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https://www.readbyqxmd.com/read/28527163/pharmacotherapy-of-insomnia-and-current-updates
#1
REVIEW
Arup Kumar Misra, Pramod Kumar Sharma
Insomnia is highly prevalent and is associated with a range of psychological, psychiatric, and medical conditions. Insomnia affects health by influencing cognitive, emotional and social functioning. Circadian and sleep homeostatic processes play an important role in insomnia development and its maintenance. Several efficacious treatments, both pharmacologic and non-pharmacologic, exist for the management of insomnia. Among non-pharmacologic treatments including stimulus control therapy, sleep restriction, relaxation, sleep hygiene and cognitive therapy have been shown to be efficacious...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28527065/migraine-with-aura-white-matter-lesions-preliminary-data-on-clinical-aspects
#2
Alberto Galli, P Di Fiore, G D'Arrigo, C Uggetti, S Squarza, M Leone, D D'Amico, F Frediani
A few clinic-based magnetic resonance imaging studies report an increased risk of signal abnormalities in migraineurs brain's white matter, especially in migraine with aura subjects. A vascular genesis has been hypnotized and migraine with aura was considered an independent risk factor for stroke. Available data of magnetic resonance imaging alterations are often nonspecific and sometimes controversial. The aim of our study is to investigate migraine with aura patients with standardized brain magnetic resonance imaging to detect and to quantify the presence of white matter lesions and to analyze their relation with clinical data...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28526163/new-hypnotic-drug-development-and-pharmacologic-considerations-for-clinical-anesthesia
#3
REVIEW
Mariah Kincaid Tanious, Sascha S Beutler, Alan D Kaye, Richard D Urman
Since the public demonstration of ether as a novel, viable anesthetic for surgery in 1846, the field of anesthesia has continually sought the ideal anesthetic-rapid onset, potent sedation-hypnosis with a high therapeutic ratio of toxic dose to minimally effective dose, predictable clearance to inactive metabolites, and minimal side effects. This article aims to review current progress of novel induction agent development and provide an update on the most promising drugs poised to enter clinical practice. In addition, the authors describe trends in novel agent development, implications for health care costs, and implications for perioperative care...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28524102/sleep-promoting-effects-and-possible-mechanisms-of-action-associated-with-a-standardized-rice-bran-supplement
#4
Hyejin Yang, Minseok Yoon, Min Young Um, Jaekwang Lee, Jonghoon Jung, Changho Lee, Yun-Tai Kim, Sangoh Kwon, Boknam Kim, Suengmok Cho
Natural sleep aids are becoming more popular due to the widespread occurrence of sleep disorders. The objective of this study was to assess the sleep-promoting effects of rice bran-a product that is considered as a functional ingredient. To evaluate the sleep-promoting effects of a standardized rice bran supplement (RBS), we employed a pentobarbital-induced sleep test and conducted analyses of sleep architecture. In addition, the effect of RBS on a caffeine-induced sleep disturbance was investigated. Oral administration of RBS (500 and 1000 mg/kg) produced a significant decrease in sleep latency and increase in sleep duration in pentobarbital-induced sleep in mice...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28514325/an-etomidate-analogue-with-less-adrenocortical-suppression-stable-hemodynamics-and-improved-behavioral-recovery-in-rats
#5
Bin Wang, Jun Yang, Jun Chen, Yi Kang, Ling-Hui Yang, Jin Liu, Wen-Sheng Zhang
BACKGROUND: ET-26 hydrochloride (ET-26HCl) is a novel etomidate analogue designed to alleviate the adrenocortical suppression caused by etomidate while retaining the rapid sedative-hypnotic onset and stable hemodynamic features of etomidate. This study compared the anesthetic effect, hemodynamic stability, and recovery profiles of ET-26HCl, etomidate, and the sedative-hypnotic drug propofol in rats. METHODS: The metabolic half-life of ET-26HCl was determined in vitro using high performance liquid chromatography analysis of samples of rat plasma and liver homogenates taken from 3 animals...
