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https://www.readbyqxmd.com/read/30317451/inter-patient-modelling-of-2d-lung-variations-from-chest-x-ray-imaging-via-fourier-descriptors
#1
Ali Afzali, Farshid Babapour Mofrad, Majid Pouladian
Detailed knowledge of anatomical lung variation is very important in medical image processing. Normal variations of lung consistent with the maintenance of pulmonary health and abnormal lung variations can be as a result of a pulmonary disease. Inter-patient lung variations can be due to the several factors such as sex, age, height, weight and type of disease. This study tries to show the inter-patient lung variations by using one of the shape-based descriptions techniques which is called Fourier descriptors...
October 13, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/30306817/automatic-segmentation-of-cardiac-substructures-from-noncontrast-ct-images-accurate-enough-for-dosimetric-analysis
#2
Yangkun Luo, Yujin Xu, Zhongxing Liao, Daniel Gomez, Jingqian Wang, Wei Jiang, Rongrong Zhou, Ryan Williamson, Laurence E Court, Jinzhong Yang
PURPOSE: We evaluated the feasibility of using an automatic segmentation tool to delineate cardiac substructures from noncontrast computed tomography (CT) images for cardiac dosimetry and toxicity analyses for patients with nonsmall cell lung cancer (NSCLC) after radiotherapy. MATERIAL AND METHODS: We used an in-house developed multi-atlas segmentation tool to delineate 11cardiac substructures, including the whole heart, four heart chambers, and six greater vessels, automatically from the averaged 4D-CT planning images of 49 patients with NSCLC...
October 11, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/30267211/feasibility-of-anatomical-feature-points-for-the-estimation-of-prostate-locations-in-the-bayesian-delineation-frameworks-for-prostate-cancer-radiotherapy
#3
Kenta Ninomiya, Hidetaka Arimura, Motoki Sasahara, Yudai Kai, Taka-Aki Hirose, Saiji Ohga
This study aimed to investigate the feasibility of anatomical feature points for the estimation of prostate locations in the Bayesian delineation frameworks for prostate cancer radiotherapy. The relationships between the reference centroids of prostate regions (CPRs) (prostate locations) and anatomical feature points were explored, and the most feasible anatomical feature points were selected based on the smallest location estimation errors of CPRs and the largest Dice's similarity coefficient (DSC) between the reference and extracted prostates...
September 28, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/30235702/implementation-of-temporal-lobe-contouring-protocol-in-head-and-neck-cancer-radiotherapy-planning-a-quality-improvement-project
#4
Francis Ho, Jeremy Tey, David Chia, Yu Yang Soon, Chek Wee Tan, Sarahatul Bahiah, Timothy Cheo, Ivan Weng Keong Tham
Temporal lobe necrosis as result of radiation for nasopharyngeal cancer (NPC) occurs up to 28% of NPC patients. The only effective mitigation is by strict adherence to temporal lobe dose tolerances during radiotherapy planning, which in turn hinges on accurate temporal lobe delineation. We aim to improve the accuracy and to standardize temporal lobe contouring for patients receiving head and neck radiotherapy for NPC in a tertiary teaching hospital in Singapore.The baseline data were obtained from 10 patients in the diagnostic phase and the effect of interventions were measured in 37 patients who underwent head and neck radiotherapy over a 6-month period...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30224202/guidelines-for-clinical-target-volume-definition-for-perineural-spread-of-major-salivary-gland-cancers
#5
K Armstrong, J Ward, N M Hughes, A Mihai, A Blayney, C Mascott, R Kileen, J Armstrong
AIMS: Postoperative radiotherapy is the standard of care for resected major salivary cancers that are at risk of locoregional recurrence. Of the various histological subtypes, perineural invasion is most common in adenoidcystic carcinomas of the three major salivary glands - parotid, submandibular and sublingual. The clinical target volume (CTV) for these cases must include the relevant cranial nerve pathways at risk. A contouring atlas was devised for delineation of the CTV of the nerves supplying the major salivary glands...
