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meta analysis or systematic reviews

Loriann C Garcia, Micky D Eubanks
Not all herbivory is detrimental to plants. In some cases, plants can compensate for herbivory and maintain growth and fitness following damage or even overcompensate for herbivory and perform better than if left undamaged. Examples of overcompensation to vertebrate herbivory are well known, but here we review the literature for examples of reproductive overcompensation (i.e., increased production of traits associated with fitness) and increased vegetative growth (i.e., vegetative overcompensation) following insect herbivory...
December 16, 2018: Ecology
Hong-Xia Wu, Min Zhu, Xiao-Feng Xiong, Jia Wei, Kai-Quan Zhuo, De-Yun Cheng
INTRODUCTION: Cystic fibrosis (CF) is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. The combination of a cystic fibrosis transmembrane conductance regulator (CFTR) corrector and potentiator has provided a benefit by decreasing sweat chloride concentration in CF for the F508del-CFTR homozygous mutation, but it remains controversial in lung function, nutritional status, clinical score and safety. METHODS: The authors performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of combination therapy on lung function, nutritional status, clinical score and safety in CF for the F508del-CFTR homozygous mutation...
December 15, 2018: Advances in Therapy
Melissa Knott, Sherrilene Classen, Sarah Krasniuk, Marisa Tippett, Liliana Alvarez
BACKGROUND: The majority of shift workers experience insufficient sleep as a result of their employment. Insufficient sleep is associated with impaired neurocognitive functioning, affecting key skills required for driving, resulting in shift workers experiencing a disproportionate burden of RTC injuries and fatalities. Yet, to our knowledge, no systematic literature review (SLR) exists to critically appraise and synthesise evidence on the determinants of fitness to drive (assessed on-road) and driving performance (assessed in a driving simulator) in shift workers with insufficient sleep...
December 15, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Manu Gill, Elizabeth Andersen, Norma Hilsmann
OBJECTIVE: In this systematic review we describe best practices for teaching pharmacology to undergraduate baccalaureate nursing students based on the available evidence. Numerous teaching strategies employed in undergraduate pharmacology courses for nursing students have been summarized and compared for their impact on pharmacology knowledge retention, application of pharmacology theory to practice, and student satisfaction. Future directions for research are discussed. DESIGN: The review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews and meta-analyses...
December 7, 2018: Nurse Education Today
Zhiyuan Yu, Jun Zheng, Lu Ma, Rui Guo, Chao You, Hao Li
OBJECTIVE: Intracerebral hemorrhage (ICH) is a kind of stroke which leads to high mortality. Hematoma growth (HG) happens in about one third of all ICH patients and independently related to poor outcome. Previous studies have shown that an indicator on non-contrast computed tomography (NCCT), called hypodensities, can predict HG in ICH patients. Thus, this study was done to assess that predictive validity of this marker for HG prediction. METHODS: Bibliographic databases were searched without language restriction for original investigation on hypodensities an HG in ICH...
December 13, 2018: World Neurosurgery
Brian A Bernet, Erin T Peskura, Samuel T Meyer, Patrick C Bauch, Megan B Donaldson
PURPOSE: To investigate the effects of physical therapy interventions of the hip on outcomes of pain and disability in patients with low back pain. DATA SOURCES: PubMed, CINAHL, Scopus, Web of Science, and SPORTDiscus were searched from inception to 18 April 2018. STUDY SELECTION/ELIGIBILITY CRITERIA: The following inclusion criteria were required to be met: (1) randomized controlled trials; (2) populations with diagnosed low back pain; and (3) interventions that target the hip joint...
December 1, 2018: Musculoskeletal Science & Practice
Lorenzo Fuccio, Douglas Rex, Thierry Ponchon, Leonardo Frazzoni, Mário Dinis-Ribeiro, Pradeep Bhandari, Evelien Dekker, Maria Pellisè, Loredana Correale, Jeanin van Hooft, Rodrigo Jover, Diogo Libanio, Franco Radaelli, Sergio Alfieri, Franco Bazzoli, Carlo Senore, Jaroslaw Regula, Thomas Seufferlein, Thomas Rösch, Prateek Sharma, Alessandro Repici, Cesare Hassan
BACKGROUND & AIMS: Outcomes of endoscopic surveillance following surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection, at anastomoses or non- anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer. METHODS: We searched PubMed, EMBASE, SCOPUS, and the Cochrane Central Register of Clinical Trials through January 1, 2018 to identify studies investigating rates of CRCs at anastomoses or other locations in the colorectum after curative surgery for primary CRC...
