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https://www.readbyqxmd.com/read/30094478/electroacupuncture-induces-antihyperalgesic-effect-through-endothelin-b-receptor-in-the-chronic-phase-of-a-mouse-model-of-complex-regional-pain-syndrome-type-i
#1
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidra-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
Complex regional pain syndrome (CRPS) is a disorder that involves abnormal inflammation and nerve dysfunction frequently resistant to a broad range of treatments. Peripheral nerve stimulation with electroacupuncture (EA) has been widely used in different clinical conditions to control pain and inflammation; however, the use of EA in the treatment of CRPS is under investigation. In this study, we explore the effects of EA on hyperalgesia and edema induced in an animal model of chronic post-ischemia pain (CPIP model) and the possible involvement of endothelin receptor type B (ETB ) in this effect...
August 10, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30077575/regional-vulnerability-to-lipoxidative-damage-and-inflammation-in-normal-human-brain-aging
#2
Mayelín Domínguez-González, Meritxell Puigpinós, Mariona Jové, Alba Naudi, Manuel Portero-Otín, Reinald Pamplona, Isidro Ferrer
No abstract text is available yet for this article.
August 2, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/30050680/htlv-1-2-prevalence-in-two-amazonian-communities
#3
EDITORIAL
Elida Cg Mata, Roberto M Bezerra, Aldo A Proietti Júnior, Luana Ks Pamplona, Lilian O Gomes, Valmir C Corrêa, Jordan Sr Caluff, Geanny S Borges, J Casseb, Lib Kanzaki
Introduction: The human T-cell lymphotropic virus type 1 (HTLV-1) is aetiologically linked to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukaemia (ATL) besides other less incident pathologies, while the type 2 has not been definitively linked to any diseases. Objectives: To determine the HTLV-1/2 seroprevalence in two Brazilian communities in northern Brazil. Methods: In 2010 and 2015, HTLV-1/2 serological surveys were carried out in the Oiapoque county at the Brazilian border with French Guiana and in Santa Cruz do Arari, Marajó Island...
July 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/30012112/maternal-and-infant-death-after-probable-vertical-transmission-of-chikungunya-virus-in-brazil-case-report
#4
Rhaquel de Morais Alves Barbosa Oliveira, Francisca Kalline de Almeida Barreto, Ana Maria Peixoto Cabral Maia, Ileana Pitombeira Gomes, Adriana Rocha Simião, Rebeca Bandeira Barbosa, Adilina Soares Romeiro Rodrigues, Kilma Wanderley Lopes, Fernanda Montenegro de Carvalho Araújo, Regina Lúcia Sousa do Vale, John Washington Cavalcante, Luciano Pamplona de Góes Cavalcanti
BACKGROUND: Chikungunya virus infection in neonates is relatively rare and can lead to death. CASE PRESENTATION: We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks' gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms...
July 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29997171/aberrant-regulation-of-the-gsk-3%C3%AE-nrf2-axis-unveils-a-novel-therapy-for-adrenoleukodystrophy
#5
Pablo Ranea-Robles, Nathalie Launay, Montserrat Ruiz, Noel Ylagan Calingasan, Magali Dumont, Alba Naudí, Manuel Portero-Otín, Reinald Pamplona, Isidre Ferrer, M Flint Beal, Stéphane Fourcade, Aurora Pujol
The nuclear factor erythroid 2-like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early-appearing feature in X-linked adrenoleukodystrophy (X-ALD) patients and the mouse model ( Abcd1 null mouse). This rare neurometabolic disease is caused by the loss of function of the peroxisomal transporter ABCD1, leading to an accumulation of very long-chain fatty acids and the induction of reactive oxygen species of mitochondrial origin. Here, we identify an impaired NRF2 response caused by aberrant activity of GSK-3β...
