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https://www.readbyqxmd.com/read/28215479/lessons-from-individualized-cryoballoon-sizing-is-there-a-role-for-the-small-balloon
#1
Stefan Hartl, Uwe Dorwarth, Benedikt Bunz, Michael Wankerl, Ullrich Ebersberger, Ellen Hoffmann, Florian Straube
BACKGROUND: Cryoablation for paroxysmal atrial fibrillation (PAF) is well established. The single-big-balloon strategy has been preferred for pulmonary vein isolation (PVI) using the second generation cryoballoon (CBG2). Individual PV-morphologies raise the question if an individualized anatomic approach using the 23-mm or 28-mm CB is reasonable. METHODS: Consecutive patients were prospectively enrolled in the non-randomized single-center study. Patients were treated with the 28-mm CB, if any PV was >21mm, the 23-mm CB, if all PV were ≤21mm, or both sizes, if PVI was difficult...
February 16, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28215423/chads2-score-predicts-postoperative-atrial-fibrillation-in-patients-undergoing-elective-pulmonary-lobectomy
#2
Svetlana Kotova, Mansen Wang, Katie Lothrop, Gary Grunkemeier, Heather E Merry, John R Handy
BACKGROUND: Postoperative atrial fibrillation (PAF) affects 12% to 17% of patients undergoing lobectomy and is associated with increased morbidity. CHADS2 (congestive heart failure history, hypertension history, age ≥75 years, diabetes mellitus history, and stroke or transient ischemic attack symptoms previously) is used to predict stroke risk in patients with existing AF. It also has been shown also to predict new-onset PAF. Our objective was to determine whether CHADS2 can predict PAF in patients undergoing lobectomy...
February 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28207844/population-attributable-fraction-of-incident-hiv-infections-associated-with-alcohol-consumption-in-fishing-communities-around-lake-victoria-uganda
#3
Noah Kiwanuka, Ali Ssetaala, Ismail Ssekandi, Annet Nalutaaya, Paul Kato Kitandwe, Julius Ssempiira, Bernard Ssentalo Bagaya, Apolo Balyegisawa, Pontiano Kaleebu, Judith Hahn, Christina Lindan, Nelson Kaulukusi Sewankambo
BACKGROUND: Although the association between alcohol consumption and HIV risk is well documented, few studies have examined the magnitude of new HIV infections that could be prevented by controlling alcohol use. We report the population attributable fraction (PAF) of incident HIV infections due to alcohol consumption among the HIV high-risk population of fishing communities along Lake Victoria, Uganda. METHODS: In a community-based cohort study, 1607 HIV sero-negative participants aged 18-49 years were enrolled from eight fishing communities along Lake Victoria, Uganda...
2017: PloS One
https://www.readbyqxmd.com/read/28203363/an-exploratory-factor-analysis-of-the-spontaneous-reporting-of-severe-cutaneous-adverse-reactions
#4
Manfred Hauben, Eric Hung, Wen-Yaw Hsieh
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are prominent in pharmacovigilance (PhV). They have some commonalities such as nonimmediate nature and T-cell mediation and rare overlap syndromes have been documented, most commonly involving acute generalized exanthematous pustulosis (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), and DRESS and toxic epidermal necrolysis (TEN). However, they display diverse clinical phenotypes and variations in specific T-cell immune response profiles, plus some specific genotype-phenotype associations...
January 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28202694/pure-autonomic-failure-predictors-of-conversion-to-clinical-cns-involvement
#5
Wolfgang Singer, Sarah E Berini, Paola Sandroni, Robert D Fealey, Elizabeth A Coon, Mariana D Suarez, Eduardo E Benarroch, Phillip A Low
OBJECTIVE: Based on the observation that a subset of patients originally diagnosed with pure autonomic failure (PAF) eventually develops extrapyramidal or cerebellar involvement consistent with multiple system atrophy (MSA), Parkinson disease (PD), or dementia with Lewy bodies (DLB), we aimed to identify predictors of progression of PAF to more sinister synucleinopathies. METHODS: In this retrospective cohort study, we reviewed patients seen at Mayo Clinic Rochester by autonomic specialists between 2001 and 2011 and during initial evaluation diagnosed with orthostatic hypotension consistent with PAF (possible PAF)...
