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Alessio Ausili, Pablo Martinez Valera, Alejandro Torrecillas, Victoria Gómez-Murcia, Ana M deGodos, Senena Corbalan-Garcia, Jose Antonio Teruel, Juan C Gomez-Fernandez
Edelfosine is an anticancer drug with an asymmetric structure because, being a derivative of glycerol, it possesses two hydrophobic substituents of very different lengths. We showed that edelfosine destabilizes liquid ordered membranes formed by either POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine), SM (sphingomyelin) and cholesterol (1:1:1 molar ratio) or SM and cholesterol (2:1 molar ratio). This was observed by differential scanning calorimetry where a phase transition arises from either of these membrane systems after the addition of edelfosine...
June 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Annamaria Iorio, Michele Senni, Giulia Barbati, Stephen J Greene, Stefano Poli, Elena Zambon, Concetta Di Nora, Giovanni Cioffi, Luigi Tarantini, Antonello Gavazzi, Gianfranco Sinagra, Andrea Di Lenarda
AIM: To assess adverse outcomes attributable to non-cardiac co-morbidities and to compare their effects by left ventricular ejection fraction (LVEF) group [LVEF <50% (heart failure with reduced ejection fraction, HFrEF), LVEF ≥50% (heart failure with preserved ejection fraction, HFpEF)] in a contemporary, unselected chronic heart failure population. METHODS AND RESULTS: This community-based cohort enrolled patients from October 2009 to December 2013. Adjusted hazard ratio (HR) and the population attributable fraction (PAF) were used to compare the contribution of 15 non-cardiac co-morbidities to adverse outcome...
June 19, 2018: European Journal of Heart Failure
Tormod Landmark, Pål Romundstad, Ola Dale, Petter C Borchgrevink, Lars Vatten, Stein Kaasa
Background The reported prevalence of chronic pain ranges from 11% to 64%, and although consistently high, the calculated economic burden estimates also vary widely between studies. There is no standard way of classifying chronic pain. We have repeated measurements of pain in a longitudinal population study to improve validity ofthe case ascertainment. In this paper, associations between chronic pain and demographic characteristics, self reported health and functioning, work Incapacity and health care use were investigated in a sample from the general Norwegian population...
December 29, 2017: Scandinavian Journal of Pain
Bing Lei, Shugang Liu
We report a new quantitative measurement method of polarization direction based on the polarization axis finder (PAF) and digital image processing. The PAF acts as an azimuthal analyzer to determine the polarization direction of linearly polarized light and form an "hourglass" intensity pattern, and a digital camera is employed to record the pattern, and then the lightwave's polarization direction is obtained accurately by analyzing the pattern with a specially designed digital image processing algorithm...
June 15, 2018: Optics Letters
Mingxia Sun, Chongdong Liu, Na Zhao, Kaikai Meng, Zhenyu Zhang
The present study investigated the predictive value of the platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism. From January 2014 to January 2016, 23 patients with postpartum deep vein thrombosis of lower extremity treated in the Department of Obstetrics of Beijing Chaoyang Hospital were as assigned as the observation group. At the same time, 25 cases with normal recovery were assigned as the control group. Blood samples were collected from all the subjects. The platelet aggregation rate was measured using a platelet aggregation apparatus...
June 2018: Experimental and Therapeutic Medicine
Yuda Chen, Axel Loredo, Aviva Gordon, Juan Tang, Chenfei Yu, Janett Ordonez, Han Xiao
Genetically site-specific introduction of noncanonical amino acids (ncAAs) for protein conjugation generally requires incorporation through exogenous feeding of chemically synthesized ncAAs. We developed a p-amino-phenylalanine (pAF)-based relay system that enables site-specific functionalization of proteins without chemical synthesis of the building blocks. pAF was biosynthesized under optimized conditions, followed by site-specific incorporation into a specific protein residue. The resulting protein was ready for functionalization using an oxidative conjugation reaction...
June 13, 2018: Chemical Communications: Chem Comm
Christian Wejse
The role of vitamin D in tuberculosis (TB) has been a hot topic for decades, and it is still an unresolved matter. Vitamin D deficiency and other micronutrient deficiencies have been considered as important risk factors for TB and malnutrition is overall a highly important risk factor for TB. In fact with the highest population attributable fraction (PAF) for TB at 27% (1), which means the fraction of all TB cases that would NOT have occurred if exposure (to e.g. malnutrition) was not there. This article is protected by copyright...
