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https://www.readbyqxmd.com/read/30029684/quality-assurance-analysis-of-hippocampal-avoidance-in-a-melanoma-whole-brain-radiotherapy-randomized-trial-shows-good-compliance
#1
Geoffrey Martinage, Angela M Hong, Mike Fay, Thanuja Thachil, Daniel Roos, Narelle Williams, Serigne Lo, Gerald Fogarty
BACKGROUND: Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 - WBRT-Mel) evaluates the role of adjuvant whole brain radiotherapy (WBRT) following local treatment of MBM. Hippocampal avoidance during WBRT (HA-WBRT) has shown memory and neurocognitive function (NCF) preservation in the RTOG-0933 phase II study. This study assessed the quality assurance of HA-WBRT within the WBRT-Mel trial according to RTOG-0933 study criteria...
July 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30010554/can-atlas-based-auto-segmentation-ever-be-perfect-insights-from-extreme-value-theory
#2
Bas Schipaanboord, Djamal Boukerroui, Devis Peressutti, Johan van Soest, Tim Lustberg, Timor Kadir, Andre Dekker, Wouter van Elmpt, Mark Gooding
Atlas-based segmentation is used in radiotherapy planning to accelerate the delineation of organs at risk (OARs). Atlas selection has been proposed to improve the performance of segmentation, assuming that the more similar the atlas is to the patient the better the result. It follows that the larger the database of atlases from which to select, the better the results should be. This work seeks to estimate a clinically achievable expected performance under this assumption. Assuming a perfect atlas selection, Extreme Value Theory has been applied to estimate accuracy of single-atlas and multi-atlas segmentation given a large database of atlases...
July 16, 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29981051/a-fast-segmentation-free-fully-automated-approach-to-white-matter-injury-detection-in-preterm-infants
#3
Subhayan Mukherjee, Irene Cheng, Steven Miller, Ting Guo, Vann Chau, Anup Basu
White matter injury (WMI) is the most prevalent brain injury in the preterm neonate leading to developmental deficits. However, detecting WMI in magnetic resonance (MR) images of preterm neonate brains using traditional WM segmentation-based methods is difficult mainly due to lack of reliable preterm neonate brain atlases to guide segmentation. Hence, we propose a segmentation-free, fast, unsupervised, atlas-free WMI detection method. We detect the ventricles as blobs using a fast linear maximally stable extremal regions algorithm...
July 6, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29975151/automatic-multiatlas-based-organ-at-risk-segmentation-in-mice
#4
Brent van der Heyden, Mark Podesta, Daniëlle Bp Eekers, Ana Vaniqui, Isabel P Almeida, Lotte Ejr Schyns, Stefan J van Hoof, Frank Verhaegen
OBJECTIVE: During the treatment planning of a preclinical small animal irradiation, which has time limitations for reasons of animal wellbeing and workflow efficiency, the time consuming organ at risk (OAR) delineation is performed manually. This work aimed to develop, demonstrate, and quantitatively evaluate an automated contouring method for six OARs in a preclinical irritation treatment workflow. METHODS: Microcone beam CT images of nine healthy mice were contoured with an in-house developed multiatlas-based image segmentation (MABIS) algorithm for six OARs: kidneys, eyes, heart, and brain...
July 25, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29947264/the-use-of-new-delineation-tool-mirada-at-the-level-of-regional-lymph-nodes-step-by-step-development-and-first-results-for-early-stage-breast-cancer-patients
#5
HaoPing Xu, Alexandre Arsene Henry, Magalie Robillard, Malika Amessis, Youlia M Kirova
OBJECTIVE: To describe the practical procedure of implementation and optimization of delineation using "Mirada" software, as well as evaluation of the automatic segmentation for the daily practice of lymph nodes (LN) and organs at risk (OARs) in early stage breast cancer patients. METHODS: 40 patients' CT scans in treatment position were selected and recontoured according to the European Society of Therapeutic Radiation Oncology guidelines. The atlas of data set was then created for automatic delineation...
