunohistochemical expression of autophagy-related protein Beclin 1 and Microtubule-associated protein 1A/1B-light chain 3 (LC3) within surgical CRC specimens, first in a training cohort (205 patients), then in an inner validation cohort (160 patients) and an independent cohort (161 patients)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938607/hgfl-mediated-ron-signaling-supports-breast-cancer-stem-cell-phenotypes-via-activation-of-non-canonical-%C3%AE-catenin-signaling
#5
Sasha J Ruiz-Torres, Nancy M Benight, Rebekah A Karns, Elyse E Lower, Jun-Lin Guan, Susan E Waltz
Breast cancer stem cells (BCSCs), which drive tumor progression, recurrence, and metastasis, are considered a major challenge for breast cancer treatments, thus the discovery of novel pathways regulating BCSC maintenance remains essential to develop new strategies to effectively target this population and combat disease mortality. The HGFL-RON signaling is overexpressed in human breast cancers and is associated with increased breast cancer progression, metastasis, and poor prognosis. Here, we report that overexpression of RON/MST1R and HGFL/MST1 in cell lines and primary tumors increases BCSC self-renewal, numbers, and tumorigenic potential after syngeneic transplantation...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938335/statistical-analysis-of-influences-on-the-psychosocial-status-of-children-with-hemangiomas-and-their-families
#6
Ji Ung Park, Soohee Kang, Tae Hyun Choi
The psychologic stress on the child and family, which arise from hemangiomas, the most common neoplasm of childhood, cannot be overestimated. This study determined the preoperative and postoperative psychosocial status and variation among Oriental children with hemangiomas and their families by questionnaire. Thirty patients who underwent surgery for hemangiomas were assessed for preoperative and postoperative psychosocial status by questionnaire. The distribution of the total mean score and variation between the preoperative and postoperative status was estimated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938332/mandibular-condyle-reconstruction-with-fibula-free-tissue-transfer-the-role-of-the-masseter-muscle
#7
Andreas Gravvanis, Dimitrios Anterriotis, Despoina Kakagia
BACKGROUND: Free fibula flap is an option for primary restoration after disarticulation mandibular resection, though literature on technique refinements is scarce. The authors hypothesized that inset of the masseter, the key mandibular elevator muscle, at the reconstructed mandible may optimize functional recovery. METHODS: All patients undergoing reconstruction of mandibulectomy-condylectomy defect (January 2009 to January 2014) by means of a fibular flap were prospectively studied...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938303/optimizing-education-in-difficult-airway-management-meeting-the-challenge
#8
Sheila N Myatra, Rupali S Kalkundre, Jigeeshu V Divatia
PURPOSE OF REVIEW: The last 2 decades have seen a vast change in the science and technology of airway management. As a result, there is an increasing need to equip anesthesiologists with the new knowledge and skills for the safe management of a difficult airway. RECENT FINDINGS: In addition to knowledge and expertise, human factors and nontechnical skills (NTS), including situational awareness, communication and team work, play an important role during difficult airway management and contribute to the outcome...
September 21, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28938204/natural-outdoor-environments-and-mental-health-stress-as-a-possible-mechanism
#9
Margarita Triguero-Mas, David Donaire-Gonzalez, Edmund Seto, Antònia Valentín, David Martínez, Graham Smith, Gemma Hurst, Glòria Carrasco-Turigas, Daniel Masterson, Magdalena van den Berg, Albert Ambròs, Tania Martínez-Íñiguez, Audrius Dedele, Naomi Ellis, Tomas Grazulevicius, Martin Voorsmit, Marta Cirach, Judith Cirac-Claveras, Wim Swart, Eddy Clasquin, Annemarie Ruijsbroek, Jolanda Maas, Michael Jerret, Regina Gražulevičienė, Hanneke Kruize, Christopher J Gidlow, Mark J Nieuwenhuijsen
INTRODUCTION: Better mental health has been associated with exposure to natural outdoor environments (NOE). However, comprehensive studies including several indicators of exposure and outcomes, potential effect modifiers and mediators are scarce. OBJECTIVES: We used novel, objective measures to explore the relationships between exposure to NOE (i.e. residential availability and contact) and different indicators of mental health, and possible modifiers and mediators...
