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https://www.readbyqxmd.com/read/27918197/educational-inequalities-in-mortality-of-patients-with-atrial-fibrillation-in-norway
#1
Rupali Akerkar, Marta Ebbing, Gerhard Sulo, Inger Ariansen, Jannicke Igland, Grethe S Tell, Grace M Egeland
OBJECTIVES: Socioeconomic gradients provide an indication of mortality's preventable fraction. Given the high mortality associated with atrial fibrillation (AF), we explored the educational gradient in all-cause and cardiovascular mortality in an AF patient population. DESIGN: We prospectively followed patients hospitalized with AF as primary discharge diagnosis. Patients were identified in a nationwide Cardiovascular Disease in Norway 2008-2012 project. The average length of follow-up was 2...
December 5, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27913731/disentangling-polydispersity-in-the-pcna-p15paf-complex-a-disordered-transient-and-multivalent-macromolecular-assembly
#2
Tiago N Cordeiro, Po-Chia Chen, Alfredo De Biasio, Nathalie Sibille, Francisco J Blanco, Jochen S Hub, Ramon Crehuet, Pau Bernadó
The intrinsically disordered p15(PAF) regulates DNA replication and repair when interacting with the Proliferating Cell Nuclear Antigen (PCNA) sliding clamp. As many interactions between disordered proteins and globular partners involved in signaling and regulation, the complex between p15(PAF) and trimeric PCNA is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational fluctuations, and relative population of the five species that coexist in solution by combining small-angle X-ray scattering (SAXS) with molecular modelling...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27910906/analysis-of-the-serum-lipid-profile-in-polypoidal-choroidal-vasculopathy
#3
Miaoling Li, Xiongze Zhang, Nanying Liao, Baikang Ye, Yuting Peng, Yuying Ji, Feng Wen
Polypoidal choroidal vasculopathy (PCV), the predominant subtype of neovascular age-related macular degeneration in the Asian population, is associated with genetic polymorphism of lipid metabolism. In this study, we performed the untargeted lipidomics approach of ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS) to reveal the potential discriminating lipid profile of PCV patients in serum (21 PCV patients and 19 age-matched controls). Unsupervised principal component, supervised orthogonal partial least squares analysis, correlation analysis, and heatmap analysis were performed with the data obtained by UPLC-MS...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909911/obesity-as-an-avoidable-cause-of-cancer-attributable-risks
#4
Andrew G Renehan, Isabelle Soerjomataram
Excess body weight, commonly categorised as overweight (body mass index, BMI 25.0-29.9 kg/m(2)) and obesity (BMI ≥30 kg/m(2)) is an established risk factor for increased incidence of several adult cancers. As body weight is modifiable, there is a potential for cancer prevention. Calculation of attributable risk (here expressed at population attributable fraction, PAF) offers an estimate of the burden of excess cancers attributable to elevated BMI in populations, and thus an approximation of avoidable cases and the opportunity for prevention...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27909504/long-term-evolution-of-patients-treated-for-paroxysmal-atrial-fibrillation-with-first-and-second-generation-cryoballoon-catheter-ablation-with-a-prospective-protocol-guided-by-complete-bidirectional-left-atrium-pulmonary-veins-disconnection-after-adenosine
#5
Jesus M Paylos Md PhD, Aracelis Morales Md, Luis Azcona Md, Marisol Paradela Md, Raquel Yagüe Md, Fernando Gómez-Guijarro Md, Lourdes Lacal Md, Clara Ferrero Rn, Octavio Rodríguez Md
INTRODUCTION: Cryoballoon ablation (CB) has proven effective for treating patients with paroxysmal atrial fibrillation (PAF). We analyzed our seven year follow-up of patients, treated for PAF with first (CB1) and second generation (CB2), with demonstration of LA-PV disconnection with bidirectional block (BB) after adenosine (AD). METHODS: Since November 2008 to May 2015, 128 patients, 97 male (58±7 years), without heart disease, highly symptomatic, refractory to antiarrhythmic drugs (AAD) were treated, and follow-up (1411 ±727 days)...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908762/bioactive-chemical-constituents-from-the-root-bark-of-morus-australis
#6
Yu-Ren Liao, Ping-Chung Kuo, Wei-Jern Tsai, Guan-Jhong Huang, Kuo-Hsiung Lee, Tian-Shung Wu
Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1-10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation...
