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Raquel Almansa, Silvia Martín, Marta Martin-Fernandez, María Heredia-Rodríguez, Esther Gómez-Sánchez, Marta Aragón, Cristina Andrés, Dolores Calvo, Jesus Rico-Feijoo, Maria Carmen Esteban-Velasco, Luis Mario Vaquero-Roncero, Alicia Ortega, Estefania Gómez-Pesquera, Mario Lorenzo-López, Iñigo López de Cenarruzabeitia, Diana Benavides, Jaime López-Sanchez, Cristina Doncel, Carmen González-Sanchez, Esther Zarca, Alberto Ríos-Llorente, Agustín Diaz, Elisa Sanchez-Barrado, Juan Beltran de Heredia, Jose Maria Calvo-Vecino, Luis Muñoz-Bellvís, Jose Ignacio Gomez-Herreras, César Aldecoa, Eduardo Tamayo, Jesus F Bermejo-Martin
Early recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since it allows prompt control of the infectious source. Combining pro-inflammatory and immunosupression biomarkers could represent a good strategy to improve sepsis detection. Here we evaluated the combination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in a cohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression was quantified using droplet digital PCR, a next-generation PCR technology...
August 10, 2018: Scientific Reports
Joy K Adewusi, Marios Hadjivassiliou, Ana Vinagre-Aragón, Karen Ruth O'Connor, Aijaz Khan, Richard Adam Grünewald, Panagiotis Zis
BACKGROUND AND PURPOSE: Pain is a frequent and debilitating non-motor symptom of Idiopathic Parkinson's Disease (IPD). The present study investigated the prevalence of pain and specifically peripheral neuropathic pain (PNP) in IPD, and ascertained any impact of PNP on quality of life (QoL). METHODS: Patients with IPD and age- and gender-matched controls were screened for overall pain using the King's Parkinson's Pain Scale (KPPS). PNP was assessed using the Michigan Neuropathy Screening Instrument (MNSI)...
September 15, 2018: Journal of the Neurological Sciences
Ana Vinagre-Aragón, Panagiotis Zis, Richard Adam Grunewald, Marios Hadjivassiliou
Gluten related disorders (GRD) represent a wide spectrum of clinical manifestations that are triggered by the ingestion of gluten. Coeliac disease (CD) or gluten sensitive enteropathy is the most widely recognised, but extra-intestinal manifestations have also been increasingly identified and reported. Such manifestations may exist in the absence of enteropathy. Gluten sensitivity (GS) is another term that has been used to include all GRD, including those where there is serological positivity for GS related antibodies in the absence of an enteropathy...
August 8, 2018: Nutrients
Scott A Walper, Guillermo Lasarte Aragones, Kim E Sapsford, Carl W Brown Iii, Clare E Rowland, Joyce C Breger, Igor L Medintz
Although a fundamental understanding of the pathogenicity of most biothreat agents has been elucidated and available treatments have increased substantially over the last decades, they still represent a significant public health threat in this age of (bio)terrorism, indiscriminate warfare, pollution, climate change, unchecked population growth, and globalization. The key step to almost all prevention, protection, prophylaxis, post-exposure treatment, and mitigation of any bioagent is early detection. Here, we review available methods for detecting bioagents including pathogenic bacteria and viruses along with their toxins...
August 6, 2018: ACS Sensors
Cristina O'Callaghan-Gordo, Manolis Kogevinas, Marta Cirach, Gemma Castaño-Vinyals, Nuria Aragonés, Josu Delfrade, Tania Fernández-Villa, Pilar Amiano, Trinidad Dierssen-Sotos, Adonina Tardon, Rocio Capelo, Rosana Peiró-Perez, Víctor Moreno, Aina Roca-Barceló, Beatriz Perez-Gomez, Juana Vidan, Antonio José Molina, Madalen Oribe, Esther Gràcia-Lavedan, Ana Espinosa, Antònia Valentin, Marina Pollán, Mark J Nieuwenhuijsen
BACKGROUND: Breast cancer is the main cause of cancer mortality among women. Green spaces have been recently associated with reduced cancer mortality among women. Mechanisms explaining the beneficial effect of green spaces include increased levels of physical activity and reduced exposure to air pollution, which have been both associated with cancer development. OBJECTIVES: To investigate the associations between presence of urban green areas, presence of agricultural areas and surrounding greenness and risk of breast cancer, and to assess whether these associations are mediated by physical activity and/or air pollution levels...
