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Su-Xian Zhou, Dong-Mei Huo, Xiao-Yun He, Ping Yu, Yan-Hua Xiao, Chun-Lin Ou, Ren-Mei Jiang, Dan Li, Hao Li
Platelet-activating factor (PAF), protein kinase C (PKC)βI, transforming growth factor (TGF)‑β1 and aberrant extracellular matrix (ECM) deposition have been associated with diabetic nephropathy (DN). However, the mechanistic basis underlying this association remains to be elucidated. The present study investigated the association among the aforementioned factors in a DN model consisting of human mesangial cells (HMCs) exposed to high glucose (HG) and lysophosphatidylcholine (LPC) treatments. HMCs were divided into the following treatment groups: Control; PAF; PAF+PKCβI inhibitor LY333531; HG + LPC; PAF + HG + LPC; and PAF + HG + LPC + LY333531...
November 20, 2017: Molecular Medicine Reports
Qi Zhang, Jingjun Zhang, Yuzhong Yan, Pengyue Zhang, Wei Zhang, Rong Xia
Background and Objective: Stroke may cause neuropsychiatric problems, which have negative effects on cognitive functions and behavior. Exercise plays an important role in reducing the occurrence and development of stroke, the concrete mechanism is not fully clarified. In this study, we attempted to determine whether early treadmill exercise attenuates anxiety-like behavior by regulation of inflammation after brain ischemia. Method: We subjected adult male rats to middle cerebral artery occlusion (MCAO) for 90 min and trained rats started to run on a treadmill from postoperative day 1 to day 14...
November 2017: Brain and Behavior
Yuki Osaka, Masateru Takigawa, Atsushi Takahashi, Taishi Kuwahara, Kenji Okubo, Yoshihide Takahashi, Yasuaki Tanaka, Naohiko Kawaguchi, Kazuya Yamao, Yuji Watari, Emiko Nakashima, Jun Nakajima, Katsumasa Takagi, Tadashi Fujino, Shigeki Kimura, Hiroyuki Hikita, Kenzo Hirao, Mitsuaki Isobe
BACKGROUND: Catheter ablation (CA) of paroxysmal atrial fibrillation (PAF) is an effective treatment. However, the frequency of asymptomatic AF recurrence after CA in patients with PAF and sick sinus syndrome (SSS) is not clear. The aim of this study was to elucidate the real AF recurrence after CA in patients with PAF and a pacemaker for SSS. METHODS AND RESULTS: Fifty-one consecutive patients (mean age 66.6 ± 7.0 years, male 34) with PAF and SSS and pacemakers underwent CA...
September 2017: Indian Pacing and Electrophysiology Journal
Yudi Wang, Shuhao Zhang, Jionghua Wu, Kuan Liu, Dongmei Li, Qingbo Meng, Guangshan Zhu
PAF-86 film is electropolymerization (EP) by targeted monomer M1 tethered bifunctional carbozolyl moieties which not only serve electron-donation but also provides effective electro-chemical (EC) active sites. The resulting PAF-86 film possess fairly compact surface, remarkable stability, efficient hole extraction capacity and hole transporting materials (HTM) for inverted heterojunction perovskite solar cells (PSCs). Likewise, our investigation shows that, PAF-86 film based perovskite solar cells (PSCs) retained about 80% power conversion efficiency (PCE) without encapsulation in air than poly(3,4-ethylenedio-xythiophene): poly(styrenesulfonate) (PEDOT:PSS) based PSCs devices reduces 4% under the same conditions...
November 28, 2017: ACS Applied Materials & Interfaces
Hariharan Sugumar, Stuart P Thomas, Sandeep Prabhu, Aleksandr Voskoboinik, Peter M Kistler
Catheter ablation (CA) has become standard of care in patients with symptomatic atrial fibrillation (AF). Although there have been significant advances in our understanding and technology, a substantial proportion of patients have ongoing AF requiring repeat procedures. Pulmonary vein isolation (PVI) is the cornerstone of AF ablation; however, it is less effective in patients with persistent as opposed to paroxysmal atrial fibrillation (PAF). Left atrial posterior wall isolation (PWI) is commonly performed as an adjunct to PVI in patients with persistent AF with non-randomized studies showing improved outcomes...
November 27, 2017: Journal of Cardiovascular Electrophysiology
Andrew J Furman, Timothy J Meeker, Jeremy C Rietschel, Sooyoung Yoo, Janusiya Muthulingam, Mariya Prokhorenko, Michael L Keaser, Ronald N Goodman, Ali Mazaheri, David A Seminowicz
The identification of neurobiological markers that predict individual predisposition to pain are not only important for development of effective pain treatments, but would also yield a more complete understanding of how pain is implemented in the brain. In the current study using electroencephalography (EEG), we investigated the relationship between the peak frequency of alpha activity over sensorimotor cortex and pain intensity during capsaicin-heat pain (C-HP), a prolonged pain model known to induce spinal central sensitization in primates...