July 11, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29959761/abortion-in-cases-of-zika-virus-congenital-infection
#6
Vivian Maria Ribeiro Mota, Luciano Pamplona de Góes Cavalcanti, Alanna Dos Santos Delfino, Thayse Elaine Costa Figueiredo Lopes, André Luiz Santos Pessoa, Erlane Marques Ribeiro
The emergency in international public health caused by the Zika virus gave rise to the discussion about abortion in cases of congenital Zika virus syndrome (CZS). Therefore, we propose to carry out a bibliographic review on abortion in these cases. Five databases were searched using the following terms: abortion , miscarriage , and zika , with the interposition of the Boolean operator "AND." In the selected literature, we found references to the lack of information concerning the risks and severity of CZS, to the great psychological distress suffered by pregnant women, and to the risk of unsafe abortions as a justification for abortion in cases of CZS...
June 29, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29947163/kidney-transplantation-from-uncontrolled-donation-after-circulatory-death-donors-maintained-by-necmo-has-long-term-outcomes-comparable-to-standard-criteria-donation-after-brain-death
#7
María Molina, Félix Guerrero-Ramos, Mario Fernández-Ruiz, Esther González, Jimena Cabrera, Enrique Morales, Eduardo Gutierrez, Eduardo Hernández, Natalia Polanco, Ana Hernández, Manuel Praga, Alfredo Rodriguez-Antolín, Manuel Pamplona, Federico de la Rosa, Teresa Cavero, Mario Chico, Alicia Villar, Iago Justo, Amado Andrés
Uncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplantation (KT) with short-term outcomes similar to those obtained from donation after brain death (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year outcomes between 237 KT recipients from uDCD donors maintained by normothermic extracorporeal membrane oxygenation (nECMO) and 237 patients undergoing KT from standard criteria DBD donors during the same period at our institution...
June 27, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29945183/essential-physiological-differences-characterise-short-and-long-lived-strains-of-drosophila-melanogaster
#8
Nina Gubina, Alba Naudi, Rhoda Stefanatos, Mariona Jove, Filippo Scialo, Daniel J Fernandez-Ayala, Tommi Rantapero, Ihor Yurkevych, Manuel Portero-Otin, Matti Nykter, Oleh Lushchak, Placido Navas, Reinald Pamplona, Alberto Sanz
Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulation is the most accepted explanation but the proximal causes remain to be elucidated. There is also evidence indicating that aging has an important genetic component. Animal species age at different rates and specific signalling pathways, such as insulin/insulin-like growth factor, can regulate lifespan of individuals within a species by reprogramming cells in response to environmental changes. Here, we use an unbiased approach to identify novel factors that regulate lifespan in Drosophila melanogaster...
June 26, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29916979/deliberate-practice-preliminary-results-of-a-useful-strategy-for-correcting-articulation-in-children-with-cleft-palate
#9
María Del Carmen Pamplona, Pablo Antonio Ysunza
Children with cleft palate frequently show speech and language disorders. In the related scientific literature, several reports have described the use of different strategies for treating speech disorders in children with cleft palate. However, only a few studies have addressed the use of these strategies within a meaningful linguistic context.Deliberate practice is a procedure or strategy, which proposes that the key for achieving high levels of expert performance is dedicating long time for practice. Deliberate practice has been studied mainly in the areas of sports and intellectual games...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29912613/cryptic-exon-splicing-function-of-tardbp-interacts-with-autophagy-in-nervous-tissue
#10
Pascual Torres, Omar Ramírez-Núñez, Ricardo Romero-Guevara, Gisel Barés, Ana B Granado-Serrano, Victòria Ayala, Jordi Boada, Laia Fontdevila, Monica Povedano, Daniel Sanchís, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otín
TARDBP (TAR DNA binding protein) is one of the components of neuronal aggregates in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. We have developed a simple quantitative method to evaluate TARDBP splicing function that was applied to spinal cord, brainstem, motor cortex, and occipital cortex in ALS (n = 8) cases compared to age- and gender-matched control (n = 17). Then, we quantified the abundance of a TARDBP-spliced cryptic exon present in ATG4B (autophagy related 4B cysteine peptidase) mRNA...
