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https://www.readbyqxmd.com/read/30096401/nanotechnology-mediated-immunochemotherapy-combined-with-docetaxel-and-pd-l1-antibody-increase-therapeutic-effects-and-decrease-systemic-toxicity
#1
Zili Gu, Qingjie Wang, Yanbin Shi, Yi Huang, Jing Zhang, Xinke Zhang, Guimei Lin
Immunotherapy has exhibited enormous practice in the treatment of melanoma because of the intrinsic properties of tumor. Tumor can downmodulate immune function via multiple mechanisms such as immune checkpoint pathways. The PD-L1 monoclonal antibodies that block the PD1/PD-L1 pathway, which induced tumor cells to evade an immune attack, can delay tumor growth efficiently with inevitable disadvantages such as low selectivity and systemic toxicity. Nanomedicine is clearly an approach that holds tremendous potential for addressing the shortcomings and assisting delivery of drugs with proper biodistribution...
August 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30093906/construction-of-a-protective-vaccine-against-lipopolysaccharide-heterologous-pseudomonas-aeruginosa-strains-based-on-expression-profiling-of-outer-membrane-proteins-during-infection
#2
Chang Liu, Xiaolei Pan, Bin Xia, Fei Chen, Yongxin Jin, Fang Bai, Gregory Priebe, Zhihui Cheng, Shouguang Jin, Weihui Wu
Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen, which causes infectious disease in patients with cystic fibrosis and compromised immunity. P. aeruginosa is difficult to eradicate because of its intrinsic resistance to most traditional antibiotics as well as acquired resistance mechanisms after decades of antibiotic usage. A full understanding of the P. aeruginosa pathogenesis mechanisms is necessary for the development of novel prevention and treatment strategies. To identify novel vaccine candidates, here we comprehensively examined the expression levels of all the known outer membrane proteins in two P...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30084323/targeted-liposomes-for-sirna-delivery-to-cancer
#3
Josimar O Eloy, Raquel Petrilli, Giovanni Loureiro Raspantini, Robert J Lee
BACKGROUND: RNA interference is a promising therapeutic tool for the treatment of a variety of diseases, with great potential for cancer therapy. Small interfering RNA (siRNA), however, presents several drawbacks that hamper its therapeutic application. Lipid nanoparticles, including liposomes, are delivery systems with great potential for siRNA delivery, protecting it from degradation, enhancing its cell uptake with the ability of controlled release. However, non-specific delivery and side effects could potentially limit the in vivo application...
August 7, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/30074202/soft-and-hard-lipid-nanoparticles-a-novel-approach-to-lymphatic-drug-delivery
#4
REVIEW
Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee
With the current advance in nanotechnology, the development has accelerated of a number of nanoparticle-type drugs such as nano-emulsions, lipid emulsions, liposomes, and cell therapeutics. With these developments, attempts are being made to apply these new drugs to healing many intractable diseases related to antibody production, autoimmune disorders, cancer, and organ transplantation in both clinical and nonclinical trials. Drug delivery to the lymphatic system is indispensable for treating these diseases, but the core technologies related to the in vivo distribution characteristics and lymphatic delivery evaluation of these particle-type drugs have not yet been established...
August 3, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30033326/corrigendum-to-antibody-fragment-conjugated-gemcitabine-and-paclitaxel-based-liposome-for-effective-therapeutic-efficacy-in-pancreatic-cancer-mater-sci-eng-c-89-2018-328-335
#5
Wentao Yang, Qian Hu, Yanmei Xu, Hailang Liu, Lin Zhong
No abstract text is available yet for this article.