May 12, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28509855/the-hypnotic-anxiolytic-and-antinociceptive-profile-of-a-novel-%C3%A2%C2%B5-opioid-agonist
#6
Guilherme Carneiro Montes, Bianca Nascimento Monteiro da Silva, Bismarck Rezende, Roberto Takashi Sudo, Vitor Francisco Ferreira, Fernando de Carvalho da Silva, Angelo da Cunha Pinto, Bárbara Vasconcellos da Silva, Gisele Zapata-Sudo
5'-4-Alkyl/aryl-1H-1,2,3-triazole derivatives PILAB 1-12 were synthesized and a pharmacological screening of these derivatives was performed to identify a possible effect on the Central Nervous System (CNS) and to explore the associated mechanisms of action. The mice received a peritoneal injection (100 µmol/kg) of each of the 12 PILAB derivatives 10 min prior to the injection of pentobarbital and the mean hypnosis times were recorded. The mean hypnosis time increased for the mice treated with PILAB 8, which was prevented when mice were administered CTOP, a µ-opioid antagonist...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28508438/the-effect-of-chronotherapy-on-delirium-in-critical-care%C3%A2-%C3%A2-a-systematic-review
#7
Roseanne Luther, Anne McLeod
BACKGROUND: Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including disruption of the circadian rhythm. Chronotherapeutic interventions, such as light therapy, music and use of eye shades, have been suggested as an option to improve circadian rhythm within intensive care units. AIM: This review aims to answer the question: Can chronotherapy reduce the prevalence of delirium in adult patients in critical care? DESIGN: This study is a systematic review of quantitative studies...
May 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28506141/a-pragmatic-guide-to-the-setting-up-of-integrated-hypnotherapy-services-in-primary-care-and-clinical-settings
#8
Paul Andrew Entwistle
Despite the continued debate and lack of a clear consensus about the true nature of the hypnotic phenomenon, hypnosis is increasingly being utilized successfully in many medical, health, and psychological spheres as a research method, motivational tool, and therapeutic modality. Significantly, however, although hypnotherapy is widely advertised, advocated, and employed in the private medical arena for the management and treatment of many physical and emotional disorders, too little appears to be being done to integrate hypnosis into primary care and national health medical services...
July 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/28506140/a-multifaceted-hypnosis-smoking-cessation-program-enhancing-motivation-and-goal-attainment
#9
Joseph P Green, Steven Jay Lynn
Smoking cessation remains a major health priority. Despite public campaigns against smoking and widespread availability of smoking-cessation treatments, many people continue to smoke. The authors argue that the "problem of motivation," that is, suboptimal or fluctuating motivation to resist smoking urges and to comply with the demands of treatment, commonly undermines treatment seeking and adherence, appreciably reducing the success rates of smoking-cessation programs. The authors describe the history of the Winning Edge smoking-cessation program and discuss ways to enhance motivation before, during, and after formal treatment...
July 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/28505500/increase-in-the-prescription-rate-of-antidepressants-after-the-sewol-ferry-disaster-in-ansan-south-korea
#10
Kyu-Man Han, Kyoung-Hoon Kim, Mikyung Lee, Sang-Min Lee, Young-Hoon Ko, Jong-Woo Paik
BACKGROUND: Previous pharmaco-epidemiological studies have reported increases in the prescription of psychotropic medications after a disaster, reflecting post-disaster changes in psychiatric conditions and mental health service utilization. We investigated changes in the prescription of psychotropic medications in the Danwon district of Ansan city (Ansan Danwon) compared to a control community before and after the Sewol Ferry disaster on April 16, 2014. METHODS: Data was collected from the Korean Health Insurance Review and Assessment Service database...
