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https://www.readbyqxmd.com/read/28449406/a-water-stable-dual-channel-luminescence-sensor-for-uo22-ion-based-on-an-anionic-terbium-iii-metal-organic-framework
#1
Junwei Ye, Raji Feyisa Bogale, Yangwei Shi, Yanzhen Chen, Xigang Liu, Yaoyao Yang, Siqi Zhang, Jianzhang Zhao, Guiling Ning
A stable 3D Tb(III)-based metal-organic framework [Tb(BPDC)2]*(CH3)2NH2 (DUT-101) was synthesized, and it is the first efficient dual-channel luminescence sensor for aqueous UO22+ ion. DUT-101 possesses an anionic three-dimensional framework and protonated dimethylamine molecules embedded within the channels. Intense green emission of DUT-101 could be highly selectively and sensitively quenched by UO22+ ions even in the coexistence of other competing metal ions. The possible sensing mechanism was proposed as well based on both suppression of luminescence resonance energy transfer and enhancement of intermolecular electronic transfer...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28448473/transcriptomic-analysis-of-calcium-remodeling-in-colorectal-cancer
#2
Enrique Pérez-Riesgo, Lucía G Gutiérrez, Daniel Ubierna, Alberto Acedo, Mary P Moyer, Lucía Núñez, Carlos Villalobos
Colorectal cancer (CRC) cells undergo the remodeling of intracellular Ca(2+) homeostasis, which contributes to cancer hallmarks such as enhanced proliferation, invasion and survival. Ca(2+) remodeling includes critical changes in store-operated Ca(2+) entry (SOCE) and Ca(2+) store content. Some changes have been investigated at the molecular level. However, since nearly 100 genes are involved in intracellular Ca(2+) transport, a comprehensive view of Ca(2+) remodeling in CRC is lacking. We have used Next Generation Sequencing (NGS) to investigate differences in expression of 77 selected gene transcripts involved in intracellular Ca(2+) transport in CRC...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28447626/familial-hyperaldosteronism-type-iii
#3
REVIEW
S Monticone, M Tetti, J Burrello, F Buffolo, R De Giovanni, F Veglio, T A Williams, P Mulatero
Primary aldosteronism is the most common form of endocrine hypertension. This disorder comprises both sporadic and familial forms. Four familial forms of primary aldosteronism (FH-I to FH-IV) have been described. FH-III is caused by germline mutations in KCNJ5, encoding the potassium channel Kir3.4 (also called GIRK4). These mutations alter the selectivity filter of the channel and lead to abnormal ion currents with loss of potassium selectivity, sodium influx and consequent increased intracellular calcium that causes excessive aldosterone biosynthesis...
April 27, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28446951/power-spectral-density-analysis-of-purkinje-cell-tonic-and-burst-firing-patterns-from-a-rat-model-of-ataxia-and-riluzole-treated
#4
Samira Abbasi, Ataollah Abbasi, Yashar Sarbaz, Mahyar Janahmadi
INTRODUCTION: Purkinje Cell (PC) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. Riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. Here, the spectral analysis of PCs firing in control, 3-acetylpyridine (3-AP), neurotoxin agent, treated alone and riluzole plus 3-AP treated were investigated to determine changes in the firing properties...
January 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28446427/airway-epithelial-anion-secretion-and-barrier-function-following-exposure-to-fungal-aeroallergens-role-of-oxidative-stress
#5
Nathan A Zaidman, Kelly E O'Grady, Nandadevi Patil, Francesca Milavetz, Peter J Maniak, Hirohito Kita, Scott M O'Grady
Aeroallergens produced by Alternaria alternata can elicit life-threatening exacerbations of asthma in patients sensitized to this fungus. In this study, the effect of Alternaria on ion transport mechanisms underlying mucociliary clearance and airway epithelial barrier function was investigated in human airway epithelial cells. Apical exposure to Alternaria induced an increase in anion secretion that was inhibited by blockers of CFTR and Ca(2+)-activated Cl(-) channels. Stimulation of anion secretion was dependent on Ca(2+) uptake from the apical solution...
