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Janaina M Alves, Antonio H Martins, Claudiana Lameu, Talita Glaser, Nawal M Boukli, Vinicius Bassaneze, Rafael Dariolli, Isis C Nascimento, Poliana C M Martins, Héllio D N de Souza, José Eduardo Krieger, Dulce E Casarini, Vicencia M Sales, João B Pesquero, Henning Ulrich
The bioactive peptide bradykinin obtained from cleavage of precursor kininogens activates the kinin-B2 receptor functioning in induction of inflammation and vasodilatation. In addition, bradykinin participates in kidney and cardiovascular development and neuronal and muscle differentiation. Here we show that kinin-B2 receptors are expressed throughout differentiation of murine C2C12 myoblasts into myotubes. An autocrine loop between receptor activation and bradykinin secretion is suggested, since bradykinin secretion is significantly reduced in the presence of the kinin-B2 receptor antagonist HOE-140 during differentiation...
October 18, 2018: Stem Cell Reviews
Nancy Krieger, Mary Huynh, Wenhui Li, Pamela D Waterman, Gretchen Van Wye
BACKGROUND: Severe stressors can induce preterm birth (PTB; gestation <37 weeks), with such stressors including social and economic threats, interpersonal violence, hate crimes and severe sociopolitical stressors (ie, arising from political leaders' threatening rhetoric or from political legislation). We analysed temporal changes in risk of PTB among immigrant, Hispanic and Muslim populations targeted in the US 2016 presidential election and its aftermath. METHODS: Trend analysis of all singleton births in New York City from 1 September 2015 to 31 August 2017 (n=230 105)...
October 16, 2018: Journal of Epidemiology and Community Health
K Tretbar, M Basilowski, K Wiedmann, C Bartels, P Heßmann, M Kownatka, J Signerski-Krieger, N Scherbaum, S Meuret, M Fuchs, J Wiltfang, B Kis, M Abdel-Hamid
BACKGROUND: Hearing-impairment can lead to a reduced quality of life and thus represents a vulnerability factor for mental disorders. OBJECTIVE: This study represents the first psychiatric analysis of subjective quality of life and depression in people with hearing-impairment in Germany. MATERIALS AND METHODS: The patient group included 30 hearing-impaired participants (27 women, 3 men) with a current or previous mental disorder and/or psychiatric/psychotherapeutic treatment (age: mean, M = 49...
October 15, 2018: HNO
Raphaël Leman, Pascaline Gaildrat, Gérald L Gac, Chandran Ka, Yann Fichou, Marie-Pierre Audrezet, Virginie Caux-Moncoutier, Sandrine M Caputo, Nadia Boutry-Kryza, Mélanie Léone, Sylvie Mazoyer, Françoise Bonnet-Dorion, Nicolas Sevenet, Marine Guillaud-Bataille, Etienne Rouleau, Brigitte Bressac-de Paillerets, Barbara Wappenschmidt, Maria Rossing, Danielle Muller, Violaine Bourdon, Françoise Revillon, Michael T Parsons, Antoine Rousselin, Grégoire Davy, Gaia Castelain, Laurent Castéra, Joanna Sokolowska, Florence Coulet, Capucine Delnatte, Claude Férec, Amanda B Spurdle, Alexandra Martins, Sophie Krieger, Claude Houdayer
No abstract text is available yet for this article.
October 13, 2018: Nucleic Acids Research
Sarah-Maria Krieger, Manja Reimann, Rocco Haase, Elena Henkel, Markolf Hanefeld, Tjalf Ziemssen
Objective: The performance of the Sudoscan technology for diagnosing diabetic polyneuropathy (DPN) was evaluated against the quantitative sudomotor axon reflex test (QSART). Furthermore, the association of Sudoscan with two clinical neuropathy scoring systems was evaluated. Methods: Forty-seven patients with type 2 diabetes (20 without DPN, 27 with DPN) and 16 matched controls were examined for neuropathic symptoms and for the extent of sensory deficits. Sweat latency and volume by QSART and the skin electrochemical conductance (ESC) by Sudoscan were measured...
2018: Frontiers in Neurology
Aashish Ahuja, Jillian N Noblet, Tony Trudnowski, Bhavesh Patel, Joshua F Krieger, Sean Chambers, Ghassan S Kassab
Aortic dissection (AD) involves tearing of the medial layer, creating a blood-filled channel called false lumen (FL). To treat dissections, clinicians are using endovascular therapy using stent grafts to seal the FL. This procedure has been successful in reducing mortality but has failed in completely re-attaching the torn intimal layer. The use of computational analysis can predict the radial forces needed to devise stents that can treat ADs. To quantify the hyperelastic material behavior for therapy development, we harvested FL wall, true lumen (TL) wall, and intimal flap from the middle and distal part of five dissected aortas...
