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https://www.readbyqxmd.com/read/30506944/dedicated-mri-simulation-for-cervical-cancer-radiation-treatment-planning-assessing-the-impact-on-clinical-target-volume-delineation
#1
Jacqueline Veera, Karen Lim, Jason A Dowling, Chelsie O'Connor, Lois C Holloway, Shalini K Vinod
INTRODUCTION: Magnetic Resonance Imaging (MRI) provides excellent soft tissue definition of pelvic tumours and organs. The aim of this study was to quantify differences in delineated clinical target volumes (CTVs) between computed tomography (CT) and MRI. METHODS: Twenty patients with locally advanced gynaecological malignancies were recruited. Patients underwent dedicated MRI simulation following CT simulation. Four clinicians independently contoured each CT and MRI...
December 3, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/30468849/cardiac-substructure-segmentation-and-dosimetry-using-a-novel-hybrid-mr-ct-cardiac-atlas
#2
Eric D Morris, Ahmed I Ghanem, Milan V Pantelic, Eleanor M Walker, Xiaoxia Han, Carri K Glide-Hurst
PURPOSE: Radiation dose to the heart and cardiac substructures has been linked to cardiotoxicities. As cardiac substructures are poorly visualized on treatment planning computed tomography (CT), we employed the superior soft tissue contrast of magnetic resonance (MR) imaging to optimize a hybrid MR/CT atlas for substructure dose assessment using CT. METHODS: Thirty-one left breast cancer patients underwent a T2-weighted MR and non-contrast simulation CTs. A radiation oncologist delineated 13 substructures (chambers, great vessels, coronary arteries etc...
November 20, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30465543/autosegmentation-of-prostate-anatomy-for-radiation-treatment-planning-using-deep-decision-forests-of-radiomic-features
#3
Meghan W Macomber, Mark Phillips, Ivan Tarapov, Rajesh Jena, Aditya Nori, David Carter, Loic Le Folgoc, Antonio Criminisi, Matthew J Nyflot
Machine learning for image segmentation could provide expedited clinic workflow and better standardization of contour delineation. We evaluated a new model using deep decision forests of image features in order to contour pelvic anatomy on treatment planning CTs. 193 CT scans from one UK and two US institutions for patients undergoing radiotherapy treatment for prostate cancer from 2012-2016 were anonymized. A decision forest autosegmentation model was trained on a random selection of 94 images from Institution 1 and tested on 99 scans from Institution 1, 2, and 3...
November 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/30416046/doses-of-radiation-to-the-pericardium-instead-of-heart-are-significant-for-survival-in-patients-with-non-small-cell-lung-cancer
#4
Jianxin Xue, Chengbo Han, Andrew Jackson, Chen Hu, Huan Yao, Weili Wang, James Hayman, Weijun Chen, Jianyue Jin, Gregory P Kalemkerian, Martha Matuzsak, Struti Jolly, Feng-Ming Spring Kong
BACKGROUND AND PURPOSE: Higher cardiac dose was associated with worse overall survival in the RTOG0617 study. Pericardial effusion (PCE) is a common cardiac complication of thoracic radiation therapy (RT). We investigated whether doses of radiation to the heart and pericardium are associated with PCE and overall survival in patients treated with thoracic radiation for non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: A total of 94 patients with medically inoperable/unresectable NSCLC treated with definitive RT in prospective studies were reviewed for this secondary analysis...
November 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30406290/assessment-of-a-guideline-based-heart-substructures-delineation-in-left-sided-breast-cancer-patients-undergoing-adjuvant-radiotherapy-quality-assessment-within-a-randomized-phase-iii-trial-testing-a-cardioprotective-treatment-strategy-safe-2014
#5
Giulio Francolini, Isacco Desideri, Icro Meattini, Carlotta Becherini, Francesca Terziani, Emanuela Olmetto, Camilla Delli Paoli, Donato Pezzulla, Mauro Loi, Pierluigi Bonomo, Daniela Greto, Silvia Calusi, Marta Casati, Stefania Pallotta, Lorenzo Livi
BACKGROUND AND PURPOSE: In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made. PATIENTS AND METHODS: Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators...
