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radiotherapy cervical cancer review

Tae Hyung Kim, Ik Jae Lee, Ji-Hyun Kim, Chang Geol Lee, Yong Chan Lee, Jun Won Kim
BACKGROUND: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). METHODS: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. RESULTS: The median follow-up was 35 months for surviving patients...
December 12, 2018: Head & Neck
Ewa Burchardt, Andrzej Roszak
Background: This article reviews the salient features of recent results of clinical studies. It puts a special emphasis on technical aspects, mechanisms of action together with radiotherapy and chemotherapy and points out areas for additional investigation. Aim: To present the current state of knowledge on hyperthermia (HT) and to highlight its role in the treatment of cervical cancer. Materials and methods: The literature on the clinical use of combined hyperthermia for cervical cancer was analyzed...
November 2018: Reports of Practical Oncology and Radiotherapy
Adela Poitevin Chacón, Jessica Chavez-Nogueda, Rubí Ramos-Prudencio, Michelle Aline Villavicencio-Queijeiro, Francisco Lozano-Ruiz
The current standard of care for locally advanced cervical cancer is whole pelvis and para-aortic radiation when indicated, delivered concomitantly with chemotherapy and brachytherapy. Para-aortic node involvement is a predictor of survival in locally advanced disease but presence of metastases is difficult to determine because the currently available imaging methods lack enough sensitivity to be able to detect accurately para-aortic metastases when surgical staging is not feasible. The objective of this review is to describe the current status of para-aortic lymph node irradiation in locally advanced cervical cancer...
November 2018: Reports of Practical Oncology and Radiotherapy
Iván Ríos, Ilse Vásquez, Elsa Cuervo, Óscar Garzón, Johnny Burbano
The contribution of Image-guided Radiotherapy (IGRT) to modern radiotherapy is undeniable, being the way to bring into daily practice the dosimetric benefits of Intensity-Modulated Radiotherapy (IMRT). Organ and target motion is constant and unpredictable at the pelvis, thus posing a challenge to the safe execution of IMRT. There are potential benefits of IMRT in the radical treatment of cervical cancer patients, both in terms of dose escalation and decrease of toxicity. But it is essential to find IGRT solutions to control the aspects that can lead to geographic miss targeting or organs at risk (OAR) overdose...
November 2018: Reports of Practical Oncology and Radiotherapy
Ariel Gustavo Glickman, Sergio Valdes, Blanca Gil-Ibañez, Pilar Paredes, Karen Sttephannía Cortés, Aureli Angel Torné Blade
Cervical cancer is the fourth most common cancer in women, and seventh overall. This disease represents a medical, economic and social burden. In early FIGO stage patients (IA, IB1 and IIA1), nodal involvement is the most important prognostic factor. Imaging evaluation of nodal metastasis is of limited value. In order to determine lymph node involvement, allow loco-regional control of the disease, define the need for adjuvant radiotherapy and improve survival, standard surgery for early disease is radical hysterectomy with systematic pelvic lymphadenectomy...
November 2018: Reports of Practical Oncology and Radiotherapy
Paul Lesueur, Valentin Calugaru, Catherine Nauraye, Dinu Stefan, Kim Cao, Evelyne Emery, Yves Reznik, Jean Louis Habrand, Thomas Tessonnier, Abdulhamid Chaikh, Jacques Balosso, Juliette Thariat
INTRODUCTION: The depth-dose distribution of a proton beam, materialized by the Bragg peak makes it an attractive radiation modality as it reduces exposure of healthy tissues to radiations, compared with photon therapy Prominent indications, based on a long-standing experience are: intraocular melanomas, low-grade skull-base and spinal canal malignancies. However, many others potential indications are under investigations such as the benign morbid conditions that are compatible with an extended life-expectancy: low grade meningiomas, paragangliomas, pituitary adenomas, neurinomas craniopharyngioma or recurrent pleomorphic adenomas...
December 1, 2018: Cancer Treatment Reviews
Christina Small, Grant Harmon, John Weaver, Vince Vivirito, Ramon Durazo-Arvizu, William Small, Matthew M Harkenrider
PURPOSE: Concurrent chemoradiotherapy and brachytherapy is the standard of care for locally advanced cervical cancer. Brachytherapy is an integral part of treatment and has improved overall survival. Research is needed to ascertain the planning modalities and schedules to best use resources and optimize treatment time course. We hypothesized that MRI-based brachytherapy when delivered with the described regimen would not prolong, and potentially shorten, overall treatment time as compared with CT-based brachytherapy...
