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https://www.readbyqxmd.com/read/30537643/molecular-docking-molecular-dynamics-simulations-and-qsar-studies-on-some-of-2-arylethenylquinoline-derivatives-for-inhibition-of-alzheimer-s-amyloid-beta-aggregation-insight-into-mechanism-of-interactions-and-parameters-for-design-of-new-inhibitors
#1
Hossein Safarizadeh, Zahra Garkani-Nejad
Alzheimer's disease is characterized using amyloid-beta (Aβ) aggregation. The present work was carried out to extend and design a novel quantitative structure-activity relationship (QSAR) model on inhibition efficiency of some of new 2-arylethenylquinoline derivatives against the Aβ1-42 peptide aggregation. The QSAR study, molecular docking and molecular dynamics (MD) simulations were performed to explore the influence of the structural features and investigate the molecular mechanism of ligands interactions with the Aβ1-42 peptide...
December 4, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/30537569/the-neurophysiological-and-neurochemical-effects-of-alcohol-on-the-brain-are-inconsistent-with-current-evidence-based-models-of-sleepwalking
#2
REVIEW
Mark R Pressman
The DSM-5 and ICSD-3 have removed alcohol from the list of potential triggers for sleepwalking due to the lack of empirical evidence. Recent imaging and EEG based studies of sleepwalking and confusional arousals have provided a more data-based method of examining if alcohol is compatible with what is known about the neurophysiology and neurochemistry of sleepwalking. These studies have demonstrated a deactivation of the frontal areas of the brain, while the cingulate or motor cortex remains active and characterized activation in the form of beta EEG...
November 10, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/30537565/influence-of-patient-positioning-on-reported-clinical-outcomes-after-greater-occipital-nerve-block-for-treatment-of-headache-results-from-prospective-single-centre-non-randomised-proof-of-concept-study
#3
Jitka Vanderpol, Leon Jonker
OBJECTIVE: Greater occipital nerve (GON) block is a treatment option applied for a variety of primary headache disorders. Although a patient's body position is known to have an impact on the effect of local anaesthetics, this has not before been investigated for patients undergoing GON block. Therefore, the clinical effectiveness of either a sitting or supine position was assessed. PATIENTS AND METHODS: This evaluative prospective study took place in a single neurology department in the UK...
December 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30537553/analysis-of-single-nucleotide-polymorphisms-in-the-gamma-block-of-the-major-histocompatibility-complex-in-association-with-clinical-outcomes-of-hematopoietic-cell-transplantation-a-cibmtr-study
#4
Medhat Askar, David Sayer, Tao Wang, Michael Haagenson, Stephen R Spellman, Stephanie J Lee, Abeer Madbouly, Katharina Fleischhauer, Katharine C Hsu, Michael R Verneris, Dawn Thomas, Aiwen Zhang, Ronald M Sobecks, Navneet S Majhail
HLA haplotype mismatches have been associated with higher risk of acute graft versus host disease (aGVHD) in patients receiving HLA matched unrelated donor (URD) hematopoietic cell transplant (HCT) unrelated donors. The Gamma block (GB) is located in the central MHC region between beta and delta blocks (encoding C & B and DR & DQ antigens, respectively). GB contains many inflammatory and immune regulatory genes such as Bf, C2 and C4 genes. A single center study showed that mismatches in SNP c.2918+98G, c...
December 8, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30537533/impact-of-a-multimodal-strategy-combining-a-new-standard-of-care-and-restriction-of-carbapenems-fluoroquinolones-and-cephalosporins-on-antibiotic-consumption-and-resistance-of-p-aeruginosa-in-an-icu
#5
Salam Abbara, Aurélia Pitsch, Sébastien Jochmans, Kyann Hodjat, Dr Pascale Cherrier, Mehran Monchi, Christophe Vinsonneau, Sylvain Diamantis
OBJECTIVES: To assess if the postprescription review and feedback (PPRF) of all antibiotics with restriction of carbapenems, fluoroquinolones and third generation cephalosporins, along with a change of medical standard of care, impacted the consumption of antibiotics and bacterial resistance in a medical/surgical intensive care unit (MSICU). METHODS: A four years before (2007-2010) and after (2011-2014) retrospective comparative study. Antibiotics consumption was evaluated in Defined Daily Doses per 1000 patient days...