November 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30367906/a-3-dimensional-mapping-analysis-of-regional-nodal-recurrences-in-breast-cancer
#6
Carl DeSelm, T Jonathan Yang, Oren Cahlon, Jamie Tisnado, Atif J Khan, Erin F Gillespie, Chun Ting Siu, Simon N Powell, Alice Y Ho
PURPOSE: The primary goal was to map the anatomic pattern of isolated nodal recurrences (NR) in the supraclavicular (SCV), axillary (Ax), and internal mammary nodes (IMN) in breast cancer patients treated with curative-intent surgery +/- radiation therapy (RT). Secondary objectives were to assess clinical and pathologic factors associated with patterns of NR and survival rates. MATERIALS AND METHODS: Breast cancer patients with NR post-treatment at a single cancer center between 1998-2013 were identified...
October 24, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30322669/mapping-of-the-functional-anatomy-of-lymphatic-drainage-to-the-axilla-in-early-breast-cancer-a-cohort-study-of-933-cases
#7
Bence Dorogi, Bence Bukovszky, Tamás Mátrai, Ákos Sávolt, Csaba Polgár, Péter Kelemen, Tibor Kovács, Ferenc Rényi-Vámos, Gabriella Ivády, Eszter Kovács, Melinda Téglás, Miklós Kásler, Zoltán Mátrai
INTRODUCTION: The aims of this study were to investigate the correlation between lymphatic drainage and the sentinel lymph node (SLN) status of the subregions in the context of the clinic-pathological parameters of the tumour and the coverage of the axillary volumes by standard and high tangential fields (STgF and HTgF) for whole breast radiotherapy and axillary reverse mapping (ARM). PATIENTS AND METHODS: 933 women with early breast cancer and clinically negative axillary status underwent breast surgery and SLN biopsy followed by axillary lymph node dissection in SLN-positive cases...
October 7, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30317451/inter-patient-modelling-of-2d-lung-variations-from-chest-x-ray-imaging-via-fourier-descriptors
#8
Ali Afzali, Farshid Babapour Mofrad, Majid Pouladian
Detailed knowledge of anatomical lung variation is very important in medical image processing. Normal variations of lung consistent with the maintenance of pulmonary health and abnormal lung variations can be as a result of a pulmonary disease. Inter-patient lung variations can be due to the several factors such as sex, age, height, weight and type of disease. This study tries to show the inter-patient lung variations by using one of the shape-based descriptions techniques which is called Fourier descriptors...
October 13, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/30306817/automatic-segmentation-of-cardiac-substructures-from-noncontrast-ct-images-accurate-enough-for-dosimetric-analysis
#9
Yangkun Luo, Yujin Xu, Zhongxing Liao, Daniel Gomez, Jingqian Wang, Wei Jiang, Rongrong Zhou, Ryan Williamson, Laurence E Court, Jinzhong Yang
PURPOSE: We evaluated the feasibility of using an automatic segmentation tool to delineate cardiac substructures from noncontrast computed tomography (CT) images for cardiac dosimetry and toxicity analyses for patients with nonsmall cell lung cancer (NSCLC) after radiotherapy. MATERIAL AND METHODS: We used an in-house developed multi-atlas segmentation tool to delineate 11cardiac substructures, including the whole heart, four heart chambers, and six greater vessels, automatically from the averaged 4D-CT planning images of 49 patients with NSCLC...
October 11, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/30267211/feasibility-of-anatomical-feature-points-for-the-estimation-of-prostate-locations-in-the-bayesian-delineation-frameworks-for-prostate-cancer-radiotherapy
#10
Kenta Ninomiya, Hidetaka Arimura, Motoki Sasahara, Yudai Kai, Taka-Aki Hirose, Saiji Ohga
This study aimed to investigate the feasibility of anatomical feature points for the estimation of prostate locations in the Bayesian delineation frameworks for prostate cancer radiotherapy. The relationships between the reference centroids of prostate regions (CPRs) (prostate locations) and anatomical feature points were explored, and the most feasible anatomical feature points were selected based on the smallest location estimation errors of CPRs and the largest Dice's similarity coefficient (DSC) between the reference and extracted prostates...
