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Shuhei Yoshida, Isao Koshima, Ayano Sasaki, Yumio Fujioka, Shogo Nagamatsu, Kazunori Yokota, Shuji Yamashita, Mitsunobu Harima
Despite advances in supermicrosurgical techniques, the ability to anastomose vessels with a diameter of less than 0.2 mm remains limited. One of the reasons for this limitation is that the dilation methods currently available, such as inserting the tip of a microforceps into the lumen or topical application of a vasodilator such as papaverine hydrochloride or xylocaine spray, are not effective in very small vessels. To overcome this problem, we have developed a method whereby nylon monofilaments are placed inside the vessel lumen to act as a dilator...
October 9, 2018: Annals of Plastic Surgery
Sik Namgoong, Jong-Phil Yang, Seong Ho Jeong, Seung Kyu Han, Woo Kyung Kim, Eun Sang Dhong
Microvascular free flap transfer has become a prevailing surgery with a failure rate of <5%. However, pedicle thrombosis occurs more frequently than indicated by the failure rate. This difference is due to the successful salvage of failing flaps. During exploration, thrombi are often encountered at anastomotic sites, whereas these causes could not explain vascular compromise in other patients. Thus, we hypothesized that thrombogenic processes might occur at remote sites, specifically within microvessels of the transferred flap...
October 4, 2018: Journal of Plastic Surgery and Hand Surgery
Rachel K Smith, Rebecca J Stacey, Ed Bergström, Jane Thomas-Oates
A method has been developed for extracting poppy alkaloids from oily matrices, specifically lipid residues associated with archaeological ceramics. The protocol has been applied to fresh and artificially aged poppyseed oil and to residue from a Late Bronze Age Cypriot juglet in the collections of the British Museum. The juglet is of a type that has been linked with ancient trade in opium due to its poppy-head shape and wide distribution; it is a rare example of an intact vessel with contents sealed inside. Bulk analysis of the residue by GC-EI-MS and pyGC-EI-MS indicated a degraded plant oil and possible presence of papaverine...
October 3, 2018: Analyst
Szilvia Berkó, Stella Zsikó, Gábor Deák, Attila Gácsi, Anita Kovács, Mária Budai-Szűcs, László Pajor, Zoltán Bajory, Erzsébet Csányi
Purpose: Papaverine hydrochloride (PaHCl) is an old, well-known drug with spasmolytic activity but it has therapeutic effect in erectile dysfunction, too. As an intracavernous injection, it is not used in urologic clinics today because the side effects of the injection are pain, scarring or priapism. Our aim was to develop and test a topical semi-solid preparation containing PaHCl that would provide an alternative administration option by eliminating the undesirable side effects of the injection...
2018: Drug Design, Development and Therapy
Jonathan Hédouin, Cédric Schneider, Isabelle Gillaizeau, Christophe Hoarau
Palladium-catalyzed intramolecular carbopalladation onto allenamides completed by direct C-H allylation of heterocycles is studied. The domino construction/heteroarylation of isoquinolone process is first achieved. A general three-step one-pot strategy, involving in situ generation of allenamide, π-allyl-Pd complex generation, and interception with heteroarenes, has been subsequently set up. This methodology has been extended to the construction/heteroarylation of indoles, dihydroquinolines, isoquinolin(on)es, and medium-sized nitrogen heterocycles, which are known to be key challenging structural motifs with pharmaceutical significance...
October 5, 2018: Organic Letters
Y Lin, J-F He, X Zhang, H-M Wang
The aim of this study was to identify intraoperative factors associated with free flap failure. The outcomes of 216 patients (220 flaps) were analyzed retrospectively. A statistical analysis was performed to determine the association of flap failure with the intraoperative factors of prolonged operation time, flap type, vascular pedicle at the recipient site, and use of vasoactive medication. A review of the recent literature was also conducted to identify other intraoperative risk factors. Univariate regression analysis revealed that a prolonged operative time (P=0...
