Ya-Yu Tsai, Chenxu Qu, Joseph D Bonner, Rebeca Sanz-Pamplona, Sidney S Lindsey, Marilena Melas, Kevin J McDonnell, Gregory E Idos, Christopher P Walker, Kevin K Tsang, Diane M Da Silva, Ferran Moratalla-Navarro, Asaf Maoz, Hedy S Rennert, W Martin Kast, Joel K Greenson, Victor Moreno, Gad Rennert, Stephen B Gruber, Stephanie L Schmit
OBJECTIVE: Reduced diversity at Human Leukocyte Antigen (HLA) loci may adversely affect the host's ability to recognize tumor neoantigens and subsequently increase disease burden. We hypothesized that increased heterozygosity at HLA loci is associated with a reduced risk of developing colorectal cancer (CRC). METHODS: We imputed HLA class I and II four-digit alleles using genotype data from a population-based study of 5,406 cases and 4,635 controls from the Molecular Epidemiology of Colorectal Cancer Study (MECC)...
2023: Frontiers in Immunology