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Qingliang Shen, Veer S Bhatt, Inna Krieger, James C Sacchettini, Jae-Hyun Cho
CT-10 regulator of kinase (CRK) proteins play important roles in human cancer metastasis and invasion. Moreover, CRK proteins are the major phosphorylation substrates of ABL kinase and its oncogenic mutant BCR-ABL kinase. The interaction between CRK and BCR-ABL plays important roles in chronic myeloid leukemia. Hence, inhibiting the interaction of CRK with BCR-ABL is an attractive way to attenuate cancer metastasis. Herein, we report the development of a peptide inhibitor, PRM-3, targeting the interaction between CRK-II and ABL kinase...
March 1, 2018: MedChemComm
Reza Monfaredi, Iulian Iordachita, Emmanuel Wilson, Raymond Sze, Karun Sharma, Axel Krieger, Stanley Fricke, Kevin Cleary
PURPOSE: This paper presents new quantitative data on a signal-to-noise ratio (SNR) study, distortion study, and targeting accuracy phantom study for our patient-mounted robot (called Arthrobot). Arthrobot was developed as an MRI-guided needle placement device for diagnostic and interventional procedures such as arthrography. METHODS: We present the robot design and inverse kinematics. Quantitative assessment results for SNR and distortion study are also reported...
August 11, 2018: International Journal of Computer Assisted Radiology and Surgery
K Sjöström, S Sternberg-Lewerin, I Blanco-Penedo, J E Duval, M Krieger, U Emanuelson, N Fall
The animal health and welfare status in European organic dairy production does not in all aspects meet the organic principles and consumers' expectations and needs to be improved. To achieve this, tailored herd health planning, targeted to the specific situation of individual farms could be of use. The aim of this study was to apply herd health planning in a structured participatory approach, with impact matrix analysis, not previously used in this context, in European organic dairy farms and to assess changes in animal health and welfare...
August 10, 2018: Animal: An International Journal of Animal Bioscience
Sylvia Klineova, Rebecca Farber, Joshua Friedman, Colleen Farrell, Fred D Lublin, Stephen Krieger
Background: Multiple sclerosis affects mobility in over 80% of patients. Dalfampridine is the only approved treatment for walking impairment in multiple sclerosis. We assessed dalfampridine utilization in our practice and investigated response using timed 25 foot walk (T25FW) improvement and a patient-reported ambulation inventory. Methods: Chart review identified patients with multiple sclerosis for whom dalfampridine was prescribed. T25FW data were extracted from medical records...
July 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Patricia Claudel, Quentin Chesnais, Quentin Fouché, Célia Krieger, David Halter, Florent Bogaert, Sophie Meyer, Sylvaine Boissinot, Philippe Hugueney, Véronique Ziegler-Graff, Arnaud Ameline, Véronique Brault
Aphids are important pests which cause direct damage by feeding or indirect prejudice by transmitting plant viruses. Viruses are known to induce modifications of plant cues in ways that can alter vector behavior and virus transmission. In this work, we addressed whether the modifications induced by the aphid-transmitted Turnip yellows virus (TuYV) in the model plant Arabidopsis thaliana also apply to the cultivated plant Camelina sativa , both belonging to the Brassicaceae family. In most experiments, we observed a significant increase in the relative emission of volatiles from TuYV-infected plants...
August 7, 2018: International Journal of Molecular Sciences
Anja Krieger-Liszkay, Sébastien Thomine
No abstract text is available yet for this article.
August 2, 2018: Molecular Plant
Jill S Roncarati, Travis P Baggett, James J O'Connell, Stephen W Hwang, E Francis Cook, Nancy Krieger, Glorian Sorensen
Importance: Previous studies have shown high mortality rates among homeless people in general, but little is known about the patterns of mortality among "rough sleepers," the subgroup of unsheltered urban homeless people who avoid emergency shelters and primarily sleep outside. Objectives: To assess the mortality rates and causes of death for a cohort of unsheltered homeless adults from Boston, Massachusetts. Design, Setting, and Participants: A 10-year prospective cohort study (2000-2009) of 445 unsheltered homeless adults in Boston, Massachusetts, who were seen during daytime street and overnight van clinical visits performed by the Boston Health Care for the Homeless Program's Street Team during 2000...