September 5, 2018: International Journal of Oral and Maxillofacial Surgery
Masahiro Shibata, Tomohiro Komine, Yuki Maeda, Hiroki Nakamura
Our previous studies demonstrated that vascular wall oxygen consumption rate (QO2 ) of arteriole under in vivo functional condition was dramatically greater than that reported by isolated vascular segment. Furthermore, such high QO2 of vascular wall decreases during vasodilation. However, it is unknown whether such a reduction in QO2 during vasodilation would be caused by a decrease in consumption of vascular endothelial cell (EC) or smooth muscle. In this study, we aimed to explain whether vascular EC or smooth muscle affects the decrease in vascular wall QO2 during vasodilation...
2018: Advances in Experimental Medicine and Biology
Seung-Hyun Jeong, Ji-Hun Jang, Seong-Ho Ham, Seung-Jeong Yang, Hea-Young Cho, Yong-Bok Lee
The purpose of this study was to develop a method for simultaneous analysis of schizandrin, ephedrine, paeoniflorin, and cinnamic acid as constituents of Socheongryong-tang tablet in human plasma using UPLC-MS/MS. These four components were separated using water containing 0.01% formic acid and methanol as a mobile phase by gradient elution at a flow rate of 0.3 mL/min with a HALO-C18 column (2.1 mm × 100 mm, 2.7 μm particle size). Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique operated in multiple reaction monitoring mode...
September 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Arthur Hosmann, Steffen Rauscher, Wei-Te Wang, Philippe Dodier, Gerhard Bavinzski, Engelbert Knosp, Andreas Gruber
OBJECTIVE: After subarachnoid hemorrhage, delayed onset vasospasm can result in devastating ischemic stroke. The phenomenon of delayed cerebral ischemia (DCI) is not yet fully understood, and the correlation of angiographic vasospasm and cerebral infarction is still unclear. Therefore, we investigated the effect of endovascular treatment on the angiographic response and occurrence of DCI. METHODS: Eighty patients with subarachnoid hemorrhage and serious cerebral vasospasm underwent endovascular treatment using intra-arterial papaverine-hydrochloride (IAP) or transluminal balloon angioplasty (TBA)...
July 24, 2018: World Neurosurgery
Hugh Hekierski, Philip Pastor, Victor Curvello, William M Armstead
Traumatic brain injury (TBI) contributes to morbidity in children, and boys are disproportionately represented. Cerebral blood flow (CBF) is reduced and autoregulation is impaired after TBI, contributing to poor outcome. Cerebral perfusion pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of male and female newborn and juvenile pigs, we observed that phenylephrine, norepinephrine, epinephrine, and dopamine demonstrated different sex- and age-dependent abilities to prevent impairment of cerebral autoregulation and limit histopathology after TBI, despite equivalent CPP values...
September 6, 2018: Journal of Neurotrauma
Chunyan Liu, Xiaohui Xu, Wenxin Hu, Xing Yang, Panpan Zhou, Guoyu Qiu, Weichun Ye, Yumin Li, Chaoyang Jiang
Clean cabbagelike (111) faceted silver crystals were synthesized via a facile galvanic replacement reaction of [Ag(NH3 )2 ]OH and a commercial aluminum foil, a surfactant-free formation process. The cabbagelike silver crystals consisted of interconnected nanoplates and exhibited a single-crystal structure along with preferential (111) facet oriented growth. These silver crystals showed high and reliable surface-enhanced Raman scattering (SERS) activity due to electromagnetic mechanism, and they could be easily transferred onto other rigid or flexible surfaces, making their SERS applications more versatile...
August 21, 2018: Analytical Chemistry
Federico Lo Torto, Juste Kaciulyte, Pedro Ciudad, Emanuele Cigna, Diego Ribuffo
No abstract text is available yet for this article.
September 2018: Plastic and Reconstructive Surgery
Bingbo Bao, Hongyi Zhu, Xianyou Zheng
No abstract text is available yet for this article.
