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https://www.readbyqxmd.com/read/30308906/cfd-modelling-of-air-quality-in-pamplona-city-spain-assessment-stations-spatial-representativeness-and-health-impacts-valuation
#1
Esther Rivas, Jose Luis Santiago, Yolanda Lechón, Fernando Martín, Arturo Ariño, Juan José Pons, Jesús Miguel Santamaría
A methodology based on CFD-RANS simulations (WA CFD-RANS, Weighted Averaged Computational Fluid Dynamic-Reynolds-Averaged Navier-Stokes simulations) which includes appropriate modifications, has been applied to compute the annual, seasonal, and hourly average concentration of NO2 and NOX throughout the city of Pamplona (Spain) at pedestrian level during 2016. The results have been evaluated using measurements provided both by the city's network of air quality monitoring stations and by a network of mobile microsensors carried around by cyclists during their daily commutes, obtaining a maximum relative error lower than 30% when computing NO2 annual average concentrations...
February 1, 2019: Science of the Total Environment
https://www.readbyqxmd.com/read/30308018/location-dependent-effects-of-trauma-on-oxidative-stress-in-humans
#2
Luis Servia, José C E Serrano, Reinald Pamplona, Mariona Badia, Neus Montserrat, Manuel Portero-Otin, Javier Trujillano
Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. For this reason, we evaluated the relationship between the anatomical location of trauma and plasma total antioxidant capacity (TAC) in a prospective study, where the anatomical locations of trauma in polytraumatic patients (n = 66) were categorized as primary affecting the brain -traumatic brain injury (TBI)-, thorax, abdomen and pelvis or extremities...
2018: PloS One
https://www.readbyqxmd.com/read/30283144/colon-specific-eqtl-analysis-to-inform-on-functional-snps
#3
Victor Moreno, M Henar Alonso, Adrià Closa, Xavier Vallés, Anna Diez-Villanueva, Laura Valle, Sergi Castellví-Bel, Rebeca Sanz-Pamplona, Adriana Lopez-Doriga, David Cordero, Xavier Solé
BACKGROUND: Genome-wide association studies on colorectal cancer have identified more than 60 susceptibility loci, but for most of them there is no clear knowledge of functionality or the underlying gene responsible for the risk modification. Expression quantitative trail loci (eQTL) may provide functional information for such single nucleotide polymorphisms (SNPs). METHODS: We have performed detailed eQTL analysis specific for colon tissue on a series of 97 colon tumours, their paired adjacent normal mucosa and 47 colon mucosa samples donated by healthy individuals...
October 4, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30269018/genetic-toxicity-of-water-contaminated-by-microcystins-collected-during-a-cyanobacteria-bloom
#4
Maria Tereza Pamplona-Silva, Letícia Cristina Gonçalves, Maria Aparecida Marin-Morales
Microcystin-LR (MCLR) is a toxin mainly produced by Microcystis aeruginosa, cyanobacteria most commonly found in eutrophic environments. Cyanobacteria blooms have affected Salto Grande reservoir (Americana, State of São Paulo/Brazil) for several decades, often observed during periods of drought. In this study, the genotoxic effects of MCLR (95% purity) and water samples contaminated by this toxin were evaluated during cyanobacteria bloom using assays with the test organism Allium cepa. The results showed genotoxic action for pure microcystin and cytotoxic, genotoxic and mutagenic action for water samples collected during flowering...
September 27, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30258398/potential-clinical-benefits-of-cbd-rich-cannabis-extracts-over-purified-cbd-in-treatment-resistant-epilepsy-observational-data-meta-analysis
#5
Fabricio A Pamplona, Lorenzo Rolim da Silva, Ana Carolina Coan
This meta-analysis paper describes the analysis of observational clinical studies on the treatment of refractory epilepsy with cannabidiol (CBD)-based products. Beyond attempting to establish the safety and efficacy of such products, we also investigated if there is enough evidence to assume any difference in efficacy between CBD-rich extracts compared to purified CBD products. The systematic search took place in February/2017 and updated in December/2017 using the keywords "epilepsy" or "Dravet" or "Lennox-Gastaut" or "CDKL5" combined with "Cannabis," "cannabinoid," "cannabidiol," or "CBD" resulting in 199 papers...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30247743/abstracts-of-the-12th-international-comet-assay-workshop-held-at-the-university-of-navarra-pamplona-spain-29-31-august-2017-https-icaw-vito-be
#6
(no author information available yet)
No abstract text is available yet for this article.
