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Ricardo Becerro de Bengoa Vallejo, David Sevillano Fernandez, Luis Alou Cervera, Laura Martín Aragón, Marta Elena Losa Iglesias, Luis Rodolfo Collado Yurrita, Daniel Lopez Lopez
BACKGROUND: Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy "in vivo. METHODS: We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1)...
October 2018: Medicine (Baltimore)
Amanda Nizam, Jeanny B Aragon-Ching
Nivolumab is a programmed death 1 (PD-1) inhibitor currently approved as second-line treatment for advanced renal cell carcinomas (RCC) after failure of standard antiangiogenic treatment. Motzer et al. have recently published in the New England Journal of Medicine the findings of CheckMate 214 trial, using nivolumab and ipilimumab, a cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitor, versus sunitinib in previously untreated advanced RCC. The combination demonstrated a higher 18-month overall survival rate of 75% versus 60%, and a higher objective response rate of 42% versus 27%, for the combination in favor over sunitinib monotherapy...
October 17, 2018: Cancer Biology & Therapy
Miguel Salavert, Javier Cobo, Álvaro Pascual, Belén Aragón, Stefano Maratia, Yiling Jiang, Susana Aceituno, Santiago Grau
INTRODUCTION: Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated with considerable morbidity, mortality and economic impact. Bezlotoxumab administered in combination with standard of care (SoC) antibiotic therapy prevents recurrent CDI. This study assessed the cost-effectiveness of bezlotoxumab added to SoC, compared to SoC alone, to prevent the recurrence of CDI in high-risk patients from the Spanish National Health System perspective...
October 16, 2018: Advances in Therapy
Vanesa Carmona, Sagrario Martín-Aragón, Joshua Goldberg, David Schubert, Paloma Bermejo-Bescós
Long-term consumption of phytochemicals has been associated with a decreased risk of dementia. The modes of action of two flavonols (morin and isoquercitrin) and two flavanones (hesperidin and neohesperidin) were characterized as single-compound drugs in several Alzheimer's disease (AD)-related assays. First, these phytochemicals were assayed in an amyloid toxicity model (MC65 cells). Second, we examined the activity of the flavonoids in cell-free assays against β- and γ-secretases and acetylcholinesterase activities, as well as agents able to modify the fibrillogenesis of the amyloid β-peptide...
October 16, 2018: Nutritional Neuroscience
Gamal Cerda, Estíbaliz Aragón, Carlos Pérez, José I Navarro, Manuel Aguilar
This article presents the results of a comparative study regarding the impact and contribution of two instructional approaches to formal and informal mathematical reasoning with two groups of Spanish students, aged four and five. Data indicated that for both age groups, children under the ABN method [Open Algorithm Based on Numbers (ABN)] ( n = 147) achieved better results than the group under the CBC approach (Closed Algorithms Based on Ciphers) ( n = 82), which is the widespread approach in Spanish schools to teach formal and informal mathematical reasoning...
2018: Frontiers in Psychology
Cristina Benito-Muñoz, Almudena Perona, David Abia, Helena G Dos Santos, Enrique Núñez, Carmen Aragón, Beatriz López-Corcuera
Neurotransmitter removal from glycine-mediated synapses relies on two sodium-driven high-affinity plasma membrane GlyTs that control neurotransmitter availability. Mostly glial GlyT1 is the main regulator of glycine synaptic levels, whereas neuronal GlyT2 promotes the recycling of synaptic glycine and supplies neurotransmitter for presynaptic vesicle refilling. The GlyTs differ in sodium:glycine symport stoichiometry, showing GlyT1 a 2:1 and GlyT2 a 3:1 sodium:glycine coupling. Sodium binds to the GlyTs at two conserved Na+ sites: Na1 and Na2...
2018: Frontiers in Molecular Neuroscience
Soto-Castro Delia, Gutiérrez Miguel Chávez, M León-Martínez Frank, Santiago-García Patricia Araceli, Aragón-Lucero Irais, Antonio-Antonio Franco
In this work the capacity of Opuntia ficus indica mucilage as a wall agent in the microencapsulation of Escontria chiotilla and Stenocereus queretaroensis pulp and skin pigments through a spray drying process was studied. The acidified mucilage was used as an extracting medium for betalains present in the skin of these fruits. The shear-thinning behavior of the mucilage-betalain solutions was suitable for spray drying, wherein microcapsules with smooth and spherical morphologies were observed by SEM and characterized by FTIR...
January 30, 2019: Food Chemistry
M García-Carmona, H García-Robles, C Turpín Torrano, E Fernández Ondoño, J Lorite Moreno, M Sierra Aragón, F J Martín Peinado
The present work assesses the residual pollution in the Guadiamar Green Corridor (SW, Spain) after a long-term aging process (18 years) since the accident of the Aznalcóllar pyrite mine. We have focused on the study of trace elements (Cu, Zn, Cd, As and Pb) in soils, their fractionation and the transference to the surrounding vegetation. The residual polluted areas are characterized by scattered plots with absence of vegetation, presenting high concentrations of trace elements, acidic pH and low organic carbon content...