February 15, 2017: Neurology
https://www.readbyqxmd.com/read/28197274/early-changes-in-the-antithrombin-and-thrombin-antithrombin-complex-in-patients-with-paroxysmal-atrial-fibrillation
#6
Mariya Negreva, Svetoslav Georgiev, Krasimira Prodanova, Julia Nikolova
BACKGROUND: Data on coagulation changes in paroxysmal atrial fibrillation (PAF) are scarce. The aim of this study was to examine plasma antithrombin (AT) levels and activity as well as thrombin-antithrombin (TAT) complex levels in the early hours of the clinical manifestation of PAF. METHODS: Fifty-one patients (26 men and 25 women; mean age 59.84 ± 1.60 years) were consecutively selected with PAF duration < 24 hours, and 52 controls (26 men and 26 women; mean age 59...
June 2016: Cardiology Research
https://www.readbyqxmd.com/read/28196501/taking-multi-morbidity-into-account-when-attributing-dalys-to-risk-factors-comparing-dynamic-modeling-with-the-gbd2010-calculation-method
#7
Hendriek C Boshuizen, Wilma J Nusselder, Marjanne H D Plasmans, Henk H Hilderink, Bianca E P Snijders, René Poos, Coen H van Gool
BACKGROUND: Disability Adjusted Life Years (DALYs) quantify the loss of healthy years of life due to dying prematurely and due to living with diseases and injuries. Current methods of attributing DALYs to underlying risk factors fall short on two main points. First, risk factor attribution methods often unjustly apply incidence-based population attributable fractions (PAFs) to prevalence-based data. Second, it mixes two conceptually distinct approaches targeting different goals, namely an attribution method aiming to attribute uniquely to a single cause, and an elimination method aiming to describe a counterfactual situation without exposure...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28194982/porous-aromatic-framework-48-gel-hybrid-material-coated-solid-phase-microextraction-fiber-for-the-determination-of-the-migration-of-styrene-from-polystyrene-food-contact-materials
#8
Yuanyuan Jin, Zhongyue Li, Lei Yang, Jun Xu, Le Zhao, Zhonghao Li, Jiajia Niu
A novel solid-phase microextraction (SPME) fiber was fabricated by a porous aromatic framework 48 (PAF-48)/gel hybrid material through a sol-gel process. PAF-48 is a porous organic framework (POF) material that was polymerized from 1,3,5-triphenylbenzene. The uniform pore structure, high surface area, continuous conjugate network, and hydrophobicity make PAF-48 expected to have special abilities to absorb and extract styrene as well as some other harmful volatile aromatic compounds (VACs). The PAF-48/gel-coated fiber was explored for the extraction of styrene and six VACs (benzene, toluene, ethylbenzene, and xylenes) from aqueous food simulants followed by gas chromatography (GC) separation...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28187531/cutaneous-melanoma-attributable-to-solar-radiation-in-cali-colombia
#9
Esther de Vries, Julio R Amador, Carlos Javier Rincon, Claudia Uribe, D Maxwell Parkin
Estimating the population attributable fraction (PAF) of melanomas due to sun exposure is challenging as there are no unexposed population nor reliable exposure data. In high incidence countries, a historic cohort of the South Thames cancer registry was used as a minimally exposed population using the formula PAF = (observed incidence-incidence in minimally exposure)/observed incidence. In this study we apply this method, constructing a minimally exposed cohort for Colombia and also using the historical South Thames data, using melanoma incidence data from the population-based cancer registry of Cali, Colombia for the period 1967-2012...
February 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28181276/modulation-of-autonomic-nervous-activity-in-the-termination-of-paroxysmal-atrial-fibrillation
#10
Jen-Hung Huang, Yung-Kuo Lin, Ming-Hsiung Hsieh, Shih-Ann Chen, Wan-Chun Chiu, Yi-Jen Chen
BACKGROUND: Autonomic nervous activity plays a critical role in the genesis of paroxysmal atrial fibrillation (AF, PAF). However, the role of autonomic nervous activity on AF termination has not been elucidated. Heart rate variability (HRV) is widely used to evaluate autonomic nervous activity in humans. The purpose of this study was to assess whether autonomic nervous activity assessed by HRV contributes to AF termination. METHODS: Electrocardiograms (ECGs) and HRV were studied in patients with termination of sustained (>30 s) PAF by 24-h ambulatory Holter monitoring...