May 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28499448/comparison-of-demographic-characteristics-and-psychiatric-comorbidity-among-methamphetamine-heroin-and-methamphetamine-heroin-co-dependent-males-in-hunan-china
#11
Huixi Dong, Mei Yang, Liang Liu, Chenxi Zhang, Mengqi Liu, Yidong Shen, Huanzhong Liu, Wei Hao
BACKGROUND: There is little research of psychiatric comorbidity differences among people with different types of drug dependence in Chinese population. We explored demographic and comorbid psychiatric differences among methamphetamine- dependent males (MDs), heroin-dependent males (HDs) and methamphetamine and heroin co-dependent males (M/HDs) in Hunan province, China. METHODS: A cross-sectional, structured and clinical interview method was used to examine differences in DSM-IV-TR Axis I Disorders among 346 MDs, 698 HDs and 247 M/HDs from three compulsory rehabilitation centers and two voluntary rehabilitation centers in Hunan...
May 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28490941/effectiveness-of-hypnosis-in-combination-with-conventional-techniques-of-behavior-management-in-anxiety-pain-reduction-during-dental-anesthetic-infiltration
#12
A Ramírez-Carrasco, C Butrón-Téllez Girón, O Sanchez-Armass, M Pierdant-Pérez
Background and Objective. Anxiety/pain are experiences that make dental treatment difficult for children, especially during the time of anesthesia. Hypnosis is used in pediatric clinical situations to modify thinking, behavior, and perception as well as, recently, in dentistry; therefore the aim of this study was to evaluate the effectiveness of hypnosis combined with conventional behavior management techniques during infiltration anesthetic. Methods. Anxiety/pain were assessed with the FLACC scale during the anesthetic moment, as well as heart rate variability and skin conductance before and during the anesthetic moment, between the control and experimental group...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28489797/a-previously-published-propofol-remifentanil-response-surface-model-does-not-predict-patient-response-well-in-video-assisted-thoracic-surgery
#13
Hsin-Yi Wang, Chien-Kun Ting, Jing-Yang Liou, Kun-Hui Chen, Mei-Young Tsou, Wen-Kuei Chang
Modern anesthesia usually employs a hypnotic and an analgesic to produce synergistic sedation and analgesia. Two remifentanil-propofol interaction response surface models were used to predict sedation using Observer's Assessment of Alertness/Sedation (OAA/S) scores; one predicts an OAA/S <2 and the other <4. We hypothesized that both models would predict regained responsiveness (RR) after video-assisted thoracic surgery (VATS) to reduce total anesthesia time and make early extubation clinically relevant...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489735/impact-of-a-preoperative-conversational-hypnotic-session-on-propofol-consumption-using-closed-loop-anesthetic-induction-guided-by-the-bispectral-index-a-randomized-controlled-trial
#14
Aurélien Bataille, Sébastien Besset, Barbara Szekely, Mireille Michel-Cherqui, Virginie Dumans, Ngai Liu, Thierry Chazot, Marc Fischler, Morgan Le Guen
OBJECTIVE: The automated administration of propofol in a closed loop could be used to objectively evaluate the nonpharmacological anesthetic action of hypnotherapy. The objective of this study was to evaluate the impact of a conversational hypnosis session on the consumption of propofol for anesthetic induction. DESIGN: A randomized, usual care-controlled, single-center, patient-blind trial. SETTING: Tertiary care center in France from November 2012 to December 2013...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489008/-do-opioids-sedatives-and-proton-pump-inhibitors-increase-the-risk-of-fractures
#15
Gudlaug Thorsdottir, Elisabet Benedikz, Sigridur A Thorgeirsdottir, Magnus Johannsson
INTRODUCTION: A pharmacoepidemiological study was conducted to analyse the relationship between bone fracture and the use of certain drugs. MATERIAL/METHODS: The study includes patients 40 years and older, diagnosed with bone fractures in the Emergency Department of Landspitali University Hospital in Reykjavik, Iceland, during a 10-year period (2002-2011). Also were included those who picked up from a pharmacy 90 DDD or more per year of the drugs included in the study in the capital region of Iceland during same period...