August 1, 2018: International Journal of Hygiene and Environmental Health
Austin I McDonald, Aditya S Shirali, Raquel Aragón, Feiyang Ma, Gloria Hernandez, Don A Vaughn, Julia J Mack, Tiffany Y Lim, Hannah Sunshine, Peng Zhao, Vladimir Kalinichenko, Tsonwin Hai, Matteo Pelegrini, Reza Ardehali, M Luisa Iruela-Arispe
The cellular and mechanistic bases underlying endothelial regeneration of adult large vessels have proven challenging to study. Using a reproducible in vivo aortic endothelial injury model, we characterized cellular dynamics underlying the regenerative process through a combination of multi-color lineage tracing, parabiosis, and single-cell transcriptomics. We found that regeneration is a biphasic process driven by distinct populations arising from differentiated endothelial cells. The majority of cells immediately adjacent to the injury site re-enter the cell cycle during the initial damage response, with a second phase driven by a highly proliferative subpopulation...
August 2, 2018: Cell Stem Cell
Mariana Ferreira-Saab, Damien Formey, Martha Torres, Wendy Aragón, Emir A Padilla, Alexandre Tromas, Christian Sohlenkamp, Kátia R F Schwan-Estrada, Mario Serrano
Plant diseases induced by fungi are among the most important limiting factors during pre- and post-harvest food production. For decades, synthetic chemical fungicides have been used to control these diseases, however, increase on worldwide regulatory policies and the demand to reduce their application, have led to searching for new ecofriendly alternatives such as the biostimulants. The commercial application of yeasts as biocontrol agents, has shown low efficacy compared to synthetic fungicides, mostly due to the limited knowledge of the molecular mechanisms of yeast-induced responses...
2018: Frontiers in Microbiology
J Arimany-Manso, L Aragonès Rodríguez, J Benet-Travé, C Martin-Fumadó, R Bruguera Villagrasa, F Fuz, E L Gómez-Durán
BACKGROUND: Wrong site surgery (WSS) is a potentially preventable adverse event in healthcare. METHODS: We performed a retrospective analysis of the 9,129 claims managed by the Professional Liability Service of the Catalonian's Colleges of Physicians from 1986 to 2017. RESULTS: We identified 57 claims for WSS (1.78 per year), with an increase in the final ten years (0.92 to 3.83). One patient identification error corresponded to the anesthetic procedure; surgery involving fingers (17...
July 27, 2018: Anales del Sistema Sanitario de Navarra
José María Peña Porta, Hilda Mercedes Villafuerte Ledesma, Carmen Vicente de Vera Floristán, Ana Ferrer Dufol, Tránsito Salvador Gómez, Rafael Álvarez Lipe
OBJECTIVES: To determine the incidence of metformin-induced lactic acidosis during the period January 2014 to March 2017 in Aragon Healthcare Area III. To analyse the associated clinical and analytical factors and mortality. RESULTS: A total of 31 cases (61.3% males). Incidence: 79.76 cases/100,000 patients-year; mean age 75.39±9.34 years; 23 of them with levels of serum metformin (21.91±15.52 mcg/ ml); milligrams/day of metformin ingested: 1790.32±499; 96.8% of cases in the context of acute kidney failure; 11 cases with a history of chronic kidney disease (35...
