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Albert C Aragonès, Nadim Darwish, Simone Ciampi, Li Jiang, Raphael Roesch, Eliseo Ruiz, Christian A Nijhuis, Ismael Díez-Pérez
This paper reports highly efficient coherent tunneling in single-molecule wires of oligo-ferrocenes with one to three Fc units. The Fc units were directly coupled to the electrodes, i.e. without chemical anchoring groups between the Fc units and the terminal electrodes. We found that a single Fc unit readily interacts with the metal electrodes of an STM-break junction (STM = scanning tunneling microscope) and that the zero-voltage bias conductance of an individual Fc molecular junction increased 5-fold, up to 80% of the conductance quantum Go (77...
December 5, 2018: Journal of the American Chemical Society
Mirela C M Prates, Edwin Tamashiro, José L Proenca-Modena, Miriã F Criado, Tamara H Saturno, Anibal S Oliveira, Guilherme P Buzatto, Bruna L S Jesus, Marcos G Jacob, Lucas R Carenzi, Ricardo C Demarco, Eduardo T Massuda, Davi Aragon, Fabiana C P Valera, Eurico Arruda, Wilma T Anselmo-Lima
We sought to investigate the prevalence of potentially pathogenic bacteria in secretions and tonsillar tissues of children with chronic adenotonsillitis hypertrophy compared to controls. Prospective case-control study comparing patients between 2 and 12 years old who underwent adenotonsillectomy due to chronic adenotonsillar hypertrophy to children without disease. We compared detection of Streptococcus pneumoniae , Haemophilus influenzae , Staphylococcus aureus, Pseudomonas aeruginosa , and Moraxella catarrhalis by real-time PCR in palatine tonsils, adenoids, and nasopharyngeal washes obtained from 37 children with and 14 without adenotonsillar hypertrophy...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
Stephania Aragón-Rojas, María Ximena Quintanilla-Carvajal, Humberto Hernández-Sánchez
This study aims to evaluate the multifunctional role of whey culture medium during the spray drying microencapsulation of Lactobacillus fermentum K73. Whey culture medium containing growing microorganisms served to hydrate different mixtures (gum arabic, maltodextrin and whey). We evaluated the use of these mixtures as carbon sources and their protective effects on simulated gastrointestinal conditions. The optimal mixture was spray-dried while varying the outlet temperature and atomizing pressure using a response surface design...
September 2018: Food Technology and Biotechnology
Shashikant Apte, Jordi Navarro-Puerto, Sharat Damodar, Vijay Ramanan, Joseph John, Giraldo Kato, Cecil Ross, Chirag Shah, Marcela Torres, Chieh-Lin 'Kathy' Fu, Karen Rucker, Paul Pinciaro, Gladis Barrera, Maria Esperança Aragonés, Jaume Ayguasanosa
AIM: To evaluate the safety and efficacy of 10% intravenous immunoglobulin (IVIG; Flebogamma®  10% DIF) in individuals with chronic immune thrombocytopenic purpura (ITP). PATIENTS & METHODS: Patients aged 3-70 years, diagnosed with chronic ITP, received 1 g/kg IVIG over two consecutive days. RESULTS:  64 evaluable patients (51 adults, 13 children) with chronic ITP received IVIG. The primary efficacy end point (increased platelet counts from ≤20 × 109 /l to ≥50 × 109 /l by day 8) was achieved by 81...
November 30, 2018: Immunotherapy
Sebastian Steiner, Jakob Wolf, Stefan Glatzel, Anna Andreou, Jarosław M Granda, Graham Keenan, Trevor Hinkley, Gerardo Aragon-Camarasa, Philip J Kitson, Davide Angelone, Leroy Cronin
The synthesis of complex organic compounds is largely a manual process that is often incompletely documented. To address these shortcomings, we developed an abstraction that maps commonly reported methodological instructions into discrete steps amenable to automation. These unit operations were implemented in a modular robotic platform using a chemical programming language which formalizes and controls the assembly of the molecules. We validated the concept by directing the automated system to synthesize three pharmaceutical compounds, Nytol, rufinamide, and sildenafil, without any human intervention...