July 28, 2018: Autophagy
https://www.readbyqxmd.com/read/29908233/telomere-length-alterations-in-microsatellite-stable-colorectal-cancer-and-association-with-the-immune-response
#11
Adriana Lopez-Doriga, Laura Valle, M Henar Alonso, Susanna Aussó, Adrià Closa, Xavier Sanjuan, David Barquero, Francisco Rodríguez-Moranta, Rebeca Sanz-Pamplona, Victor Moreno
Telomeres are repetitive sequences (TTAGGG) located at the end of chromosomes. Telomeres progressively shorten with each cell replication cycle, ultimately leading to chromosomal instability and loss of cell viability. Telomere length anomaly appears to be one of the earliest and most prevalent genetic alterations in malignant transformation. Here we aim to estimate telomere length from whole-exome sequencing data in colon tumors and normal colonic mucosa, and to analyze the potential association of telomere length with clinical factors and gene expression in colon cancer...
June 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29848446/predicting-the-likelihood-and-intensity-of-mosquito-infection-from-sex-specific-plasmodium-falciparum-gametocyte-density
#12
John Bradley, Will Stone, Dari F Da, Isabelle Morlais, Alassane Dicko, Anna Cohuet, Wamdaogo M Guelbeogo, Almahamoudou Mahamar, Sandrine Nsango, Harouna M Soumaré, Halimatou Diawara, Kjerstin Lanke, Wouter Graumans, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Ingrid Chen, Alfred Tiono, Bronner Pamplona Gonçalves, Roland Gosling, Robert W Sauerwein, Chris Drakeley, Thomas S Churcher, Teun Bousema
Understanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a complex relationship between gametocyte density and mosquito infection. Here we use data from 148 feeding experiments on naturally infected gametocyte carriers to show that the relationship is much simpler and depends on both female and male parasite density. The proportion of mosquitoes infected is primarily determined by the density of female gametocytes though transmission from low gametocyte densities may be impeded by a lack of male parasites...
May 31, 2018: ELife
https://www.readbyqxmd.com/read/29843810/a-new-aura-virus-isolate-in-brazil-shows-segment-duplication-in-the-variable-region-of-the-nsp3-gene
#13
Ana Luiza Pamplona Mosimann, Mirian Krystel de Siqueira, Ligia Fernanda Ceole, Claudia Nunes Duarte Dos Santos
BACKGROUND: A new isolate of Aura virus serendipitously discovered as a cell culture contaminant is reported in this manuscript. Aura virus belongs to the family Togaviridae and is classified in the genus Alphavirus. There are only two reports of Aura virus isolation from mosquitoes in the scientific literature, and the existence of a vertebrate host is still unknown. The discovery of this new isolate was based on transmission electron microscopy and nucleic acid amplification through a non-specific RT-PCR amplification protocol followed by sequencing...
May 29, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29764170/all-with-you-a-new-method-for-developing-compassionate-communities-experiences-in-spain-and-latin-america
#14
Silvia Librada Flores, Emilio Herrera Molina, Jaime Boceta Osuna, Rafael Mota Vargas, María Nabal Vicuña
BACKGROUND: In recent years, compassion has motivated the development of programs oriented to create communities and societies involved in the relief of suffering. The development of compassionate communities and cities begins in each one of us, though it relies on organizations, providers and societies as a whole who need tools and methodologies as a part of a set of actions to help compassionate communities and cities to become a reality rooted widely in social values. In order to describe the "All with You®" methodology and its components: a method designed to develop compassionate communities and cities at the end of life that can be extended to organizations, communities, municipalities, cities or countries...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29686737/chikungunya-and-diabetes-what-do-we-know
#15
REVIEW
Francisca Kalline de Almeida Barreto, Renan Magalhães Montenegro, Virginia Oliveira Fernandes, Rhaquel Oliveira, Lívia Aline de Araújo Batista, Akhtar Hussain, Luciano Pamplona de Góes Cavalcanti
Background: Chikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 deaths. The clinical manifestations, pathogenesis and risk factors for occurrence of severe cases are not yet well understood, although it is known that the severity of the cases is associated with the presence of comorbidities, especially diabetes mellitus (DM). Objective: To review the medical literature for the associations between DM and CHIK and to understand the potential impact on metabolic state and its complications...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29673030/dengue-fever-and-aedes-aegypti-in-indigenous-brazilians-seroprevalence-risk-factors-knowledge-and-practices
#16
Rafael Henrique Machado Sacramento, Fernanda Montenegro de Carvalho Araújo, Danielle Malta Lima, Carlos Carlos Henrique Alencar, Victor Emanuel Pessoa Martins, Lucas Venâncio Araújo, Tais Castelo de Oliveira, Luciano Pamplona de Góes Cavalcanti
OBJECTIVE: Dengue remains an important public health problem in Brazil. We estimated the associated factors of dengue seroprevalence among native Indians of the Tremembé ethnic and their knowledge about the aspects related to the presence of mosquitoes of the genus Aedes. METHODS: An analytical cross-sectional study and a prospective environmental study to monitor the trapping of mosquito eggs monthly were performed. The serological portion of the study involved indigenous people living in the village of Tapera in northeastern Brazil...
