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https://www.readbyqxmd.com/read/30084875/biomarker-signatures-predicting-10-year-all-cause-and-disease-specific-mortality
#1
Yanxia Lu, Gianni Monaco, Xavier Camous, Anand Kumar Andiappan, Olaf Rotzschke, Tze Pin Ng, Anis Larbi
Novel wide array blood biomarkers of multisystem dysregulation, compared to conventional clinical and blood biomarkers, are potentially able to provide more accurate prognostic information of long-term mortality risks. We identified biomarker signatures of all-cause and disease-specific mortality from a comprehensive range of analytes related to six major physiological functions: cytokine, chemokine, and growth factors; glucose metabolism regulators and adipokines; adhesion molecules; acute phase response; pathogen-specific antibodies; and bone remodeling...
August 6, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29986312/high-fat-diet-disrupts-bone-remodeling-by-inducing-local-and-systemic-alterations
#2
Carina Cristina Montalvany-Antonucci, Marina Campos Zicker, Adaliene Versiani Matos Ferreira, Soraia Macari, Erivan Schnaider Ramos-Junior, Ricardo Santiago Gomez, Thaís Santos Ferreira Pereira, Mila Fernandes Moreira Madeira, Sandra Yasuyo Fukada, Ildeu Andrade, Tarcília Aparecida Silva
A high-fat (HF) diet leads to detrimental effects on alveolar bone (AB); however, the mechanisms linking adiposity to bone loss are poorly understood. This study investigated if AB resorption induced by an HF diet is associated with the regulation of inflammatory gene expression and if adipocytes can directly interfere with osteoclastogenesis. We also evaluated the effects of diet restriction (DR) on bone phenotype. C57BL6/J mice were fed normal chow or an HF diet for 12 weeks. Samples of maxillae, femur, blood and white adipose tissue were analyzed...
June 12, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29969876/fat-and-bone-in-children-where-are-we-now
#3
Paul Dimitri
The risk of fracture secondary to low-impact trauma is greater in obese children, suggesting obese children are at risk of skeletal fragility. However, despite this finding, there is a lack of agreement about the impact of excessive adiposity on skeletal development. The combination of poor diet, sedentary lifestyle, greater force generated on impact through falls, and greater propensity to falls may in part explain the increased risk of fracture in obese children. To date, evidence suggests that in early childhood years, obesity confers a structural advantage to the developing skeleton...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29950543/-body-weight-and-bone-calcium-metabolism-role-of-adipokine-in-bone-metabolism
#4
Ryuichi Sakamoto, Yoshihiro Ogawa
Since leptin was discovered in 1994, we considered the adipose tissue was not a "stockroom" with energy and being the endocrine-organ which secretes a various hormone, as called adipokine, which has various physiological activity. Much research was done about the effect of adipokine to each organ and disease concept of metabolic syndrome was established that induces metabolic disorders and atherosclerotic diseases by dysregulation of adipokine following visceral fat accumulation. Also, role of adipokine in bone metabolism becomes clear gradually...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29946468/chemerin-is-elevated-in-multiple-myeloma-patients-and-is-expressed-by-stromal-cells-and-pre-adipocytes
#5
Marita Westhrin, Siv Helen Moen, Ida Bruun Kristensen, Glenn Buene, Anne Kærsgaard Mylin, Ingemar Turesson, Niels Abildgaard, Anders Waage, Therese Standal
Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29943829/adipokines-adiposity-and-bone-marrow-adipocytes-dangerous-accomplices-in-multiple-myeloma
#6
REVIEW
Emma V Morris, Claire M Edwards
Obesity has become a global epidemic influencing the establishment and progression of a wide range of diseases, such as diabetes, cardiovascular disease, and cancer. In 2016, International Agency for Research on Cancer reported that obesity is now associated with 13 different cancers, one of which is multiple myeloma (MM), a destructive cancer of plasma cells that predominantly reside in the bone marrow. Obesity is the accumulation of excess body fat, which causes metabolic, endocrine, immunologic, and inflammatory-like changes...
June 26, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29908226/visfatin-alters-the-cytokine-and-matrix-degrading-enzyme-profile-during-osteogenic-and-adipogenic-msc-differentiation
#7
L Tsiklauri, J Werner, M Kampschulte, K W Frommer, L Berninger, M Irrgang, K Glenske, D Hose, T El Khassawna, J Pons-Kühnemann, S Rehart, S Wenisch, U Müller-Ladner, E Neumann
OBJECTIVES: Age-related bone loss is associated with bone marrow adiposity. Adipokines (e.g., visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis (OP). Thus, the presence of adipokines and MMPs in bone marrow and their effects on MSC differentiation were analyzed. METHODS: MSC and Ribonucleic acid (RNA) were isolated from femoral heads after hip replacement surgery of OA or osteoporotic femoral neck fracture (FF) patients...