November 21, 2017: NeuroImage
Yasutsugu Nagamoto, Yuto Fujii, Yuichi Morita, Yusuke Ueda, Yasuko Miyake, Kenichi Yamane, Mai Fujiwara, Shinji Mito, Yuichiro Watari, Hiromichi Tamekiyo, Tomokazu Okimoto, Yuji Muraoka, Yasuhiko Hayashi
BACKGROUND: Ventricular fibrillation and atrial fibrillation are well-known arrhythmias in patients with Brugada syndrome. This study evaluated the characteristics of the atrial arrhythmogenic substrate using the signal-averaged electrogram (SAECG) in patients with Brugada syndrome. METHODS: SAECGs were performed during normal sinus rhythm in 23 normal volunteers (control group), 21 patients with paroxysmal atrial fibrillation (PAF; PAF group), and 21 with Brugada syndrome (Brugada group)...
November 2017: Indian Heart Journal
L V Randall, M J Green, L E Green, M G G Chagunda, C Mason, S C Archer, J N Huxley
It has been demonstrated that low body condition and previous occurrence of lameness increase the risk of future lameness in dairy cows. To date the population attributable fraction (PAF), which provides an estimate of the contribution that a risk factor makes toward the total number of disease events in a population, has not been explored for lameness using longitudinal data with repeated measures. Estimation of PAF helps to identify control measures that could lead to the largest improvements on-farm. The aim of this study was to use longitudinal data to evaluate the proportion of lameness that could be avoided in 2 separate herds (2 populations) through (1) reduced recurrence of previous lameness events, (2) and moving body condition score (BCS) into more optimal ranges...
November 22, 2017: Journal of Dairy Science
Marilita M Moschos, Konstantinos Laios, Sofia Androudi, Dimitrios S Ladas, Irini P Chatziralli
OBJECTIVE: The purpose of this experimental study was to investigate the role of vitamin supplements (Ocuvite, Vitalux Omega and Nutrof Total) as possible inhibitors of the onset of Age-Related Macular Degeneration (AMD). MATERIALS AND METHODS: The anti-aggregating effect of each vitamin was determined against four accumulative factors namely, Platelet Activating Factor (PAF), Adenosine diphosphate (ADP), Thrombin Receptor-activating Peptide (TRAP) and Arachidonic Acid (AA) in the Platelet Rich Plasma (PRP) of healthy volunteers...
November 24, 2017: Cutaneous and Ocular Toxicology
A Collins, T McCarthy, M Laffoy
Excess body weight (EBW) increases the risk of specific cancers. The prevalence of EBW has risen significantly in Ireland over recent decades. To highlight the impact on cancer, and to inform future policies, we calculated the proportion of cancers in Ireland that were attributable to EBW using the Population Attributable Fraction (PAF). This fraction was then applied to Irish incidence and mortality data for specific cancers from 2003-2012 to estimate the number of new cancers and cancer deaths attributable to EBW...
August 12, 2017: Irish Medical Journal
Yang Sun, Dong-Ping Xu, Zhen Qin, Peng-Yuan Wang, Bo-Han Hu, Jian-Guang Yu, Yong Zhao, Ben Cai, Yong-Ling Chen, Min Lu, Jian-Guo Liu, Xia Liu
The purpose of the present work was designed to explore protective cerebrovascular effects of hydroxysafflor yellow A (HSYA), and provide preclinical efficacy and mechanism data for its possible application in patients with cerebral ischemia. The protective effect of HSYA on ischemic stroke was evaluated by infarct sizes and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Cerebrovascular permeability was detected by Evans blue dye leakage in MCAO rats. Cerebral blood flow, as well as blood pressure and heart rate were monitored using flow probes in Beagle dogs...
November 19, 2017: European Journal of Pharmacology
Ling Guo, Murray D Esler, Carolina Sari, Sarah Phillips, Elisabeth A Lambert, Nora E Straznicky, Gavin W Lambert, Susan J Corcoran
BACKGROUND: Pure autonomic failure (PAF) is a rare sporadic disorder characterised by autonomic failure in the absence of a movement disorder or dementia and is associated with very low plasma norepinephrine levels - suggesting widespread sympathetic denervation, however the underlying pathology remains poorly elucidated. We sought to correlate clinical and neurochemical findings with sympathetic nerve protein abundances, accessed by way of a forearm vein biopsy, in patients with PAF and in healthy controls and patients with multiple systems atrophy (MSA) in whom sympathetic nerves are considered intact...
November 21, 2017: Clinical Science (1979-)
Melina Arnold, Marina Touillaud, Laure Dossus, Heinz Freisling, Freddie Bray, Irène Margaritis, Valérie Deschamps, Isabelle Soerjomataram
BACKGROUND: Overweight, as defined by high body mass index (BMI), is an established risk factor for various morbidities including cancer. Globally, its prevalence has increased markedly over the past decades. The aim of this study was to estimate the proportion and number of cancers that were attributable to high BMI in France in 2015. METHODS: Population attributable fractions (PAFs) and numbers of cancer cases attributable to high BMI (a population mean BMI above the optimum of 22kg/m(2)) were estimated by age and sex, for cancer sites with convincing or probable evidence of an established causal link...