February 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28178140/utility-of-duranta-a-wireless-patch-type-electrocardiographic-monitoring-system-developed-in-japan-in-detecting-covert-atrial-fibrillation-in-patients-with-cryptogenic-stroke-a-case-report
#11
Hisanao Akiyama, Saki Nukui, Takashi Araga, Masashi Hoshino, Keita Tanaka, Satoru Kashima, Rie Sasaki, Kenji Uchino, Yasuhiro Hasegawa
RATIONALE: Subcutaneous implantable electrocardiographs are highly effective in detecting covert atrial fibrillation (AF) in cryptogenic stroke. However, these invasive devices are not indicated for all cryptogenic stroke patients, and noninvasive improvements over conventional Holter-type ambulatory electrocardiography are needed. We evaluated the clinical application and effectiveness of Duranta (ImageONE Co., Ltd.), a wireless patch-type electrocardiographic monitoring system developed in Japan for chronically ill patients or home-based patients at the end of life...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28166764/impact-of-weight-maintenance-and-loss-on-diabetes-risk-and-burden-a-population-based-study-in-33-184-participants
#12
Adina L Feldman, Simon J Griffin, Amy L Ahern, Grainne H Long, Lars Weinehall, Eva Fhärm, Margareta Norberg, Patrik Wennberg
BACKGROUND: Weight loss in individuals at high risk of diabetes is an effective prevention method and a major component of the currently prevailing diabetes prevention strategies. The aim of the present study was to investigate the public health potential for diabetes prevention of weight maintenance or moderate weight loss on a population level in an observational cohort with repeated measurements of weight and diabetes status. METHODS: Height, weight and diabetes status were objectively measured at baseline and 10 year follow-up in a population-based cohort of 33,184 participants aged 30-60 years between 1990 and 2013 in Västerbotten County, Sweden...
February 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28157211/platelet-activating-factor-induced-expression-of-p21-is-correlated-with-histone-acetylation
#13
Elisabetta Damiani, Nahum Puebla-Osorio, Bree M Lege, Jingwei Liu, Sattva S Neelapu, Stephen E Ullrich
Ultraviolet (UV)-irradiated keratinocytes secrete the lipid mediator of inflammation, platelet-activating factor (PAF). PAF plays an essential role in UV-induced immune suppression and skin cancer induction. Dermal mast cell migration from the skin to the draining lymph nodes plays a prominent role in activating systemic immune suppression. UV-induced PAF activates mast cell migration by up-regulating mast cell CXCR4 surface expression. Recent findings indicate that PAF up-regulates CXCR4 expression via histone acetylation...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28142301/the-immunomodulatory-potential-of-leonurus-cardiaca-extract-in-relation-to-endothelial-cells-and-platelets
#14
Beata Sadowska, Bartłomiej Micota, Marek Różalski, Małgorzata Redzynia, Marcin Różalski
The immunomodulatory activity of Leonurus cardiaca L. polyphenol-rich extract (LCE) was tested in vitro on HUVECs to explore its potential therapeutic usefulness in the treatment of inflammatory lesions. The phytochemical composition of LCE, its antioxidant and cytotoxic activity, and the influence of LCE on NO and platelet-activating factor (PAF) secretion by HUVECs and platelet aggregation were all assessed. Total polyphenol contents in LCE reached 137.0 ± 0.8 mg/g, with hydroxycinnamic acid derivatives as the predominant phenolic compounds...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28142015/orthopedic-ophthalmic-and-psychiatric-diseases-primarily-affect-activity-limitation-for-japanese-males-and-females-based-on-the-comprehensive-survey-of-living-conditions
#15
Tomoya Myojin, Toshiyuki Ojima, Keiko Kikuchi, Eisaku Okada, Yosuke Shibata, Mieko Nakamura, Shuji Hashimoto
BACKGROUND: Healthy life expectancy (HLE) is used as one of the primary objectives of fundamental health promotion plans and social development plans. Activity limitation is used to calculate HLE, but little study has been done to identify determinants of activity limitation in order to extend HLE. The purpose of this study is to identify diseases and injuries that commonly lead to activity limitation to prioritize countermeasures against activity limitation. METHODS: We used anonymous data from the 2007 "Comprehensive Survey of Living Conditions," collected by the Ministry of Health, Labour and Welfare of Japan according to the Statistics Act, Article 36...
