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https://www.readbyqxmd.com/read/28335012/improving-working-memory-performance-in-brain-injured-patients-using-hypnotic-suggestion
#1
Jonas K Lindeløv, Rikke Overgaard, Morten Overgaard
Working memory impairment is prevalent in brain injured patients across lesion aetiologies and severities. Unfortunately, rehabilitation efforts for this impairment have hitherto yielded small or no effects. Here we show in a randomized actively controlled trial that working memory performance can be effectively restored by suggesting to hypnotized patients that they have regained their pre-injury level of working memory functioning. Following four 1-h sessions, 27 patients had a medium-sized improvement relative to 22 active controls (Bayes factors of 342 and 37...
February 4, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28331860/quetiapine-misuse-and-abuse-is-it-an-atypical-paradigm-of-drug-seeking-behavior
#2
REVIEW
Sean Kim, Gayoung Lee, Eric Kim, Hyejin Jung, Jongwha Chang
Recent case reports in medical literatures suggest that more and more second-generation atypical antipsychotics (AAs) have been prescribed for off-label use; quetiapine (Brand name: Seroquel(®)) showed increase in its trend for off-label use. Little is known about the reasons behind this trend, although historical sedative and hypnotic prescription patterns suggest that despite relatively superior safety profiles of quetiapine (especially for movement disorders), it may be used for treating substance abuse disorder...
January 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28330081/emerging-cam-ziziphus-nummularia-with-in-vivo-sedative-hypnotic-antipyretic-and-analgesic-attributes
#3
Abdur Rauf, Jawad Ali, Haroon Khan, Mohammad S Mubarak, Seema Patel
Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28326793/changes-in-habitual-sleep-duration-after-continuous-positive-airway-pressure-for-obstructive-sleep-apnea
#4
Ryo Tachikawa, Takuma Minami, Takeshi Matsumoto, Kimihiko Murase, Kiminobu Tanizawa, Morito Inouchi, Toru Oga, Kazuo Chin
RATIONALE: Obstructive sleep apnea (OSA) can affect not only sleep quality but also sleep duration. Determining the therapeutic effects of continuous positive airway pressure (CPAP) on habitual sleep profiles may shed light on the impact of OSA on sleep duration. OBJECTIVES: To determine whether and how CPAP affects habitual sleep duration in patients with OSA. METHODS: Assessments of sleep duration and sleep quality were performed on 57 newly diagnosed study subjects with OSA (46 men, median 63 years, apnea-hypopnea index >20 h-1) at baseline and 3 months after initiation of CPAP therapy...
March 22, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28318987/a-clinical-evaluation-of-the-pharmacokinetics-and-pharmacodynamics-of-intravenous-alfaxalone-in-cyclodextrin-in-male-and-female-rats-following-a-loading-dose-and-constant-rate-infusion
#5
Kate L White, Stuart Paine, John Harris
OBJECTIVE: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3α-hydroxy-5 α-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-β-cyclodextrin in male and female rats. STUDY DESIGN: Prospective, experimental laboratory study. ANIMALS: A total of 12 (six male and six female) adult, aged-matched Sprague Dawley rats. METHODS: Surgery and instrumentation was performed under isoflurane anaesthesia in an oxygen/nitrous oxide mixture (1:2) and local anaesthetic infiltration...
February 1, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28318068/helicid-alleviates-pain-and-sleep-disturbances-in-a-neuropathic-pain-like-model-in-mice
#6
Meng-Qi Zhang, Tian-Xiao Wang, Rui Li, Zhi-Li Huang, Wu-Jian Han, Xiao-Chang Dai, Yi-Qun Wang
Natural helicid (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia. In the current study, mechanical allodynia tests, electroencephalograms, electromyogram recordings and c-Fos expression in neuropathic pain-like model mice of partial sciatic nerve ligation were used to investigate the effect of helicid on neuropathic pain and co-morbid insomnia...
March 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28306680/anaesthesia-in-patients-with-liver-disease
#7
Malgorzata H Starczewska, Wint Mon, Peter Shirley
PURPOSE OF REVIEW: The purpose of this review is to summarize the most recent up to date research data and recommendations regarding anaesthetic management of patients with liver disease undergoing surgery. The incidence of chronic liver disease (CLD) continues to rise and perioperative mortality and morbidity remains unacceptably high in this group. Meticulous preoperative assessment and carefully planned anaesthetic management are vital in improving outcomes in patients with liver disease undergoing surgery...
