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Ali Turan
This study was conducted to determine the effects of hazelnut drying machine (DM1 and DM2 ; at 45 °C and 50 °C, respectively) and sun-drying (concrete ground and grass ground) methods on the chemical properties of Tombul, Palaz, and Ordu Levant hazelnuts. For this purpose, protein, lipid and moisture content, water activity, free fatty acid (FFA), peroxide value (PV), rancimat value (RV) and fatty acid composition were analyzed. As expected, it was observed that monounsaturated fatty acid (MUFA) was the main fatty acid group (81...
November 2018: Journal of Food Science and Technology
Lucas Busta, Won Yim, Evan William LaBrant, Peng Wang, Lindsey Grimes, Kiah Malyszka, John C Cushman, Patricia Santos, Dylan K Kosma, Edgar B Cahoon
Polyacetylenic lipids accumulate in various Apiaceae species after pathogen attack, suggesting that these compounds are naturally occurring pesticides and potentially valuable resources for crop improvement. These compounds also promote human health and slow tumor growth. Even though polyacetylenic lipids were discovered decades ago, the biosynthetic pathway underlying their production is unknown. To begin filling this gap, and ultimately enable polyacetylene engineering, we studied polyacetylenes and their biosynthesis in the major Apiaceae crop carrot (Daucus carota subsp...
October 17, 2018: Plant Physiology
Emma Rapposelli, Maria Pia Rigoldi, Daniela Satta, Donatella Delpiano, Sara Secci, Andrea Porceddu
BACKGROUND: Recent nutritional and medical studies have associated the regular consumption of almonds with a wide range of health benefits. As a consequence, kernel quality has become an important goal for breeding, considering not only the chemical composition conferring a specific organoleptic quality but also physical traits related to industrial processing. METHODS: We characterized an almond collection from Sardinia through analysis of 13 morpho-physiological traits and eight essential oil profiles...
October 15, 2018: Plants (Basel, Switzerland)
Yan Mi, Dehong Tan, Yin He, Xin Zhou, Qian Zhou, Shujuan Ji
Melatonin exists as an active ingredient in several foods and has been reported to inhibit fatty liver disease in animals; however, its molecular mechanisms are not well elucidated. Herein, we explored effects of melatonin on lipid accumulation induced by oleic acid in HepG2 cells and characterized the underlying molecular mechanisms. Pretreatment with melatonin (0.1-0.3 mM) significantly inhibited accumulation of triglyceride and cholesterol induced by incubating HepG2 cells with high concentrations of oleic acid (oleic acid overload) (p < 0...
October 15, 2018: Cell Biochemistry and Biophysics
S P Ndou, E Kiarie, N Ames, C M Nyachoti
The present study was conducted to determine the effects of adding flaxseed meal or oat hulls in pigs' diets on digestibility of dietary fiber (DF) and fatty acids (FA), and gastrointestinal flows of FA and bile acids (BA). Twelve Genesus [(Duroc♂ × Yorkshire-Landrace♀)] cannulated barrows (initial BW: 35.1 ± 0.44 kg) were individually housed and offered diets in a 2-period cross-over design (n = 8). In each period, four pigs were assigned to one of the three corn-soybean meal-based diets without (control), or with flaxseed meal (FM) or oat hulls (OH)...
October 15, 2018: Journal of Animal Science
Octavio Galindo-Hernández, Iván Córdova-Guerrero, Laura Janeth Díaz-Rubio, Ángel Pulido-Capiz, José Fernando Díaz-Villanueva, César Yahel Castañeda-Sánchez, Nicolás Serafín-Higuera, Víctor García-González
Endoplasmic reticulum stress is a cellular phenomenon that has been associated with metabolic disorders, contributing to the development of obesity, fatty liver disease, and dyslipidemias. Under metabolic overload conditions, in cells with a high protein-secretory activity, such as hepatocytes and Langerhans β cells, the unfolded protein response (UPR) is critical in to maintain protein homeostasis (proteostasis). UPR integrated by a tripartite signaling system, through activating transcription factor 6, protein kinase R-like endoplasmic reticulum kinase (PERK), and inositol-requiring enzyme 1, regulates gene transcription and translation to resolve stress and conserve proteostasis...