July 27, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Ewelina Guca, David Suñol, Lidia Ruiz, Agnieszka Konkol, Jorge Cordero, Carles Torner, Eric Aragon, Pau Martin-Malpartida, Antoni Riera, Maria J Macias
TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting with Smad2-Smad4 complexes. We found that the complex structure of TGIF1-HD bound to the TGACA motif revealed a combined binding mode that involves the HD core and the major groove, on the one hand, and the amino-terminal (N-term) arm and the minor groove of the DNA, on the other. We also show that TGIF1-HD interacts with the MH1 domain of Smad proteins, thereby indicating that TGIF1-HD is also a protein-binding domain...
July 28, 2018: Nucleic Acids Research
M Solans, G Coenders, R Marcos-Gragera, A Castelló, E Gràcia-Lavedan, Y Benavente, V Moreno, B Pérez-Gómez, P Amiano, T Fernández-Villa, M Guevara, I Gómez-Acebo, G Fernández-Tardón, M Vanaclocha-Espi, M D Chirlaque, R Capelo, R Barrios, N Aragonés, A Molinuevo, F Vitelli-Storelli, J Castilla, T Dierssen-Sotos, G Castaño-Vinyals, M Kogevinas, M Pollán, M Saez
Instead of looking at individual nutrients or foods, dietary pattern analysis has emerged as a promising approach to examine the relationship between diet and health outcomes. Despite dietary patterns being compositional (i.e. usually a higher intake of some foods implies that less of other foods are being consumed), compositional data analysis has not yet been applied in this setting. We describe three compositional data analysis approaches (compositional principal component analysis, balances and principal balances) that enable the extraction of dietary patterns by using control subjects from the Spanish multicase-control (MCC-Spain) study...
July 26, 2018: Statistical Methods in Medical Research
James Nicholas Vranish, Mario G Ancona, Eunkeu Oh, Kimihiro Susumu, Guillermo Lasarte Aragonés, Joyce C Breger, Scott A Walper, Igor L Medintz
Multistep enzymatic cascades are becoming more prevalent in industrial settings as engineers strive to synthesize complex products and pharmaceuticals in economical, environmentally friendly ways. Previous work has shown that immobilizing enzymes on nanoparticles can enhance their activity significantly due to localized interfacial effects, and this enhancement remains in place even when that enzyme's activity is coupled to another enzyme that is still freely diffusing. Here, we investigate the effects of displaying two enzymes with coupled catalytic activity directly on the same nanoparticle surface...
July 25, 2018: ACS Nano
Jaime Aron Garcia-Espinoza, Roberto Armando García-Manzano, Verónica Belem Aguilar-Aragón
No abstract text is available yet for this article.
July 2018: Archives of Plastic Surgery
Gemma Castaño-Vinyals, Nuria Aragonés, Beatriz Pérez-Gómez, Vicente Martín, Javier Llorca, Victor Moreno, Jone M Altzibar, Eva Ardanaz, Sílvia de Sanjosé, José Juan Jiménez-Moleón, Adonina Tardón, Juan Alguacil, Rosana Peiró, Rafael Marcos-Gragera, Carmen Navarro, Marina Pollán, Manolis Kogevinas
No abstract text is available yet for this article.
July 19, 2018: Gaceta Sanitaria
Javier Aragón, Simona Salerno, Loredana De Bartolo, Silvia Irusta, Gracia Mendoza
HYPOTHESIS: The development of novel scaffolds based on biocompatible polymers is of great interest in the field of bone repair for fabrication of biodegradable scaffolds that mimic the extracellular matrix and have osteoconductive and osteoinductive properties for enhanced bone regeneration. EXPERIMENTS: Polycaprolactone (PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) core-shell fibers were synthesised and decorated with poly(lactic-co-glycolic acid) [PLGA] particles loaded with bone morphogenetic protein 2 (BMP2) by simultaneous electrospinning and electrospraying...