September 14, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30216462/comparative-study-of-algorithms-for-synthetic-ct-generation-from-mri-consequences-for-mri-guided-radiation-planning-in-the-pelvic-region
#6
Hossein Arabi, Jason A Dowling, Ninon Burgos, Xiao Han, Peter B Greer, Nikolaos Koutsouvelis, Habib Zaidi
PURPOSE: Magnetic resonance imaging (MRI)-guided radiation therapy (RT) treatment planning is limited by the fact that the electron density distribution required for dose calculation is not readily provided by MR imaging. We compare a selection of novel synthetic CT generation algorithms recently reported in the literature, including segmentation-based, atlas-based and machine learning techniques, using the same cohort of patients and quantitative evaluation metrics. METHODS: Six MRI-guided synthetic CT generation algorithms were evaluated: one segmentation technique into a single tissue class (water-only), four atlas-based techniques, namely, median value of atlas images (ALMedian) 1 , atlas-based local weighted voting (ALWV) 2 , bone enhanced atlas-based local weighted voting (ALWV-Bone) 3 , iterative atlas-based local weighted voting (ALWV-Iter) 4 , and a machine learning technique using deep convolution neural network (DCNN) 5 ...
September 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/30172454/practical-contouring-guidelines-with-an-mr-based-atlas-of-brainstem-structures-involved-in-radiation-induced-nausea-and-vomiting
#7
Arnaud Beddok, Jean-Christophe Faivre, Alexandre Coutte, Jennifer Le Guévelou, Julien Welmant, Jean-Baptiste Clavier, Sébastien Guihard, Guillaume Janoray, Valentin Calugaru, Yoann Pointreau, Alexis Lacout, Julia Salleron, Michel Lefranc, Dominique Hasboun, Henri M Duvernoy, Juliette Thariat
BACKGROUND AND PURPOSE: The objective of this project was to define consensus guidelines for delineating brainstem substructures (dorsal vagal complex, including the area postrema) involved in radiation-induced nausea and vomiting (RINV). The three parts of the brainstem are rarely delineated, so this study was also an opportunity to find a consensus on this subject. MATERIALS AND METHODS: The dorsal vagal complex (DVC) was identified on autopsy sections and endoscopic descriptions...
August 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30144101/autosegmentation-for-thoracic-radiation-treatment-planning-a-grand-challenge-at-aapm-2017
#8
Jinzhong Yang, Harini Veeraraghavan, Samuel G Armato, Keyvan Farahani, Justin S Kirby, Jayashree Kalpathy-Kramer, Wouter van Elmpt, Andre Dekker, Xiao Han, Xue Feng, Paul Aljabar, Bruno Oliveira, Brent van der Heyden, Leonid Zamdborg, Dao Lam, Mark Gooding, Gregory C Sharp
PURPOSE: This report presents the methods and results of the Thoracic Auto-Segmentation Challenge organized at the 2017 Annual Meeting of American Association of Physicists in Medicine. The purpose of the challenge was to provide a benchmark dataset and platform for evaluating performance of autosegmentation methods of organs at risk (OARs) in thoracic CT images. METHODS: Sixty thoracic CT scans provided by three different institutions were separated into 36 training, 12 offline testing, and 12 online testing scans...
August 24, 2018: Medical Physics
https://www.readbyqxmd.com/read/30140944/towards-a-universal-mri-atlas-of-the-prostate-and-prostate-zones-comparison-of-mri-vendor-and-image-acquisition-parameters
#9
Kyle R Padgett, Amy Swallen, Sara Pirozzi, Jon Piper, Felix M Chinea, Matthew C Abramowitz, Aaron Nelson, Alan Pollack, Radka Stoyanova
BACKGROUND AND PURPOSE: The aim of this study was to evaluate an automatic multi-atlas-based segmentation method for generating prostate, peripheral (PZ), and transition zone (TZ) contours on MRIs with and without fat saturation (±FS), and compare MRIs from different vendor MRI systems. METHODS: T2-weighted (T2) and fat-saturated (T2FS) MRIs were acquired on 3T GE (GE, Waukesha, WI, USA) and Siemens (Erlangen, Germany) systems. Manual prostate and PZ contours were used to create atlas libraries...
August 23, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30136285/fully-automatic-multi-organ-segmentation-for-head-and-neck-cancer-radiotherapy-using-shape-representation-model-constrained-fully-convolutional-neural-networks
#10
Nuo Tong, Shuiping Gou, Shuyuan Yang, Dan Ruan, Ke Sheng
PURPOSE: Intensity modulated radiation therapy (IMRT) is commonly employed for treating head and neck (H&N) cancer with uniform tumor dose and conformal critical organ sparing. Accurate delineation of organs-at-risk (OARs) on H&N CT images is thus essential to treatment quality. Manual contouring used in current clinical practice is tedious, time-consuming, and can produce inconsistent results. Existing automated segmentation methods are challenged by the substantial inter-patient anatomical variation and low CT soft tissue contrast...