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30014244/phase-i-trial-of-lipovaxin-mm-a-novel-dendritic-cell-targeted-liposomal-vaccine-for-malignant-melanoma
#6
Tessa Gargett, M Nazim Abbas, Paul Rolan, Jason D Price, Katharine M Gosling, Antonio Ferrante, Andrew Ruszkiewicz, Ines I C Atmosukarto, Joseph Altin, Christopher R Parish, Michael P Brown
INTRODUCTION: In this phase I study using a 3 + 3 dose escalation design, the safety, dose-limiting toxicity (DLT), immunogenicity and efficacy of intravenous Lipovaxin-MM-a multi-component dendritic cell-targeted liposomal vaccine against metastatic melanoma-was investigated. METHODS: Twelve subjects with metastatic cutaneous melanoma were recruited in three cohorts. Patients in Cohort A (n = 3) and Cohort B (n = 3) received three doses of 0.1 and 1 mL of Lipovaxin-MM, respectively, every 4 weeks...
July 16, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/30005702/intranasal-administration-of-cationic-liposomes-enhanced-granulocyte-macrophage-colony-stimulating-factor-expression-and-this-expression-is-dispensable-for-mucosal-adjuvant-activity
#7
Rui Tada, Akira Hidaka, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki
OBJECTIVE: Infectious diseases remain a threat to human life. Vaccination against pathogenic microbes is a primary method of treatment as well as prevention of infectious diseases. Particularly mucosal vaccination is a promising approach to fight against most infectious diseases, because mucosal surfaces are a major point of entry for most pathogens. We recently developed an effective mucosal adjuvant of cationic liposomes composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and 3β-[N-(N',N'-dimethylaminoethane)-carbamoyl] (DC-chol) (DOTAP/DC-chol liposomes)...
July 13, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30002298/understanding-the-role-of-anti-peg-antibodies-in-the-complement-activation-by-doxil-in-vitro
#8
Barry W Neun, Yechezkel Barenholz, Janos Szebeni, Marina A Dobrovolskaia
Infusion reactions (IRs) are common immune-mediated side effects in patients treated with a variety of drug products, including, but not limited to, nanotechnology formulations. The mechanism of IRs is not fully understood. One of the best studied mechanisms of IRs to nanomedicines is the complement activation. However, it is largely unknown why some patients develop reactions to nanomedicines while others do not, and why some nanoparticles are more reactogenic than others. One of the theories is that the pre-existing anti-polyethylene glycol (PEG) antibodies initiate the complement activation and IRs in patients...
July 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29989788/high-performance-identification-of-human-bladder-cancer-using-signal-self-amplifiable-photoacoustic-nanoprobe
#9
Di Zhang, Ziqi Wang, Lu Wang, Zhichao Wang, Hongzhi Wang, Guangbin Li, Zeng-Ying Qiao, Wanhai Xu, Hao Wang
Cancer diagnostics has been an important research field and identification of small lesions that are less noticeable plays a vital role in thoroughly removing the tumor, thereby reducing the recurrence rate of cancer. Herein, we synthesized a signal self-amplifiable photoacoustic liposomal nanoprobe composed by ammonium hydrogen carbonate (AHC) payload and aggregated purpurin-18 (P18) within the bilayer. Under PA laser irradiation, P18 aggregates efficiently generated local heat, leading to the launch of wide-band ultrasonic emission...
July 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29977740/haase-sensitive-dual-targeting-irinotecan-liposomes-enhance-the-therapeutic-efficacy-of-lung-cancer-in-animals
#10
Liang Zhang, Haixin Cui
Among all cancers, lung cancer is one of the most common and serious types of cancer. It is challenging for site-specific delivery of anticancer therapeutics to tumor cells. Herein, we developed a novel"smart" dual-targeting liposomal platform to respond to the highly expressed hyaluronidase (HAase) in the tumor microenvironment and improve tumor targeting and antitumor efficacy. Methods: In our design, the HA was used as a sensitive linker between a liposomal lipid and long chain PEG block to synthesize three functional conjugates in order to prepare"smart" liposomal platform modified with epidermal growth factor receptor (EGFR) antibody (GE11) and cell-penetrating peptide (TATp)...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29973487/targeting-macrophages-as-a-potential-therapeutic-intervention-impact-on-inflammatory-diseases-and-cancer
#11
REVIEW
Mirco Ponzoni, Fabio Pastorino, Daniela Di Paolo, Patrizia Perri, Chiara Brignole
Macrophages, cells belonging to the innate immune system, present a high plasticity grade, being able to change their phenotype in response to environmental stimuli. They play central roles during development, homeostatic tissue processes, tissue repair, and immunity. Furthermore, it is recognized that macrophages are involved in chronic inflammation and that they play central roles in inflammatory diseases and cancer. Due to their large involvement in the pathogenesis of several types of human diseases, macrophages are considered to be relevant therapeutic targets...
