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meta analysis or systematic reviews

Daniel Castaneda, Violeta B Popov, Praneet Wander, Christopher C Thompson
BACKGROUND: Bariatric surgery is endorsed by multiple societies as the most effective treatment for obesity. Psychosocial functioning has also been noted to improve for most patients after bariatric surgery. However, some studies have shown an increase in post-operative suicide risk. The aim of this study was to review the published literature and evaluate the association of bariatric surgery with suicide events and suicide/self-harm attempts in patients who have undergone weight loss surgery...
October 20, 2018: Obesity Surgery
Maarten Janssen Lok, Hiromu Miyake, Joshua S O'Connell, Shogo Seo, Agostino Pierro
PURPOSE: The use of mechanical bowel preparation (MBP) before pediatric colorectal surgery remains the standard of care for many pediatric surgeons, though the value of MBP remains unclear. The aim of this study was to systematically review and analyze the effect of MBP on the incidence of postoperative complications; anastomotic leakage, intra-abdominal infection, and wound infection, following colorectal surgery in pediatric patients. METHODS: Embase, MEDLINE, Web of Science, and CINAHL databases were searched to compare the effect of MBP versus no MBP prior to elective pediatric colorectal surgery on postoperative complications...
October 20, 2018: Pediatric Surgery International
Shu-Liang Yang, Shi-Jie Huang
OBJECTIVE: The objective of this meta-analysis was to assess the association between three interleukin-10 (IL-10) promoter single nucleotide polymorphisms (rs1800871, rs1800872, and rs1800896) and periodontitis risk. METHODS: A systematic search was conducted in PubMed, Embase, and China National Knowledge Infrastructure databases and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. RESULTS: Twenty-six studies met the inclusion criteria...
October 12, 2018: Archives of Oral Biology
Baptiste Demey, Claire Tinez, Catherine François, François Helle, Gabriel Choukroun, Gilles Duverlie, Sandrine Castelain, Etienne Brochot
In the last 20 years, the management of BK polyomavirus (BKPyV) reactivation in kidney transplant patients has become a true challenge for the transplant community. The only treatment option is based on the early identification of at-risk patients. The number of reported risk factors for BKPyV reactivation has increased markedly in the literature last years, although they are sometimes in an unclear or contradictory manner. Our purpose is to provide a systematic review and meta-analysis of risk factors for BKPyV viremia and nephropathy described in multivariate analyses...
October 12, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Thomas Van den Broeck, Roderick C N van den Bergh, Nicolas Arfi, Tobias Gross, Lisa Moris, Erik Briers, Marcus Cumberbatch, Maria De Santis, Derya Tilki, Stefano Fanti, Nicola Fossati, Silke Gillessen, Jeremy P Grummet, Ann M Henry, Michael Lardas, Matthew Liew, Olivier Rouvière, Jakub Pecanka, Malcolm D Mason, Ivo G Schoots, Theo H van Der Kwast, Henk G van Der Poel, Thomas Wiegel, Peter-Paul M Willemse, Yuhong Yuan, Thomas B Lam, Philip Cornford, Nicolas Mottet
CONTEXT: In men with prostate cancer (PCa) treated with curative intent, controversy exists regarding the impact of biochemical recurrence (BCR) on oncological outcomes. OBJECTIVE: To perform a systematic review of the existing literature on BCR after treatment with curative intent for nonmetastatic PCa. Objective 1 is to investigate whether oncological outcomes differ between patients with or without BCR. Objective 2 is to study which clinical factors and tumor features in patients with BCR have an independent prognostic impact on oncological outcomes...
October 17, 2018: European Urology
Kofi D Agyeman, Dhanur Damodar, Ian Watkins, Seth D Dodds
BACKGROUND: Radial head arthroplasty is used in the treatment of nonreconstructible radial head fractures. Although traditional implants have been loosely fixed, smooth stemmed implants functioning more as spacers, modern designs have introduced press-fit, tapered implants that articulate at the capitellum with more rigidly maintained congruity. Cemented implants also use rigid initial fixation. This study was conducted to help determine which fixation method results in better functional outcomes: "fixed" or "unfixed...