June 14, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29859797/the-adipose-organ-and-multiple-myeloma-impact-of-adipokines-on-tumor-growth-and-potential-sites-for-therapeutic-intervention
#8
REVIEW
Alessandro Allegra, Vanessa Innao, Demetrio Gerace, Andrea Gaetano Allegra, Doriana Vaddinelli, Oriana Bianco, Caterina Musolino
In addition to its capacity to store lipids the adipose tissue is now identified as a real organ with both endocrine and metabolic roles. Preclinical results indicate that modifying adipose tissue and bone marrow adipose tissue (BMAT) could be a successful multiple myeloma (MM) therapy. BMAT interrelates with bone marrow cells and other immune cells, and may influence MM disease progression. The BM adipocytes may have a role in MM progression, bone homing, chemoresistance, and relapse, due to local endocrine, paracrine, or metabolic factors...
July 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29808230/relationships-between-markers-of-inflammation-and-bone-density-findings-from-the-hertfordshire-cohort-study
#9
N R Fuggle, L D Westbury, H E Syddall, N A Duggal, S C Shaw, K Maslin, E M Dennison, J Lord, C Cooper
Among 365 Hertfordshire Cohort Study participants (aged 59-71 years at baseline), higher adiponectin and adiponectin to leptin ratios were associated with lower baseline lumbar spine and femoral neck bone mineral density (BMD). Lower IL-10 was associated with accelerated decline in lumbar spine BMD. This suggests that bone health can be influenced by changes in immune phenotype and alterations in adipokine homeostasis. INTRODUCTION: The aim of this study was to examine the association between indices of inflammation and BMD in a population-based cohort of older adults in the UK...
July 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29701774/associations-between-plasma-chemerin-concentrations-and-bone-quality-in-adults-from-the-general-population
#10
Lejla Kadric, Stephanie Zylla, Matthias Nauck, Henry Völzke, Nele Friedrich, Anke Hannemann
Chemerin is an adipokine associated with parameters of inflammation and the metabolic syndrome. Small observational studies suggested that high circulating chemerin levels are also related to bone erosion. We aimed to determine whether plasma chemerin levels are related to bone quality in the general population and to investigate the influence of body mass index (BMI) on that relation. For our analyses, we obtained data from 3583 adults who participated in the population-based Study of Health in Pomerania-Trend...
June 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29662759/investigation-of-bioeffects-of-g-protein-coupled-receptor-1-on-bone-turnover-in-male-mice
#11
Jian Li, Liang Xiang, Xiaotong Jiang, Bin Teng, Yutao Sun, Guanlian Chen, Jie Chen, Jian V Zhang, Pei-Gen Ren
Maintenance of healthy bone quality and quantity requires a well-coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts. Chemerin is a novel adipokine with known functions such as regulating immunity and energy homeostasis through activation of chemokine-like receptor 1 (CMKLR1). G protein-coupled receptor 1 (GPR1) is the second mammalian chemerin receptor with similar binding affinity as CMKLR1. In male GPR1-/- mice, a phenotype with significantly low bone mineral density was observed...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29653285/adipokines-and-bone-status-in-a-cohort-of-anorexic-patients
#12
Isabelle Legroux-Gérot, Jean Vignau, Odile Viltart, Pierre Hardouin, Christophe Chauveau, Bernard Cortet
INTRODUCTION: Bone loss in anorexia nervosa (AN) is multifactorial; its mechanisms are not yet clearly understood and may vary depending on disease duration and severity. To determine to what extent adipokines may be involved in the bone alterations found in anorexic patients, we evaluated plasma levels for leptin, adiponectin and Pref-1 against other clinical and biological parameters in a population of anorexic patients split according to weight and bone status. METHODS: Plasma concentrations of leptin, total adiponectin, high molecular weight (HMW) adiponectin, and Pref-1 were measured...
April 10, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29609869/bone-status-and-adipokine-levels-in-children-on-vegetarian-and-omnivorous-diets
#13
Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Małgorzata Strucińska, Joanna Gajewska
BACKGROUND & AIMS: Measurements of bone mineral density (BMD) reflect bone status but not the dynamics of bone turnover. Biochemical markers, which show global skeletal activity, were validated for the assessment of bone formation and resorption processes. Adipokines also play a significant role in the regulation of bone metabolism. OBJECTIVE: To assess body composition, bone mineral density, bone turnover markers and adipokine levels in relation to vegetarian and omnivorous diets...