February 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28138667/high-throughput-screening-of-triplex-dna-binders-from-complicated-samples-by-96-well-pate-format-in-conjunction-with-peak-area-fading-uhplc-orbitrap-ms
#16
Hongmei Yang, Wenbin Yao, Yihan Wang, Lei Shi, Rui Su, Debin Wan, Niusheng Xu, Wenhui Lian, Changbao Chen, Shuying Liu
Conventional strategies for the screening of DNA triplex binders cannot be used for complicated samples, such as ligand libraries created by combinatorial chemistry or from natural product extracts. In the current study, an ultra-high-performance liquid chromatography coupled with an Orbitrap mass spectrometry (UHPLC-Orbitrap-MS)-based approach, which we call peak area-fading (PAF) UHPLC-Orbitrap-MS and was designed for just such a purpose, is reported. The triplex DNA modified 96-well plate and the single stranded oligonucleotide modified 96-well plate (as control) were incubated with ligand libraries, and the unbound ligands were directly determined via UHPLC-ESI-MS...
January 31, 2017: Analyst
https://www.readbyqxmd.com/read/28134937/platelet-activating-factor-paf-receptor-as-a-promising-target-for-cancer-cell-repopulation-after-radiotherapy
#17
I A da Silva-Jr, R Chammas, A P Lepique, S Jancar
A major drawback of radiotherapy is the accelerated growth of the surviving tumor cells. Radiotherapy generates a variety of lipids that bind to the receptor for platelet-activating factor, expressed by cells in the tumor microenvironment. In the present study, using the TC-1 tumor cell line, we found that irradiation induced a twofold increase in receptor expression and generated agonists of receptor. Irradiated cells induced a 20-fold increase in live TC-1 proliferation in vitro. Furthermore, subcutaneous co-injection of irradiated TC-1 cells with TC-1 expressing luciferase (TC-1 fluc(+)) markedly increased TC-1 fluc(+) proliferation in a receptor-dependent way...
January 30, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28127812/the-impact-of-transforming-growth-factor-%C3%AE-1-level-on-outcome-after-catheter-ablation-in-patients-with-atrial-fibrillation
#18
Hideyuki Kishima, Takanao Mine, Satoshi Takahashi, Kenki Ashida, Masaharu Ishihara, Tohru Masuyama
INTRODUCTION: Transforming growth factor-β1 (TGF-β1 ) is an important factor that induces atrial fibrosis and atrial fibrillation (AF). The purpose of this study was to evaluated the association between TGF-β1 level and clinical factors before catheter ablation (CA), and to investigated the impact of TGF-β1 level on the outcome after CA for AF. METHODS AND RESULTS: This prospective study included 151 patients (persistent AF [PeAF] group: n = 59, paroxysmal AF [PAF] group: n = 54, control group, n = 38)...
January 27, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28124593/the-short-and-long-term-efficacy-of-pulmonary-vein-isolation-as-a-sole-treatment-strategy-for-paroxysmal-atrial-fibrillation-a-systematic-review-and-meta-analysis
#19
Zsuzsanna Kis, Taulant Muka, Oscar H Franco, Wichor M Bramer, Lennart J De Vries, Attila Kardos, Tamas Szili-Torok
BACKGROUND: Pulmonary vein isolation (PVI) is an accepted treatment strategy for catheter ablation (CA) of paroxysmal atrial fibrillation (PAF). In this study we aimed to assess the short, mid- and long-term outcome of PVI as a sole treatment strategy for PAF. METHODS: Six bibliographic electronic databases were searched to identify all published relevant studies until December 14, 2015. Search of the scientific literature was performed for studies describing outcomes with mean follow-up > 24 months after PAF ablation...
January 17, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28122356/hpaf1-pd2-interacts-with-oct3-4-to-promote-self-renewal-of-ovarian-cancer-stem-cells
#20
Saswati Karmakar, Parthasarathy Seshacharyulu, Imayavaramban Lakshmanan, Arokia P Vaz, Seema Chugh, Yuri M Sheinin, Sidharth Mahapatra, Surinder K Batra, Moorthy P Ponnusamy
Cancer stem cells (CSCs), which mediate drug resistance and disease recurrence in several cancers, are therapeutically relevant to ovarian cancer (OC), wherein approximately 80% of patients manifest with tumor recurrence. While there are several markers for ovarian CSCs (OCSCs), the mechanism for their self-renewal maintenance by unique driver/markers is poorly understood. Here, we evaluated the role of hPaf1/PD2, a core component of RNA Polymerase II-Associated Factor (PAF) complex, in self-renewal of OCSCs through marker and functional analyses, including CRISPR/Cas9-silencing of hPaf1/PD2 in OCSCs and provided a possible mechanism for maintenance of OCSCs...
January 20, 2017: Oncotarget
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