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meta analysis or systematic reviews

Lingyue Ma, Xiaodan Zhang, Qian Xiang, Shuang Zhou, Nan Zhao, Qiufen Xie, Xia Zhao, Ying Zhou, Yimin Cui
BACKGROUND: The effect of risperidone treatment in patients with schizophrenia varies according to the dopamine receptor genes. This study aimed to evaluate the relationship between genes of the dopamine receptors (D1, D2, and D3) and the effect of risperidone treatment. METHODS: Three electronic databases (PubMed, Embase and Cochrane Library) were searched for relevant cohort or case-control studies published before 9 May 2018. A systematic review and meta-analysis was performed for qualitative and quantitative assessment of the relationship between the dopamine receptors D1, D2 and D3 (DRD1, 2 and 3) and the effect of risperidone treatment...
August 13, 2018: Basic & Clinical Pharmacology & Toxicology
Eleni Pitsouni, Themos Grigoriadis, Athanasios Douskos, Margarita Kyriakidou, Matthew E Falagas, Stavros Athanasiou
Genitourinary syndrome of menopause (GSM) increases the probability of female sexual dysfunction (FSD). The aim of the current study is to systematically assess data regarding sexual function and use of vaginal therapies, alternative to vaginal estrogens (VE), in menopausal women with GSM. PubMed, Scopus and Cochrane Library were searched (May-September 2017) using combination keywords: "dyspareunia and vaginal therapy", "sexual function and vaginal therapy", "orgasm and vaginal therapy", "vaginal atrophy" and "genitourinary syndrome of menopause"...
August 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Virginie Dufrost, Jessie Risse, Tatiana Reshetnyak, Maria Satybaldyeva, D U Yao, Xin-Xin Yan, Stella Salta, Grigorios Gerotziafas, Zhi-Cheng Jing, Ismaël Elalamy, Denis Wahl, Stéphane Zuily
BACKGROUND: Direct oral anticoagulants (DOACs) are widely used for secondary prevention of venous thromboembolism (VTE) but their clinical efficacy and safety are not established in Antiphospholipid Syndrome (APS) patients. There is only one randomized controlled trial published while others are still ongoing. Many non-randomized studies have been published in this field with conflicting opinions. PURPOSE OF REVIEW: We conducted a systematic review using MEDLINE, EMBASE and Cochrane databases from 2000 until March 2018 regarding APS patients treated with DOACs...
August 10, 2018: Autoimmunity Reviews
Ruchao Ma, Xiaoyun Zhu, Bo Yan
BACKGROUND: Studies have suggested that high-density lipoprotein (HDL) stimulates scavenger receptor class B type 1 (SR-B1) to promote hepatic uptake of cholesterol. SR-B1 is encoded by scavenger receptor class B member 1 (SCARB1) gene in human. A rare mutation in SCARB1 gene has been associated with coronary heart disease (CHD). A polymorphism rs5888 of SCARB1 gene has been linked to CHD risk in humans. OBJECTIVES: The objective was to investigate the relationship between the SCARB1 gene polymorphism rs5888 and risk of CHD...
August 10, 2018: Gene
Huideng Long, Ganxiong Li, Xiaoman Wen, Yanmin Lv, Min Zhang, Yuanfeng Wei, Wenting Xie, Peng Zhong, Lijuan Pang
AIM: The purpose of this study was to evaluate the impact of β-catenin immunohistochemical expression on the prognostic of ovarian cancer (OC) for that β-catenin could be responsible for the development and progress of OC. METHODS: We searched various databases to identify eligible studies, and Review Managers 5.2 software was fulfilled in the meta-analysis. RESULTS: A total of 11 studies were defined and composed in 1858 cases. β-catenin expression was significantly correlated with poor overall survival (OS) in OC patients (HR: 2...
August 10, 2018: Gene
Guillaume Butler-Laporte, Samuel de l'Étoile-Morel, Matthew P Cheng, Emily G McDonald, Todd C Lee
BACKGROUND: Vancomycin is often used as empiric therapy for methicillin-resistant Staphylococcus aureus (MRSA), but can be associated with clinically important adverse events including renal failure. MRSA colonization swabs are primarily used for infection control; their use as a diagnostic test to inform the decision to add empiric vancomycin therapy has not been well elucidated. METHODS: We performed a Medline and Embase systematic review for peer-reviewed studies reporting the diagnostic accuracy of using MRSA colonization status to predict MRSA infections...