September 21, 2018: Mutagenesis
https://www.readbyqxmd.com/read/30210358/lipidomics-reveals-a-tissue-specific-fingerprint
#7
Irene Pradas, Kevin Huynh, Rosanna Cabré, Victòria Ayala, Peter J Meikle, Mariona Jové, Reinald Pamplona
In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and organelles, as well as in tissues, whose lipid distribution remains unclear. Here, we report a mass spectrometry study of lipid abundance across 7 rat tissues, detecting and quantifying 652 lipid molecular species from the glycerolipid, glycerophospholipid, fatty acyl, sphingolipid, sterol lipid and prenol lipid categories...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30209554/correction-to-electroacupuncture-induces-antihyperalgesic-effect-through-endothelin-b-receptor-in-the-chronic-phase-of-a-mouse-model-of-complex-regional-pain-syndrome-type-i
#8
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidral-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
The original version of this article contains an error. The Author Francisco José Cidral-Filho incorrectly listed as Francisco José Cidra-Filho. The correct spelling is presented above. The original article has been corrected.
September 13, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30198852/antireflux-ureteral-stent-proof-of-concept-assessment-after-minimally-invasive-treatment-of-obstructive-uropathy-in-animal-model
#9
Federico Soria, Esther Morcillo, Julia E de la Cruz, Alvaro Serrano, Javier Estebanez, Juan Luis Sanz, Javier Chicharro, Manuel Pamplona, Francisco M Sanchez-Margallo
OBJECTIVES: To assess the efficacy of a new anti-reflux intraureteral stent design in a swine model after minimally invasive treatment of ureteral stricture to reduce ureteral stent morbidity, previous to manufacture this design in a biodegradable fashion. METHODS: Twenty-eight female pigs were included. The study began with a cystoscopic, nephrosonographic and contrast fluoroscopic assessment. Afterwards, obstructive uropathy model in right ureter was created. Obstruction was confirmed 6 weeks later and animals were randomly distributed into 2 groups...
September 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/30182281/international-symposium-trailblazing-in-cancer-immunotherapy-october-29-31-2017-pamplona-spain
#10
Pedro Berraondo, Maria Angela Aznar, Elisabeth Perez-Ruiz, Maria Esperanza Rodriguez-Ruiz, Eduardo Castañon, Jose Luis Perez-Gracia, Ignacio Melero
No abstract text is available yet for this article.
September 4, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/30142670/answer-abortion-and-zika-virus-congenital-infection
#11
Vivian Maria Ribeiro Mota, Alanna Dos Santos Delfino, Thayse Elaine Costa Figueiredo Lopes, André Luiz Santos Pessoa, Erlane Marques Ribeiro, Luciano Pamplona de Góes Cavalcanti
No abstract text is available yet for this article.
August 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/30094478/electroacupuncture-induces-antihyperalgesic-effect-through-endothelin-b-receptor-in-the-chronic-phase-of-a-mouse-model-of-complex-regional-pain-syndrome-type-i
#12
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidral-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
Complex regional pain syndrome (CRPS) is a disorder that involves abnormal inflammation and nerve dysfunction frequently resistant to a broad range of treatments. Peripheral nerve stimulation with electroacupuncture (EA) has been widely used in different clinical conditions to control pain and inflammation; however, the use of EA in the treatment of CRPS is under investigation. In this study, we explore the effects of EA on hyperalgesia and edema induced in an animal model of chronic post-ischemia pain (CPIP model) and the possible involvement of endothelin receptor type B (ETB ) in this effect...
August 10, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30077575/regional-vulnerability-to-lipoxidative-damage-and-inflammation-in-normal-human-brain-aging
#13
Mayelín Domínguez-González, Meritxell Puigpinós, Mariona Jové, Alba Naudi, Manuel Portero-Otín, Reinald Pamplona, Isidro Ferrer
Oxidative damage and inflammation coexist in healthy human brain aging. The present study analyzes levels of protein adduction by lipid peroxidation (LP) end-products neuroketal (NKT) and malondialdehyde (MDA), as markers of protein oxidative damage, cycloxygenase-2 (COX-2) levels, as a marker of inflammation, and cytochrome P450 2J2 (CYP2J2), responsible of generation of neuroprotective products, in twelve brain regions in normal middle-aged individuals (MA) and old-aged (OA) individuals. In addition, levels of these markers were evaluated as a function of age as a continuous variable and correction for multiple comparisons...
October 1, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/30050680/htlv-1-2-prevalence-in-two-amazonian-communities
#14
EDITORIAL
Elida Cg Mata, Roberto M Bezerra, Aldo A Proietti Júnior, Luana Ks Pamplona, Lilian O Gomes, Valmir C Corrêa, Jordan Sr Caluff, Geanny S Borges, J Casseb, Lib Kanzaki
Introduction: The human T-cell lymphotropic virus type 1 (HTLV-1) is aetiologically linked to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukaemia (ATL) besides other less incident pathologies, while the type 2 has not been definitively linked to any diseases. Objectives: To determine the HTLV-1/2 seroprevalence in two Brazilian communities in northern Brazil. Methods: In 2010 and 2015, HTLV-1/2 serological surveys were carried out in the Oiapoque county at the Brazilian border with French Guiana and in Santa Cruz do Arari, Marajó Island...