September 2018: Plastic and Reconstructive Surgery
Adrienn Kazsoki, Attila Domján, Károly Süvegh, Romána Zelkó
Papaverine hydrochloride loaded gels, films and electrospun fibers were prepared for buccal drug delivery with the aim of improving the oral bioavailability of the crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. The water soluble hydroxypropyl cellulose (HPC) was chosen as a mucoadhesive polymer. In order to improve the electrospinnability of HPC, the similarly mucoadhesive poly(vinyl alcohol) (PVA) was used. Since the drying of gels is of decisive role in either the formation of drug-loaded cast films or electrospun fibers, a real time ortho-positronium (o-Ps) tracking of gels was applied in order to obtain information about the supramolecular changes of the drying-induced gel-film transition...
September 15, 2018: European Journal of Pharmaceutical Sciences
Fernando Lorenzini
No abstract text is available yet for this article.
May 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Gianni Belcaro, Giuseppe Gizzi, Luciano Pellegrini, Beatrice Feragalli, Roberto Cotellese, Marisa Cacchio, Marcello Corsi
BACKGROUND: The aim of this registry was to evaluate the effects of Pycnogenol® on the main symptoms of irritable bowel syndrome (IBS) in otherwise healthy individuals. METHODS: This study included 77 healthy individuals with symptoms of IBS. The patients were divided into three groups: group 1 was treated with Buscopan (10 mg when needed), group 2 (Antispasmina col forte; 50 mg papaverine hydrochloride+10 mg belladonna extract when needed) and 3 (Pycnogenol® 150 mg/day) for 3 weeks...
June 2018: Panminerva Medica
Yoshitaka Okabe, Kanichi Otowa, Yasuhito Mitamura, Hisayoshi Murai, Soichiro Usui, Shuichi Kaneko, Masayuki Takamura
Estimation of the fractional flow reserve (FFR) is considered to be an established method by which to assess stable coronary artery stenosis. Induction of maximal coronary hyperemia is important during the FFR procedure. Papaverine has been reported to increase the risk of ventricular arrhythmia (VA). The purpose of the present study was to discover predictors of papaverine-induced VAs developing during FFR measurement. A total of 213 clinically stable patients were included in the study. FFRs were determined after intracoronary papaverine administration (12 mg into the left and 8 mg into the right coronary arteries)...
April 30, 2018: Heart and Vessels
Farzaneh Naghdi, Zahra Gholamnezhad, Mohammad Hossein Boskabady, Morteza Bakhshesh
BACKGROUND: Lavandula angustifolia (L. angustifolia) Mill. (Common name Lavender) is used in traditional and folk medicines for the treatment of various diseases including respiratory disorders worldwide. The relaxant effect of the plant on the smooth muscle of some tissues was shown previously. The present study has investigated the role of different receptors and pathways in the relaxant effect of L. angustifolia on tracheal smooth muscle. METHODS: Cumulative concentrations of the hydro-ethanolic extract of L...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Masahiro Nauchi, Tsuyoshi Sakai, Masahiro Yamawaki, Yoshiaki Ito
A 78-year-old woman had paroxysmal atrial fibrillation and effort angina. Two months before she was admitted for a coronary angiography, she had been feeling dizzy. A Holter 24-hour electrocardiography monitor exhibited an asymptomatic episode of 2.9 seconds of RR interval. She underwent a coronary angiography, which showed intermediate stenosis in the left descending artery. Fractional flow reserve (FFR) measurement using intracoronary papaverine administration was performed. After intracoronary papaverine (12 mg) administration, pause of 4 seconds led to polymorphic ventricular tachycardia (VT), although the VT terminated spontaneously...
May 30, 2018: International Heart Journal
Nurcan Yurtsever Kum, Yavuz F Yilmaz, Seren G Gurgen, Rauf O Kum, Muge Ozcan, Adnan Unal
Introduction: Noise exposure, the main cause of hearing loss in countries with lot of industries, may result both in temporary or permanent hearing loss. The goal of this study was to investigate the effects of parenteral papaverine and piracetam administration following an acoustic trauma on hearing function with histopathologic correlation. Materials and Methods: Eighteen Wistar albino rats exposed to noise for 8 h in a free environment were included. We divided the study population into three groups, and performed daily intraperitoneal injections of papaverine, piracetam, and saline, respectively, throughout the study...
March 2018: Noise & Health
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