July 17, 2018: Journal of Colloid and Interface Science
Nello Mosca, Rebecca Vismara, José Fernandes, Giulia Tuci, Corrado Di Nicola, Konstantin Domasevitch, Carlotta Giacobbe, Giuliano Giambastiani, Claudio Pettinari, Marta Aragones-Anglada, Peyman Moghadam, David Fairen-Jimenez, Andrea Rossin, Simona Galli
The MOFs M(BPZNO2) (M = Co, Cu, Zn) (H2BPZNO2 = 3-nitro-4,4'-bipyrazole) were prepared through solvothermal routes and fully investigated in the solid state. They show a good thermal stability both under nitrogen and in air, with decomposition temperatures peaking up to 663 K for Zn(BPZNO2). Their crystal structure is characterized by 3-D networks with square (M = Co, Zn) or rhombic (M = Cu) channels decorated by the polar NO2 groups. As revealed by N2 adsorption at 77 K, they are micro-mesoporous materials with BET specific surface areas ranging between 400 and 900 m2/g...
July 20, 2018: Chemistry: a European Journal
J M Molina Aragonés, R Bausà Peris, R Carreras Valls, A Carrillo Castillo, F Fiblà Nicolau, E Gaynés Palou, J Guerrero Monge, J Inglés Torruella, J A López Muñoz, E Martinez Martínez-Carrasco, J Matllo Aguilar, J A Medina Lavela, M T Mestre Prad, P Peña García, S Rodriguez Vallecillos, G Tapias Oller, M Vilardell Ynaraja
The presence of formaldehyde at workplace remains significant. Exposure to it results in local irritation of the eye, nose and upper respiratory tract mucous membranes, and it has been chronically related to a higher risk of cancer development at the paranasal sinuses, naso-oropharynx and lungs. The aim of our work has been the updating of the bibliography and the categorization of the most up to date scientific evidence of formaldehyde effects on human body. Bibliographic search on the electronic database Medline / PubMed, restricted to the last 10 years through a combination of free and controlled language...
July 2018: Archivos de Prevención de Riesgos Laborales
Aleix Gimeno, Andrea Ardid-Ruiz, María José Ojeda-Montes, Sarah Tomás-Hernández, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Miquel Mulero, Cristina Valls, Gerard Aragonès, Manuel Suárez, Gerard Pujadas, Santiago Garcia-Vallvé
Protein tyrosine phosphatase 1B (PTP1B) is a potential drug target for diabetes and obesity. However, designing PTP1B inhibitors that combine potency and bioavailability is a great challenge and new leads are needed to circumvent this problem. Virtual screening (VS) workflows can be used to find new PTP1B inhibitors with little chemical similarity to existing ones. Unfortunately, previous VS workflows for the identification of PTP1B inhibitors have several limitations, such as a small number of experimentally tested compounds and the low bioactivity of those compounds...
July 19, 2018: ChemMedChem
Jesús I Martínez-Costa, Roberto Leyva-Ramos, Erika Padilla-Ortega, Antonio Aragón-Piña, Damarys H Carrales-Alvarado
The competitive sorption of the antibiotics sulfamethoxazole (SMX) and trimethoprim (TMP) and SMX-Cd(II) on a hybrid clay nanosorbent (NanoSorb) was investigated in detail in this work. NanoSorb was synthesized by sorbing a surfactant on bentonite. Besides, the sorption of SMX on the NanoSorb was confirmed by FTIR analysis, and SMX was mainly sorbed on NanoSorb by a partition mechanism due to hydrophobic interactions. Otherwise, the single adsorption of Cd(II) and TMP onto NanoSorb were due to electrostatic interaction and hydrophobic partition, respectively...
November 1, 2018: Science of the Total Environment
Pilar Aragón, Patricia Noguera, María-José Bañuls, Rosa Puchades, Ángel Maquieira, Miguel Ángel González-Martínez
Modulation of support wettability used for microarray format biosensing has led to an improvement of results. Hydrophobicity of glass chips was set by derivatizing with single vinyl organosilanes of different chain length and silane mixtures. Thiol-ene photochemical linking has been used as effective chemistry for covalent anchoring of thiolated probes. Lowest unspecific binding and highest signal intensity and SNR were obtained with large hydrocarbon chain (C22 ) silanes or a shorter one (C10 ) containing fluorine atoms...
July 17, 2018: Analytical and Bioanalytical Chemistry
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