March 16, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28300761/incorporating-hypnosis-into-pediatric-clinical-encounters
#8
Robert A Pendergrast
Increasing numbers of licensed health professionals who care for children have been trained in clinical hypnosis. The evidence base for the safety and efficacy of this therapeutic approach in a wide variety of conditions is also growing. Pediatricians and other health professionals who have received training may wish to apply these skills in appropriate clinical scenarios but still may be unsure of the practical matters of how to incorporate this skill-set into day to day practice. Moreover, the practical application of such skills will take very different forms depending on the practice setting, types of acute or chronic conditions, patient and family preferences, and the developmental stages of the child or teen...
March 16, 2017: Children
https://www.readbyqxmd.com/read/28300521/volitional-and-nonvolitional-responses-to-hypnotic-suggestions-predictors-and-subjective-experience
#9
John C Mohl, Meriel J Schutkofsky
This investigation combined the data from two studies that used modified scoring of the Harvard Group Scale of Hypnotic Susceptibility (Shor & Orne, 1962) to evaluate deliberate, volitional responses to suggestions. One study also employed subjective ratings of each item of the Harvard Scale, with comparisons of nonvolitional, volitional, and non-responses. Based on the assumption that participants would have marked volitional responses as positive responses using the traditional scale, the traditional scoring method was found to inflate mean hypnotic responsiveness by nearly one point...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28300519/on-suggestibility-and-placebo-a-follow-up-study
#10
Michael Lifshitz, Eli O Sheiner, Jay A Olson, Rémi Thériault, Amir Raz
Identifying what makes some people respond well to placebos remains a major challenge. Here, we attempt to replicate an earlier study in which we found a relationship between hypnotic suggestibility and subjective ratings of relaxation following the ingestion of a placebo sedative (Sheiner, Lifshitz, & Raz, 2016). To assess the reliability of this effect, we tested 34 participants using a similar design. Participants ingested a placebo capsule in one of two conditions: (1) relaxation, wherein we described the capsule as a herbal sedative, or (2) control, wherein we described the capsule as inert...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28300515/the-social-before-sociocognitive-theory-explaining-hypnotic-suggestion-in-german-speaking-europe-1900-1960
#11
Anthony D Kauders
The article intends to retrace and review German discourse on hypnotic suggestion from 1900 onward, demonstrating the variety of arguments advanced to account for the social relationship in the hypnotic setting well before the emergence of sociocognitive theory. Using Spanos's distinction between "happenings" and "doings," it shows how, in the case of the "social" in early 20th century German texts on (hypnotic) suggestion, the passive observer, recipient, or victim of hypnosis, a trope familiar to the discipline for many decades, was called into question...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28300512/the-hypnotic-induction-in-the-broad-scheme-of-hypnosis-a-sociocognitive-perspective
#12
Steven Jay Lynn, Reed Maxwell, Joseph P Green
Researchers and clinicians typically divide hypnosis into two distinct parts: the induction and the suggestions that follow. We suggest that this distinction is arbitrary and artificial. Different definitions of hypnosis ascribe different roles to the hypnotic induction, yet none clearly specifies the mechanisms that mediate or moderate subjective and behavioral responses to hypnotic suggestions. Researchers have identified few if any differences in responding across diverse hypnotic inductions, and surprisingly little research has focused on the specific ingredients that optimize responsiveness...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28300462/an-update-on-the-advancements-in-the-treatment-of-agitation-in-alzheimer-s-disease
#13
Anton P Porsteinsson, Inga M Antonsdottir
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are associated with significant negative outcomes for patients and their caregivers. Agitation, one of the most distressing NPS, lacks well-established long term interventions that are both effective and safe. While nonpharmacological interventions are suggested as first-line treatment, they aren't effective in managing symptoms for every patient, resulting in pharmacological interventions for some patients. Traditionally these interventions consist of off-label use of antipsychotics, sedative/hypnotics, anxiolytics, acetylcholinesterase inhibitors, memantine, and antidepressants; where the efficacy doesn't necessarily outweigh the associated risks...