October 2018: Medical Physics
https://www.readbyqxmd.com/read/30118822/fdg-pet-ct-based-lymph-node-atlas-in-breast-cancer-patients
#11
Kai Joachim Borm, Julia Voppichler, Mathias Düsberg, Markus Oechsner, Tibor Vag, Wolfgang Weber, Stephanie Elisabeth Combs, Marciana Nona Duma
PURPOSE: The aim of this study was to localize loco-regional lymph node metastases using positron emission tomography with fluorine 18 fluorodeoxyglucose/computed tomography (FDG-PET/CT) datasets in a large cohort of patients and to evaluate the existing Radiation Therapy Oncology Group (RTOG) clinical target volume (CTV) and the European SocieTy for Radiotherapy & Oncology (ESTRO) CTV contouring guidelines. METHODS: 235 patients with 580 FDG/PET-CT positive loco-regional lymph node metastases were included in our analysis...
August 14, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30107948/geometric-and-dosimetric-evaluation-of-atlas-based-auto-segmentation-of-cardiac-structures-in-breast-cancer-patients
#12
Robert Kaderka, Erin F Gillespie, Robert C Mundt, Alex K Bryant, Camila B Sanudo-Thomas, Anna L Harrison, Emilie L Wouters, Vitali Moiseenko, Kevin L Moore, Todd F Atwood, James D Murphy
BACKGROUND AND PURPOSE: Auto-segmentation represents an efficient tool to segment organs on CT imaging. Primarily used in clinical setting, auto-segmentation plays an increasing role in research, particularly when analyzing thousands of images in the "big data" era. In this study we evaluate the accuracy of cardiac dosimetric endpoints derived from atlas based auto-segmentation compared to gold standard manual segmentation. MATERIAL AND METHODS: Heart and cardiac substructures were manually delineated on 54 breast cancer patients...
August 11, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30029684/quality-assurance-analysis-of-hippocampal-avoidance-in-a-melanoma-whole-brain-radiotherapy-randomized-trial-shows-good-compliance
#13
Geoffrey Martinage, Angela M Hong, Mike Fay, Thanuja Thachil, Daniel Roos, Narelle Williams, Serigne Lo, Gerald Fogarty
BACKGROUND: Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 - WBRT-Mel) evaluates the role of adjuvant whole brain radiotherapy (WBRT) following local treatment of MBM. Hippocampal avoidance during WBRT (HA-WBRT) has shown memory and neurocognitive function (NCF) preservation in the RTOG-0933 phase II study. This study assessed the quality assurance of HA-WBRT within the WBRT-Mel trial according to RTOG-0933 study criteria...
July 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30010554/can-atlas-based-auto-segmentation-ever-be-perfect-insights-from-extreme-value-theory
#14
Bas Schipaanboord, Djamal Boukerroui, Devis Peressutti, Johan van Soest, Tim Lustberg, Timor Kadir, Andre Dekker, Wouter van Elmpt, Mark Gooding
Atlas-based segmentation is used in radiotherapy planning to accelerate the delineation of organs at risk (OARs). Atlas selection has been proposed to improve the performance of segmentation, assuming that the more similar the atlas is to the patient the better the result. It follows that the larger the database of atlases from which to select, the better the results should be. This work seeks to estimate a clinically achievable expected performance under this assumption. Assuming a perfect atlas selection, Extreme Value Theory has been applied to estimate accuracy of single-atlas and multi-atlas segmentation given a large database of atlases...
July 16, 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29981051/a-fast-segmentation-free-fully-automated-approach-to-white-matter-injury-detection-in-preterm-infants
#15
Subhayan Mukherjee, Irene Cheng, Steven Miller, Ting Guo, Vann Chau, Anup Basu
White matter injury (WMI) is the most prevalent brain injury in the preterm neonate leading to developmental deficits. However, detecting WMI in magnetic resonance (MR) images of preterm neonate brains using traditional WM segmentation-based methods is difficult mainly due to lack of reliable preterm neonate brain atlases to guide segmentation. Hence, we propose a segmentation-free, fast, unsupervised, atlas-free WMI detection method. We detect the ventricles as blobs using a fast linear maximally stable extremal regions algorithm...