September 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28938116/a-unifying-theory-of-branching-morphogenesis
#10
Edouard Hannezo, Colinda L G J Scheele, Mohammad Moad, Nicholas Drogo, Rakesh Heer, Rosemary V Sampogna, Jacco van Rheenen, Benjamin D Simons
The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochastically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts...
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28938105/how-people-from-ethnic-minorities-describe-their-experiences-of-managing-type-2-diabetes-mellitus-a-qualitative-meta-synthesis
#11
REVIEW
Virginia Jones, Marie Crowe
BACKGROUND: The increasing prevalence of diabetes is well-documented along with the findings that some ethnic minorities have a higher prevalence than non-minority individuals. Along with possible biological differences between ethnicities, access to economic, social, cultural and symbolic capital may impact on the success of managing type-2 diabetes. OBJECTIVES: To examine how people from ethnic minorities in Western countries describe their experiences of managing type-2 diabetes mellitus...
August 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28938102/self-management-support-at-the-end-of-life-patients-carers-and-professionals-perspectives-on-managing-medicines
#12
N Campling, A Richardson, M Mulvey, M Bennett, B Johnston, S Latter
BACKGROUND: Pain is a frequently reported symptom by patients approaching the end of life and well-established that patients and carers hold fears relating to opioids, and experience side effects related to their use. The management of medicines is intrinsic to achieving effective pain relief. The concept of self-management support whilst well characterised in the context of chronic illness has not been elaborated with respect to end of life care. AIM: To identify patient, carer and professional views on the concept of self-management support at end of life, specifically in relation to analgesia and related medicines (for side-effect management) in order to describe, characterise and explain self-management support in this context...
September 6, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28938078/online-lactation-education-for-healthcare-providers-a-theoretical-approach-to-understanding-learning-outcomes
#13
Amanda L Watkins, Joan E Dodgson, Darya Bonds McClain
BACKGROUND: Breastfeeding competencies are not standardized in healthcare education for any of the health professions. A few continuing education/professional development programs have been implemented, but research regarding the efficacy of these programs is scarce. Research aim: After a 45-hour lactation course, (a) Does breastfeeding knowledge increase? (b) Do beliefs and attitudes about infant feeding improve? (c) Does perceived behavioral control over performance of evidence-based lactation support practices increase? and (d) Do intentions to carry out evidence-based lactation support practices increase? METHODS: A nonexperimental pretest-posttest self-report survey design was conducted with a nonprobability sample of participants ( N = 71) in a lactation course...
September 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28938076/fabrication-of-robust-reference-tips-and-reference-electrodes-for-kelvin-probe-applications-in-changing-atmospheres
#14
Matthias Uebel, Ashokanand Vimalanandan, Abdelaziz Laaboudi, Stefan Evers, Martin Stratmann, Detlef Diesing, Michael Rohwerder
The scanning Kelvin probe (SKP) is a versatile method for the measurement of the Volta potential difference between a sample and the SKP tip (Δψsample, SKP-tip). Based on suitable calibration, this technique is highly suited for the application in corrosion science due to its ability to serve as a very sensitive non-contact and non-destructive method for determining the electrode potential, even at buried interfaces beneath coatings or on surfaces covered by ultra-thin electrolyte layers, which are not accessible by standard reference electrodes...
September 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28938068/direct-patterning-of-zinc-sulfide-on-a-sub-10-nanometer-scale-via-electron-beam-lithography
#15
Mohammad S M Saifullah, Mohamed Asbahi, Maryam Binti-Kamran Kiyani, Sudhiranjan Tripathy, Esther A H Ong, Asadullah Ibn Saifullah, Hui Ru Tan, Tanmay Dutta, Ramakrishnan Ganesan, Suresh Valiyaveettil, Karen Siew-Ling Chong
Nanostructures of metal sulfides are conventionally prepared via chemical techniques and patterned using self-assembly. This poses a considerable amount of challenge when arbitrary shapes and sizes of nanostructures are desired to be placed at precise locations. Here we describe an alternative approach of nanoscale patterning of zinc sulfide (ZnS) directly using a spin-coatable and electron beam-sensitive zinc butylxanthate resist without the lift-off or etching step. Time-resolved electron beam damage studies using micro-Raman and micro-FTIR spectroscopies suggest that exposure to a beam of electrons lead to quick disappearance of xanthate moieties most likely via the Chugaev elimination, and further increase of electron dose results in the appearance of ZnS, thereby making the exposed resist insoluble in organic solvents...