July 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29963081/immunoprophylactic-potential-of-a-cocktail-of-three-low-molecular-weight-antigens-of-leishmania-donovani-along-with-various-adjuvants-against-experimental-visceral-leishmaniasis
#12
Harpreet Kaur, Ankita Thakur, Sukhbir Kaur
Background: Currently, there is no vaccine available for any form of leishmaniasis for human use, including visceral leishmaniasis (VL). The treatment relies on drugs associated with severe toxic side effects and increased parasite drug resistance. At present, there is a strong need to develop and implement a successful vaccine against this disease. Therefore, we evaluated immunoprophylactic potential of a cocktail of low molecular weight antigens along with various adjuvants. Methods: The three antigens (2015, Department of Zoology, Panjab University, Chandigarh), 31kDa, 36 kDa and 51 kDa of L...
January 2018: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29962407/development-of-a-screening-system-for-targeting-carriers-using-peptide-modified-liposomes-and-tissue-sections
#13
Yoichi Negishi, Nobuhito Hamano, Hinako Sato, Fumihiko Katagiri, Kyohei Takatori, Yoko Endo-Takahashi, Yamato Kikkawa, Motoyoshi Nomizu
Liposomes have been used as targeting carriers for drug delivery systems (DDSs), and the carriers are able to be modified with targeting ligands, such as antibodies and peptides. To evaluate the targetability of DDS carriers modified with a targeting ligand, culture cells expressing the targeting molecules as well as small animals are used. Furthermore, in vitro and in vivo screening analyses must be repeatedly performed. Therefore, it is important to establish an easy and high-precision screening system for targeting carriers...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29950829/docetaxel-trastuzumab-stealth-immunoliposome-development-and-in-vitro-proof-of-concept-studies-in-breast-cancer
#14
Anne Rodallec, Jean-Michel Brunel, Sarah Giacometti, Helene Maccario, Florian Correard, Eric Mas, Caroline Orneto, Ariel Savina, Fanny Bouquet, Bruno Lacarelle, Joseph Ciccolini, Raphaelle Fanciullino
Background: Trastuzumab plus docetaxel is a mainstay to treat HER2-positive breast cancers. However, developing nanoparticles could help to improve the efficacy/toxicity balance of this doublet by improving drug trafficking and delivery to tumors. This project aimed to develop an immunoliposome in breast cancer, combining docetaxel encapsulated in a stealth liposome engrafted with trastuzumab, and comparing its performances on human breast cancer cell lines with standard combination of docetaxel plus trastuzumab...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29933078/multivalent-targeting-and-killing-of-her2-overexpressing-breast-carcinoma-cells-with-methotrexate-encapsulated-tetra-specific-non-overlapping-variable-domain-heavy-chain-anti-her2-antibody-peg-liposomes-in-vitro-proof-of-concept
#15
Shahryar Khoshtinat Nikkhoi, Fatemeh Rahbarizadeh, Davoud Ahmadvand, Seyed Moein Moghimi
The variable domain of the heavy chain antibodies (VHHs) is the smallest (15 kDa) intact single domain antigen-binding fragment. VHHs often exhibit sub-nanomolar affinity for their designated targets and therefore are receiving increasing attention in molecular targeting and nanomedicine engineering. We cloned and expressed four non-overlapping anti-HER2 VHHs in a prokaryotic expression system that yielded disulfide-bonded VHHs. Purified VHHs, before and after thiolation, were characterized by Western blot and their functionality against the ecto-domain of HER2 receptor was confirmed by ELISA and flow cytometry...