April 26, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28445756/membrane-mechanics-of-primary-afferent-neurons-in-the-dorsal-root-ganglia-of-rats
#6
Hirosato Kanda, Jianguo G Gu
Membrane mechanics is an important biological factor regulating many cellular functions including cell motility, intercellular and intracellular signaling, gene expression, and membrane ion channel activity. Primary afferent neurons transduce sensory information about temperature, touch, and pain. These sensory functions may be profoundly affected by the states of primary afferent neuron mechanics. However, membrane mechanics of primary afferent neurons is largely unknown. In this study, we established the optical trapping technique for determining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG)...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28444701/is-electrolyte-transfer-across-the-urothelium-important-ici-rs-2015
#7
REVIEW
Karen D McCloskey, Bahareh Vahabi, Christopher H Fry
AIMS: This article summarizes discussion at the International Consultation on Incontinence Research Society (ICI-RS) 2015 meeting of urine modification in the urinary tract by the urothelium. It considers the literature and proposes pertinent questions that need to be addressed to understand this phenomenon within a physiological context. METHODS: Following the ICI-RS meeting, publications in PubMed relating to urine modification in the renal pelvis, ureter, and bladder were reviewed...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28443815/molecular-mechanism-of-voltage-dependent-potentiation-of-kcnh-potassium-channels
#8
William N Zagotta, Gucan Dai
EAG-like (ELK) voltage-gated potassium channels are abundantly expressed in the brain. These channels exhibit a behavior called voltage-dependent potentiation (VDP), which appears to be a specialization to dampen the hyperexitability of neurons. VDP manifests as a potentiation of current amplitude, hyperpolarizing shift in voltage sensitivity, and slowing of deactivation in response to a depolarizing prepulse. Here we show that VDP of D. rerio ELK channels involves the structural interaction between the intracellular N-terminal eag domain and C-terminal CNBHD...
April 26, 2017: ELife
https://www.readbyqxmd.com/read/28443635/expression-and-localisation-of-two-pore-domain-k2p-background-leak-potassium-ion-channels-in-the-mouse-retina
#9
Steven Hughes, Russell G Foster, Stuart N Peirson, Mark W Hankins
Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels have been identified in mammals and these channels perform important roles in a wide number of physiological systems. However, to date there is only limited data available concerning the expression and role of K2P channels in the retina. In this study we conduct the first comprehensive study of K2P channel expression in the retina...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442943/flow-shear-stress-enhances-the-proliferative-potential-of-cultured-radial-glial-cells-possibly-via-an-activation-of-mechanosensitive-calcium-channel
#10
Min Gu Park, Heeyeong Jang, Sang-Hoon Lee, C Justin Lee
Radial glial cells (RGCs) which function as neural stem cells are known to be non-excitable and their proliferation depends on the intracellular calcium (Ca(2+)) level. It has been well established that Inositol 1,4,5-trisphosphate (IP3)-mediated Ca(2+) release and Ca(2+) entry through various Ca(2+) channels are involved in the proliferation of RGCs. Furthermore, RGCs line the ventricular wall and are exposed to a shear stress due to a physical contact with the cerebrospinal fluid (CSF). However, little is known about how the Ca(2+) entry through mechanosensitive ion channels affects the proliferation of RGCs...