November 29, 2018: Science
Irene Lorenzo, Nerea Fernández-de-Larrea, Angelika Michel, Beatriz Romero, Virginia Lope, Xavier Bessa, Victor Moreno, Vicente Martín, Pilar Amiano, Jesús Castilla, Adonina Tardón, Trinidad Dierssen-Sotos, Rosana Peiró, Marian Díaz-Santos, Carmen Navarro, José J Jiménez-Moleón, Julia Butt, Aurelio Barricarte, Irune Ruiz, Antonio J Molina-de-la-Torre, Delphine Casabonne, Beatriz Pérez-Gómez, Manolis Kogevinas, Rosa Del Campo, Silvia de Sanjosé, Marina Pollán, Tim Waterboer, Nuria Aragonés
Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. The aim of this study was to describe the association of adult and childhood sociodemographic factors with the seroprevalence of H. pylori, and with CagA and VacA antigen-specific seropositivity among H. pylori-seropositive individuals in the Spanish adult population. Serum antibody reactivity to H...
November 26, 2018: European Journal of Cancer Prevention
M C Castillejos, C Martín-Pérez, F Mayoral-Cleries, A Bordallo-Aragón, J Sepúlveda-Muñoz, B Moreno-Küstner
BACKGROUND: Patients with psychiatric disorders have more physical problems than other patients, so their follow-up by the general practitioner is particularly important for them. METHODS: We aimed to elaborate a multilevel explanatory model of general practitioner (GP) visits made by patients with schizophrenia and related disorders (SRD). An observational, cross-sectional study was conducted from January 1, 2008 to July 1, 2011, in the area of the Clinical Management Unit of Mental Health (CMU-MH) of the Regional Hospital of Malaga (Spain)...
November 28, 2018: BMC Family Practice
José María Llorente, Bárbara Oliván-Blázquez, María Zuñiga-Antón, Bárbara Masluk, Eva Andrés, Javier García-Campayo, Rosa Magallón-Botaya
Major depression etiopathogenesis is related to a wide variety of genetics, demographic and psychosocial factors, as well as to environmental factors. The objective of this study is to analyze sociodemographic and environmental variables that are related to the prevalence of depression through correlation analysis and to develop a regression model that explains the behavior of this disease from an ecological perspective. This is an ecological, retrospective, cross-sectional study. The target population was 1,148,430 individuals over the age of 16 who were registered in Aragon (Spain) during 2010, with electronic medical records in the community's primary health care centers...
2018: Frontiers in Psychology
Luis Aragón
Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and condensin with functions in DNA repair. As novel functions for cohesin and condensin complexes in the organization of long-range chromatin architecture have recently emerged, new unsuspected roles for Smc5/6 have also surfaced. Here, I aim to provide a comprehensive overview of our current knowledge of the Smc5/6 complex, including its long-established function in genome stability, its multiple roles in DNA repair, and its recently discovered connection to the transcription inhibition of hepatitis B virus genomes...
November 23, 2018: Annual Review of Genetics
Cristina Ramírez-Aragón, Joaquín Ordieres-Meré, Fernando Alba-Elías, Ana González-Marcos
The purpose of this work was to analyse the compaction of a cohesive material using different Discrete Element Method (DEM) simulators to determine the equivalent contact models and to identify how some simulation parameters affect the compaction results (maximum force and compact appearance) and computational costs. For this purpose, three cohesion contact models were tested: linear cohesion in EDEM, and simplified Johnson-Kendall-Roberts (SJKR) and modified SJKR (SJKR2) in LIGGGHTS. The influence of the particle size distribution (PSD) on the results was also investigated...
November 21, 2018: Materials
Kevin A Hughes, Peter Convey, Luis R Pertierra, Greta C Vega, Pedro Aragón, Miguel Á Olalla-Tárraga
The distribution of terrestrial biodiversity within Antarctica is complex, with 16 distinct biogeographic regions (Antarctic Conservation Biogeographic Regions) currently recognised within the Antarctic continent, Peninsula and Scotia Arc archipelagos of the Antarctic Treaty area. Much of this diversity is endemic not only to Antarctica as a whole, but to specific regions within it. Further complexity is added by inclusion of the biodiversity found on the islands located in the Southern Ocean north of the Treaty area...
November 20, 2018: Journal of Environmental Management
Ruth Link-Gelles, Karrie-Ann Toews, William Schaffner, Kathryn M Edwards, Carolyn Wright, Bernard Beall, Brenda Barnes, Brenda Jewell, Lee H Harrison, Pam D Kirley, Lauren Lorentzson, Deborah Aragon, Susan Petit, Joseph Bareta, Nancy L Spina, Paul R Cieslak, Chris Van Beneden
Background: Few data on intracranial group A Streptococcus (GAS) infection in children are available. Here, we describe the demographic, clinical, and diagnostic characteristics of 91 children with intracranial GAS infection. Methods: Cases of intracranial GAS infection in persons ≤18 years of age reported between 1997 and 2014 were identified by the Centers for Disease Control and Prevention's population- and laboratory-based Active Bacterial Core surveillance (ABCs) system...