October 15, 2018: Journal of Cellular Biochemistry
Yu Jeong Kim, Yongcheol Lee, Jaecheol Kim, Sun Young Park, Kiuk Lee, Keum Taek Hwang
Physicochemical characteristics and anti-oxidant capacities of seeds from two farm-cultivated and one mountain-cultivated ginsengs ( Panax ginseng Meyer) (MG) were determined. The seeds had 17.9-22.1% (dry basis) crude lipids, 11.5-15.2% crude proteins, and 1.4-1.7% ash. Oleic acid (77.9-78.5%) was the predominant fatty acid in the seed oils, followed by linoleic acid (16.6-17.4%). The highest Hunter b value, carotenoids, (β + γ)-tocotrienol, and δ-tocotrienol, and the lowest α-tocotrienol were observed in the seed oils from MG...
October 2018: Food Science and Biotechnology
Y P Zhou, R Wu, W Shen, H H Yu, S J Yu
Objective: To explore the effects of oleic acid and palmitic acid on lipid deposition and mTOR/S6K1/SREBP-1c pathways in HepG2 cells. Methods: The model of steatosis was established with induction of oleic acid and palmitic acid and was intervened by rapamycin. The changes in lipid droplets were observed after staining the cells with oil Red O. Intracellular triglyceride (TG) contents in cells were measured by TG kit. mTOR, S6K1, and SREBP-1c mRNA expression levels were detected using QRT-PCR. Western blot was used to determine protein expression levels of mTOR, S6K1 and SREBP-1c...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Yung-Yu Tsai, Takao Ohashi, Chih-Chan Wu, Dolgormaa Bataa, Ryo Misaki, Savitree Limtong, Kazuhito Fujiyama
The oil plants provide a sufficient source of renewable lipid production for alternative fuel and chemical supplies as an alternative to the depleting fossil source, but the environmental effect from these plants' cropping is a concern. The high oleic acid (OA; C18:1) content in plant-derived products provide advantages of multiple uses with improved oxidative stability and a wide range of applicable temperature. Here we used a promising lipid producer, the oleaginous yeast Rhodosporidium toruloides, to attempt to obtain an OA-enriched lipid...
October 10, 2018: Journal of Bioscience and Bioengineering
Clarissa Santos, Donald F Weaver
The topical application of linoleic and linolenic acids is a potential prophylactic approach to migraine via an anti-inflammatory mechanism. We present a 45-year-old woman with chronic migraine without aura. Previous use of abortive or prophylactic therapies including sumatriptan, amitriptyline and topiramate had failed due to lack of efficacy or side-effects, especially vomiting. In search of a topical agent she performed an n-of-1 trial comparing application of linoleic acid (safflower oil) versus oleic acid (olive oil) for migraine relief...
October 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Birol Kılıç, Cem Okan Özer
The aim of the study was to investigate the effects of replacing beef fat with interesterified palm kernel oil (IPKO) on the quality characteristics and storage stability of frankfurters. Five treatment groups were: control (C) and four levels of IPKO replacements; 25, 50, 75 and 100%. Study results revealed that replacement of beef fat with IPKO resulted in a significant increase in caprylic (C8:0), capric (C10:0), lauric (C12:0) and miristic acid (C14:0) levels and a decrease in palmitic (C16:0), palmitoleic (C16:1), stearic (C18:0) and oleic acid (C18:1) levels in frankfurters (P < 0...
October 10, 2018: Meat Science
Moazameh Peyrovi, Mohammadreza Hadjmohammadi, Iman Saeidi
In the present study, a novel and efficient adsorbent constructed of molecularly imprinted polymer on the surface of modified magnetic nanoparticles with oleic acid (MNPs) was applied for the selective extraction of ezetimibe. The magnetic molecularly imprinted polymer (MMIP) was polymerized at the surface of modified MNPs using methacrylic acid (MAA) as functional monomer, ezetimibe as template and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The resulting MMIP showed high adsorption capacity, good selectivity and fast kinetic binding for the template molecule...
October 12, 2018: Biomedical Chromatography: BMC
Qi Liu, Yuying Guo, Mengtian Shan, Chao Lan, Rongchang Chen
OBJECTIVE: To explore the effect of lung strain on breathing mechanics in dogs with acute respiratory distress syndrome (ARDS). METHODS: Twenty-four healthy male Beagle dogs were recruited to reproduce medium ARDS models with venous injection of 0.18 mL/kg oleic acid, and they were randomly assigned to five groups with random numbers table method. In lung protective ventilation (LPV) group (n = 4), the ventilation was supported for 24 hours with tidal volume (VT) at 6-8 mL/kg, and in lung strain 1...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Olga Otrubova, Monika Jerigova, Sona Halaszova, Ladislav Turecky, Jana Muchova, Dusan Velic
This work provides complex characterisation of cirrhotic rat liver tissue induced by carbon tetrachloride using biochemical and histopathological analyses, and also presents a novel approach, secondary ion mass spectrometry (SIMS). According to our knowledge, this is the first report that compares these three different approaches in study of liver damage. We observed increased levels of triacylglycerols and total cholesterol in the liver and decreased levels of those parameters in the plasma. Histopathological observations include fat accumulation in the cells and changes in internal configuration of cells such as shift of position of organelles from the centre to the edge...