December 13, 2018: Gastroenterology
Xia Qiu, Ying Tang, Yan Yue, Yan Zeng, Wenxing Li, Yi Qu, Dezhi Mu
BACKGROUND: Effective diagnostic methods for detecting latent tuberculosis infection (LTBI) are important for its eradication. A number of studies have evaluated the use of interferon gamma-induced protein 10 (IP-10), which is elevated after tuberculosis infection, as a biomarker for LTBI, but conclusive results regarding its effectiveness have not been reported. OBJECTIVES: Our objective was to assess the diagnostic value of IP-10 for LTBI. DATA SOURCES: We searched the PubMed, Embase, the Cochrane Library and Web of Science databases to find eligible studies...
December 13, 2018: Clinical Microbiology and Infection
Flavio D'Ascenzi, Francesca Anselmi, Pietro Piu, Caterina Fiorentini, Salvatore Francesco Carbone, Luca Volterrani, Marta Focardi, Marco Bonifazi, Sergio Mondillo
OBJECTIVES: The aim of this meta-analysis was to derive normal reference values of biventricular size and function estimated by cardiac magnetic resonance (CMR) in competitive athletes. BACKGROUND: Exercise-induced enlargement of cardiac chambers is commonly observed in competitive athletes. However, ventricular dilatation is also a common phenotypic expression of life-threatening cardiomyopathies. The use of CMR for the exclusion of pathology is growing. However, normal reference values have not been established for athletes...
December 6, 2018: JACC. Cardiovascular Imaging
Mohammad Abufaraj, Beat Foerster, Eva Schernhammer, Marco Moschini, Shoji Kimura, Melanie R Hassler, Mark A Preston, Pierre I Karakiewicz, Mesut Remzi, Shahrokh F Shariat
CONTEXT: The optimal treatment of urothelial bladder cancer (UBC) with micropapillary (MP) variant histology is not clear. OBJECTIVE: To review the current literature on disease characteristics and treatment outcomes of MP UBC. EVIDENCE ACQUISITION: A systematic search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Cochrane Handbook for Systematic Reviews of Interventions...
December 12, 2018: European Urology
Pietro Parcesepe, Guido Giordano, Caterina Zanella, Jacopo Giuliani, Filippo Greco, Andrea Bonetti, Massimo Pancione, Erminia Manfrin, Enrico Molinari, Tiziana Pia Latiano, Mario Rosario D'Andrea, Matteo Fassan, Nunzio Olivieri, Andrea Remo
Ewing Sarcoma is a highly lethal undifferentiated tumor of bone. ES is a small round cell tumor with etiological and characteristic chromosomal translocations between TET/FET (TLS/FUS, EWSR1, and TAF15) and ETS (E26 transformation-specific) family genes. Generally, therapeutic approach for metastatic Ewing Sarcoma includes both local (surgery and radiotherapy) and systemic (chemotherapy) disease control with an overall cure rate of 20%. For extra-osseous tumors, the most common primary sites of disease are trunk, extremities, head and neck, retroperitoneum...
November 29, 2018: Pathology, Research and Practice
Wouter R Berger, Eva R Meulendijks, Jacqueline Limpens, Nicoline W E van den Berg, Jolien Neefs, Antoine H G Driessen, Sébastien P J Krul, Wim Jan P van Boven, Joris R de Groot
BACKGROUND: Persistent atrial fibrillation (AF) is associated with higher stroke and mortality risk than paroxysmal AF (pAF). Outcomes of catheter or surgical ablation are worse in patients with persistent AF than in pAF, and the optimal invasive rhythm control strategy has not been established. PURPOSE: We provide a contemporary systematic overview on efficacy and safety of catheter and minimally-invasive surgical ablation for persistent AF. METHODS: We systematically searched EMBASE, MEDLINE and CENTRAL from inception to July 2018 for randomized trials on surgical and catheter ablation, and included all study arms on persistent AF...
November 29, 2018: International Journal of Cardiology
Rajshri M Gartland, Kristin Alves, Níssia C Brasil, Matthew Mossanen, Elizabeth Mort, Cameron D Wright, Carrie C Lubitz, Collin May
BACKGROUND: The practice of overlapping surgery impacts patients, providers, and policy-makers. While several studies have examined the relationship between overlapping surgery and clinical outcomes, a combined analysis of all available data has not been performed. We aimed to evaluate the impact of overlapping surgery on 30-day mortality, morbidity, and length of surgery. METHODS: A systematic literature review revealed all relevant studies examining outcomes of overlapping versus non-overlapping surgery as of March 2018...