May 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28485704/the-power-of-suggestion-posthypnotically-induced-changes-in-the-temporal-binding-of-intentional-action-outcomes
#16
Peter Lush, Emilie A Caspar, Axel Cleeremans, Patrick Haggard, Pedro Alexandre Magalhães De Saldanha da Gama, Zoltan Dienes
The sense of agency is the experience of initiating and controlling one's voluntary actions and their outcomes. Intentional binding (i.e., when voluntary actions and their outcomes are perceived to occur closer together in time than involuntary actions and their outcomes) is increased in intentional action but requires no explicit reflection on agency. The reported experience of involuntariness is central to hypnotic responding, during which strategic action is experienced as involuntary. We report reduced intentional binding in a hypnotically induced experience of involuntariness, providing an objective correlate of reports of involuntariness...
May 2017: Psychological Science
https://www.readbyqxmd.com/read/28484067/patient-entered-wellness-data-and-tailored-electronic-recommendations-increase-preventive-care
#17
Julie Foucher-Urcuyo, David Longworth, Michael Roizen, Bo Hu, Michael B Rothberg
PURPOSE: We investigated whether a tool using patient-entered wellness data to generate tailored electronic recommendations improved preventive care delivery. METHODS: We conducted a mixed-methods retrospective study of primary care encounters utilizing an Integrated Wellness Tool with a matched-comparison before-and-after study design. Encounters took place at a single clinic within the Cleveland Clinic Health System. The primary outcome was preventive orders placed...
May 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28476551/emergency-department-visits-involving-benzodiazepines-and-non-benzodiazepine-receptor-agonists
#18
Christopher N Kaufmann, Adam P Spira, G Caleb Alexander, Lainie Rutkow, Ramin Mojtabai
OBJECTIVE: Sedative-hypnotic medications (e.g., Benzodiazepines [BZDs] and non-benzodiazepine receptor agonists [nBZRAs]) are associated with adverse events, especially in the elderly, that may require emergency department (ED) treatment. This study assessed outcomes from ED visits attributed to BZDs and/or nBZRAs, and variations in these associations by age group. METHODS: Data came from the 2004-2011 waves of the Drug Abuse Warning Network (DAWN). Visits were categorized as involving: (1) BZDs-only, (2) nBZRAs-only, (3) combination of BZDs and nBZRAs, or (4) any other sedative-hypnotic medication...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28473323/gabaa-receptor-%C3%AE-4-subunit-knockout-enhances-lung-inflammation-and-airway-reactivity-in-a-murine-asthma-model
#19
Gene T Yocum, Damian L Turner, Jennifer Danielsson, Matthew B Barajas, Yi Zhang, Dingbang Xu, Neil Harrison, Gregg E Homanics, Donna L Farber, Charles W Emala
Emerging evidence indicates that hypnotic anesthetics affect immune function. Many anesthetics potentiate γ-aminobutyric acid A receptor (GABAAR) activation, and these receptors are expressed on multiple subtypes of immune cells, providing a potential mechanistic link. Like immune cells, airway smooth muscle (ASM) cells also express GABAARs, particularly isoforms containing α4 subunits, and activation of these receptors leads to ASM relaxation. We sought to determine if GABAAR signaling modulates the ASM contractile and inflammatory phenotype of a murine allergic asthma model utilizing GABAAR α4 subunit global knockout (KO; Gabra4(0/0)) mice...
May 4, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28467623/opioids-and-other-central-nervous-system-active-polypharmacy-in-older-adults-in-the-united-states
#20
Lauren B Gerlach, Mark Olfson, Helen C Kales, Donovan T Maust
OBJECTIVES: To determine patterns of and trends in contributions to central nervous system (CNS) polypharmacy, defined by the Beers Criteria as three or more CNS-active medications of each medication class, of adults aged 65 and older seen in U.S. outpatient medical practices. DESIGN: National Ambulatory Medical Care Survey (2004-2013). SETTING: U.S. outpatient medical care. PARTICIPANTS: Visits by older adults to outpatient physicians (N = 97,910)...
May 3, 2017: Journal of the American Geriatrics Society
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