October 17, 2018: Journal of Shoulder and Elbow Surgery
Richard A Armstrong, Yolande G Squire, Chris A Rogers, Robert J Hinchliffe, Ronelle Mouton
OBJECTIVE: Endovascular aneurysm repair (EVAR) is used increasingly in the management of patients with abdominal aortic aneurysms (AAAs), including in the emergency setting for ruptured AAA. The lower mortality among patients undergoing emergency EVAR under local anesthesia (LA) observed in the Immediate Management of Patients with Rupture: Open Versus Endovascular Repair trial has sparked renewed interest in the anesthesia choice for EVAR. This systematic review evaluates the effect of mode of anesthesia on outcomes after EVAR...
September 15, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Jessell Owens, Jocelyn Compton, Molly Day, Natalie Glass, Ericka Lawler
PURPOSE: The purpose of this study was to systematically review all available literature reporting nonunion rates of ulnar-shortening osteotomies (USO) used for the treatment of ulnar impaction syndrome (UIS) and to compare those rates among transverse versus oblique cuts for the osteotomy. METHODS: Electronic databases including PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched for studies that evaluated outcomes of both transverse and oblique USO for UIS...
October 17, 2018: Journal of Hand Surgery
Li-Jie Xiang, Yan Wang, Guo-Yuan Lu, Qin Huang
OBJECTIVE: Microangiopathy is common after a long duration in type 1 diabetes mellitus (T1DM). Pregnancies with end-age vascular complications are a big challenge to multidisciplinary physicians. The objective of this study was to assess the risk of microangiopathy for adverse pregnancy outcome in T1DM. MATERIALS AND METHODS: PubMed, EMBASE, and Cochrane Library databases were searched for relevant articles appearing in the literature up to October 1, 2017. Analysis of cohort studies were performed with Review Manager 5...
October 2018: Taiwanese Journal of Obstetrics & Gynecology
Mohamed A Abd El Aziz, Ahmed Iraqi, Parvin Abedi, Shayesteh Jahanfar
BACKGROUND: Postpartum hemorrhage (PPH) and the amount of blood loss are directly related to management of the third stage of labor. No previous report has compared the effects of carbetocin to those of misoprostol. The aim of this systematic review was to compare the effects of carbetocin to those of misoprostol for management of the third stage of labor and for the prevention of PPH. METHODS: We searched the Cochrane Library (Central), Web of Science, Scopus, Science Direct, Ovid, clinicaltrial...
October 20, 2018: Systematic Reviews
Øystein Eiring, Kjetil Gundro Brurberg, Kari Nytrøen, Magne Nylenna
BACKGROUND: Conducting systematic reviews is time-consuming but crucial to construct evidence-based patient decision aids, clinical practice guidelines and decision analyses. New methods might enable developers to produce a knowledge base more rapidly. However, trading off scientific rigour for speed when creating a knowledge base is controversial, and the consequences are insufficiently known. We developed and applied faster methods including systematic reviews and network meta-analyses, assessed their feasibility and compared them to a gold standard approach...
October 20, 2018: Systematic Reviews
Christian Ovesen, Jan Purrucker, Christian Gluud, Janus Christian Jakobsen, Hanne Christensen, Thorsten Steiner
BACKGROUND: Acute critical bleeding is one of the most feared complications during treatment with oral anticoagulating agents. As more patients undergo treatment with anticoagulating agents, critically bleeding episodes in patients with vitamin K antagonists, thrombin inhibitor, or factor Xa inhibitor-inducted coagulopathy will be encountered frequently by physicians. Hence, an effective treatment capable of reversing the iatrogenic coagulopathy in the acute setting is needed. In randomised clinical trials and observational studies, prothrombin complex concentrate has been reported to be superior to other acute interventions, and many guidelines recommend prothrombin complex concentrate in treatment of critically bleeding patients...
October 20, 2018: Systematic Reviews
Tawanda M Nyambuya, Phiwayinkosi V Dludla, Bongani B Nkambule
INTRODUCTION: The burden of non-communicable diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) has drastically increased in developing countries over the years. Although recent evidence points to chronic immune activation to be a significant aspect in the pathogenesis and development of T2DM and CVDs, the exact role of T cells is not fully understood. Therefore, we aim to investigate T cell function and cardio vascular risk in T2DM. In addition, the therapeutic effect of blood glucose-lowering drugs to reverse hyperglycaemia induced T cell dysfunction and myocardial infarction will be reviewed...