December 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/30235702/implementation-of-temporal-lobe-contouring-protocol-in-head-and-neck-cancer-radiotherapy-planning-a-quality-improvement-project
#11
Francis Ho, Jeremy Tey, David Chia, Yu Yang Soon, Chek Wee Tan, Sarahatul Bahiah, Timothy Cheo, Ivan Weng Keong Tham
Temporal lobe necrosis as result of radiation for nasopharyngeal cancer (NPC) occurs up to 28% of NPC patients. The only effective mitigation is by strict adherence to temporal lobe dose tolerances during radiotherapy planning, which in turn hinges on accurate temporal lobe delineation. We aim to improve the accuracy and to standardize temporal lobe contouring for patients receiving head and neck radiotherapy for NPC in a tertiary teaching hospital in Singapore.The baseline data were obtained from 10 patients in the diagnostic phase and the effect of interventions were measured in 37 patients who underwent head and neck radiotherapy over a 6-month period...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30224202/guidelines-for-clinical-target-volume-definition-for-perineural-spread-of-major-salivary-gland-cancers
#12
K Armstrong, J Ward, N M Hughes, A Mihai, A Blayney, C Mascott, R Kileen, J Armstrong
AIMS: Postoperative radiotherapy is the standard of care for resected major salivary cancers that are at risk of locoregional recurrence. Of the various histological subtypes, perineural invasion is most common in adenoidcystic carcinomas of the three major salivary glands - parotid, submandibular and sublingual. The clinical target volume (CTV) for these cases must include the relevant cranial nerve pathways at risk. A contouring atlas was devised for delineation of the CTV of the nerves supplying the major salivary glands...
December 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30216462/comparative-study-of-algorithms-for-synthetic-ct-generation-from-mri-consequences-for-mri-guided-radiation-planning-in-the-pelvic-region
#13
Hossein Arabi, Jason A Dowling, Ninon Burgos, Xiao Han, Peter B Greer, Nikolaos Koutsouvelis, Habib Zaidi
PURPOSE: Magnetic resonance imaging (MRI)-guided radiation therapy (RT) treatment planning is limited by the fact that the electron density distribution required for dose calculation is not readily provided by MR imaging. We compare a selection of novel synthetic CT generation algorithms recently reported in the literature, including segmentation-based, atlas-based and machine learning techniques, using the same cohort of patients and quantitative evaluation metrics. METHODS: Six MRI-guided synthetic CT generation algorithms were evaluated: one segmentation technique into a single tissue class (water-only), four atlas-based techniques, namely, median value of atlas images (ALMedian), atlas-based local weighted voting (ALWV), bone enhanced atlas-based local weighted voting (ALWV-Bone), iterative atlas-based local weighted voting (ALWV-Iter), and a machine learning technique using deep convolution neural network (DCNN)...
September 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/30172454/practical-contouring-guidelines-with-an-mr-based-atlas-of-brainstem-structures-involved-in-radiation-induced-nausea-and-vomiting
#14
Arnaud Beddok, Jean-Christophe Faivre, Alexandre Coutte, Jennifer Le Guévelou, Julien Welmant, Jean-Baptiste Clavier, Sébastien Guihard, Guillaume Janoray, Valentin Calugaru, Yoann Pointreau, Alexis Lacout, Julia Salleron, Michel Lefranc, Dominique Hasboun, Henri M Duvernoy, Juliette Thariat
BACKGROUND AND PURPOSE: The objective of this project was to define consensus guidelines for delineating brainstem substructures (dorsal vagal complex, including the area postrema) involved in radiation-induced nausea and vomiting (RINV). The three parts of the brainstem are rarely delineated, so this study was also an opportunity to find a consensus on this subject. MATERIALS AND METHODS: The dorsal vagal complex (DVC) was identified on autopsy sections and endoscopic descriptions...
August 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30144101/autosegmentation-for-thoracic-radiation-treatment-planning-a-grand-challenge-at-aapm-2017
#15
Jinzhong Yang, Harini Veeraraghavan, Samuel G Armato, Keyvan Farahani, Justin S Kirby, Jayashree Kalpathy-Kramer, Wouter van Elmpt, Andre Dekker, Xiao Han, Xue Feng, Paul Aljabar, Bruno Oliveira, Brent van der Heyden, Leonid Zamdborg, Dao Lam, Mark Gooding, Gregory C Sharp
PURPOSE: This report presents the methods and results of the Thoracic Auto-Segmentation Challenge organized at the 2017 Annual Meeting of American Association of Physicists in Medicine. The purpose of the challenge was to provide a benchmark dataset and platform for evaluating performance of autosegmentation methods of organs at risk (OARs) in thoracic CT images. METHODS: Sixty thoracic CT scans provided by three different institutions were separated into 36 training, 12 offline testing, and 12 online testing scans...