August 10, 2018: Journal of Infection
Bibiana Sgorla de Almeida, Yara Costa Netto Muniz, Alice Heidrich Prompt, Erick C Castelli, Celso Teixeira Mendes-Junior, Eduardo Antonio Donadi
BACKGROUND: HLA-G is an immune checkpoint molecule. Since a differential molecule expression has been reported even for healthy individuals, many studies have focused on polymorphisms at HLA-G regulatory regions, particularly the 3' untranslated region (3'UTR). The presence/absence of a 14-bp sequence was the first polymorphism described and it is the most studied in association between HLA-G and disorders. METHODS: In this study, we performed a systematic review and meta-analysis of all association studies published regarding the HLA-G 14-bp...
August 10, 2018: Human Immunology
Elizabeth A Martin, Amanda McCleery, Melody M Moore, Jonathan K Wynn, Michael F Green, William P Horan
BACKGROUND: Although individuals with, or at risk for, psychotic disorders often show difficulties with performance monitoring and feedback processing, findings from studies using event-related potentials (ERPs) to index these processes are not consistent. This meta-analytic review focused on studies of two different indexes of performance monitoring, the early error-related negativity (ERN; n = 25) and the later error positivity (Pe; n = 17), and one index of feedback processing, the feedback negativity (FN; n = 6)...
August 10, 2018: International Journal of Psychophysiology
Kathryn E Smith, Tyler B Mason, Jeffrey S Johnson, Jason M Lavender, Stephen A Wonderlich
OBJECTIVE: In recent years there has been increasing clinical and empirical interest in neurocognitive functioning in eating disorders (EDs), which has resulted in numerous quantitative and qualitative reviews. However, there has yet to be a comprehensive synthesis or critical review of this literature to identify future directions to advance the field in this area. Therefore the aim of this systematic review of systematic reviews was to (a) characterize the existing literature on neurocognitive functioning in EDs based on recent reviews (i...
August 13, 2018: International Journal of Eating Disorders
Michiel H F Poorthuis, Eelco C Brand, Alison Halliday, Richard Bulbulia, Michiel L Bots, Gert J de Borst
OBJECTIVE: To examine the association between operator or hospital volume and procedural outcomes of carotid revascularization. BACKGROUND: Operator and hospital volume have been proposed as determinants of outcome after carotid endarterectomy (CEA) or carotid artery stenting (CAS). The magnitude and clinical relevance of this relationship are debated. METHODS: We systematically searched PubMed and EMBASE until August 21, 2017. The primary outcome was procedural (30 days, in-hospital, or perioperative) death or stroke...
August 10, 2018: Annals of Surgery
Trevor A McGrath, Patrick M Bossuyt, Paul Cronin, Jean-Paul Salameh, Noémie Kraaijpoel, Nicola Schieda, Matthew D F McInnes
As defined by the Cochrane Collaboration, a systematic review is a review of evidence with a clearly formulated question that uses systematic and explicit methods to identify, select, and critically appraise relevant primary research, and to extract and analyze data from the studies that are included in the review. Meta-analysis is a statistical method to combine the results from primary studies that accounts for sample size and variability to provide a summary measure of the studied outcome. Systematic reviews of diagnostic test accuracy present unique methodological and reporting challenges not present in systematic reviews of interventions...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
F Crawford, G Cezard, M Chappell
AIMS: Diabetes guidelines recommend screening for the risk of foot ulceration but vary substantially in the underlying evidence base. Our purpose was to derive and validate a prognostic model of independent risk factors for foot ulceration in diabetes using all available individual patient data from cohort studies conducted worldwide. METHODS: We conducted a systematic review and meta-analysis of individual patient data from 10 cohort studies of risk factors in the prediction of foot ulceration in diabetes...
August 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Abby Hunter, Rachael Murray, Laura Asher, Jo Leonardi-Bee
Introduction: The association between cigarette smoking and schizophrenia is well established. However, up to 90% of people with schizophrenia begin smoking before the onset of their illness, thus smoking could be an independent risk factor for schizophrenia. Prenatal exposure to maternal cigarette smoke is also associated with psychiatric problems in adolescence. Therefore, our aim was to undertake a systematic review and meta-analysis to explore the effect of smoking, and prenatal smoke exposure, on risk of schizophrenia...
August 9, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Amirhossein Sahebkar, Luis E Simental-Mendía, Dimitri P Mikhailidis, Matteo Pirro, Maciej Banach, Cesare R Sirtori, Željko Reiner
BACKGROUND: Apolipoprotein C-III (apo C-III) is a key regulator of triglycerides metabolism. The aim of this meta-analysis was to assess the effect of fish omega-3 polyunsaturated fatty acids (PUFAs) on apo C-III levels. METHODS: Randomized placebo-controlled trials investigating the impact of omega-3 on apo C-III levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar. A random-effects model and generic inverse variance method were used for quantitative data synthesis...