July 6, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29975151/automatic-multiatlas-based-organ-at-risk-segmentation-in-mice
#16
Brent van der Heyden, Mark Podesta, Daniëlle Bp Eekers, Ana Vaniqui, Isabel P Almeida, Lotte Ejr Schyns, Stefan J van Hoof, Frank Verhaegen
OBJECTIVE: During the treatment planning of a preclinical small animal irradiation, which has time limitations for reasons of animal wellbeing and workflow efficiency, the time consuming organ at risk (OAR) delineation is performed manually. This work aimed to develop, demonstrate, and quantitatively evaluate an automated contouring method for six OARs in a preclinical irritation treatment workflow. METHODS: Microcone beam CT images of nine healthy mice were contoured with an in-house developed multiatlas-based image segmentation (MABIS) algorithm for six OARs: kidneys, eyes, heart, and brain...
July 25, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29947264/the-use-of-new-delineation-tool-mirada-at-the-level-of-regional-lymph-nodes-step-by-step-development-and-first-results-for-early-stage-breast-cancer-patients
#17
HaoPing Xu, Alexandre Arsene Henry, Magalie Robillard, Malika Amessis, Youlia M Kirova
OBJECTIVE: To describe the practical procedure of implementation and optimization of delineation using "Mirada" software, as well as evaluation of the automatic segmentation for the daily practice of lymph nodes (LN) and organs at risk (OARs) in early stage breast cancer patients. METHODS: 40 patients' CT scans in treatment position were selected and recontoured according to the European Society of Therapeutic Radiation Oncology guidelines. The atlas of data set was then created for automatic delineation...
October 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29938298/bridging-the-gap-in-global-advanced-radiation-oncology-training-impact-of-a-web-based-open-access-interactive-three-dimensional-contouring-atlas-on-radiation-oncologist-practice-in-russia
#18
Shearwood McClelland, Marina Chernykh, Natalia Dengina, Erin F Gillespie, Anna Likhacheva, Sergey Usychkin, Alexandr Pankratov, Ekaterina Kharitonova, Yulia Egorova, Ilya Tsimafeyeu, Sergei Tjulandin, Charles R Thomas, Timur Mitin
Radiation oncologists in Russia face a number of unique professional difficulties including lack of standardized training and continuing medical education. To combat this, under the auspices of the Russian Society of Clinical Oncology (RUSSCO), our group has developed a series of ongoing in-person interactive contouring workshops that are held during the major Russian oncology conferences in Moscow, Russia. Since November 2016 during each workshop, we utilized a web-based open-access interactive three-dimensional contouring atlas as part of our didactics...
June 25, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29928706/variability-of-clinical-target-volume-delineation-for-rectal-cancer-patients-planned-for-neoadjuvant-radiotherapy-with-the-aid-of-the-platform-anatom-e
#19
Pierfrancesco Franco, Francesca Arcadipane, Elisabetta Trino, Elena Gallio, Stefania Martini, Giuseppe Carlo Iorio, Cristina Piva, Francesco Moretto, Maria Grazia Ruo Redda, Roberta Verna, Vassiliki Tseroni, Cristina Bona, Gabriele Pozzi, Christian Fiandra, Riccardo Ragona, Oscar Bertetto, Umberto Ricardi
Objective: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. Materials and methods: Two clinical cases of locally advanced rectal cancer were chosen...
June 2018: Clinical and translational radiation oncology
https://www.readbyqxmd.com/read/29894155/informing-molecular-design-by-stereoelectronic-theory-the-fluorine-gauche-effect-in-catalysis
#20
Marialuisa Aufiero, Ryan Gilmour
The axioms of stereoelectronic theory constitute an atlas to navigate the contours of molecular space. All too rarely lauded, the advent and development of stereoelectronic theory has been one of organic chemistry's greatest triumphs. Inevitably, however, in the absence of a comprehensive treatise, many of the field's pioneers do not receive the veneration that they merit. Rather their legacies are the stereoelectronic pillars that persist in teaching and research. This ubiquity continues to afford practitioners of organic chemistry with an abundance of opportunities for creative endeavor in reaction design, in conceiving novel activation modes, in preorganizing intermediates, or in stabilizing productive transition states and products...
July 17, 2018: Accounts of Chemical Research
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