July 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29938298/bridging-the-gap-in-global-advanced-radiation-oncology-training-impact-of-a-web-based-open-access-interactive-three-dimensional-contouring-atlas-on-radiation-oncologist-practice-in-russia
#6
Shearwood McClelland, Marina Chernykh, Natalia Dengina, Erin F Gillespie, Anna Likhacheva, Sergey Usychkin, Alexandr Pankratov, Ekaterina Kharitonova, Yulia Egorova, Ilya Tsimafeyeu, Sergei Tjulandin, Charles R Thomas, Timur Mitin
Radiation oncologists in Russia face a number of unique professional difficulties including lack of standardized training and continuing medical education. To combat this, under the auspices of the Russian Society of Clinical Oncology (RUSSCO), our group has developed a series of ongoing in-person interactive contouring workshops that are held during the major Russian oncology conferences in Moscow, Russia. Since November 2016 during each workshop, we utilized a web-based open-access interactive three-dimensional contouring atlas as part of our didactics...
June 25, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29928706/variability-of-clinical-target-volume-delineation-for-rectal-cancer-patients-planned-for-neoadjuvant-radiotherapy-with-the-aid-of-the-platform-anatom-e
#7
Pierfrancesco Franco, Francesca Arcadipane, Elisabetta Trino, Elena Gallio, Stefania Martini, Giuseppe Carlo Iorio, Cristina Piva, Francesco Moretto, Maria Grazia Ruo Redda, Roberta Verna, Vassiliki Tseroni, Cristina Bona, Gabriele Pozzi, Christian Fiandra, Riccardo Ragona, Oscar Bertetto, Umberto Ricardi
Objective: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. Materials and methods: Two clinical cases of locally advanced rectal cancer were chosen...
June 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29894155/informing-molecular-design-by-stereoelectronic-theory-the-fluorine-gauche-effect-in-catalysis
#8
Marialuisa Aufiero, Ryan Gilmour
The axioms of stereoelectronic theory constitute an atlas to navigate the contours of molecular space. All too rarely lauded, the advent and development of stereoelectronic theory has been one of organic chemistry's greatest triumphs. Inevitably, however, in the absence of a comprehensive treatise, many of the field's pioneers do not receive the veneration that they merit. Rather their legacies are the stereoelectronic pillars that persist in teaching and research. This ubiquity continues to afford practitioners of organic chemistry with an abundance of opportunities for creative endeavor in reaction design, in conceiving novel activation modes, in preorganizing intermediates, or in stabilizing productive transition states and products...
July 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29882749/geometric-and-dosimetric-evaluations-of-atlas-based-segmentation-methods-of-mr-images-in-the-head-and-neck-region
#9
J P Kieselmann, C P Kamerling, N Burgos, M J Menten, C D Fuller, S Nill, M J Cardoso, U Oelfke
Owing to its excellent soft-tissue contrast, magnetic resonance (MR) imaging has found an increased application in radiation therapy (RT). By harnessing these properties for treatment planning, automated segmentation methods can alleviate the manual workload burden to the clinical workflow. We investigated atlas-based segmentation methods of organs at risk (OARs) in the head and neck (H&N) region using one approach that selected the most similar atlas from a library of segmented images and two multi-atlas approaches...
July 11, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29787381/multi-atlas-based-segmentation-should-we-prefer-the-best-atlas-group-over-the-group-of-best-atlases
#10
Paolo Zaffino, Delia Ciardo, Patrik Raudaschl, Karl Fritscher, Rosalinda Ricotti, Daniela Alterio, Giulia Marvaso, Cristiana Fodor, Guido Baroni, Francesco Amato, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Gregory C Sharp, Maria Francesca Spadea
Multi atlas based segmentation (MABS) uses a database of atlas images, and an atlas selection process is used to choose an atlas subset for registration and voting. In the current state of the art, atlases are chosen according to a similarity criterion between the target subject and each atlas in the database. In this paper, we propose a new concept for atlas selection that relies on selecting the best performing group of atlases rather than the group of highest scoring individual atlases. Experiments were performed using CT images of 50 patients, with contours of brainstem and parotid glands...