June 11, 2018: Journal of Internal Medicine
Zhi-Zhao Li, Xin Du, Xue-Yuan Guo, Ri-Bo Tang, Chao Jiang, Nian Liu, San-Shuai Chang, Rong-Hui Yu, De-Yong Long, Rong Bai, Cai-Hua Sang, Song-Nan Li, Jian-Zeng Dong, Chang-Sheng Ma
BACKGROUND Dyslipidemia is the most frequent comorbidity in patients with cardiovascular disease. However, studies examining the relationship between blood lipid profiles and AF have produced inconsistent results. MATERIAL AND METHODS A total of 651 patients were enrolled into 3 groups: Healthy controls (n=64), Paroxysmal AF (PAF; n=270), and Continuous AF (CAF; n=317). All enrolled patients underwent routine baseline 12-lead electrocardiography (ECG) and 24-h dynamic ECG along with blood testing, which included the following: complete metabolic panel, hepatic function, renal function, circulating thyroxine, fasting high-density lipoprotein cholesterol (HDL -C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC)...
June 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Alexandros Tsoupras, Ronan Lordan, Martina Demuru, Katie Shiels, Sushanta Kumar Saha, Constantina Nasopoulou, Ioannis Zabetakis
While several marine polar lipids (PL) have exhibited cardioprotective properties through their effects on the platelet-activating factor (PAF) pathways, salmon PL have not been tested so far. In this study, the antithrombotic activities of salmon PL were assessed in human platelets and the structural characterisation of bioactive salmon PL was performed by GC-MS and LC-MS analyses. PL from fillets of Irish organic farmed salmon ( Salmo salar ) were extracted and separated into several lipid subclasses by thin-layer chromatography (TLC), while their fatty acid profile was fully characterised by GC-MS...
May 23, 2018: Marine Drugs
Yuanchen Chen, Lu Zang, Wei Du, Da Xu, Guofeng Shen, Quan Zhang, Qiaoli Zou, Jinyuan Chen, Meirong Zhao, Defei Yao
In recent years, ambient air has been severely contaminated by particulate matters (PMs) and some gas pollutants (nitrogen dioxide (NO2 ) and sulfur dioxide (SO2 )) in China, and many studies have demonstrated that exposure to these pollutants can induce great adverse impacts on human health. The concentrations of the pollutants were much higher in winter than those in summer, and the average concentrations in this studied area were lower than those in northern China. In the comparison between high-resolution emission inventory and spatial distribution of PM2...
June 6, 2018: Environmental Science and Pollution Research International
Tina Van Regenmortel, Dimitri Van de Perre, Colin R Janssen, Karel A C De Schamphelaere
It is generally assumed that as long as the majority of species experiences no direct adverse effects due to a single substance (i.e. Potentially Affected Fraction, PAF < 5%), no significant structural or functional effects at community-level are expected to occur. Whether this assumption holds for mixed metal contamination is not known. Here, we tested this by performing a microcosm experiment in which a naturally occurring freshwater planktonic community was exposed to a Cu-Ni-Zn mixture for 8 weeks, and in which various structural and functional community-level traits were assessed...
June 5, 2018: Environmental Toxicology and Chemistry
Tomoko Minamisaka, Tetsuya Watanabe, Yukinori Shinoda, Kuniyasu Ikeoka, Hidetada Fukuoka, Hirooki Inui, Keisuke Ueno, Soki Inoue, Kentaro Mine, Shiro Hoshida
BACKGROUND: In patients with atrial fibrillation, ablation procedure decreases left atrial (LA) compliance, which may lead to left ventricular (LV) diastolic dysfunction. We aimed to examine serial changes in LV diastolic function after two ablation procedures and their related factors in patients with paroxysmal atrial fibrillation (PAF). METHODS: We enrolled 132 patients with PAF [76 men, cryoballoon (CB) ablation/radiofrequency (RF) ablation 60/72, mean 67 years] who underwent a single ablation procedure...
June 4, 2018: Clinical Cardiology
Klára Kobetičová, Robert Černý
Short chain chlorinated paraffins (SCCPs) have been commonly used as plasticizers and flame retardants in polyvinyl-chloride (PVC) products for the construction industry. During the last few years the production of SCCPs has been banned or reduced in Europe, Japan, USA, and Canada due to their toxic and bioaccumulative effects but they have been still produced and used under less controlled conditions worldwide. Middle chain chlorinated paraffins (MCCPs) were suggested as a suitable alternative to SCCPs for PVC production instead...
June 1, 2018: Science of the Total Environment
Gianfranco Cervellin, Fabian Sanchis-Gomar, Ida Filice, Giuseppe Lippi
An enhanced risk of atrial fibrillation (AF) has been clearly documented in endurance athletes over the past decades. In this regard, we have recently described the 'PAFIYAMA' ('paroxysmal AF in young and middle-aged athletes') syndrome, provided that other risk factors for AF and underlying conditions have been ruled out. We report here a paradigmatic case of PAFIYAMA syndrome. A 32 years old man was admitted to the Emergency Department (ED) complaining for palpitations, lasting for 3 hours. He had never smoked and other risk factors for AF could be ruled out...