December 8, 2018: American Journal of Surgery
Kartiga Thiyagarajah, Leah Ellingwood, Kaitlin Endres, Aaron Hegazi, James Radford, Alla Iansavitchene, Alejandro Lazo-Langner
INTRODUCTION: There is limited data on the occurrence of complications in patients with upper extremity deep vein thrombosis (UEDVT). AIMS: We aimed to determine the frequency of post-thrombotic syndrome (PTS), thrombosis recurrence and major bleeding (MB) in patients with UEDVT. MATERIAL AND METHODS: We conducted a systematic review of the literature including studies from 1970 onwards. We included observational studies, randomized trials, or cases series including >20 patients...
December 8, 2018: Thrombosis Research
Minmin Leng, Peng Liu, Ping Zhang, Mingyue Hu, Haiyan Zhou, Guichen Li, Huiru Yin, Li Chen
This study aims to systematically evaluate the efficacy of Pet robot intervention (PRI) for people with dementia. Two waves of electronic searches of the PubMed, EMBASE, Web of Science, Cochrane library, IEEE Digital Library and PsycINFO databases were conducted. In total, eight articles from six randomized controlled trials (RCTs) met the eligibility criteria and were included in this systematic review. The results of the meta-analysis showed a statistically significant decrease in behavioral and psychological symptoms of dementia (BPSD), especially agitation and depression, in people with dementia who were treated with PRI...
December 6, 2018: Psychiatry Research
A Sampath Kumar, Arun G Maiya, B A Shastry, K Vaishali, N Ravishankar, Animesh Hazari, Shubha Gundmi, Radhika Jadhav
BACKGROUND: Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the literature is lacking. OBJECTIVE: This systematic review and meta-analysis focused on identifying evidence for the effectiveness of a structured exercise intervention program for insulin resistance in T2DM. METHODS: We searched MEDLINE via PubMed, CINHAL, Scopus and Web of Science, and the Cochrane Central Register of Controlled Trials for reports of studies on fasting insulin, homeostatic model assessment for insulin resistance (Homa-IR), fasting blood sugar, glycated hemoglobin and body mass index in patients with T2DM and healthy controls that were published between 1990 and 2017...
December 13, 2018: Annals of Physical and Rehabilitation Medicine
M Vahdaninia, H Mackenzie, T Dean, S Helps
No abstract text is available yet for this article.
December 12, 2018: Annals of Allergy, Asthma & Immunology
Perrine Créquit, Tania Martin-Montoya, Nassima Attiche, Ludovic Trinquart, Alexandre Vivot, Philippe Ravaud
OBJECTIVE: To assess the feasibility of live cumulative network meta-analysis (NMA) taking into account the pace of evidence generation across different medical areas. STUDY DESIGN AND SETTING: We performed a systematic review to identify published NMAs. For each NMA, we calculated the cumulative number of new trials. To assess the feasibility of live cumulative NMA, we considered different update frequencies (4, 6 and 12 months), then evaluated the number of new trials to be included at each update in the NMA and the workload percentage for an update relative to the initial NMA...
December 12, 2018: Journal of Clinical Epidemiology
Hyun Young Lee, Seung Whan Doo, Won Jae Yang, Yun Seob Song, Hwa Yeon Sun, Eli Jongchan Nho, Bora Lee, Jae Heon Kim
OBJECTIVE: To investigate the efficacy and safety of non-invasive intravesical instillation of OBTX-A through systematic review and meta-analysis. Recently, several studies of non-invasive intravesical instillation of Onabotulinum Toxin-A (OBTX-A) have been published. However, its efficacy is not well validated yet compared to well-known efficacy of minimally invasive intravesical injection of OBTX-A. METHOD: Systematic review and meta-analysis were performed to evaluate the efficacy of non-invasive intravesical instillation of OBTX-A in patients with overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS) by measuring outcomes such as urgency episode per 72 hours, frequency per 72 hours, urgency urinary incontinence (UUI), voided volume (VV), post-voided residual volume (PVR), maximum flow rate (Qmax), and patient perception of bladder condition (PPBC)...
December 12, 2018: Urology
Rebecca S Holmes, Elizabeth Crabtree, Marian S McDonagh
AIMS: To review evidence comparing benefits and harms of long-acting insulins in Type 1 and 2 diabetes. METHODS: MEDLINE and two Cochrane databases were searched through February 2018. Two authors selected studies meeting inclusion criteria and assessed their quality. Comparative studies of adult or pediatric patients with diabetes treated with insulin degludec, detemir, or glargine were included. Meta-analysis was used to combine results of similar studies, and the I2 statistic calculated to assess statistical heterogeneity...
December 15, 2018: Diabetes, Obesity & Metabolism
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