December 8, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/30537475/serious-asthma-events-with-mometasone-furoate-plus-formoterol-compared-with-mometasone-furoate
#6
Cindy L J Weinstein, Nicholas Ryan, Tulin Shekar, Davis Gates, Stephen J Lane, Ioana Agache, Robert A Nathan
BACKGROUND: The safety of long-acting beta agonists added to inhaled corticosteroids for the treatment of persistent asthma has been controversial. OBJECTIVE: To determine whether administering formoterol in combination with mometasone furoate increases the risk of serious asthma outcomes compared to mometasone furoate alone. METHODS: We conducted a 26-week, randomized, double-blind trial in adolescent and adult patients (≥12 years) with persistent asthma in 35 countries with the primary objective of evaluating whether mometasone furoate-formoterol increases the risk of serious asthma outcomes (adjudicated hospitalization, intubation, or death) compared to mometasone furoate alone...
December 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30537413/the-histone-like-protein-hupb-influences-biofilm-formation-and-virulence-in-xanthomonas-citri-subsp-citri-through-the-regulation-of-flagellar-biosynthesis
#7
Valeria P Conforte, Florencia Malamud, Pablo M Yaryura, Laila Toum Terrones, Pablo S Torres, Verónica De Pino, Cristian N Chazarreta, Gustavo E Gudesblat, Atilio P Castagnaro, María Rosa Marano, Adrian A Vojnov
Citrus canker is an important disease of citrus, whose causal agent is the bacterium Xanthomonas citri subsp. citri (Xcc). In previous studies, we found a group of Xcc mutants, generated by the insertion of the Tn5 transposon, which show impaired ability to attach to an abiotic substrate. One of these mutants carries the Tn5 insertion in hupB, a gene encoding a bacterial histone-like protein, homologue to the beta subunit of the Heat-Unstable (HU) nucleoid protein of Escherichia coli. These kinds of proteins are necessary to maintain the bacterial nucleoid organization and the global regulation of gene expression...
December 8, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/30537162/classic-pseudoxanthoma-elasticum-in-a-girl-with-sickle-cell-disease
#8
Victoria Mitre, Danielle Brown, Thuy Phung, Raegan D Hunt
A pseudoxanthoma elasticum (PXE)-like phenotype develops in a subset of patients with inherited hemoglobinopathies. Although PXE tissue changes are thought to develop in the absence of ABCC6 mutations in patients with beta-thalassemia, ABCC6 mutations have not been well evaluated among sickle cell disease patients with PXE-like disease. To our knowledge, we describe the first patient with sickle cell disease, PXE skin findings, and two confirmed pathogenic ABCC6 mutations. This case suggests that ABCC6 testing is warranted for sickle cell disease patients with the PXE-like phenotype and that the pathogenesis of PXE manifestations in beta-thalassemia and sickle cell disease may differ...
December 9, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/30537047/selective-formation-of-helical-tetrapyrrin-fused-porphyrins-by-oxidation-of-beta-to-beta-linked-meso-aminoporphyrin-dimers
#9
Atsuhiro Osuka, Keisuke Fujimoto, Daiki Shimizu, Tadashi Mori, Yuanyuan Li, Mingbo Zhou, Jianxin Song
Oxidation of β-to-β directly linked and sulfur-bridged meso-amino NiII-porphyrin dimers with PbO2 gave helical tetrapyrrin (biliverdin analogue)-fused NiII-porphyrins. These ring cleaving reactions differ markedly from the previously reported oxidation of a β-β linked NiII-porphyrin dimer carrying one amino-group that gave an azepine-fused porphyrin dimer. The tetrapyrrin-fused NiII-porphyrins display intense NIR absorption bands reaching at 1200-1400 nm and reversible redox processes because of the highly π-conjugated networks and rigid structures...