April 2018: Cardiovascular Diagnosis and Therapy
Kátia Regina F Lopes, Erica Camila G Praxedes, Livia B Campos, Marcelo B Bezerra, Gabriela L Lima, Márcia Viviane A Saraiva, Alexandre R Silva
The aim of this study was to assess a vitrification protocol for asinine ovarian tissue, to preserve preantral follicles using different cryoprotectant solutions, composed of various concentrations (EG 3 M or 6 M) of dimethyl sulfoxide or ethylene glycol isolate, or as a combination (DMSO 3 M + EG 3 M). Ten pairs of ovaries from Brazilian north-eastern breed jennies were obtained through videolaparoscopy, and cortical fragments were submitted to a solid-surface vitrification (SSV) using each cryoprotectant solution...
May 29, 2018: Reproduction in Domestic Animals, Zuchthygiene
Can Cao, Qiuxiang Tan, Chanjuan Xu, Lingli He, Linlin Yang, Ye Zhou, Yiwei Zhou, Anna Qiao, Minmin Lu, Cuiying Yi, Gye Won Han, Xianping Wang, Xuemei Li, Huaiyu Yang, Zihe Rao, Hualiang Jiang, Yongfang Zhao, Jianfeng Liu, Raymond C Stevens, Qiang Zhao, Xuejun C Zhang, Beili Wu
Platelet-activating-factor receptor (PAFR) responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. PAFR is considered an important drug target for treating asthma, inflammation and cardiovascular diseases. Here we report crystal structures of human PAFR in complex with the antagonist SR 27417 and the inverse agonist ABT-491 at 2.8-Å and 2.9-Å resolution, respectively. The structures, supported by molecular docking of PAF, provide insights into the signal-recognition mechanisms of PAFR...
May 28, 2018: Nature Structural & Molecular Biology
Kageyuki Oba, Minetaka Maeda, Gulinu Maimaituxun, Satoshi Yamaguchi, Osamu Arasaki, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Susumu Nishio, Takashi Iwase, Shoichiro Takao, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Hiroaki Masuzaki, Masataka Sata, Michio Shimabukuro
BACKGROUND: Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.Methods and Results:Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups...
May 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Chunxia Yao, Tina Veleva, Larry Scott, Shuyi Cao, Luge Li, Gong Chen, Prince Jeyabal, Xiaolu Pan, Katherina M Alsina, Issam Abu-Taha, Shokoufeh Ghezelbash, Corey L Reynolds, Ying H Shen, Scott A LeMaire, Wilhelm Schmitz, Frank U Müller, Ali El-Armouche, N Tony Eissa, Christine Beeton, Stanley Nattel, Xander H T Wehrens, Dobromir Dobrev, Na Li
Background -Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The "NACHT, LRR and PYD domain containing protein 3" (NLRP3)-inflammasome mediates caspase-1 activation and interleukin-1β release in immune cells, but is not known to play a role in cardiomyocytes (CMs). Here, we assessed the role of CM NLRP3-inflammasome in AF. Methods -NLRP3-inflammasome activation was assessed by immunoblot in atrial whole-tissue lysates and CMs from patients with paroxysmal (pAF) or long-standing persistent (chronic) AF (cAF)...
May 25, 2018: Circulation
Algirdas J Jesaitis, Jeannie Gripentrog, Jovanka M Voyich
N-formyl-Met-Leu-Phe (fMLF) is a model PAMP/DAMP driving human PMN to sites of injury/infection utilizing the GPCR, FPR1. We examined a microtiter plate format for measurement of FPR1 phosphorylation in adherent PMN at high densities and found that a new phosphosensitive FPR1 fragment, 25K-FPR1, accumulates in SDS-PAGE extracts. 25K-FPR1 is fully inhibited by diisopropylfluorophosphate PMN pretreatment but is not physiologic, as its formation failed to be significantly perturbed by ATP depletion, time and temperature of adherence, or adherence mechanism...
2018: Journal of Immunology Research
Li-Ping Jing, Jin-Shi Sun, Fuxing Sun, Peng Chen, Guangshan Zhu
A strategy using a mesoporous amine-tagged porous aromatic framework ( PAF70-NH2 ) to immobilize a palladium (Pd)-based molecular catalyst has been developed. The resulting immobilized catalyst PAF70-Pd , in which the framework is entirely constructed by phenyl rings linked with stable carbon-carbon bonds, has high structural rigidity and stability. Compared with the known porous organic material immobilized Pd-based catalysts, PAF70-Pd has the highest Pd content so far. Moreover, PAF70-Pd has extremely high catalytic activity with good size selectivity and very easy recyclability in catalyzing the Suzuki-Miyaura coupling reaction...
April 14, 2018: Chemical Science
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