November 26, 2018: Brachytherapy
A P Caresia-Aróztegui, R C Delgado-Bolton, S Alvarez-Ruiz, M Del Puig Cózar-Santiago, J Orcajo-Rincon, M de Arcocha-Torres, M J García-Velloso
Cervical cancer is the second most common gynecological cancer worldwide. In locally advanced cervical cancer, 18 F-FDG PET/CT has become important in the initial staging, particularly in the detection of nodal and distant metastasis, aspects with treatment implications and prognostic value. The aims of this study were to review the role of 18 F-FDG PET/CT in uterine cervical cancer, according to the guidelines of the main scientific institutions (FIGO, NCCN, SEGO, SEOM, ESGO, and ESMO) and its diagnostic accuracy compared to conventional radiological techniques, as well as to review the acquisition protocol and its utility in radiotherapy planning, response assessment and detection of recurrence...
November 11, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Komsan Thamronganantasakul, Narudom Supakalin, Chumnan Kietpeerakool, Porjai Pattanittum, Pisake Lumbiganon
BACKGROUND: The para-aortic lymph nodes (located along the major vessels in the mid and upper abdomen) are a common place for disease recurrence after treatment for locally advanced cervical cancer. The para-aortic area is not covered by standard pelvic radiotherapy fields and so treatment to the pelvis alone is inadequate for women at a high risk of occult cancer within para-aortic lymph nodes. Extended-field radiotherapy (RT) widens the pelvic RT field to include the para-aortic lymph node area...
October 26, 2018: Cochrane Database of Systematic Reviews
Haruo Matsushita, Keiichi Jingu, Rei Umezawa, Takaya Yamamoto, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Katagiri, Noriyuki Kadoya
In recent years, the concept of oligometastases has become accepted and reports on stereotactic body radiotherapy as a treatment method have been published. Lesions in the brain, lung, and liver have been reported as target lesions. However, lymph node oligometastases could be a good candidate for stereotactic body radiotherapy as well. In this study, the usability of stereotactic body radiotherapy for oligometastases to lymph nodes is assessed by researching for each primary site. As a result, we could consider that stereotactic body radiotherapy could be almost well applied for lymph node oligometastases from the breast, gynecological organs, and prostate...
January 1, 2018: Technology in Cancer Research & Treatment
S Espenel, M-A Garcia, A Vallard, J Langrand-Escure, J-B Guy, J-C Trone, M Ben Mrad, C Chauleur, G de Laroche, P Moreno-Acosta, C Rancoule, N Magné
PURPOSE: The aim of the present study was to identify management strategies and outcomes of patients with stage IB1 cervical cancer with high recurrence risk. MATERIALS AND METHODS: Medical files of all consecutive patients treated between 2004 and 2017 with external beam radiotherapy and/or brachytherapy for IB1 cervical cancer, whatever the lymph node status, were retrospectively reviewed. RESULTS: Forty-two patients were included, with a median age of 49...
October 19, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
David Cibula, Nadeem R Abu-Rustum, Daniela Fischerova, Selvan Pather, Katie Lavigne, Jiri Slama, Kaled Alektiar, Lin Ming-Yin, Roman Kocian, Anna Germanova, Filip Frühauf, Lukas Dostalek, Ladislav Dusek, Kailash Narayan
OBJECTIVES: The role of adjuvant radiotherapy for lymph node-negative stage IB patients with tumor-related negative prognostic factors is not uniformly accepted. It is advocated based on the GOG 92 trial, which was initiated in 1989. The aim of the current study is to report the oncological outcome of "intermediate risk" patients treated by tailored surgery without adjuvant radiotherapy. Data from two institutions that refer these patients for adjuvant radiotherapy served as a control group...
October 20, 2018: Gynecologic Oncology
Han Liu, James Kinard, Jacqueline Maurer, Qingyang Shang, Caroline Vanderstraeten, Lane Hayes, Benjamin Sintay, David Wiant
Modern three-dimensional image-guided intracavitary high dose rate (HDR) brachytherapy is often used in combination with external beam radiotherapy (EBRT) to manage cervical cancer. Intrafraction motion of critical organs relative to the HDR applicator in the time between the planning CT and treatment delivery can cause marked deviations between the planned and delivered doses. This study examines offline adaptive planning techniques that may reduce intrafraction uncertainties by shortening the time between the planning CT and treatment delivery...