June 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29778321/submandibular-gland-sparing-when-irradiating-neck-level-ib-in-the-treatment-of-oral-squamous-cell-carcinoma
#11
William C Jackson, Peter G Hawkins, George S Arnould, John Yao, Charles Mayo, Michelle Mierzwa
Patients with oral squamous cell carcinoma (OSqCCA) frequently require postoperative radiation (PORT), which may include contralateral level IB within the clinical target volume (CTV). The submandibular gland (SMG) is typically included within the level IB CTV; however, the SMG does not contain lymph nodes or lymphatic vessels. We hypothesized that level IB could be adequately irradiated while sparing the SMG to reduce xerostomia. Twelve patients with OSqCCA receiving PORT, which included the contralateral level IB within the planning target volume (PTV), were retrospectively reviewed and replanned using volumetric modulated arc therapy...
May 16, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29714086/a-dosimetric-evaluation-on-applying-rtog-based-and-ct-mri-based-delineation-methods-to-brachial-plexus-in-radiotherapy-of-nasopharyngeal-carcinoma-treated-with-helical-tomotherapy
#12
Chi-Him Li, Vincent Wc Wu, George Chiu
OBJECTIVE: In radiotherapy of nasopharyngeal carcinoma (NPC) patients, the brachial plexus (BP) situated at both sides of the neck is often irradiated to high dose. This study was to evaluate different BP delineation methods and analyse the dosimetric consequences when applying BP dose constraints in radiotherapy planning of NPC. METHODS: 15 NPC cases radically treated with helical tomotherapy were recruited. Apart from the original treatment plan (Plan A), two new plans (Plans B and C) with additional BP dose constraints were computed using the same planning CT images, structures and planning parameters...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29689283/geometry-processing-of-conventionally-produced-mouse-brain-slice-images
#13
Nitin Agarwal, Xiangmin Xu, M Gopi
BACKGROUND: Brain mapping research in most neuroanatomical laboratories relies on conventional processing techniques, which often introduce histological artifacts such as tissue tears and tissue loss. NEW METHOD: In this paper, we present techniques and algorithms for automatic registration and 3D reconstruction of conventionally produced mouse brain slices in a standardized atlas space. This is achieved first by constructing a virtual 3D mouse brain model from annotated slices of Allen Reference Atlas (ARA)...
August 1, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29684463/non-imaged-based-method-for-matching-brains-in-a-common-anatomical-space-for-cellular-imagery
#14
Maëllie Midroit, Marc Thevenet, Arnaud Fournel, Joelle Sacquet, Moustafa Bensafi, Marine Breton, Laura Chalençon, Matthias Cavelius, Anne Didier, Nathalie Mandairon
BACKGROUND: Cellular imagery using histology sections is one of the most common techniques used in Neuroscience. However, this inescapable technique has severe limitations due to the need to delineate regions of interest on each brain, which is time consuming and variable across experimenters. NEW METHOD: We developed algorithms based on a vectors field elastic registration allowing fast, automatic realignment of experimental brain sections and associated labeling in a brain atlas with high accuracy and in a streamlined way...
July 1, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29609039/computer-aided-diagnosis-of-cavernous-malformations-in-brain-mr-images
#15
Huiquan Wang, S Nizam Ahmed, Mrinal Mandal
Cavernous malformation or cavernoma is one of the most common epileptogenic lesions. It is a type of brain vessel abnormality that can cause serious symptoms such as seizures, intracerebral hemorrhage, and various neurological disorders. Manual detection of cavernomas by physicians in a large set of brain MRI slices is a time-consuming and labor-intensive task and often delays diagnosis. In this paper, we propose a computer-aided diagnosis (CAD) system for cavernomas based on T2-weighted axial plane MRI image analysis...