October 20, 2018: Systematic Reviews
Wen-Li Fang, Mu-Jun Jiang, Bei-Bei Gu, Ying-Mei Wei, Sheng-Nuo Fan, Wang Liao, Yu-Qiu Zheng, Shao-Wei Liao, Ying Xiong, Yi Li, Song-Hua Xiao, Jun Liu
BACKGROUND: Tooth loss is suggested to be associated with an increased risk of dementia in many studies. But the relationship between tooth loss and dementia is not yet fully understood. This systematic review and meta-analysis aimed to determine the relative effect of tooth loss on dementia risk. METHODS: An electronic search of PubMed, Scopus, Embase, and Web of Knowledge was conducted in March 2018 to identify relevant observational studies with the English language restriction...
October 20, 2018: BMC Psychiatry
Michael Van der Elst, Birgitte Schoenmakers, Daan Duppen, Deborah Lambotte, Bram Fret, Bert Vaes, Jan De Lepeleire
BACKGROUND: According to some studies, interventions can prevent or delay frailty, but their effect in preventing adverse outcomes in frail community-dwelling older people is unclear. The aim is to investigate the effect of an intervention on adverse outcomes in frail older adults. METHODS: A systematic review and meta-analysis of Medline, Embase, the Cochrane Library, and Social Sciences Citation Index. Randomized controlled studies that aimed to treat frail community-dwelling older adults, were included...
October 20, 2018: BMC Geriatrics
Antonio Travaglino, Antonio Raffone, Gabriele Saccone, Luigi Insabato, Antonio Mollo, Giuseppe De Placido, Fulvio Zullo
OBJECTIVE: Several markers have been studied to predict the responsiveness of endometrial hyperplasia (EH) and early endometrial cancer (EEC) to progestin therapy. PTEN has played a major role in this field, although its predictive significance is still undefined. We aimed to assess if loss of PTEN expression on pre-treatment endometrial specimen may be a predictive markers of response to progestins in EH and EEC. STUDY DESIGN: MEDLINE, EMBASE, Web of Sciences, Scopus, ClinicalTrial...
October 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Han Mi Jung, Yu Seok Jung, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae
No abstract text is available yet for this article.
October 17, 2018: Journal of the American Academy of Dermatology
Thomas C Randall, Catherine Sauvaget, Richard Muwonge, Edward L Trimble, Jose Jeronimo
Treatment of preinvasive lesions is critical to the success of secondary prevention of cervical cancer. In many settings, however, excision or ablation of preinvasive lesions can prove challenging. Thermal ablation (TA) is a form of treatment for cervical precancer that may present fewer logistical challenges in resource limited settings. In 2013, Dolman and colleagues wrote a meta-analysis of publications reporting cure rates from TA. This included only one article from a low or middle-income country (LMIC)...
October 17, 2018: Preventive Medicine
Junchen Zhu, Yu Zhang, Lvlin Chen, Yan He, Xiaoming Qing
Levosimendan is an inotropic agent that has been shown in small studies to treat low cardiac output syndrome in cardiac surgery. However, large randomised controlled trials (RCTs) have been recently published and presented neutral results. We sought to determine the effect of levosimendan on mortality in adults with low ejection fraction undergoing cardiac surgery. We searched different databases: Medline, Embase, Cochrane Central Register of Controlled Trials, and clinical trial registries. We included RCTs comparing events in the levosimendan versus placebo in adult patients with ejection fraction≤ 35% undergoing cardiac surgery...
October 17, 2018: Anaesthesia, Critical Care & Pain Medicine
Kevin Kn Ho, Paulo H Ferreira, Marina B Pinheiro, Danielle Aquino Silva, Christopher B Miller, Ron Grunstein, Milena Simic
OBJECTIVES: To determine if sleep interventions improve pain and sleep in people with osteoarthritis and/or spinal pain compared to control/placebo. DESIGN: Medline, Embase, AMED, PsycINFO, CENTRAL, CINAHL and PEDro were searched from their inception date to July 2017. Keywords relating to "sleep", "osteoarthritis", "spinal pain", and "randomized controlled trial" were combined. Included RCTs investigated the use of sleep interventions for people with osteoarthritis and/or spinal pain, and measured at least one sleep and health related outcome...
October 17, 2018: Osteoarthritis and Cartilage
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