November 21, 2018: Journal of the Pediatric Infectious Diseases Society
Logan P Rhea, Brinda Gupta, Jeanny B Aragon-Ching
No abstract text is available yet for this article.
November 20, 2018: Asian Journal of Andrology
Ayesha Girach, Ana Vinagre Aragon, Panagiotis Zis
OBJECTIVE: Dystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This review aimed to evaluate variations in QoL between different subtypes of dystonia, identify the determinants of QoL and assess the effects of different treatments on QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in idiopathic focal, segmental, multifocal and generalized dystonia...
November 20, 2018: Journal of Neurology
Daniel Urda, Francisco Aragón, Rocío Bautista, Leonardo Franco, Francisco J Veredas, Manuel Gonzalo Claros, José Manuel Jerez
BACKGROUND: In RNA-Seq gene expression analysis, a genetic signature or biomarker is defined as a subset of genes that is probably involved in a given complex human trait and usually provide predictive capabilities for that trait. The discovery of new genetic signatures is challenging, as it entails the analysis of complex-nature information encoded at gene level. Moreover, biomarkers selection becomes unstable, since high correlation among the thousands of genes included in each sample usually exists, thus obtaining very low overlapping rates between the genetic signatures proposed by different authors...
November 20, 2018: BMC Systems Biology
M A Quiroz-Juárez, O Jiménez-Ramírez, J L Aragón, J L Del Río-Correa, R Vázquez-Medina
We propose a simple model of the electrical activity of the heart that reproduces realistic healthy electrocardiogram (ECG) signals. The model consists of two RLC linear oscillators periodically kicked by impulses of the main pacemaker with the frequency rate of a real heart. In the proposed model, one oscillator represents the atria, another represents the ventricles, and an electrical cardiac conduction system is included using a coupling capacitor, which can be either unidirectional or bidirectional. The network of the two capacitively coupled oscillators is periodically kicked by the main pacemaker to introduce the periodic forcing of limit cycles into the system; a time delay is introduced to represent the electrical transport delay from atria to ventricles...
May 18, 2018: Computers in Biology and Medicine
Laura Pasca, María Teresa Coello, Juan Ignacio Aragonés, Cynthia McPherson Frantz
The Connectedness to Nature Scale has been used in many different countries and settings. However, no one has yet tested the equivalence of these measures. Equivalence of measures has been the subject of much research in recent years, due to the importance of measuring in the same way when comparing between different groups. The present work studied the differential item functioning (DIF) of the CNS in a Spanish group and a North American group of respondents, using two different methods of detecting DIF. It also evaluated the overall equivalence of the scale...
2018: PloS One
Elbio Saidman, Ana K Chattah, Leslie Aragón, Matías Sancho, Gerardo Camí, Claudia Garnero, Marcela Longhi
Mebendazole (MBZ), designated as a WHO essential drug, can exist in diverse solid forms and presents low absorption at the gastrointestinal level. Considering the potential of cyclodextrins to enhance the solubility and permeability of drugs, inclusion complexes of polymorphs A and C of MBZ with β‑cyclodextrin were obtained. The characterization of the complexes in solid state was performed by using a combination of experimental techniques including Fourier transform infrared spectroscopy, powder X-ray diffractometry and solid state nuclear magnetic resonance...
November 13, 2018: European Journal of Pharmaceutical Sciences
Andrea Ardid-Ruiz, Maria Ibars, Pedro Mena, Daniele Del Rio, Begoña Muguerza, Cinta Bladé, Lluís Arola, Gerard Aragonès, Manuel Suárez
Bioactive compounds such as polyphenols have increased in importance in recent years, and among them, resveratrol (3,5,4'-trihydroxy-trans-stilbene) has generated great interest as an anti-obesity agent. Recent investigations have highlighted the importance of leptin signaling in lipid metabolism in peripheral organs. The aims of this study were (1) to investigate whether resveratrol can reduce fat accumulation in peripheral tissues by increasing their leptin sensitivity and (2) to identify which resveratrol-derived circulating metabolites are potentially involved in these metabolic effects...
November 14, 2018: Nutrients
Rowena Jacobs, Martin Chalkley, María José Aragón, Jan R Böhnke, Michael Clark, Valerie Moran
Funding for mental health services in England faces many challenges including operating under financial constraints where it is not easy to demonstrate the link between activity and funding. Mental health services need to operate alongside and collaborate with acute hospital services where there is a well-established system for paying for activity . The funding landscape is shifting at a rapid pace and we outline the distinctions between the three main options - block contracts, episodic payment and capitation...
November 2018: BJPsych Advances
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