June 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29670036/anti-inflammatory-and-antinociceptive-studies-of-hydroalcoholic-extract-from-the-leaves-of-phyllanthus-brasiliensis-aubl-poir-and-isolation-of-5-o-%C3%AE-d-glucopyranosyljusticidin-b-and-six-other-lignans
#17
Luziane da C Borges, Raimundo Negrão-Neto, Sônia Pamplona, Luanna Fernandes, Mayra Barros, Enéas Fontes-Júnior, Cristiane Maia, Consuelo Y Yoshioka E Silva, Milton Nascimento da Silva
The aim of this study was to investigate the chemical composition and the antiinflammatory/antinociceptive properties of the hydroalcoholic extract derived from the leaves of Phyllanthus brasiliensis (HEPB) in rodents. A new arylnaphthalene lignan glycoside, 5- O -β-d-glucopyranosyljusticidin B, together with six known lignans, were isolated from HEPB. 1D and 2D NMR experiments and HRMS were used to elucidate the structure of the new compound. HEPB toxicity and antinociceptive activity were evaluated through acute oral toxicity and formalin models in mice, respectively...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29649505/do-hema-free-adhesive-systems-have-better-clinical-performance-than-hema-containing-systems-in-noncarious-cervical-lesions-a-systematic-review-and-meta-analysis
#18
REVIEW
Taíse Sousa Pamplona da Silva, Roberta Fonseca de Castro, Marcela Baraúna Magno, Lucianne Copple Maia, Mário Honorato da Silva E Souza
OBJECTIVES: To determine through a systematic review whether HEMA-free adhesive systems have better clinical performance than HEMA-containing systems in noncarious cervical lesion (NCCL) restorations. SOURCES: We systematically searched PubMed, The Cochrane Library, Scopus, Web of Science, and Open Grey databases using MeSH terms, synonyms, and keywords, with no language or date restriction. The reference lists of included articles were manually searched. STUDY SELECTION: Randomized controlled clinical trials comparing the effectiveness of HEMA-free and HEMA-containing adhesive systems in NCCL restorations were included...
July 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29648570/ret-fusions-a-novel-paradigm-in-colorectal-cancer
#19
C Santos, R Sanz-Pamplona, R Salazar
No abstract text is available yet for this article.
June 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29642999/treatment-of-stress-urinary-incontinence-after-prostatectomy-with-the-adjustable-transobturator-male-system-atoms%C3%A2-with-preattached-scrotal-port
#20
C Esquinas, I Arance, J Pamplona, A Moraga, J F Dorado, J C Angulo
INTRODUCTION: Stress urinary incontinence (SUI) is a significant sequela of prostate cancer surgery. In this article, we present the surgical technique and safety and efficacy of the adjustable transobturator male system (ATOMS®) with preattached scrotal port. MATERIAL AND METHOD: An open prospective study was conducted at a university hospital with the main objective of changing the baseline condition after adjustment in the daily pad count and their wet weight (pad test)...
April 8, 2018: Actas Urologicas Españolas
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