October 2018: Medical Physics
https://www.readbyqxmd.com/read/30140944/towards-a-universal-mri-atlas-of-the-prostate-and-prostate-zones-comparison-of-mri-vendor-and-image-acquisition-parameters
#16
Kyle R Padgett, Amy Swallen, Sara Pirozzi, Jon Piper, Felix M Chinea, Matthew C Abramowitz, Aaron Nelson, Alan Pollack, Radka Stoyanova
BACKGROUND AND PURPOSE: The aim of this study was to evaluate an automatic multi-atlas-based segmentation method for generating prostate, peripheral (PZ), and transition zone (TZ) contours on MRIs with and without fat saturation (±FS), and compare MRIs from different vendor MRI systems. METHODS: T2-weighted (T2) and fat-saturated (T2FS) MRIs were acquired on 3T GE (GE, Waukesha, WI, USA) and Siemens (Erlangen, Germany) systems. Manual prostate and PZ contours were used to create atlas libraries...
August 23, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30136285/fully-automatic-multi-organ-segmentation-for-head-and-neck-cancer-radiotherapy-using-shape-representation-model-constrained-fully-convolutional-neural-networks
#17
Nuo Tong, Shuiping Gou, Shuyuan Yang, Dan Ruan, Ke Sheng
PURPOSE: Intensity modulated radiation therapy (IMRT) is commonly employed for treating head and neck (H&N) cancer with uniform tumor dose and conformal critical organ sparing. Accurate delineation of organs-at-risk (OARs) on H&N CT images is thus essential to treatment quality. Manual contouring used in current clinical practice is tedious, time-consuming, and can produce inconsistent results. Existing automated segmentation methods are challenged by the substantial inter-patient anatomical variation and low CT soft tissue contrast...
October 2018: Medical Physics
https://www.readbyqxmd.com/read/30118822/fdg-pet-ct-based-lymph-node-atlas-in-breast-cancer-patients
#18
Kai Joachim Borm, Julia Voppichler, Mathias Düsberg, Markus Oechsner, Tibor Vag, Wolfgang Weber, Stephanie Elisabeth Combs, Marciana Nona Duma
PURPOSE: The aim of this study was to localize locoregional lymph node metastases using positron emission tomography with fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) data sets in a large cohort of patients and to evaluate the existing Radiation Therapy Oncology Group (RTOG) clinical target volume (CTV) and the European Society for Radiation Therapy & Oncology (ESTRO) CTV contouring guidelines. METHODS AND MATERIALS: A total of 235 patients with 580 FDG/PET-CT positive locoregional lymph node metastases were included in our analysis...
August 14, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30107948/geometric-and-dosimetric-evaluation-of-atlas-based-auto-segmentation-of-cardiac-structures-in-breast-cancer-patients
#19
Robert Kaderka, Erin F Gillespie, Robert C Mundt, Alex K Bryant, Camila B Sanudo-Thomas, Anna L Harrison, Emilie L Wouters, Vitali Moiseenko, Kevin L Moore, Todd F Atwood, James D Murphy
BACKGROUND AND PURPOSE: Auto-segmentation represents an efficient tool to segment organs on CT imaging. Primarily used in clinical setting, auto-segmentation plays an increasing role in research, particularly when analyzing thousands of images in the "big data" era. In this study we evaluate the accuracy of cardiac dosimetric endpoints derived from atlas based auto-segmentation compared to gold standard manual segmentation. MATERIAL AND METHODS: Heart and cardiac substructures were manually delineated on 54 breast cancer patients...
August 11, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30029684/quality-assurance-analysis-of-hippocampal-avoidance-in-a-melanoma-whole-brain-radiotherapy-randomized-trial-shows-good-compliance
#20
Geoffrey Martinage, Angela M Hong, Mike Fay, Thanuja Thachil, Daniel Roos, Narelle Williams, Serigne Lo, Gerald Fogarty
BACKGROUND: Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 - WBRT-Mel) evaluates the role of adjuvant whole brain radiotherapy (WBRT) following local treatment of MBM. Hippocampal avoidance during WBRT (HA-WBRT) has shown memory and neurocognitive function (NCF) preservation in the RTOG-0933 phase II study. This study assessed the quality assurance of HA-WBRT within the WBRT-Mel trial according to RTOG-0933 study criteria...
July 20, 2018: Radiation Oncology
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