July 30, 2018: JAMA Internal Medicine
Annette Kienle, Alexander Krieger, Karel Willems, Hans-Joachim Wilke
In order to improve osseointegration, polyetheretherketone (PEEK) interbody fusion cages are frequently surface coated. The bonding strength of the coatings is mostly investigated under unrealistic loading conditions. To close this gap, in this study, uncoated and coated cages were loaded in a clinical setup in order to investigate their real resistance against abrasion. Six uncoated, six calcium phosphate (CaP) nanocoated, and six titanium (Ti) nanocoated PEEK cages were tested in this study. The experimental setup was designed to mimic cage impaction into the intervertebral disc space using polyurethane (PU) foam blocks as vertebral body substitutes...
July 1, 2018: Journal of Applied Biomaterials & Functional Materials
Mariacarla Gadebusch Bondio, Anna Julia Maria Wagner, Rico Krieger, Leonard Weiß, Susanne Kinnebrock
BACKGROUND: The desire to retain control over one's life until the end has become highly important in our society. Women and men of different ages and of diverse social, cultural, and educational backgrounds increasingly decide in advance about prospective medical treatment (Advance Care Planning, ACP). OBJECTIVES: Identification and analysis of literature on advance care planning behavior of men and women in Germany. The focus is on gender-specific differences...
July 31, 2018: Das Gesundheitswesen
Hazem Shoirah, Achilles Ntranos, Rachel Brandstadter, Yangbo Liu, Elisha Medina, Jamie Kwan, Stephen Krieger
OBJECTIVE: To enhance residency education by implementing the 6 principles of adult learning theory (ALT) in a large academic neurology residency program. METHODS: We implemented a set of curricular interventions aimed at Resident Education through Adult Learning in Neurology (REAL Neurology), in a large, academic neurology residency program. Interventions included didactic reform, increasing resident-as-teacher activities, and enhancing residents' interaction. The primary outcome was the change in mean Residency In-service Training Examination (RITE) percentile between the preintervention and postintervention cohorts, adjusting for US Medical Licensing Examination step 1 and 2 score...
July 31, 2018: Neurology
Michael L Hecht, YoungJu Shin, Jonathan Pettigrew, Michelle Miller-Day, Janice L Krieger
This study examined how cultural adaptation and delivery quality of the school-based intervention keepin' it REAL (kiR) influenced adolescent substance use. The goal of the study was to compare the effectiveness of the multi-cultural, urban (non-adapted) kiR intervention, a re-grounded (adapted) rural version of the kiR intervention and control condition in a new, rural setting. A total of 39 middle schools in rural communities of two states in the USA were randomly assigned to one of three conditions (i.e...
July 28, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
Baeckkyoung Sung, Jess Krieger, Bing Yu, Min-Ho Kim
Despite a promising potential for mesenchymal stem cells (MSCs) in tissue regeneration, a major challenge in MSC-based therapy has been associated with poor cell survival and low levels of cell integration into host tissue following transplantation. The objective of this study was to develop a gelatin-based colloidal microgel platform that enables the encapsulation of viable MSCs as well as confer fine-tuning of mechanical stiffness and low cytotoxicity. In this study, we report a facile method of fabricating gelatin-based microgel spheres for the encapsulation of MSCs using a water-in-oil mini-emulsification method, which is covalently crosslinked by genipin...
July 28, 2018: Journal of Biomedical Materials Research. Part A
Letícia C Tavares, Nubia E Duarte, Leiliane R Marcatto, Renata A G Soares, Jose E Krieger, Alexandre C Pereira, Paulo Caleb Junior Lima Santos
PURPOSE: Interpatient variation of warfarin dose requirements may be explained by genetic variations and general and clinical factors. In this scenario, diverse population-calibrated dosing algorithms, which incorporate the main warfarin dosing influencers, have been widely proposed for predicting supposed warfarin maintenance dose, in order to prevent and reduce adverse events. The aim of the present study was to evaluate the impact of the inclusion of ABCB1 c.3435C>T and CYP4F2 c...