July 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/30012112/maternal-and-infant-death-after-probable-vertical-transmission-of-chikungunya-virus-in-brazil-case-report
#15
Rhaquel de Morais Alves Barbosa Oliveira, Francisca Kalline de Almeida Barreto, Ana Maria Peixoto Cabral Maia, Ileana Pitombeira Gomes, Adriana Rocha Simião, Rebeca Bandeira Barbosa, Adilina Soares Romeiro Rodrigues, Kilma Wanderley Lopes, Fernanda Montenegro de Carvalho Araújo, Regina Lúcia Sousa do Vale, John Washington Cavalcante, Luciano Pamplona de Góes Cavalcanti
BACKGROUND: Chikungunya virus infection in neonates is relatively rare and can lead to death. CASE PRESENTATION: We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks' gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms...
July 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29997171/aberrant-regulation-of-the-gsk-3%C3%AE-nrf2-axis-unveils-a-novel-therapy-for-adrenoleukodystrophy
#16
Pablo Ranea-Robles, Nathalie Launay, Montserrat Ruiz, Noel Ylagan Calingasan, Magali Dumont, Alba Naudí, Manuel Portero-Otín, Reinald Pamplona, Isidre Ferrer, M Flint Beal, Stéphane Fourcade, Aurora Pujol
The nuclear factor erythroid 2-like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early-appearing feature in X-linked adrenoleukodystrophy (X-ALD) patients and the mouse model ( Abcd1 null mouse). This rare neurometabolic disease is caused by the loss of function of the peroxisomal transporter ABCD1, leading to an accumulation of very long-chain fatty acids and the induction of reactive oxygen species of mitochondrial origin. Here, we identify an impaired NRF2 response caused by aberrant activity of GSK-3β...
August 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29959761/abortion-in-cases-of-zika-virus-congenital-infection
#17
Vivian Maria Ribeiro Mota, Luciano Pamplona de Góes Cavalcanti, Alanna Dos Santos Delfino, Thayse Elaine Costa Figueiredo Lopes, André Luiz Santos Pessoa, Erlane Marques Ribeiro
The emergency in international public health caused by the Zika virus gave rise to the discussion about abortion in cases of congenital Zika virus syndrome (CZS). Therefore, we propose to carry out a bibliographic review on abortion in these cases. Five databases were searched using the following terms: abortion , miscarriage , and zika , with the interposition of the Boolean operator "AND." In the selected literature, we found references to the lack of information concerning the risks and severity of CZS, to the great psychological distress suffered by pregnant women, and to the risk of unsafe abortions as a justification for abortion in cases of CZS...
July 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29947163/kidney-transplant-from-uncontrolled-donation-after-circulatory-death-donors-maintained-by-necmo-has-long-term-outcomes-comparable-to-standard-criteria-donation-after-brain-death
#18
María Molina, Félix Guerrero-Ramos, Mario Fernández-Ruiz, Esther González, Jimena Cabrera, Enrique Morales, Eduardo Gutierrez, Eduardo Hernández, Natalia Polanco, Ana Hernández, Manuel Praga, Alfredo Rodriguez-Antolín, Manuel Pamplona, Federico de la Rosa, Teresa Cavero, Mario Chico, Alicia Villar, Iago Justo, Amado Andrés
Uncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplant (KT) with short-term outcomes similar to those obtained from donation after brain death (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year outcomes between 237 KT recipients from uDCD donors maintained by normothermic extracorporeal membrane oxygenation (nECMO) and 237 patients undergoing KT from standard criteria DBD donors during the same period at our institution...
June 27, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29945183/essential-physiological-differences-characterise-short-and-long-lived-strains-of-drosophila-melanogaster
#19
Nina Gubina, Alba Naudi, Rhoda Stefanatos, Mariona Jove, Filippo Scialo, Daniel J Fernandez-Ayala, Tommi Rantapero, Ihor Yurkevych, Manuel Portero-Otin, Matti Nykter, Oleh Lushchak, Placido Navas, Reinald Pamplona, Alberto Sanz
Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulation is the most accepted explanation but the proximal causes remain to be elucidated. There is also evidence indicating that aging has an important genetic component. Animal species age at different rates and specific signalling pathways, such as insulin/insulin-like growth factor, can regulate lifespan of individuals within a species by reprogramming cells in response to environmental changes. Here, we use an unbiased approach to identify novel factors that regulate lifespan in Drosophila melanogaster...
June 26, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29916979/deliberate-practice-preliminary-results-of-a-useful-strategy-for-correcting-articulation-in-children-with-cleft-palate
#20
María Del Carmen Pamplona, Pablo Antonio Ysunza
Children with cleft palate frequently show speech and language disorders. In the related scientific literature, several reports have described the use of different strategies for treating speech disorders in children with cleft palate. However, only a few studies have addressed the use of these strategies within a meaningful linguistic context.Deliberate practice is a procedure or strategy, which proposes that the key for achieving high levels of expert performance is dedicating long time for practice. Deliberate practice has been studied mainly in the areas of sports and intellectual games...
June 18, 2018: Journal of Craniofacial Surgery
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