2018: Frontiers in Physiology
Emily S C Rittershaus, Seung-Hun Baek, Inna V Krieger, Samantha J Nelson, Yu-Shan Cheng, Subhalaxmi Nambi, Richard E Baker, John D Leszyk, Scott A Shaffer, James C Sacchettini, Christopher M Sassetti
Upon inhibition of respiration, which occurs in hypoxic or nitric oxide-containing host microenvironments, Mycobacterium tuberculosis (Mtb) adopts a non-replicating "quiescent" state and becomes relatively unresponsive to antibiotic treatment. We used comprehensive mutant fitness analysis to identify regulatory and metabolic pathways that are essential for the survival of quiescent Mtb. This genetic study identified a protein acetyltransferase (Mt-Pat/Rv0998) that promoted survival and altered the flux of carbon from oxidative to reductive tricarboxylic acid (TCA) reactions...
October 4, 2018: Cell Chemical Biology
Kate B Carey, Kate M Guthrie, Carla M Rich, Naomi H Krieger, Alyssa L Norris, Clair Kaplan, Michael P Carey
Alcohol use and sexual behavior co-occur frequently in young women, increasing risk for HIV and other sexually transmitted infections. To inform preventive interventions, we used qualitative methods to better understand how women think about the contribution of alcohol use to sexual risk-taking. Young women (N = 25; M = 22.8 years; 64% White) were recruited from a community-based reproductive health clinic to attend focus groups; a semi-structured agenda was used to investigate both a priori explanatory mechanisms as well as participant-driven explanations for the alcohol-sex association...
October 12, 2018: AIDS and Behavior
A V Smirnov, M A Zakharova, S V Berelavichus, A B Varava, A G Krieger
A rare case of virsungorrhagia in a 65 y/o patient with a mucinous tumor of the tail of the pancreas is presented. Recurrent gastrointestinal bleeding was associated with an arrosis of the splenic artery adjacent to the tumor, which required a two-step treatment - endovascular occlusion of the splenic artery and distal resection of the pancreas.
2018: Khirurgiia
William Jones Dartora, Marcelo Krieger Maestri, Maria Inês Schmidt, Bruce Bartholow Duncan, Lloyd Chambless, Ronald Klein, Stacy Meuer, Vivian Cristine Luft
BACKGROUND: Investigation of alterations to retinal microvasculature may contribute towards understanding the role of such changes in the pathophysiology of several chronic non-communicable diseases. The objective here was to evaluate the validity and reproducibility of retinal arteriole and venule diameter measurements made by Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) graders. DESIGN AND SETTING: Cross-sectional study at six teaching and research institutions...
July 2018: São Paulo Medical Journal, Revista Paulista de Medicina
Lauren C Bayliss, Janice L Krieger
The U.S. Food and Drug Administration (FDA) recently made changes to the nutrition facts label so that calories will be emphasized over all other nutrient information (U.S. Food and Drug Administration (FDA), 2016a, August 3). In light of calories' increased visibility, strategic health communicators need to understand both how individuals perceive calorie information and how calories influence consumption decisions. Therefore, a qualitative study was conducted to analyze the metaphors that structure consumers' thoughts about calorie information and food choices...
2018: Journal of Health Communication
Leiliane Rodrigues Marcatto, Luciana Sacilotto, Letícia Camargo Tavares, Mirella Facin, Natália Olivetti, Celia Maria Cassaro Strunz, Francisco Carlos Costa Darrieux, Maurício Ibrahim Scanavacca, Jose Eduardo Krieger, Alexandre Costa Pereira, Paulo Caleb Junior Lima Santos
Thromboembolic events are associated with high mortality and morbidity indexes. In this context, warfarin is the most widely prescribed oral anticoagulant agent for preventing and treating these events. This medication has a narrow therapeutic range and, consequently, patients usually have difficulty in achieving and maintaining stable target therapeutics. Some studies on the literature about oral anticoagulant management showed that pharmacists could improve the efficiency of anticoagulant therapy. However, the majority of these studies included general patients retrospectively...
2018: Frontiers in Pharmacology
Rafael Amorim Belo Nunes, Larissa Barbosa Lima, Nelson Ithiro Tanaka, Alexandre da Costa Pereira, José Eduardo Krieger, Alfredo José Mansur
Background: Physiological pathways such as bradykinin, renin-angiotensin, neurohormones and nitric oxide have been shown to play an important role in the regulation of cardiovascular function. Genetic variants of these pathways may impact blood pressure and left ventricular (LV) mass in different populations. To evaluate associations of genetic polymorphisms of bradykinin B2 receptor (BDKRB2), alpha-adrenergic receptors (ADRA) and endothelial nitric oxide synthase (eNOS) on the modulation of the blood pressure and the left ventricular mass...