February 10, 2019: Science of the Total Environment
Michelle C Turner, Esther Gracia-Lavedan, Franco Momoli, Chelsea E Langer, Gemma Castaño-Vinyals, Michael Kundi, Milena Maule, Franco Merletti, Siegal Sadetzki, Roel Vermeulen, Alex Albert, Juan Alguacil, Nuria Aragones, Francesc Badia, Revital Bruchim, Gema Carretero, Noriko Kojimahara, Brigitte Lacour, Maria Morales-Suarez-Varela, Katja Radon, Thomas Remen, Tobias Weinmann, Naohito Yamaguchi, Elisabeth Cardis
BACKGROUND: MOBI-Kids is a 14-country case-control study designed to investigate the potential effects of electromagnetic field exposure from mobile telecommunications devices on brain tumor risk in children and young adults conducted from 2010-2016. This work describes differences in cellular telephone use and personal characteristics among interviewed participants and refusers responding to a brief non-respondent questionnaire. It also assesses the potential impact of non-participation selection bias on study findings...
October 1, 2018: Epidemiology
F Javier Del Río, Marina A Cabello-García, Francisco Cabello-Santamaría, Laura Verdugo, Jerónimo Aragón-Vela
INTRODUCTION: Premature ejaculation may be due to many factors and one of them may be drug use. AIMS: The main objective of this study is to show how drug abuse affects the ejaculatory response, keeping in mind the different substances consumed, the level of anxiety and the period of withdrawal. METHOD: Two samples were used, one for men who were addicted to drugs (N=925) and one of non-consumers (N=82). Both samples were selected from 28 treatment centers...
October 2018: Revista Internacional de Andrología
María de Los Ángeles Carrasco-Ruiz, Laura G Hernández-Aragón, Jesús Ramsés Chávez-Ríos, Jorge Rodríguez-Antolín, Pablo Pacheco, Margarita Martínez-Gómez, Estela Cuevas-Romero, Francisco Castelán
PURPOSE: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. METHODS: The muscles were excised from virgin rats during the metestrus and proestrus stages of the estrous cycle, and from sham and ovariectomized rats implanted with empty or estradiol benzoate-filled capsules. The expression of estrogen receptors (ERs) was inspected in the muscles at metestrus and proestrus...
September 2018: International Neurourology Journal
C Grávalos, O Sanmartín, A Gúrpide, A España, M Majem, H J Suh Oh, I Aragón, S Segura, C Beato, R Botella
Progress in the understanding of many tumors has enabled the development of new therapies, such as those targeted at specific molecules involved in cell growth (targeted therapies) or intended to modulate the immune system (immunotherapy). However, along with the clinical benefit provided by these new treatments, new adverse effects have also appeared. Dermatological toxicities such as papulopustular eruptions, xerosis, and pruritus are common with EGFR inhibitors. Other adverse effects have also been described with PDGFR, BCR-ABL, and MAPK tyrosine kinase inhibitors, antiangiogenic drugs, and inhibitors at immune checkpoints such as CTLA-4 and PD-1/PD-L1...
October 3, 2018: Clinical & Translational Oncology
Andrea Correa-Pérez, Eva Delgado-Silveira, Sagrario Martín-Aragón, Aurora M Rojo-Sanchís, Alfonso J Cruz-Jentoft
BACKGROUND: Polypharmacy and fall-risk increasing drugs (FRIDS) have been associated with injurious falls. We aimed to estimate the prevalence of polypharmacy and FRIDS in older patients discharged from an Orthogeriatric Unit after a hip fracture surgery. METHODS: This study describes the baseline findings of a 2-year retrospective cohort study. We included patients older than 80 years discharged from an Orthogeriatric Unit who were able to walk before surgery...
October 1, 2018: Aging Clinical and Experimental Research
Ana Ferro, Samantha Morais, Claudio Pelucchi, Nuria Aragonés, Manolis Kogevinas, Lizbeth López-Carrillo, Reza Malekzadeh, Shoichiro Tsugane, Gerson S Hamada, Akihisa Hidaka, Raúl U Hernández-Ramírez, Malaquias López-Cervantes, David Zaridze, Dmitry Maximovitch, Farhad Pourfarzi, Zuo-Feng Zhang, Guo-Pei Yu, Mohammadreza Pakseresht, Weimin Ye, Amelie Plymoth, Marcis Leja, Evita Gasenko, Mohammad H Derakhshan, Eva Negri, Carlo La Vecchia, Bárbara Peleteiro, Nuno Lunet
Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case-control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis...