November 2018: Journal of Applied Clinical Medical Physics
Y Y Tang, B P Miao
Summary Early glottic laryngeal cancer usually refers to the Tis-T2 lesion without cervical lymph node and distant metastases. Radiotherapy of early glottic laryngeal cancer, CO₂ laser microsurgery, open surgery, plasma radiofrequency ablation, photodynamic therapy, biological targeting therapy have achieved good therapeutic effect. However, due to the special nature of its anatomy, it is controversial about the treatment of early glottic laryngeal cancer which involves the anterior commissure. In this article, we reviewed the conventional treatment of radiation therapy, CO₂ laser microsurgery, open surgery, plasma radiofrequency ablation...
August 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Mustapha Dahiri, Nariman Salmi, Anas Ahallat, Nezha El Bahaoui, Omar Belkouchi, Amine Souadka, Anas Majbar, Amine Benkabbou, Abdeslam Bougtab, Raouf Mohsine
Cervical cancer is the second most common cancer and the third cause of cancer death in women. Radiotherapy occupies a prominent place in the therapeutic arsenal of cervical cancer in localized stages. Radiation induced secondary cancer is an entity that has been well described in the literature. We report a case of a rectal adenocarcinoma occurring in a woman previously treated by radiotherapy and brachytherapy for a squamous cell carcinoma of the cervix.
2018: AME case reports
Julian Künzel, Sebastian Strieth, Gesine Wirth, Alessandro Bozzato
High-resolution ultrasonography, including color duplex modes, is a well-established and proven imaging method that is used in addition to computed tomography for re-staging after primary nonsurgical therapy for head and neck cancer in many European countries. No evidence-based international re-staging guidelines are available. Decisions as to whether to carry out neck dissection after primary radiotherapy or chemoradiotherapy are often made in the relevant tumor boards and are therefore subject to variance...
September 20, 2018: Ultraschall in der Medizin
Sarah L Platt, Amit Patel, Pauline J Humphrey, Hoda Al-Booz, Jo Bailey
The standard treatment for locally advanced cervical cancer is chemo-radiotherapy. The presence of the residual disease after treatment is directly related to the relapse risk and to poor survival. There is a lack of consensus on the role of a subsequent surgery due to morbidity concerns. Oncological and peri-operative outcomes of completion surgery for cervical cancer were reviewed by retrospective descriptive analysis of the eligible cases between March 2012 and March 2016. Fifteen women were identified. Ten (66...
September 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
A Cree, J Livsey, L Barraclough, M Dubec, T Hambrock, M Van Herk, A Choudhury, A McWilliam
The reference standard treatment for cervical cancer is concurrent chemoradiotherapy followed by magnetic resonance imaging (MRI)-guided brachytherapy. Improvements in brachytherapy have increased local control rates, but late toxicity remains high with rates of 11% grade ≥3. The primary clinical target volume (CTV) for external-beam radiotherapy includes the cervix and uterus, which can show significant inter-fraction motion. This means that generous margins are required to cover the primary CTV, increasing the radiation dose to organs at risk and, therefore, toxicity...
September 9, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Xiangfei Zhao, Jingbo Kang, Rugang Zhao
The Abscopal effect is a rare phenomenon observed in the treatment of metastatic cancer, where localized irradiation causes a response in non-irradiated tumor sites. Due to the recent success of immunotherapies, the Abscopal effect of radiation therapy has received renewed clinical interest. However, there is limited knowledge regarding the Abscopal effect and radiotherapy treatment of patients with esophageal carcinoma. The present study reports the case of a 65-year-old male patient, who presented with esophageal carcinoma and lymph node metastasis...
September 2018: Oncology Letters
C Chargari, S Gouy, P Pautier, C Haie-Meder
During the recent past years, the therapeutic management of locally advanced cervical cancer patients has consistently improved, with the integration of image guided brachytherapy and dose escalation strategies leading to an improvement of local control rates. In parallel, the evolution of external beam radiotherapy techniques and the better control of organs at risk doses in brachytherapy have contributed to decrease the probability of severe normal tissue complication. In case of advanced disease, patients prognosis remains however marked by a high risk of distant failure, and this finding has encouraged the assessment of various research pathways in order to better predict and/or prevent tumor relapse...
October 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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