December 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30537025/oscillatory-dynamics-of-cortical-functional-connections-in-semantic-prediction
#10
Fahimeh Mamashli, Sheraz Khan, Jonas Obleser, Angela D Friederici, Burkhard Maess
An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences...
December 7, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/30536951/microtubules-from-understanding-their-dynamics-to-using-them-as-potential-therapeutic-targets
#11
REVIEW
Yaron Ilan
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. This makes MT potential therapeutic targets for various disorders. Disturbances in MT and their associated proteins are the underlying cause of diseases such as Alzheimer's disease, cancer, and several genetic diseases...
December 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30536899/highly-sensitive-spectrofluorimetric-method-for-rapid-determination-of-orciprenaline-in-biological-fluids-and-pharmaceuticals
#12
F A Ibrahim, M E Fathy, H M Elmansi
Orciprenaline sulphate (ORP) is a direct-acting sympathomimetic with mainly beta-adrenoceptor stimulant activity. It is used as a bronchodilator in the management of reversible airway obstruction. For the first time, a rapid highly sensitive spectrofluorimetric method is described that is relied on measuring the fluorescence spectra of ORP at acidic pH and without addition of any chemical reagents. The relative fluorescence intensity was measured at 310 nm and after excitation at 224 nm. ORP native fluorescence was calibrated in both water and acetonitrile as diluting solvents...
December 11, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/30536884/the-effects-of-incretin-based-therapies-on-beta-cell-function-and-insulin-resistance-in-type-2-diabetes-a-systematic-review-and-network-meta-analysis-combining-360-trials
#13
Shanshan Wu, Le Gao, Andrea Cipriani, Yi Huang, Zhirong Yang, Jun Yang, Shuqing Yu, Yuan Zhang, Sanbao Chai, Zilu Zhang, Feng Sun, Siyan Zhan
AIM: To evaluate the comparative effects of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4Is), on beta-cell function and insulin resistance in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Medline, Embase, the Cochrane Library and www.clinicaltrials.gov were searched for randomized controlled trials (RCTs) with duration≥4 weeks. Network meta-analysis was performed, followed by subgroup analysis and meta-regression...
December 9, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30536875/human-anti-nkp46-antibody-for-studies-of-nkp46-dependent-nk-cell-function-and-its-applications-for-type-1-diabetes-and-cancer-research
#14
Orit Berhani, Ariella Glasner, Shira Kahlon, Alexandra Duev-Cohen, Rachel Yamin, Elad Horwitz, Jonatan Enk, Ofra Moshel, Alexandar Varvak, Angel Porgador, Stipan Jonjic, Ofer Mandelboim
Natural Killer (NK) cells are innate lymphocytes that efficiently eliminate cancerous and infected cells. NKp46 is an important NK activating receptor shown to participate in recognition and activation of NK cells against pathogens, tumor cells, virally infected cells, and self-cells in autoimmune conditions, including type I and II diabetes. However, some of the NKp46 ligands are unknown and therefore investigating human NKp46 activity and its critical role in NK cell biology is problematic. We developed a unique anti-human NKp46 monocloncal antibody, denoted hNKp46...
December 7, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30536410/prostate-cancer-induces-c-ebp%C3%AE-expression-in-surrounding-epithelial-cells-which-relates-to-tumor-aggressiveness-and-patient-outcome
#15
Hanibal Adamo, Peter Hammarsten, Christina Hägglöf, Tove Dahl Scherdin, Lars Egevad, Pär Stattin, Sofia Halin Bergström, Anders Bergh
BACKGROUND: Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein-β (C/EBPβ). METHODS: To explore this further, we examined C/EBPβ expression by quantitative RT-PCR, immunohistochemistry, and Western blot in normal rat prostate tissue surrounding slow-growing non-metastatic Dunning G, rapidly growing poorly metastatic (AT-1), and rapidly growing highly metastatic (MatLyLu) rat prostate tumors-and also by immunohistochemistry in a tissue microarray (TMA) from prostate cancer patients managed by watchful waiting...