April 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/28442564/on-the-permeation-of-large-organic-cations-through-the-pore-of-atp-gated-p2x-receptors
#11
Mahboubi Harkat, Laurie Peverini, Adrien H Cerdan, Kate Dunning, Juline Beudez, Adeline Martz, Nicolas Calimet, Alexandre Specht, Marco Cecchini, Thierry Chataigneau, Thomas Grutter
Pore dilation is thought to be a hallmark of purinergic P2X receptors. The most commonly held view of this unusual process posits that under prolonged ATP exposure the ion pore expands in a striking manner from an initial small-cation conductive state to a dilated state, which allows the passage of larger synthetic cations, such as N-methyl-d-glucamine (NMDG(+)). However, this mechanism is controversial, and the identity of the natural large permeating cations remains elusive. Here, we provide evidence that, contrary to the time-dependent pore dilation model, ATP binding opens an NMDG(+)-permeable channel within milliseconds, with a conductance that remains stable over time...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28442425/aquaporin-3-is-down-regulated-in-jejunum-villi-epithelial-cells-during-enterotoxigenic-escherichia-coli-induced-diarrhea-in-mice
#12
Di Zhang, Kaiqi Zhang, Weiheng Su, Yuan Zhao, Xin Ma, Gong Qian, Guijuan Qu, Zhihua Pei, Shuming Liu, Hongxia Ma
Enterotoxigenic Escherichia coli (ETEC)-induced diarrhea is a complex pathological process, involving ion channel regulation and water efflux. While the mechanism underlying water efflux in ETEC-induced diarrhea is still largely unknown, aquaporins (AQPs) play important roles in transcellular water movement, but their expression profile has not been demonstrated in the murine small intestine. We identified AQP3 expression in the jejunum, but not the duodenum or ileum, using reverse transcription PCR and western blotting...
April 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28440877/bdnf-nt3-regulate-ais-location-and-affect-neuronal-excitability-in-cultured-hippocampal-neurons
#13
Yu Guo, Zi-Jun Su, Yi-Kun Chen, Zhen Chai
Plasticity of the axon initial segment (AIS) has aroused great interest in recent years because it regulates action potential initiation and neuronal excitability. AIS plasticity manifests as modulation of ion channels or variation in AIS structure. However, the mechanisms underlying structural plasticity of the AIS are not well understood. Here, we combined immunofluorescence, patch-clamp recordings, and pharmacological methods in cultured hippocampal neurons to investigate the factors participating in AIS structural plasticity during development...
April 25, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28440633/syntheses-structures-and-characterization-of-quaternary-tellurites-li3mte4o11-m-al-ga-and-fe
#14
Minfeng Lü, Hongil Jo, Seung-Jin Oh, Suheon Lee, Kwang-Yong Choi, Yang Yu, Kang Min Ok
Three new quaternary lithium metal tellurites, Li3MTe4O11 (M = Al, Ga, and Fe), have been synthesized through hydrothermal and solid-state reactions by heating a mixture of LiOH·H2O, TeO2, and M2O3. The structures of the title compounds have been determined by single-crystal and powder X-ray diffraction. Li3MTe4O11 reveal three-dimensional (3D) frameworks that consist of MO6 octahedra, TeO3 trigonal pyramids, and TeO4 polyhedra. The variable coordination mode of Te(4+) within the framework leads to the formation of 1D channels that host Li(+) cations on both tetrahedral and octahedral sites...
April 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28440622/understanding-carbapenem-translocation-through-occd3-opdp-of-pseudomonas-aeruginosa
#15
Gowrishankar Soundararajan, Satya Prathyusha Bhamidimarri, Mathias Winterhalter
Pseudomonas aeruginosa utilizes a plethora of substrate specific channels for the uptake of small nutrients. OccD3 (OpdP or PA4501) is an OprD like arginine uptake channel of P. aeruginosa whose role has been implicated in carbapenem uptake. To understand the mechanism of selective permeation we reconstituted single OccD3 channels in planar lipid bilayer and characterized the interaction with Imipenem and Meropenem analyzing the ion current fluctuation in presence of substrates. We performed point mutations in the constriction region of OccD3 to understand the binding and translocation of antibiotic in OccD3...