March 16, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28290942/increased-postdeployment-use-of-medication-for-common-mental-disorders-in-danish-gulf-war-veterans
#14
Lars Ravnborg Nissen, Christian Stoltenberg, Mia Sadowa Vedtofte, Anni Brit Sternhagen Nielsen, Jacob Louis Marott, Finn Gyntelberg, Bernadette Guldager
BACKGROUND: Gulf War veterans (GWVs) have an elevated risk of reporting symptoms of mental disorders as compared with nondeployed military controls. A difficulty in the Gulf War health research is that most health outcomes are self-reported; therefore, it is highly relevant to study objective outcomes in this line of research. The Danish National Prescription Registry provides an opportunity to use the prescription of drugs as an objective evaluation of the impact of mental health disorders at the individual level...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28281386/effects-of-depression-and-melatonergic-antidepressant-treatment-alone-and-in-combination-with-sedative-hypnotics-on-heart-rate-variability-implications-for-cardiovascular-risk
#15
Chuan-Chia Chang, Nian-Sheng Tzeng, Chin-Bin Yeh, Terry B J Kuo, San-Yuan Huang, Hsin-An Chang
OBJECTIVES: To examine heart rate variability (HRV) in unmedicated patients with major depressive disorder (MDD) and its changes after treatment with agomelatine alone and in combination with sedative-hypnotics. METHODS: We recruited 152 physically healthy, unmedicated patients with MDD and 472 age- and sex-matched healthy volunteers. Frequency-domain measures of HRV were obtained during enrolment for all participants and again for MDD patients after 6 weeks of treatment with agomelatine alone and combining sedative-hypnotics...
March 10, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28278155/combined-association-of-clinical-and-lifestyle-factors-with-non-restorative-sleep-the-nagahama-study
#16
Takeshi Matsumoto, Yasuharu Tabara, Kimihiko Murase, Yoshimitsu Takahashi, Kazuya Setoh, Takahisa Kawaguchi, Shigeo Muro, Hiroshi Kadotani, Shinji Kosugi, Akihiro Sekine, Ryo Yamada, Takeo Nakayama, Michiaki Mishima, Fumihiko Matsuda, Kazuo Chin
BACKGROUND: Non-restorative sleep (NRS) was suggested to be associated with cardiovascular outcomes. However, causative factors for NRS have not been fully elucidated. This study aimed to clarify factors and their relationships with NRS to better understand the clinical and epidemiological implications of NRS and to develop a score that can objectively evaluate NRS status. METHODS: Study subjects consisted of 9,788 community residents (age 53.6 ± 13.4 y). Subjective NRS as well as possible clinical and lifestyle factors for NRS were investigated by questionnaires...
2017: PloS One
https://www.readbyqxmd.com/read/28277276/the-use-of-eriksonian-hypnosis-to-improve-patient-outcomes-in-pharmacy-practice-a-novel-communication-skill-for-pharmacists
#17
John M Lonie, Cherie Tsingos-Lucas
Motivational Interviewing, pharmacist-based health coaching and traditional patient counseling techniques all show merit in improving communication between patients and health care providers. However, in order to effectively utilize these techniques one should have the ability to draw upon internal cognitive and psychological resources. Some patients have difficulty obtaining optimal health outcomes due to an unconscious inability to learn and connect with psychological resources. When this is the case, other methods of communication may need to be considered...
October 22, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28274147/lipid-nanoparticles-of-zaleplon-for-improved-oral-delivery-by-box-behnken-design-optimization-in-vitro-and-in-vivoevaluation
#18
Narendar Dudhipala, Karthik Yadav Janga
PURPOSE: Zaleplon (ZL) is a hypnotic drug prescribed for the management of insomnia and convulsions. The oral bioavailability of ZL was low (∼30%) owing to poor water solubility and hepatic first-pass metabolism. The cornerstone of this investigation is to develop and optimize solid lipid nanoparticles (SLNs) of ZL with the aid of Box-Behnken design (BBD) to improve the oral bioavailability. METHODS: A design space with three formulation variables at three levels were evaluated in BBD...
March 9, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28272097/electroconvulsive-therapy-at-a-veterans-health-administration-medical-center
#19
Samuel T Wilkinson, Robert A Rosenheck
OBJECTIVES: Little epidemiologic research has examined the practice of electroconvulsive therapy (ECT). We investigated sociodemographic and clinical characteristics, service use, and psychotropic medication prescription patterns associated with ECT use at a Veterans Health Administration Medical Center. METHODS: Among veterans receiving specialty mental health services, we compared those who received ECT with those who did not using bivariate χ and t tests and multivariate logistic regression...
March 8, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28270270/a-review-of-suvorexant-doxepin-ramelteon-and-tasimelteon-for-the-treatment-of-insomnia-in-geriatric-patients
#20
Chelsey Edmonds, Michael Swanoski
Geriatric patients often experience insomnia because of physiological and neurological changes that occur during the aging process. Use of benzodiazepines, nonbenzodiazepine hypnotics, and diphenhydramine for the treatment of insomnia pose an increased risk of cognitive impairment, falls, and fractures in this patient population. Therapeutic alternatives approved by the Food and Drug Administration include suvorexant, doxepin, ramelteon, and tasimelteon, which have shown efficacy and safety in various studies...
March 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
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