August 13, 2018: Annals of Medicine
Rafael G Dos Santos, José Carlos Bouso, Miguel Ángel Alcázar-Córcoles, Jaime E C Hallak
Mood, anxiety, and substance use disorders are among the most prevalent psychiatric disorders in the population. Although several pharmacological treatments are available, they are not effective for a significant proportion of patients and are associated with several adverse reactions. Therefore, new treatments should be explored. Recent with serotonergic hallucinogens/psychedelics including ayahuasca, psilocybin and lysergic acid diethylamide (LSD) suggest that these drugs have anxiolytic, antidepressive, and antiaddictive effects...
August 13, 2018: Expert Review of Clinical Pharmacology
Abbas Peymani, Anna Rose Johnson, Arriyan S Dowlatshahi, Johannes G G Dobbe, Samuel J Lin, Joseph Upton, Geert J Streekstra, Simon D Strackee
BACKGROUND: Madelung deformity is a congenital wrist condition characterized by volar subluxation of the wrist caused by premature growth arrest of the distal radius. Progressive symptoms can necessitate surgical intervention, yet optimal treatment strategy remains unknown. The aim of this study is to determine treatment options, surgical indications, and operative outcomes for Madelung deformity. METHODS: This study adhered to the Meta-Analyses of Observational Studies in Epidemiology (MOOSE) guidelines...
August 13, 2018: Hand: Official Journal of the American Association for Hand Surgery
Courtney Casserly, Estelle E Seyman, Paula Alcaide-Leon, Melanie Guenette, Carrie Lyons, Stephanie Sankar, Anton Svendrovski, Stefan Baral, Jiwon Oh
BACKGROUND AND PURPOSE: Spinal cord atrophy (SCA) is an important emerging outcome measure in multiple sclerosis (MS); however, there is limited consensus on the magnitude and rate of atrophy. The objective of this study was to synthesize the available data on measures of SCA in MS. METHODS: Using published guidelines, relevant literature databases were searched between 1977 and 2017 for case-control or cohort studies reporting a quantitative measure of SCA in MS patients...
August 13, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Stuart B Murray, Daniel S Quintana, Katharine L Loeb, Scott Griffiths, Daniel Le Grange
BACKGROUND: To determine the impact of specialized treatments, relative to comparator treatments, upon the weight and psychological symptoms of anorexia nervosa (AN) at end-of-treatment (EOT) and follow-up. METHODS: Randomized controlled trials (RCTs) between January 1980 and December 2017 that reported the effects of at least two treatments on AN were screened. Weight and psychological symptoms were analyzed separately for each study. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed, and studies were assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria and Cochrane risk of bias tool...
August 13, 2018: Psychological Medicine
Pavlos Texakalidis, Stefanos Giannopoulos, Anil K Jonnalagadda, Rohan V Chitale, Pascal Jabbour, Ehrin J Armstrong, Gregory G Schwartz, Damianos G Kokkinidis
PURPOSE: To determine through meta-analysis whether administration of statins before carotid artery stenting (CAS) is associated with fewer periprocedural adverse events. METHODS: All randomized and observational English-language studies of periprocedural statin administration prior to CAS that reported the outcomes of interest (stroke, transient ischemic attack, myocardial infarction, and death at 30 days) were included in a random-effects meta-analysis. The I2 statistic was used to assess heterogeneity...
August 13, 2018: Journal of Endovascular Therapy
Wen Li, Zhong Qin, Jie Gao, Zhibin Jiang, Yihui Chai, Liancheng Guan, Yunzhi Chen
Non-cystic fibrosis (non-CF) bronchiectasis is a condition characterized by an airway inflammatory response to bacterial pathogens. Frequent exacerbations have a major influence on the quality of life. Macrolide antibiotics have not only antibacterial but also immune-regulation effects. It is proved that macrolides have a benefit in preventing exacerbations. However, it is still uncertain whether azithromycin or erythromycin is more effective and safe. The purpose of this study was to answer the following question: Which kind of macrolide antibiotic is more effective and safe in preventing non-CF bronchiectasis exacerbation? We conducted a systematic review to identify randomized clinical trials published up to May 2017 that reported on macrolides for non-CF bronchiectasis and an adjusted indirect treatment comparison (AITC) between macrolides to evaluate their efficacy and safety...
August 12, 2018: Chronic Respiratory Disease
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