April 25, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28440512/astemizole-protects-against-human-umbilical-vein-endothelial-cell-injury-induced-by-hydrogen-peroxide-via-the-p53-signaling-pathway
#16
Jia-Nan Tian, Xiao-Dong Shi, Xiao-Kun Wang, Shuang Wang, Jing-Xue Xu, Chun-Xiao Yang
Astemizole has gained attention as an antineoplastic drug that targets important ion channels. The present study aimed to investigate the protective effects of astemizole against hydrogen peroxide (H2O2)‑induced oxidative damage to human umbilical vein endothelial cells (HUVECs). HUVECs were pretreated with astemizole (0.5 and 1 µM) for 12 h, then exposed to H2O2 (200 µM) for 12 h. Cell viability was measured using the MTT assay. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px), reactive oxygen species (ROS) and apoptotic percentage were determined...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440281/short-channel-effects-on-electrokinetic-energy-conversion-in-solid-state-nanopores
#17
Yan Zhang, Yuhui He, Makusu Tsutsui, Xiang Shui Miao, Masateru Taniguchi
The ion selectivity of nanopores due to the wall surface charges is capable of inducing strong coupling between fluidic and ionic motion within the system. This interaction opens up the prospect of operating nanopores as nanoscale devices for electrokinetic energy conversion. However, the very short channel lengths make the ionic movement and fluidics inside the pore to be substantially affected by the ion depletion/accumulation around the pore ends. Based on three-dimensional electrokinetic modeling and simulation, we present a systematic theoretical study of nanopore electrical resistance, fluidic impedance, and streaming conductance...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438981/acute-inflammation-reveals-gabaa-receptor-mediated-nociception-in-mouse-dorsal-root-ganglion-neurons-via-pge2-receptor-4-signaling
#18
In Jeong Jang, Alexander J Davies, Nozomi Akimoto, Seung Keun Back, Pa Reum Lee, Heung Sik Na, Hidemasa Furue, Sung Jun Jung, Yong Ho Kim, Seog Bae Oh
Gamma-aminobutyric acid (GABA) depolarizes dorsal root ganglia (DRG) primary afferent neurons through activation of Cl(-) permeable GABAA receptors but the physiologic role of GABAA receptors in the peripheral terminals of DRG neurons remains unclear. In this study, we investigated the role of peripheral GABAA receptors in nociception using a mouse model of acute inflammation. In vivo, peripheral administration of the selective GABAA receptor agonist muscimol evoked spontaneous licking behavior, as well as spinal wide dynamic range (WDR) neuron firing, after pre-conditioning with formalin but had no effect in saline-treated mice...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28438613/stress-altered-synaptic-plasticity-and-damp-signaling-in-the-hippocampus-pfc-axis-elucidating-the-significance-of-igf-1-igf-1r-camkii%C3%AE-expression-in-neural-changes-associated-with-a-prolonged-exposure-therapy
#19
Olalekan M Ogundele, Philip J Ebenezer, Charles C Lee, Joseph Francis
Traumatic stress patients showed significant improvement in behavior after a prolonged exposure to an unrelated stimulus. This treatment method attempts to promote extinction of the fear memory associated with the initial traumatic experience. However, the subsequent prolonged exposure to such stimulus creates an additional layer of neural stress. Although the mechanism remains unclear, prolonged exposure therapy (PET) likely involve changes in synaptic plasticity, neurotransmitter function and inflammation; especially in parts of the brain concerned with the formation and retrieval of fear memory (Hippocampus and Prefrontal Cortex: PFC)...
April 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28438053/scorpion-venom-causes-upregulation-of-p53-and-downregulation-of-bcl-xl-and-bid-protein-expression-by-modulating-signaling-proteins-erk-1-2-and-stat3-and-dna-damage-in-breast-and-colorectal-cancer-cell-lines
#20
Abdulrahman Khazim Al-Asmari, Anvarbatcha Riyasdeen, Mozaffarul Islam
Scorpion venoms efficiently block the normal neurotransmitter signaling pathway by prejudicing the ion channel operating mechanism in the body system. Besides its negative effect, venoms also possess some beneficial qualities for humans. They have also been shown to exhibit anticancer properties in various cancer types. This unique property of the venom as an anticancer agent is mainly a result of its role in initiating apoptosis and inhibiting several signaling cascade mechanisms that promote cancer cell proliferation and growth...
April 1, 2017: Integrative Cancer Therapies
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