December 2018: IJC Heart & Vasculature
L E Tellier, J R Krieger, A L Brimeyer, A C Coogan, A A Falis, T E Rinker, A Schudel, S N Thomas, C D Jarrett, N J Willett, E A Botchwey, J S Temenoff
To examine how the chemotactic agent stromal cell-derived factor-1alpha (SDF-1α) modulates the unique cellular milieu within rotator cuff muscle following tendon injury, we developed an injectable, heparin-based microparticle platform to locally present SDF-1α within the supraspinatus muscle following severe rotator cuff injury. SDF-1α loaded, degradable, N-desulfated heparin-based microparticles were fabricated, injected into a rat model of severe rotator cuff injury, and were retained for up to 7 days at the site...
June 2018: Regenerative Engineering and Translational Medicine
Roberto Jun Arai, Irene de Lourdes Noronha, José Carlos Nicolau, Charles Schmidt, Gustavo Moreira de Albuquerque, Kenneth W Mahaffey, Eduardo Moacyr Krieger, José Otávio Costa Auler Júnior
No abstract text is available yet for this article.
September 21, 2018: Clinics
Jana Krieger, Katja Stifter, Petra Riedl, Reinhold Schirmbeck
The HBV core protein self-assembles into particles and encapsidates immune-stimulatory bacterial RNA through a cationic COOH-terminal (C150-183) domain. To investigate if different cationic domains have an impact on the endogenous RNA-binding of HBV-C antigens in mammalian cells, we developed a strep-tag (st) based expression/purification system for HBV-C/RNA antigens in vector-transfected HEK-293 cells. We showed that HBV-stC but not HBV-stC149 particles (lacking the cationic domain) capture low amounts of mammalian RNA...
October 2, 2018: Scientific Reports
Samantha R Paige, Michael Stellefson, Janice L Krieger, Charkarra Anderson-Lewis, JeeWon Cheong, Christine Stopka
BACKGROUND: Electronic health (eHealth) literacy was conceptualized in 2006 as the ability of internet users to locate, evaluate, and act upon web-based health information. Now, advances in eHealth technology have cultivated transactional opportunities for patients to access, share, and monitor health information. However, empirical evidence shows that existing models and measures of eHealth literacy have limited theoretical underpinnings that reflect the transactional capabilities of eHealth...
October 2, 2018: Journal of Medical Internet Research
K C Nicolaou, Marek Buchman, Gabriel Bellavance, Johannes Krieger, Parthasarathi Subramanian, Kiran Kumar Pulukuri
Modular syntheses of disorazoles A1 and B1 analogues in which the epoxide moieties of the natural products were replaced with cyclopropyl units have been achieved. Targeted as part of a structure-activity relationships study, these syntheses were successfully extended to the thiazole counterparts of these analogues. The retrosynthetically defined fragments were assembled through Yamaguchi esterification, Cu/Pd-catalyzed cross-coupling, Yamaguchi macrolactonization, and Cu-catalyzed cross-coupling as the key reactions...
October 2, 2018: Journal of Organic Chemistry
Ana Cristina Souto, Marcio H Miname, Julia Fukushima, Cinthia E Jannes, Jose E Krieger, Martin Hagger, Alexandre C Pereira, Raul D Santos
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder associated with high risk of early major cardiovascular events (MACE) that can impact the health related quality of life (HRQoL), however, this association is unclear. This study evaluated HRQoL in index cases (IC) and first-degree relatives (FDR) of individuals at high risk of FH undergoing genetic cascade screening. METHODS: Data collection was performed before awareness of molecular diagnosis results...
October 2018: Atherosclerosis
Julie Schanz, Francesc Solé, Mar Mallo, Elisa Luño, Jose Cervera, Isabel Granada, Barbara Hildebrandt, Marylin L Slovak, Kazuma Ohyashiki, Christa Fonatsch, Michael Pfeilstöcker, Thomas Nösslinger, Peter Valent, Aristoteles Giagounidis, Carlo Aul, Michael Lübbert, Reinhard Stauder, Otto Krieger, Michelle M Le Beau, John M Bennett, Peter Greenberg, Ulrich Germing, Detlef Haase
The study analyzes the clonal architecture and the abnormalities involved in a series of 191 patients with myelodysplastic syndromes (MDS) and 2-3 clonal abnormalities. All patients were extracted from an international database. The patients were classified into six clonal subtypes (2A-3C) based on the number of abnormalities and the presentation of unrelated clones (UC) and/or a clonal evolution. UC were detected in 23/191 patients (12%). The composition of UC showed great variability. The only recurrent combination of abnormalities was del(5q) and + 8 in 8 of 23 patients (35%)...
September 24, 2018: Genes, Chromosomes & Cancer
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