November 18, 2017: Cancer Epidemiology
Tengda Si, Bowen Li, Wenrui Xiong, Bin Xu, Wenjun Tang
Aryl-secondary alkyl cross-coupling with aryl sulfonate esters as coupling partners remains a significant challenge. Efficient cross-coupling between aryl/alkenyl triflates and acyclic secondary alkylboronic acids is realized for the first time to provide a series of sterically congested acyclic secondary alkyl arenes/olefins in good to excellent yields. The employment of sterically bulky P,P[double bond, length as m-dash]O ligand L1/L2 is crucial for the high yields and selectivities. The method has enabled a concise and 4-step synthesis of a key intermediate of male contraceptive agent and PAF antagonist gossypol...
November 21, 2017: Organic & Biomolecular Chemistry
K H Boon, M Khalil-Hani, M B Malarvili
This paper presents a method that able to predict the paroxysmal atrial fibrillation (PAF). The method uses shorter heart rate variability (HRV) signals when compared to existing methods, and achieves good prediction accuracy. PAF is a common cardiac arrhythmia that increases the health risk of a patient, and the development of an accurate predictor of the onset of PAF is clinical important because it increases the possibility to electrically stabilize and prevent the onset of atrial arrhythmias with different pacing techniques...
January 2018: Computer Methods and Programs in Biomedicine
Emily L McClung, Joanne Kraenzle Schneider
BACKGROUND: Dishonesty in the classroom suggests dishonesty in practice. There is need to better understand nursing students' perceptions of dishonest behaviors in the classroom and clinical setting. There is currently no instrument to assess perceptions in the classroom and clinical setting. OBJECTIVE: The purpose of this study was to develop an instrument to assess nursing students' perceptions of academically dishonest behaviors in the classroom and clinical setting...
November 10, 2017: Nurse Education Today
Yukihiro Fukuda, Mitsunori Okamoto, Shunsuke Tomomori, Hiroya Matsumura, Takehito Tokuyama, Yukiko Nakano, Yasuki Kihara
Objective The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that can be used to detect atrial inflammatory changes, which may contribute to a reduced left atrial (LA) function and thrombosis. Our study aimed to determine whether or not the association of NLR with the LA appendage (LAA) function in relation to thrombogenesis differs from the association with the LA body function in paroxysmal atrial fibrillation (PAF) patients. Methods A total of 183 PAF patients were studied. The LA volume index, mitral flow velocity (A), and mitral annular motion velocity (A') were examined using transthoracic echocardiography...
November 20, 2017: Internal Medicine
Onur Kaypakli, Hasan Koca, Durmuş Yıldıray Şahin, Sefa Okar, Fadime Karataş, Mevlüt Koç
AIM: We aimed to investigate the relationship between the recurrence of AF and P wave duration index (PWDI) in patients with nonvalvular PAF. METHODS: We included 114 patients who underwent cryoballoon catheter ablation with the diagnosis of paroxysmal atrial fibrillation (PAF) (55 male, 59 female; mean age 55.5±10,9years). PWDI was calculated by dividing the Pwd by the PR interval in DII lead of 12‑lead ECG. Patients had regular follow-up visits with 12-lead ECG, medical history and clinical evaluation...
October 9, 2017: Journal of Electrocardiology
Célina Lichtl, Thomas Lutz, Joachim Szecsenyi, Kayvan Bozorgmehr
BACKGROUND: Hospitalizations for ambulatory care sensitive (ACS) conditions are established indicators for the availability and quality of ambulatory care. We aimed to assess the differences between asylum-seeking children and children of the general population in a German city with respect to (i) the prevalence of ACS hospitalizations, and (ii) the utilization of emergency outpatient services for ACS conditions. METHODS: Using anonymous account data, all children admitted to the University Hospital Heidelberg in 2015 were included in our study...
November 15, 2017: BMC Health Services Research
Zehour AlSabban, Nicholas Carman, Rahim Moineddin, Ryan T Lo, Sebastian K King, Jacob C Langer, Thomas D Walters, Anne M Griffiths, Peter C Church, Mary-Louise C Greer
BACKGROUND: Pediatric Crohn's disease is associated with perianal disease (PAD). Magnetic resonance enterography (MRE) assesses small bowel involvement in pediatric inflammatory bowel disease (PIBD). Pelvic MRI (P-MRI) is the gold standard for assessing PAD. PURPOSE: To determine if MRE can accurately detect PAD in PIBD, distinguishing perianal fistulae (PAF) from perianal abscesses (PAA), referenced against P-MRI. STUDY TYPE: Retrospective...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
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