September 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28938052/effectiveness-of-tb-sensitization-initiatives-in-improving-the-involvement-of-self-help-group-members-in-rural-tb-control-in-south-india
#16
Beena Thomas, B Priscilla Rebecca, A Dhanalakshmi, S Rani, A Deepa Lakshmi, Basilea Watson, R Vijayalakshmi, M Muniyandi, N Karikalan
Background: The 'End TB strategy' has highlighted the importance of inter-sectoral collaboration and community mobilization for achieving zero TB deaths by 2020. Objective: The aim of the study was to develop and test a model TB sensitization programme involving self help groups (SHGs). Methodology: This experimental study was conducted in two blocks (intervention and control), in Tiruvallur district. The intervention content included short-lecture, musical story telling activity, role play, short film on TB...
December 1, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28938050/markers-of-poor-adherence-among-adults-with-hiv-attending-themba-lethu-hiv-clinic-helen-joseph-hospital-johannesburg-south-africa
#17
Maria Nnambalirwa, Caroline Govathson, Denise Evans, Lynne McNamara, Mhairi Maskew, Peter Nyasulu
Background: To date, there is no consensus on ideal ways to measure antiretroviral treatment (ART) adherence in resource limited settings. This study aimed to identify markers of poor adherence to ART. Methods: Retrospective data of HIV-positive ART-naïve adults initiating standard first-line ART at Themba Lethu Clinic, Helen Joseph Hospital, Johannesburg, South Africa from April 2004 to December 2011 were analysed. Poisson regression models with robust error variance were used to assessed the following potential markers of poor adherence 'last self-reported adherence, missed clinic visits, mean corpuscular volume (MCV), CD4 count against definition of adherence, suppressed HIV viral load using traditional test metrics'...
December 1, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28938023/exploration-of-genetic-architecture-through-sib-ship-reconstruction-in-advanced-breeding-population-of-eucalyptus-nitens
#18
Jaroslav Klápště, Mari Suontama, Emily Telfer, Natalie Graham, Charlie Low, Toby Stovold, Russel McKinley, Heidi Dungey
Accurate inference of relatedness between individuals in breeding population contributes to the precision of genetic parameter estimates, effectiveness of inbreeding management and the amount of genetic progress delivered from breeding programs. Pedigree reconstruction has been proven to be an efficient tool to correct pedigree errors and recover hidden relatedness in open pollinated progeny tests but the method can be limited by the lack of parental genotypes and the high proportion of alien pollen from outside the breeding population...
2017: PloS One
https://www.readbyqxmd.com/read/28937973/oral-and-dental-health-issues-in-people-with-mental-disorders
#19
Julio Torales, Iván Barrios, Israel González
Patients with mental disorders are subject to a greater number of risk factors for oral and dental disease than the general population. This is mostly caused by the side effects of the medications that they receive, lack of self-care, difficulty to access health services, a negative attitude towards healthcare providers, and patients’ lack of cooperation in dental treatments. The most common psychiatric disorders in our population are depression, anxiety disorders, schizophrenia, bipolar disorder, and dementia...
September 21, 2017: Medwave
https://www.readbyqxmd.com/read/28937951/effect-of-stress-level-on-different-forms-of-self-touch-in-pre-and-postadolescent-girls
#20
Kyra Densing, Hippokrates Konstantinidis, Melanie Seiler
Self-touch serves for regulation of both hyper- and hypoarousal. It remains unclear if different forms of self-touch occur in different contexts, and if the regulatory mechanisms are learned or innate. The authors describe forms and context of self-touch, and explore age differences in stress processing. They analyzed hand movements of 10 pre- and 10 postadolescent girls in low-stress and high-stress settings and found 3 forms of self-touch. In postadolescent participants, self-touch 2 (irregular structure, rhythmical, medium intensity) and 3 (phasic structure, single accent, medium intensity) were used for self-regulation, whereas self-touch 1 (irregular structure, single accent, low intensity) had conversational reasons...
September 22, 2017: Journal of Motor Behavior
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