November 17, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27902745/utility-of-the-health-of-the-nation-outcome-scales-honos-in-predicting-mental-health-service-costs-for-patients-with-common-mental-health-problems-historical-cohort-study
#7
Conal Twomey, A Matthew Prina, David S Baldwin, Jayati Das-Munshi, David Kingdon, Leonardo Koeser, Martin J Prince, Robert Stewart, Alex D Tulloch, Alarcos Cieza
BACKGROUND: Few countries have made much progress in implementing transparent and efficient systems for the allocation of mental health care resources. In England there are ongoing efforts by the National Health Service (NHS) to develop mental health 'payment by results' (PbR). The system depends on the ability of patient 'clusters' derived from the Health of the Nation Outcome Scales (HoNOS) to predict costs. We therefore investigated the associations of individual HoNOS items and the Total HoNOS score at baseline with mental health service costs at one year follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27890215/-incidence-of-distal-ulna-fractures-associated-with-distal-radius-fractures-treatment-options
#8
G Herzberg, T Castel
Fractures of the neck and/or head of the ulna or distal ulna fracture (DUF) other than ulnar styloid fractures can occur in combination with distal radius fractures (DRF). This combination can have a significant influence on the treatment and prognosis since it causes the entire distal forearm to be unstable. In a series of 1279 consecutive unilateral DRFs, we found an associated ulnar neck fracture in 5.9% of cases, ulnar head and neck fracture in 1.6%, and isolated ulnar head fracture in 1.4%. Overall, 9% of cases in this study had a DUF with a DRF...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27890209/-patient-accident-fracture-paf-classification-of-distal-radius-fractures
#9
M Burnier, G Herzberg, Y Izem
Despite the huge amount of literature devoted to acute distal radius fractures, there is currently no consensus as to treatment recommendations. There is no universally accepted anatomical classification other than the three main categories of the AO classification. The authors believe that the only way to improve this field is to stratify the patients according to their general health and functional needs. They propose a new classification system that they have used since 2009 and demonstrate its therapeutic, epidemiological and teaching values...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27890206/-distal-radius-fractures-which-classification-is-the-right-one
#10
L Obert, D Lepage, R Saadnia, F Mille, P-B Rey, F Loisel
None of the classification systems for distal radius fractures is ideal. However a validated system to analyze these fractures is available that is based on the "metaphysis, epiphysis, ulna" (MEU) classification and the "patient, accident, fracture" (PAF) system. It makes it possible to understand the injury and select the best treatment.