June 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29605479/is-accurate-contouring-of-salivary-and-swallowing-structures-necessary-to-spare-them-in-head-and-neck-vmat-plans
#16
Alexander R Delaney, Max Dahele, Ben J Slotman, Wilko F A R Verbakel
BACKGROUND AND PURPOSE: Current standards for organ-at-risk (OAR) contouring encourage anatomical accuracy which can be resource intensive. Certain OARs may be suitable for alternative delineation strategies. We investigated whether simplified salivary and swallowing structure contouring can still lead to good OAR sparing in automated head and neck cancer (HNC) plans. MATERIALS AND METHODS: For 15 HNC patients, knowledge-based plans (KBPs) using RapidPlan™ were created using: (1) standard clinical contours for all OARs (benchmark-plans), (2) automated knowledge-based contours for the salivary glands, with standard contours for the remaining OARs (SS-plans) and (3) simplified contours (SC-plans) consisting of quick-to-draw tubular structures to account for the oral cavity, salivary glands and swallowing muscles...
May 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29594231/radiotherapy-dose-distribution-to-the-perirectal-fat-space-prs-is-related-to-gastrointestinal-control-related-complications
#17
S L Gulliford, S Ghose, M A Ebert, A Kennedy, J Dowling, J Mitra, D J Joseph, J W Denham
Traditionally rectal symptoms following pelvic/prostate radiotherapy are correlated to the dosimetry of the anorectum or a substructure of this. It has been suggested that the perirectal fat space (PRS) surrounding the rectum may also be relevant. This study considers the delineation and dosimetry of the PRS related to both rectal bleeding and control-related toxicity. Initially, a case-control cohort of 100 patients from the RADAR study were chosen based on presence/absence of rectal control-related toxicity...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29589259/prostate-segmentation-in-transrectal-ultrasound-using-magnetic-resonance-imaging-priors
#18
Qi Zeng, Golnoosh Samei, Davood Karimi, Claudia Kesch, Sara S Mahdavi, Purang Abolmaesumi, Septimiu E Salcudean
PURPOSE: In the current standard of care, real-time transrectal ultrasound (TRUS) is commonly used for prostate brachytherapy guidance. As TRUS provides limited soft tissue contrast, segmenting the prostate gland in TRUS images is often challenging and subject to inter-observer and intra-observer variability, especially at the base and apex where the gland boundary is hard to define. Magnetic resonance imaging (MRI) has higher soft tissue contrast allowing the prostate to be contoured easily...
June 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29576492/hippocampal-sparing-in-stereotactic-radiotherapy-for-brain-metastases-to-contour-or-not-contour-the-hippocampus
#19
C Di Carlo, M Trignani, L Caravatta, A Vinciguerra, A Augurio, F Perrotti, M Di Tommaso, M Nuzzo, S Giancaterino, M D Falco, D Genovesi
PURPOSE: The aim of our study was to evaluate hippocampal irradiation in patients treated with fractionated stereotactic brain radiotherapy. PATIENTS AND METHODS: Retrospective hippocampal dosimetric analysis performed on 22 patients with one to four brain metastases treated with fractionated stereotactic radiotherapy using volumetric intensity-modulated arc therapy. Original plans did not include hippocampus as avoidance structure in optimization criteria; hippocampus was retrospectively delineated on magnetic resonance coregistered with planning CT and using as reference the RTOG 0933 atlas...
April 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29548560/the-eptn-consensus-based-atlas-for-ct-and-mr-based-contouring-in-neuro-oncology
#20
Daniëlle Bp Eekers, Lieke In 't Ven, Erik Roelofs, Alida Postma, Claire Alapetite, Neil G Burnet, Valentin Calugaru, Inge Compter, Ida E M Coremans, Morton Høyer, Maarten Lambrecht, Petra Witt Nyström, Alejandra Méndez Romero, Frank Paulsen, Ana Perpar, Dirk de Ruysscher, Laurette Renard, Beate Timmermann, Pavel Vitek, Damien C Weber, Hiske L van der Weide, Gillian A Whitfield, Ruud Wiggenraad, Esther G C Troost
PURPOSE: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. METHODS: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published...
March 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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