July 26, 2018: European Journal of Clinical Pharmacology
Xiaosheng Yang, Ina Krieger, Daniel Lüftner, Simon Weiß, Timo Heepenstrick, Michael Hollerer, Philipp Hurdax, Georg Koller, Moritz Sokolowski, Peter Puschnig, Michael G Ramsey, F Stefan Tautz, Serguei Soubatch
We report a method to achieve physical and electronic decoupling of organic molecules from a metal surface. Oxygen adsorbed on the Cu(100) surface immobilizes the surface electrons in the Cu-O covalent bonds. This results in electronic surface hardening and prevents charge transfer from the metal into perylene-tetracarboxylic dianhydride molecules subsequently deposited on this surface.
August 21, 2018: Chemical Communications: Chem Comm
Stephen C Krieger, Fred D Lublin
No abstract text is available yet for this article.
July 26, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Kiona K Weisel, Anna-Carlotta Zarski, Thomas Berger, Michael P Schaub, Tobias Krieger, Christian T Moser, Matthias Berking, David D Ebert
Introduction: Depression is highly prevalent and often accompanied by comorbid anxiety disorder. Internet-based interventions have shown to be one effective treatment modality; however, comorbidities are often not targeted. Transdiagnostic tailored internet-and mobile-based interventions (IMIs) might be promising to overcome such issues. Aim: This study aims to evaluate the efficacy, moderators, and cost-effectiveness of a transdiagnostic tailored internet- and mobile-based guided intervention for depression and comorbid anxiety in individuals with major depressive disorder (MDD)...
2018: Frontiers in Psychiatry
Emanuel S Nischik, Jakob Krieger
In the field of comparative neuroanatomy, a meaningful interspecific comparison demands quantitative data referring to method-specific artifacts. For evaluating the potential of state-of-the-art imaging techniques in arthropod neuroanatomy, micro-computed X-ray microscopy (μCT) and two different approaches using confocal laser-scanning microscopy (cLSM) were applied to obtain volumetric data of the brain and selected neuropils in Procambarus fallax forma virginalis (Crustacea, Malacostraca, Decapoda). The marbled crayfish P...
2018: PeerJ
Jessica Krieger, Byung-Wook Park, Christopher R Lambert, Christopher Malcuit
Background: Skeletal muscle wound healing is dependent on complex interactions between fibroblasts, myofibroblasts, myogenic cells, and cytokines, such as TGF-β1. This study sought to clarify the impact of TGF-β1 signaling on skeletal muscle cells and discern between the individual contributions of fibroblasts and myofibroblasts to myogenesis when in co-culture with myogenic cells. 3D tissue-engineered models were compared to equivalent 2D culture conditions to assess the efficacy of each culture model to predictively recapitulate the in vivo muscle environment...
2018: PeerJ
Brian E Crucian, Alexander Choukèr, Richard J Simpson, Satish Mehta, Gailen Marshall, Scott M Smith, Sara R Zwart, Martina Heer, Sergey Ponomarev, Alexandra Whitmire, Jean P Frippiat, Grace L Douglas, Hernan Lorenzi, Judith-Irina Buchheim, George Makedonas, Geoffrey S Ginsburg, C Mark Ott, Duane L Pierson, Stephanie S Krieger, Natalie Baecker, Clarence Sams
Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight. It appears certain aspects of adaptive immunity are dysregulated during flight, yet some aspects of innate immunity are heightened. Interaction between adaptive and innate immunity also seems to be altered. Some crews experience persistent hypersensitivity reactions during flight. This phenomenon may, in synergy with extended duration and galactic radiation exposure, increase specific crew clinical risks during deep space exploration missions...
2018: Frontiers in Immunology
Christoph Mayer, Janin Schaffer, Tore Hattermann, Dana Floricioiu, Lukas Krieger, Paul A Dodd, Torsten Kanzow, Carlo Licciulli, Clemens Schannwell
Nioghalvfjerdsfjorden is a major outlet glacier in Northeast-Greenland. Although earlier studies showed that the floating part near the grounding line thinned by 30% between 1999 and 2014, the temporal ice loss evolution, its relation to external forcing and the implications for the grounded ice sheet remain largely unclear. By combining observations of surface features, ice thickness and bedrock data, we find that the ice shelf mass balance has been out of equilibrium since 2001, with large variations of the thinning rates on annual/multiannual time scales...
July 17, 2018: Nature Communications
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