September 27, 2018: European Journal of Cancer Prevention
Rosa Oncins Torres, Mª Ángeles Aragón Sanz, Eduardo Clemente Roldán, Mª Dolores Comes García, Gorka Muñiz Unamunzaga, Lorena Guardia Dodorico, Víctor Vallés Gallego
OBJECTIVE: Uterine Cervical Cancer (UCC) screening has changed with the introduction of the High Risk Human Papilloma Virus test (HRHPV) and its evaluation is necessary. The objective of this study is to analyze the effectiveness of UCC screening with activities aimed at early detection and treatment to modify the natural history of the process and improve its prognosis. METHODS: Cytology and HR-HPV (co-testing) were performed according to the SEGO protocol of 2010 between 2011 and 2015 with follow-up until 2017...
October 2, 2018: Revista Española de Salud Pública
G Barbas Bernardos, F Herranz Amo, J Caño Velasco, M J Cancho Gil, J Mayor de Castro, J Aragón Chamizo, L Polanco Pujol, C Hernández Fernández
INTRODUCTION AND OBJECTIVE: One of the inherent features of kidney tumours is the capacity to spread inside the venous system as tumour thrombi. The aim of this study was to assess in patients with stage pT3apN0cM0 kidney cancer whether venous tumour involvement influenced tumour recurrence. MATERIALS AND METHODS: A retrospective analysis of patients with stage pT3apN0cM0 kidney cancer treated with radical nephrectomy between 1990-2015. Univariate and multivariate Cox regression analysis to identify predictive variables and independent predictive variables relating to recurrence...
September 26, 2018: Actas Urologicas Españolas
Xavier Vallès, M Henar Alonso, Juan Francisco López-Caleya, Virginia Díez-Obrero, Trinidad Dierssen-Sotos, Virginia Lope, Ana Molina-Barceló, María Dolores Chirlaque, José Juan Jiménez-Moleón, Guillermo Fernández Tardón, Jesús Castilla, Pilar Amiano, Rocío Capelo, Gemma Castaño-Vinyals, Elisabet Guinó, Antonio José Molina de la Torre, Conchi Moreno-Iribas, Beatriz Pérez Gómez, Nuria Aragonés, Javier Llorca, Vicente Martín, Manolis Kogevinas, Marina Pollán, Victor Moreno
OBJECTIVES: To explore the association of colorectal cancer with environmental solar radiation and sun exposure behavior, considering phenotypic variables (eye color, hair color and skin phenotype), dietary intake of vitamin D and calcium, and socio-demographic factors. STUDY DESIGN: Multicenter population-based frequency matched case-control study in Spain (MCC-Spain), with 2140 CRC cases and 3950 controls. METHODS: Data were obtained through personal interviews using a structured epidemiological questionnaire that included socio-demographic data, residential history, environmental exposures, behavior, phenotypic and dietary information...
September 25, 2018: Environment International
Joan Josep Cabré Vila, Yolanda Ortega Vila, Enric Aragonès Benaiges, Josep Basora Gallisà, Álvaro Araujo Bernardo, Rosa Solà Alberich
OBJECTIVE: In order to clarify the relation between deprivation and morbillity and mortality, in function of different residence places, we design this study. Main objective is to analyze the influence of place of residence on the incidence of cardiovascular events (CVD) and general mortality from any cause, in a cohort with metabolic syndrome. METHODS: Prospective study to determine the incidence of CVD according to the place of residence (rural, urban) in individuals with different combinations of clinical features of Metabolic Syndrome (MS)...
September 26, 2018: Revista Española de Salud Pública
Beatriz Aragón Martín, Elena Ruiz Peralta, Daniel García Blanco, Ruth Caravantes Vidriales
Terms such as community or community health are used more and more frequently and in multiple contexts. As healthcare workers, we acknowledge the need to reflect upon these concepts in order to shed light on the different meanings we bestow on community health. This dialogue approaches the notion of the community examining its relationships with other notions; for example, we examine how the notion of territory could trigger both communitarian networks and exclusionary practices. On the other hand, the practices that identify and help in building what is "communal" are perceived as more inclusive and as a starting point to think about what communities mean...
September 19, 2018: Gaceta Sanitaria
Inés Gómez-Acebo, Trinidad Dierssen-Sotos, María de Pedro, Beatriz Pérez-Gómez, Gemma Castaño-Vinyals, Tania Fernández-Villa, Camilo Palazuelos-Calderón, Pilar Amiano, Jaione Etxeberria, Yolanda Benavente, Guillermo Fernández-Tardón, Inmaculada Salcedo-Bellido, Rocío Capelo, Rosana Peiró, Rafael Marcos-Gragera, José M Huerta, Adonina Tardón, Aurelio Barricarte, Jone-Miren Altzibar, Jessica Alonso-Molero, Verónica Dávila-Batista, Nuria Aragonés, Marina Pollán, Manolis Kogevinas, Javier Llorca
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. METHODS: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history...
September 21, 2018: BMC Public Health
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