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https://www.readbyqxmd.com/read/28643171/elimination-of-the-negative-component-of-the-unipolar-electrogram-as-a-local-procedural-endpoint-during-paroxysmal-atrial-fibrillation-catheter-ablation-using-contact-force-sensing-the-uniforce-study
#1
Agustín Bortone, Philippe Lagrange, Bruno Cauchemez, Cyril Durand, Pierre Dieuzaide, Sébastien Prévot, Alexis Mechulan, Thomas Pambrun, Ruairidh Martin, Pauline Parlier, Alexandre Masse, Eloi Marijon, Jean-Paul Albenque
PURPOSE: Elimination of the negative component of the unipolar atrial electrogram is a reliable indicator of the creation of a transmural lesion. Contact-force (CF) sensing technology has the potential to increase the durability of pulmonary vein isolation (PVI). In the present multicenter study, we assessed the 2-year sinus rhythm (SR) maintenance rate in patients with paroxysmal atrial fibrillation (PAF) after PVI guided by these two approaches. METHODS: Two hundred fifteen consecutive PAF patients (62...
June 22, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28643029/impact-of-preventable-risk-factors-on-stroke-in-the-epicor-study-does-gender-matter
#2
Slavica Trajkova, Angelo d'Errico, Fulvio Ricceri, Francesca Fasanelli, Valeria Pala, Claudia Agnoli, Rosario Tumino, Graziella Frasca, Giovanna Masala, Calogero Saieva, Paolo Chiodini, Amalia Mattiello, Carlotta Sacerdote, Salvatore Panico
OBJECTIVES: The effect of modifiable stroke risk factors in terms of prevented cases remains unclear due to sex-specific disease rate and risk factors prevalence. Our aim was to estimate their impact on stroke by gender through population-attributable fraction (PAF), preventive fraction (PF) and their combination in EPIC-Italian cohort. METHODS: 43,976 participants, age 34-75, and free of cardiovascular disease at baseline (1993-1998) were followed up for almost 11 years...
June 22, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28639647/water-mediated-proton-conduction-in-a-sulfonated-microporous-organic-polymer
#3
C Klumpen, S Gödrich, G Papastavrou, J Senker
Polymer membranes (PEMs) within fuel cells (FCs) act as separators and efficient proton conducting electrolytes. Established systems tend to microphase separation into hydrophilic and hydrophobic regions, making these materials prone to water loss at elevated temperatures. Therefore, recent approaches utilize porous materials, which promise stronger interactions between water molecules and the framework, while still providing efficient conductive pathways. Here we show, that the microporous polymer PAF-1 exhibits proton conductivities up to 10(-1) S cm(-1) under hydrous conditions, after post-synthetic sulfonation...
June 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28639243/right-atrial-myocardial-deformation-by-two-dimensional-speckle-tracking-echocardiography-predicts-recurrence-in-paroxysmal-atrial-fibrillation
#4
Malini Govindan, Anatoli Kiotsekoglou, Samir K Saha, A John Camm
BACKGROUND: Atrial fibrillation (AF) is a bi-atrial disease yet little attention has been given to right heart function in AF. We propose that the assessment of right atrial (RA) and right ventricular function (RV) using two-dimensional speckle tracking echocardiography (2D-STE) could be valuable in predicting AF recurrence in patients with paroxysmal AF (PAF). METHODS: Thirty patients with PAF were prospectively recruited from a dedicated AF clinic. Right atrial size, volume, and area and RV dimensions were analyzed along with RA and RV strain derived from 2D-STE at baseline and at 3 and 12 months...
June 21, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28637099/aggregation-and-phosphorylation-of-%C3%AE-synuclein-with-proteinase-k-resistance-in-focal-%C3%AE-synucleinopathy-predominantly-localized-to-the-cardiac-sympathetic-nervous-system
#5
Nei Fukasawa, Takahiro Fukuda, Masato Nagaoka, Tohru Harada, Hiroyuki Takahashi, Masahiro Ikegami
Aggregates of α-synuclein, a major component of Lewy bodies (LBs) and Lewy neurites (LNs), are distributed throughout the nervous system, including the central nervous system (CNS), sympathetic ganglia, enteric nervous system (ENS), cardiac and pelvic plexuses, submandibular gland, adrenal medulla and skin, in incidental Lewy body disease (ILBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure (PAF) [1-3]. Here we report focal α-synucleinopathy predominantly localized to the cardiac sympathetic nervous system (SNS)...