September 15, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29926144/lappaconitine-a-c18-diterpenoid-alkaloid-exhibits-antihypersensitivity-in-chronic-pain-through-stimulation-of-spinal-dynorphin-a-expression
#16
Ming-Li Sun, Jun-Ping Ao, Yi-Rui Wang, Qian Huang, Teng-Fei Li, Xin-Yan Li, Yong-Xiang Wang
Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more than 30 years. This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms. Subcutaneous injection of cumulative doses of lappaconitine produced dose-dependent mechanical antiallodynia and thermal antihyperalgesia in spinal nerve ligation-induced neuropathic rats...
June 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29914561/boron-delivery-agents-for-neutron-capture-therapy-of-cancer
#17
REVIEW
Rolf F Barth, Peng Mi, Weilian Yang
Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produce high energy alpha particles. This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system. Two low molecular weight boron-containing drugs currently are being used clinically, boronophenylalanine (BPA) and sodium borocaptate (BSH). Although they are far from being ideal, their therapeutic efficacy has been demonstrated in patients with high grade gliomas, recurrent tumors of the head and neck region, and a much smaller number with cutaneous and extra-cutaneous melanomas...
June 19, 2018: Cancer communications
https://www.readbyqxmd.com/read/29911696/plasmid-dna-vaccines-where-are-we-now
#18
F Ghaffarifar
DNA vaccines are considered as third-generation vaccines. The recombinant DNA technology plays an important role in the production of DNA vaccines. These vaccines are intended to increase DNA insertion and translation in the cell, activate CD4+ T cells, and enhance cytotoxic T-lymphocyte induction and antibody production. DNA vaccines are safe with few side effects in humans and animals. Their immunogenicity can be improved by the use of suitable adjuvants and proper delivery systems. In recent years, strategies have been developed to increase the efficacy of DNA vaccines through electroporation, as well as the use of cytokines, genetically engineered vectors, liposomes, and micro- or nanoparticles...
May 2018: Drugs of Today
https://www.readbyqxmd.com/read/29908185/design-and-development-of-pegylated-liposomal-formulation-of-her2-blocker-lapatinib-for-enhanced-anticancer-activity-and-diminished-cardiotoxicity
#19
Richa Shrivastava, Shruti Trivedi, Pankaj Kumar Singh, Mohammad Asif, Manish Kumar Chourasia, Amit Khanna, Smrati Bhadauria
Breast cancer is most frequently diagnosed cancer and fifth leading cause of death in women. About 20-30% of all breast cancers overexpress HER2/neu receptors. Lapatinib is a dual tyrosin kinase inhibitor of EGFR and HER2. It exhibits its anticancer effect via blocking intracellular domain of HER2 receptor in breast cancer. Lapatinib belongs to class II of BSC classification due to its poor solubility restricting its clinical application. Due to presence of HER2 receptor on cardiomyocytes, it is associated with generation of cardiotoxicity...
June 25, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29896310/pre-existing-anti-polyethylene-glycol-antibody-reduces-the-therapeutic-efficacy-and-pharmacokinetics-of-pegylated-liposomes
#20
Yuan-Chin Hsieh, Hsin-Ell Wang, Wen-Wei Lin, Steve R Roffler, Ta-Chun Cheng, Yu-Cheng Su, Jia-Je Li, Chao-Cheng Chen, Chun-Han Huang, Bing-Mae Chen, Jaw-Yuan Wang, Tian-Lu Cheng, Fang-Ming Chen
Rationale: Increasing frequency of human exposure to PEG-related products means that healthy people are likely to have pre-existing anti-PEG antibodies (pre-αPEG Ab). However, the influence of pre-αPEG Abs on the pharmacokinetics (PK) and therapeutic efficacy of LipoDox is unknown. Methods: We generated two pre-αPEG Ab mouse models. First, naïve mice were immunized with PEGylated protein to generate an endogenous αPEG Ab titer (endo αPEG). Second, monoclonal αPEG Abs were passively transferred (αPEG-PT) into naïve mice to establish a αPEG titer...
2018: Theranostics
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