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27890202/-radiological-analysis-of-acute-distal-radius-fractures-and-clinical-outcomes
#11
G Herzberg, M Burnier
Radiological analysis of acute distal radius fractures (DRF) begins with the initial AP and lateral X-ray views. A CT scan is very often indicated. In addition to the three standard planes, 3D reconstructions are mandatory. We recommend not only AP views of the distal facets of the radius but also a complete 3D view in the surgical position. The distal ulna and carpus should also be analyzed. We describe the radiological sequence and the criteria used. These criteria are recorded in the one-page PAF chart, since they all impact the treatment choice...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27885476/does-t2-mapping-of-the-posterior-annulus-fibrosus-indicate-the-presence-of-lumbar-intervertebral-disc-herniation-a-3-0-tesla-magnetic-resonance-study
#12
Alina Messner, David Stelzeneder, Stefan Trattnig, Götz H Welsch, Martina Schinhan, Sebastian Apprich, Martin Brix, Reinhard Windhager, Siegfried Trattnig
PURPOSE: Indicating lumbar disc herniation via magnetic resonance imaging (MRI) T2 mapping in the posterior annulus fibrosus (AF). METHODS: Sagittal T2 maps of 313 lumbar discs of 64 patients with low back pain were acquired at 3.0 Tesla (3T). The discs were rated according to disc herniation and bulging. Region of interest (ROI) analysis was performed on median, sagittal T2 maps. T2 values of the AF, in the most posterior 10% (PAF-10) and 20% of the disc (PAF-20), were compared...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27885048/trends-in-educational-inequalities-in-premature-mortality-in-belgium-between-the-1990s-and-the-2000s-the-contribution-of-specific-causes-of-deaths
#13
Françoise Renard, Sylvie Gadeyne, Brecht Devleesschauwer, Jean Tafforeau, Patrick Deboosere
BACKGROUND: Reducing socioeconomic inequalities in mortality, a key public health objective may be supported by a careful monitoring and assessment of the contributions of specific causes of death to the global inequality. METHODS: The 1991 and 2001 Belgian censuses were linked with cause-of-death data, each yielding a study population of over 5 million individuals aged 25-64, followed up for 5 years. Age-standardised mortality rates (ASMR) were computed by educational level (EL) and cause...
November 24, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27880624/suicidal-ideation-among-korean-elderly-risk-factors-and-population-attributable-fractions
#14
Jong-Il Park, Jong-Chul Yang, Changsu Han, Tae Won Park, Sang-Keun Chung
OBJECTIVES: The objective of this study was to investigate the risk factors of suicidal ideation and their population attributable fraction (PAF) in a representative sample of the elderly population in Korea. METHOD: We examined the data set from the Survey of Living Conditions and Welfare Needs of Korean Older Persons, which was conducted by the Korea Institute for Health and Social Affairs (KIHASA) in 2011. In that survey, 10,674 participants were randomly selected from those older than age 65...
2016: Psychiatry
https://www.readbyqxmd.com/read/27876310/impact-of-atrial-natriuretic-peptide-value-for-predicting-paroxysmal-atrial-fibrillation-in-ischemic-stroke-patients
#15
Hiroshi Shiroto, Hirofumi Tomita, Joji Hagii, Norifumi Metoki, Ayaka Fujita, Takaatsu Kamada, Koki Takahashi, Shin Saito, Satoko Sasaki, Hiroyasu Hitomi, Satoshi Seino, Yoshiko Baba, Takamitsu Uchizawa, Manabu Iwata, Shigeo Matsumoto, Minoru Yasujima, Ken Okumura
INTRODUCTION: The impact of atrial natriuretic peptide (ANP) value for predicting paroxysmal atrial fibrillation (pAF) in ischemic stroke patients remains uncertain. METHODS: The consecutive 222 ischemic stroke patients (median 77 [IQR 68-83] years old, 93 females) within 48 hours after onset were retrospectively studied. Plasma ANP and brain natriuretic peptide (BNP) levels were simultaneously measured at admission. Of all, 158 patients had no evidence of atrial fibrillation (AF) (sinus rhythm [SR] group), 25 patients had pAF (pAF group), and the other 39 patients had chronic AF (cAF group)...
November 18, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27871986/second-generation-cryoballoon-ablation-without-the-use-of-real-time-recordings-a-novel-strategy-based-on-a-temperature-guided-approach-to-ablation
#16
Saverio Iacopino, Giacomo Mugnai, Ken Takarada, Gaetano Paparella, Erwin Ströker, Valentina De Regibus, Hugo Enrique Coutino-Moreno, Rajin Choudhury, Juan Pablo Abugattas de Torres, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
BACKGROUND: The achievement of -40°C within 60 seconds has proven to independently predict durable PV isolation in the setting of second generation cryoballoon (CB-A; Medtronic; USA) ablation. OBJECTIVE: In the present study, we sought to evaluate a strategy based on the attainment of the specific parameter of -40°C within the first 60 seconds during cryoenergy applications in the setting of CB-A without the use of an inner lumen mapping catheter (ILMC) (Achieve; Medtronic, USA) for the visualisation of real time recordings (RTR)...