September 2018: General Physiology and Biophysics
Eva Gesteiro, Jesús Galera-Gordo, Marcela González-Gross
Palm oil is obtained from Elaeis guineensis, E. oleifera or the hybrid OxG palm fruits. When crude, it contains high carotenoid concentrations (responsible for the red color), tocopherols and tocotrienols, but most of them are eliminated during its refining. Palm oil main components are palmitic and oleic acids, both near 50%, but their proportion changes depending on the fraction used. Fatty acids absorption and the effect on blood lipid profile depend on the position in the triacylglycerol, especially in the sn-2 position...
October 8, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Bin Lou, Qi Liu, Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Deyong Ye, Yang Chen, Hai H Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang
2-Hydroxy-oleic acid (2OHOA) is a potent anticancer drug that induces cancer cell cycle arrest and apoptosis. We have previously proposed that 2OHOA-mediated inhibition of sphingomyelin synthase (SMS), especially of SMS2, could be a potential therapeutic approach to manage metabolic diseases. However, other studies have suggested that 2OHOA's anticancer effect is mediated by SMS activation in cancer cells, including A549 and U118 cells. To resolve this apparent discrepancy, in this study, we treated both A549 and U118 cells with 2OHOA and measured SMS activity...
October 10, 2018: Journal of Biological Chemistry
Olena Myronycheva, Olov Karlsson, Margot Sehlstedt-Persson, Micael Öhman, Dick Sandberg
During industrial wood drying, extractives migrate towards the wood surfaces and make the material more susceptible to photo/biodegradation. The present work provides information about the distribution, quantity and nature of lipophilic substances beneath the surface in air- and kiln-dried Scots pine (Pinus sylvestris L.) sapwood boards. Samples were taken from knot-free sapwood surfaces and the composition of lipophilic extractives, phenols and low-molecular fatty/resin acids layers at different nominal depths below the surface was studied gravimetrically, by UV-spectrometry and by gas chromatography-mass spectrometry (GC-MS)...
2018: PloS One
Violaine Dubois, Albertus Viljoen, Laura Laencina, Vincent Le Moigne, Audrey Bernut, Faustine Dubar, Mickaël Blaise, Jean-Louis Gaillard, Yann Guérardel, Laurent Kremer, Jean-Louis Herrmann, Fabienne Girard-Misguich
Mycobacterium abscessus is a peculiar rapid-growing Mycobacterium (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as Mycobacterium tuberculosis A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an M. abscessus transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons with SGM and RGM genomes uncovered MmpL12 proteins as putative orthologs of MAB_0855 and a locus-scale synteny between the MAB_0855 and Mycobacterium chelonae mmpL8 loci...
October 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
Oh Yoen Kim, Su Mi Lee, Won Suk An
Fatty acids (FAs) are essential nutrients and main constituents of cell membranes that are involved in the signaling pathway and associated with health conditions. We investigated if blood or erythrocyte membrane FAs can predict the risk of cardiovascular disease (CVD), chronic kidney disease (CKD), and related complications. Omega-3 ( n -3) FAs are important predictors for metabolic syndrome, diabetes, CVD, and CKD risks, and the n -3 index is also a good biomarker for sudden cardiac death in coronary artery disease...
October 7, 2018: Nutrients
Shahram Seidi, Negar Sabahi Moosavi, Maryam Shanehsaz, Marzieh Abdolhosseini, Seyed Jamal Sadeghi
This study describes an ultrasonic assisted magnetic dispersive solid phase extraction based on oleic acid functionalized magnetic graphene oxide followed by HPLC-UV. The method was applied for simultaneous determination of ibuprofen, diclofenac, naproxen and mefenamic acid in urine. Applying of sonication led to well-dispersion of the sorbent and consequently, significant shortening of the extraction time. The sorbent was successfully characterized by different instrumental analysis. The influence of adsorption parameters were optimized using a rotational central composite design...
October 9, 2018: Journal of Separation Science
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