March 23, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29593201/adipose-tissue-critical-contributor-to-the-development-of-prostate-cancer
#14
Uehara Hisanori, Tomoko Kobayashi, Minoru Matsumoto, Shunsuke Watanabe, Akiko Yoneda, Bando Yoshimi
The prostate is surrounded by periprostatic adipose tissue. Although adipose tissue was thought to play limited physiological roles, it has recently been recognized as an active endocrine organ, secreting growth factors and adipokines. Epidemiologically, obesity is associated with prostate cancer progression. A major mechanism to explain the link between obesity and cancer includes the insulin and insulin-like growth factor (IGF)-1 axis, sex steroids, and adipokines. When prostate cancer cells invade periprostatic adipose tissue, adipose tissue contributes to create the tumor microenvironment, mainly via adipokine secretion...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29549054/knocking-out-or-pharmaceutical-inhibition-of-fatty-acid-binding-protein-4-fabp4-alleviates-osteoarthritis-induced-by-high-fat-diet-in-mice
#15
C Zhang, K Y Chiu, B P M Chan, T Li, C Wen, A Xu, C H Yan
OBJECTIVES: Adipokines play roles in the pathogenesis of osteoarthritis (OA). Fatty acid binding protein 4 (FABP4) is a novel adipokine that is closely associated with obesity and metabolic diseases. The aim of this study was to discover the potential role of FABP4 in OA. METHODS: Seventy-two FABP4 knockout mice (KO) in C57BL/6N background and wild-type littermates (WT) (male, 6-week-old) were fed with a high-fat diet (HFD, 60% calorie) or standard diet (STD, 11...
June 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29548987/bone-marrow-adiposity-and-multiple-myeloma
#16
Emma V Morris, Claire M Edwards
Multiple Myeloma (MM) is an incurable haematological malignancy and is the second most common blood cancer in adults; it is caused by the clonal expansion of abnormal plasma cells within the bone marrow and characterized by osteolytic bone lesions, bone pain, renal disease, and immunodeficiency. MM cells infiltrate the bone marrow where they hijack the microenvironment to sustain growth and survival. The contribution to this process by resident bone cells is well defined. However, the role of bone marrow adipocytes is less clear...
March 13, 2018: Bone
https://www.readbyqxmd.com/read/29528762/modifications-in-the-spectrum-of-bone-mass-predictive-factors-with-menopausal-status
#17
Stefana Catalina Bilha, Dumitru Branisteanu, Catalin Buzduga, Daniela Constantinescu, Petru Cianga, Ecaterina Anisie, Cristina Gavrilovici, Adrian Covic, Maria Christina Ungureanu
PURPOSE: Fat mass (FM) is a source of adipocytokines, with both positive and negative bone consequences. We aimed to investigate the role of body composition and adipokines as predictive factors for bone mass in women. METHODOLOGY: This cross-sectional study included 93 women (38 premenopausal and 55 postmenopausal). Bone mineral density (BMD) and body composition were assessed by dual-energy X-ray absorptiometry. Serum levels of leptin, adiponectin, resistin, and also of the phosphocalcic markers parathormone and vitamin D were measured...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29476394/good-bad-or-ugly-the-biological-roles-of-bone-marrow-fat
#18
REVIEW
Lakshman Singh, Sonia Tyagi, Damian Myers, Gustavo Duque
PURPOSE OF REVIEW: Bone marrow fat expresses mixed characteristics, which could correspond to white, brown, and beige types of fat. Marrow fat could act as either energy storing and adipokine secreting white fat or as a source of energy for hematopoiesis and bone metabolism, thus acting as brown fat. However, there is also a negative interaction between marrow fat and other elements of the bone marrow milieu, which is known as lipotoxicity. In this review, we will describe the good and bad roles of marrow fat in the bone, while focusing on the specific components of the negative effect of marrow fat on bone metabolism...
April 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29466196/-issues-of-adipokine-regulation-in-idiopathic-pulmonary-arterial-hypertension-and-systemic-osteopenia
#19
E A Kochetkova, V A Nevsorova, L G Ugay, Y V Maystrovskaya, T A Brodskaya
PURPOSE: to determine the role of adipokines and vascular remodeling in formation of osteoporosis in idiopathic pulmonary arterial hypertension (IPAH). MATERIALS AND METHODS: Functional and hemodynamic parameters, bone mineral density (BMD) T-score in lumbar spine (LS) and femoral neck (FN), blood serum levels of leptin, adiponectin, visfatin and endothelin-1 were measured in 27 patients with severe IPAH and 30 healthy volunteers. RESULTS: Half of IPAH patients had osteoporosis...
February 2018: Kardiologiia
https://www.readbyqxmd.com/read/29422077/adiponectin-aggravates-bone-erosion-by-promoting-osteopontin-production-in-synovial-tissue-of-rheumatoid-arthritis
#20
Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan, Miaojia Zhang
BACKGROUND: We have previously reported that adiponectin (AD), an adipokine that is secreted by adipocytes, correlates well with progressive bone erosion in rheumatoid arthritis (RA). The exact mechanism of AD in promoting joint destruction remains unclear. Osteopontin (OPN) is required for osteoclast recruitment. We hypothesized that AD exacerbates bone erosion by inducing OPN expression in synovial tissue. This study aimed to evaluate a novel role for AD in RA. METHODS: The serum levels of AD and OPN were determined in 38 patients with RA, 40 patients with osteoarthritis (OA), and 20 healthy controls using enzyme-linked immunosorbent assay (ELISA)...
February 8, 2018: Arthritis Research & Therapy
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