November 18, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27870162/galectin-3-contributes-to-vascular-fibrosis-in-monocrotaline-induced-pulmonary-arterial-hypertension-rat-model
#17
Xiaoyan Wang, Yanli Wang, Jinbo Zhang, Xue Guan, Minggang Chen, Yumei Li, Li Zhang
Galectin-3 (Gal-3) plays a critical role in vascular inflammation and fibrosis. The role of TGF-β1 in mediating pulmonary vascular fibrosis is well documented; thus, we suspected that Gal-3 could be an important factor in TGF-β1-induced fibrosis in pulmonary adventitial fibroblasts (PAFs). We treated rats with monocrotaline (MCT) and cultured PAFs with TGF-β1 to stimulate fibrosis. We found that MCT injection induced vessel thickening and extracellular matrix deposition in vivo. TGF-β1 stimulated the production of collagen and fibronectin (Fn) protein in vitro...
November 21, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27865966/febuxostat-attenuates-paroxysmal-atrial-fibrillation-induced-regional-endothelial-dysfunction
#18
YanGuang Li, FuKun Chen, Long Deng, Kun Lin, Xiangmin Shi, Shan Zhaoliang, YuTang Wang
BACKGROUND: Paroxysmal atrial fibrillation (PAF) can increase thrombogenesis risk, especially in the left atrium (LA). The exact mechanism is still unclear. OBJECTIVE: We assessed the effects of PAF on endothelial function, and investigated if febuxostat (FX) can attenuate endothelial dysfunction by inhibition of xanthine oxidase (XO). MATERIALS AND METHODS: Eighteen male New Zealand white rabbits were divided randomly into sham-operated (S), PAF (P) or FX+pacing (FP) groups...
November 11, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27862561/long-term-outcome-of-left-atrial-voltage-guided-substrate-ablation-during-atrial-fibrillation-a-novel-adjunctive-ablation-strategy
#19
Atsuhiko Yagishita, J Rod Gimbel, Samer DE Oliveira, Harish Manyam, Dina Sparano, Ivan Cakulev, Judith Mackall, Mauricio Arruda
INTRODUCTION: Left atrium (LA) low voltage area (LVA) on 3-D electroanatomic bipolar voltage mapping (EAVM), as a surrogate for scar, is associated with poor AF ablation outcome. We evaluated the long-term outcome of a LVA-guided atrial fibrillation (AF) substrate modification strategy as an adjunct to pulmonary vein isolation (PVI). METHODS AND RESULTS: Two hundred and one consecutive patients with AF (82% persistent / Non-PAF, age 65 years), who underwent EAVM during AF prior to PVI, were divided into two groups according to the presence or absence of LVA outside the PV antra, defined as bipolar voltage of < 0...
November 12, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27859888/changes-in-left-atrial-transport-function-in-patients-who-maintained-sinus-rhythm-after-successful-radiofrequency-catheter-ablation-for-atrial-fibrillation-a-1-year-follow-up-multi-slice-computed-tomography-study
#20
Jin-Seok Kim, Sung Il Im, Seung Yong Shin, Jun Hyuk Kang, Jin Oh Na, Cheol Ung Choi, Seong Hwan Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang, Young-Hoon Kim, Hwan Seok Yong, Hong Euy Lim
BACKGROUND: Functional remodeling of left atrium (LA) after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) has not been fully elucidated. This study aimed to determine the impact of RFCA on LA transport function in patients who maintained sinus rhythm (SR) after AF ablation. METHODS AND RESULTS: A total of 96 patients [paroxysmal AF (PAF) = 52] who maintained SR during 1 year after AF ablation were enrolled. Multi-slice computed tomography was performed to determine LA volume (LAV) and LA emptying fraction (LAEF) at pre-RFCA and 1-year post-RFCA...
November 18, 2016: Journal of Cardiovascular Electrophysiology
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