December 11, 2018: Prostate
https://www.readbyqxmd.com/read/30536324/mir-638-serves-as-a-tumor-suppressor-by-targeting-hoxa9-in-glioma
#16
D-H Zheng, X Wang, L-N Lu, D-L Chen, J-M Chen, F-M Lin, X-B Xu
OBJECTIVE: MiR-638 is constantly downregulated and serves as a tumor suppressor in various cancers. Its role in gliomas remains unclear. This study is designed to investigate the clinical significance and the pathogenic role of miR-638 in human gliomas. PATIENTS AND METHODS: Quantitative Real-time PCR was performed to analyze the expression of miR-638 in the tumor and adjacent tissues of 24 glioma patients. The association between the expression of miR-638 and clinical features were examined...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30535931/contemporary-management-of-heart-failure-in-the-elderly
#17
REVIEW
Joanna Osmanska, Pardeep S Jhund
The foundation of the treatment of heart failure with reduced ejection fraction is a number of pharmacotherapies shown to reduce morbidity and mortality in large randomised multinational clinical trials. These include angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid receptor antagonists, and more recently, a combined angiotensin receptor blocker neprilysin inhibitor, sacubitril/valsartan. In select cases, digoxin, ivabradine and hydralazine with isosorbide dinitrate have a role to play in the treatment of heart failure with reduced ejection fraction...
December 11, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/30535925/immunohistochemical-and-ultrastructural-analysis-of-sporadic-inclusion-body-myositis-a-case-series
#18
Katarzyna Haczkiewicz, Agata Sebastian, Aleksandra Piotrowska, Maria Misterska-Skóra, Agnieszka Hałoń, Marta Skoczyńska, Maciej Sebastian, Piotr Wiland, Piotr Dzięgiel, Marzenna Podhorska-Okołów
Sporadic inclusion body myositis (s-IBM) is a progressive, skeletal muscle disease with poor prognosis. However, establishing the final diagnosis is difficult because of the lack of clear biomarkers in the blood serum and very slow development of clinical symptoms. Moreover, most other organs function normally without any disturbance. Here, in patients with this untreatable disease, we have underlined the importance of immunohistochemical and ultrastructural assessment of skeletal muscle in patients diagnosed with s-IBM...
December 8, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30535599/interplay-between-metabolic-sensors-and-immune-cell-signaling
#19
Prashant Chauhan, Arup Sarkar, Bhaskar Saha
The immune system, like all other systems, responds to perturbations of the baseline, homeostatic functioning of immune cells. These perturbations come in the form of infection, tumors, autoantigens, and can occur after mismatched transplantation. During response, immune cells alter their metabolic activities. However, the subsets of the same cell type differ to distinctively associate specific immune function to a particular metabolic profile. The response is mounted as a joint function of metabolic receptor and immune receptor signaling that target various metabolic pathways: glycolysis the pentose phosphate pathway; oxidative phosphorylation; beta-oxidation of fatty acids and transamination...
2018: Experientia. Supplementum
https://www.readbyqxmd.com/read/30535592/fabrication-of-sulphonated-poly-ethylene-glycol-diacrylate-hydrogel-as-a-bone-grafting-scaffold
#20
Hao Li, Tingting Ma, Man Zhang, Jiani Zhu, Jie Liu, Fei Tan
To improve the biological performance of poly(ethylene glycol)-diacrylate (PEGDA) hydrogel as an injectable bone grafting scaffold, sodium methallyl sulphonate (SMAS) was incorporated into PEGDA hydrogel. The physiochemical properties of the resultant polymers were assessed via Fourier transform infrared spectroscopy (FTIR), swelling ratio, zeta potential, surface morphology, and protein adsorption analysis. MC3T3-E1 cells were seeded on the hydrogel to evaluate the effect of the sulphonated modification on their attachment, proliferation, and differentiation...
December 7, 2018: Journal of Materials Science. Materials in Medicine
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