June 21, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28636992/acetylsalicylic-acid-inhibits-the-growth-of-melanoma-tumors-via-sox2-dependent-paf-r-independent-signaling-pathway
#6
Anita Thyagarajan, Jeremiah Saylae, Ravi P Sahu
Acquired resistance to standard therapies remains a serious challenge, requiring novel therapeutic approaches that incorporate potential factors involved in tumor resistance. As cancers including melanoma express inflammatory cyclooxygenases generating prostaglandins implicated in tumor growth, we investigated mechanism of anti-inflammatory drug, acetylsalicylic acid (ASA) which has been shown to inhibit various tumor types, however, its effects against highly aggressive melanoma model are unclear. Given our reports that an activation of platelet-activating factor-receptor (PAF-R) augments the growth and impede efficacies of therapeutic agents in experimental melanoma, we also sought to determine if PAF-R mediates anti-melanoma activity of ASA...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28631554/the-effects-of-platelet-activating-factor-on-uterine-contractility-perfusion-hypoxia-and-pain-in-mice
#7
Kevin M Hellman, Peter Y Yu, Folabomi A Oladosu, Chaya Segel, Alice Han, Pottumarthi V Prasad, Tamas Jilling, Frank F Tu
It is widely hypothesized that menstrual pain is triggered by prostaglandin synthesis that evokes high-pressure uterine contractions and ischemia. However, the effects of molecules implicated in menstrual pain on uterine contractility, perfusion, and oxygenation in vivo have been rarely demonstrated. Studies in women that do not respond to nonsteroidal anti-inflammatory drugs (NSAIDs) have reported elevated levels of platelet-activating factor (PAF). To establish in vivo evidence of PAF's capability to impair uterine homeostasis and to elicit visceral pain, we examined the effects of the PAF receptor agonist (carbamyl PAF [CPAF]) in comparison to other molecules hypothesized to play a role in uterine pain in mice...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28627122/a-biotinylated-peptide-bp21-as-a-novel-potent-anti-anaphylactic-agent-targeting-platelet-activating-factor
#8
Akira Sato, Keiichi Ebina
Platelet-activating factor (PAF) is an important mediator of anaphylaxis and is therefore an anti-anaphylactic drug target. We recently reported that synthetic N-terminally biotinylated peptides (BP4-BP29) inhibit PAF by directly interacting with PAF and its metabolite/precursor lyso-PAF. In this study, we investigated whether the biotinylated peptides can inhibit anaphylactic reactions in vivo. In mouse models of anaphylaxis, one of the peptides, BP21, markedly and dose-dependently inhibited hypothermia with a maximum dose-response within 30 min after administration, even at doses 20 times lesser than doses of the known PAF antagonist CV-3988...
June 19, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28625975/a-naturally-generated-decoy-of-the-prostate-apoptosis-response-4-protein-overcomes-therapy-resistance-in-tumors
#9
Nikhil Hebbar, Ravshan Burikhanov, Nidhi Shukla, Shirley Qiu, Yanming Zhao, Kojo S J Elenitoba-Johnson, Vivek M Rangnekar
Primary tumors are often heterogeneous, composed of therapy-sensitive and emerging therapy-resistant cancer cells. Interestingly, treatment of therapy-sensitive tumors in heterogeneous tumor microenvironments results in apoptosis of therapy-resistant tumors. In this study, we identify a Par-4 amino-terminal fragment (PAF) that is released by diverse therapy-sensitive cancer cells following therapy-induced caspase cleavage of the tumor suppressor Par-4 protein. PAF caused apoptosis in cancer cells resistant to therapy and inhibited tumor growth...
June 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28618256/cigarette-smoke-regulates-calcium-independent-phospholipase-a2-metabolic-pathways-in-breast-cancer
#10
Shannon Kispert, Theresa Schwartz, Jane McHowat
Phospholipase A2 (PLA2)-dependent pathways are important in the regulation of cell proliferation, differentiation, motility, and immune responses, and can be dysregulated during tumor development and progression. We show herein, for the first time, that cigarette smoking leads to an increase in platelet-activating factor (PAF) content and PAF receptor expression in human breast cancer cells and tissue. PAF production could be abrogated in triple-negative breast cancer cells by inhibition of calcium-independent PLA2 (iPLA2)...
June 12, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28615275/the-burden-of-cancer-attributable-to-modifiable-risk-factors-the-australian-cancer-paf-cohort-consortium
#11
Maria E Arriaga, Claire M Vajdic, Karen Canfell, Robert MacInnis, Peter Hull, Dianna J Magliano, Emily Banks, Graham G Giles, Robert G Cumming, Julie E Byles, Anne W Taylor, Jonathan E Shaw, Kay Price, Vasant Hirani, Paul Mitchell, Barbara-Ann Adelstein, Maarit A Laaksonen
PURPOSE: To estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty. PARTICIPANTS: 365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28612230/right-atrial-diameter-and-outcome-of-catheter-ablation-of-atrial-fibrillation
#12
Song -Nan Wen, Nian Liu, Rong Bai, Ri-Bo Tang, Rong-Hui Yu, De-Yong Long, Cai-Hua Sang, Chen-Xi Jiang, Song-Nan Li, Jia-Hui Wu, Yan-Fei Ruan, Rong Hu, Xin Du, Xiao-Hui Liu, Jian-Zeng Dong, Chang-Sheng Ma
PURPOSE: While AF is considered more like a left atrial (LA) disease, to what extent the right atrium contributes to the pathogenesis and ablation outcome of AF remains unclear. This study aimed to identify if right atrial diameter (RAD) could predict arrhythmia recurrence after catheter ablation of atrial fibrillation (AF). METHODS: Four hundred and seventy patients with drug-resistant AF [paroxysmal AF (PAF) 196; non-PAF 274] who underwent primary catheter ablation were enrolled...
June 13, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28607574/massage-therapy-in-children-with-asthma-a-systematic-review-and-meta-analysis
#13
REVIEW
Ji Wu, Xi-Wen Yang, Ming Zhang
OBJECTIVE: To systematically evaluate the efficacy of massage, a traditional treatment method of traditional Chinese medicine on children with asthma. METHODS: Literatures from 5 databases using the date ranging from 1 January, 1990, to 13 December, 2016, were reviewed, which were all randomized controlled trials evaluating the efficacy on children with asthma and effect on lung function mainly by massage therapy. RESULTS: 14 researches with 1299 patients were included in the meta-analysis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28596994/recurrent-post-ablation-paroxysmal-atrial-fibrillation-shares-substrates-with-persistent-atrial-fibrillation-an-11-center-study
#14
Junaid A B Zaman, Tina Baykaner, Paul Clopton, Vijay Swarup, Robert C Kowal, James P Daubert, John D Day, John Hummel, Amir A Schricker, David E Krummen, Moussa Mansour, Gery F Tomassoni, Kevin R Wheelan, Mohan Vishwanathan, Shirley Park, Paul J Wang, Sanjiv M Narayan, John M Miller
INTRODUCTION: The role of atrial fibrillation (AF) substrates is unclear in patients with paroxysmal AF (PAF) that recurs after pulmonary vein isolation (PVI). We hypothesized that patients with recurrent post-ablation (redo) PAF despite PVI have electrical substrates marked by rotors and focal sources, and structural substrates that resemble persistent AF more than patients with (de novo) PAF at first ablation. METHODS: In 175 patients at 11 centers, we compared AF substrates in both atria using 64 pole-basket catheters and phase mapping, and indices of anatomical remodeling between patients with de novo or redo PAF and first ablation for persistent AF...
April 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28590042/changes-in-arrhythmogenic-properties-and-five-year-prognosis-after-carbon-ion-radiotherapy-in-patients-with-mediastinum-cancer
#15
Mari Amino, Koichiro Yoshioka, Makiyoshi Shima, Tohru Okada, Mio Nakajima, Yoshiya Furusawa, Shigetaka Kanda, Sadaki Inokuchi, Teruhisa Tanabe, Yuji Ikari, Tadashi Kamada
INTRODUCTION: Carbon-ion irradiation of rabbit hearts has improved left ventricular conduction abnormalities through upregulation of gap junctions. However, to date, there has been no investigation on the effect of carbon-ion irradiation on electrophysiological properties in human. We investigated this effect in patients with mediastinum extra-cardiac cancer treated with carbon-ion radiotherapy that included irradiating the heart. METHODS AND RESULTS: In April-December 2009, eight patients were prospectively enrolled (including two male, aged 72...
June 7, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28586473/exome-sequencing-identifies-two-variants-of-the-alkylglycerol-monooxygenase-gene-agmo-as-a-cause-of-relapses-in-visceral-leishmaniasis-in-children-in-sudan
#16
Sandrine Marquet, Bruno Bucheton, Camille Reymond, Laurent Argiro, Sayda Hassan El-Safi, Musa Mohamed Kheir, Jean-Pierre Desvignes, Christophe Béroud, Adil Mergani, Awad Hammad, Alain J Dessein
Background.: Visceral leishmaniasis (Kala-azar, KA) is the most severe form of leishmaniasis, characterized by fever, weight loss, hepatosplenomegaly and lymphadenopathy. During an outbreak of KA in Babar El Fugara (Sudan), 5.7% of cured patients displayed relapses, with familial clustering in half of the cases. Methods.: We performed whole-exome sequencing on 10 relapsing individuals and 11 controls from five nuclear families. Results.: Rare homozygous and compound-heterozygous nonsense (c...
June 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28584202/feasibility-of-atrial-autocapture%C3%A2-to-detect-atrial-evoked-response-experience-from-102-patients-implanted-with-dual-chamber-pacemakers
#17
Hai-Long Si, Qin Qin, Bing-Rang Zhao, Gang Chen, Ya-Ru Lu, Lu Kou, Jing-Yu Yang, Wen-Hua Lin, Zi-Wen Ren
BACKGROUND: Atrial AutoCapture™ (ACap™) was a new technological development that confirmed atrial capture by analyzing evoked response (ER) with a new method - paced depolarization integral ER detection - and optimized energy output to changes in the stimulation threshold. The purpose of this study was to evaluate the clinical performance of ACap™ function. METHODS: This was a prospective, observational, nonrandomized two-center study. Between November 2008 and August 2014, 102 patients were enrolled from two different institutions...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28582906/paroxysmal-atrial-fibrillation-recognition-based-on-multi-scale-r%C3%A3-nyi-entropy-of-ecg
#18
Yi Xin, Yizhang Zhao, Yuanhui Mu, Qin Li, Caicheng Shi
BACKGROUND: Atrial fibrillation (AF) is a common type of arrhythmia disease, which has a high morbidity and can lead to some serious complications. The ability to detect and in turn prevent AF is extremely significant to the patient and clinician. OBJECTIVE: Using ECG to detect AF and develop a robust and effective algorithm is the primary objective of this study. METHODS: Some studies show that after AF occurs, the regulatory mechanism of vagus nerve and sympathetic nerve will change...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28573445/cardiac-arrhythmias-in-patients-with-exacerbation-of-copd
#19
Tomasz Rusinowicz, Tadeusz M Zielonka, Katarzyna Zycinska
Supraventricular and ventricular arrhythmias are common among patients with chronic obstructive pulmonary disease (COPD). Multiple factors can contribute to the development of arrhythmias in patients with exacerbation of the disease, including: respiratory or heart failure, hypertension, coronary disease and also medications. In the present study we seek to determine the prevalence of cardiac arrhythmias and risk factors among patients with exacerbation of COPD. The study was a retrospective evaluation of 2753 24-h Holter recordings of patients hospitalized in 2004-2016...
June 2, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28570641/correlation-study-between-facet-joint-cartilage-and-intervertebral-discs-in-early-lumbar-vertebral-degeneration-using-t2-t2-and-t1%C3%AF-mapping
#20
Yi Zhang, Jianzhong Hu, Chunyue Duan, Ping Hu, Hongbin Lu, Xianjing Peng
Recent advancements in magnetic resonance imaging have allowed for the early detection of biochemical changes in intervertebral discs and articular cartilage. Here, we assessed the feasibility of axial T2, T2* and T1ρ mapping of the lumbar facet joints (LFJs) to determine correlations between cartilage and intervertebral discs (IVDs) in early lumbar vertebral degeneration. We recruited 22 volunteers and examined 202 LFJs and 101 IVDs with morphological (sagittal and axial FSE T2-weighted imaging) and axial biochemical (T2, T2* and T1ρ mapping) sequences using a 3...
2017: PloS One
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