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Pediatric Asthma

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https://www.readbyqxmd.com/read/29667338/variation-in-the-tek-gene-is-not-associated-with-asthma-but-with-allergic-conjunctivitis
#1
L E Fodor, A Gézsi, Z Gál, A Nagy, A Kiss, A Bikov, C Szalai
The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Recently, variations in the TEK gene have been found associated with asthma. The objective of the present study was to investigate whether variations in the TEK gene influenced the susceptibility to pediatric asthma and/or associated phenotypes like GINA status, viral- or exercise-induced asthma, allergic asthma, indoor, outdoor, inhalative allergies, IgE and eosonophil levels, allergic rhinitis and allergic conjunctivitis...
April 18, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29664908/a-new-model-of-wheezing-severity-in-young-children-using-the-validated-isaac-wheezing-module-a-latent-variable-approach-with-validation-in-independent-cohorts
#2
Steven M Brunwasser, Tebeb Gebretsadik, Diane R Gold, Kedir N Turi, Cosby A Stone, Soma Datta, James E Gern, Tina V Hartert
BACKGROUND: The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) consortium. However, there is no consensus model for operationalizing wheezing severity with this instrument in explanatory research studies. Severity is typically measured using coarsely-defined categorical variables, reducing power and potentially underestimating etiological associations...
2018: PloS One
https://www.readbyqxmd.com/read/29657076/gasping-for-a-diagnosis-pediatric-vocal-cord-dysfunction
#3
Mariel Wenzel
Vocal cord dysfunction is an obstruction of the upper airway, primarily on inspiration, due to the paradoxical adduction of the vocal cords. Vocal cord dysfunction continues to be underdiagnosed as its own entity. The lack of diagnosis can be attributed to the overlap of symptoms between asthma and exercise-induced bronchospasm. It is possible for patients diagnosed with asthma and/or exercise-induced bronchospasm to have underlying vocal cord dysfunction, which needs to be considered when prescribing asthma medications...
April 13, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29653255/promoting-father-involvement-for-child-and-family-health
#4
REVIEW
Brandon S Allport, Sara Johnson, Anushka Aqil, Alain B Labrique, Timothy Nelson, Angela Kc, Yorghos Carabas, Arik V Marcell
Paternal involvement in children's lives is associated with a variety of child outcomes, from improved cognition and mental health to reduced obesity rates and asthma exacerbations. Given this evidence, the American Academy of Pediatrics has promoted actions by pediatricians to engage fathers in pediatric care. Despite these recommendations, the mother-child dyad remains a frequent focus of care, rather than the mother-father-child triad. Furthermore, pediatric care is often leveraged to improve maternal health, such as screening for maternal depression, but paternal health is infrequently addressed even as men tend to exhibit riskier behaviors, poorer primary care utilization, and lower life expectancy...
April 10, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29653238/the-pediatric-asthma-yardstick-practical-recommendations-for-a-sustained-step-up-in-asthma-therapy-for-children-with-inadequately-controlled-asthma
#5
Bradley E Chipps, Leonard B Bacharier, Judith R Farrar, Daniel J Jackson, Kevin R Murphy, Wanda Phipatanakul, Stanley J Szefler, W Gerald Teague, Robert S Zeiger
Current asthma guidelines recommend a control-based approach to management involving assessment of impairment and risk followed by implementation of treatment strategies individualized according to the patient's needs and preferences. However, for children with asthma, achieving control can be elusive. While tools are available to help children (and families) track and manage day-to-day symptoms, when and how to implement a longer-term step-up in care is less clear. Furthermore, treatment is challenged by the three age groups of childhood - adolescence (12-18 years old), school age (6-11 years old), and young children (≤ 5 years old), and what works for one age group may not be the best approach for another...
April 10, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29652870/surveillance-for-the-identification-of-cases-of-acute-respiratory-infection-by-enterovirus-d68-in-children-in-a-tertiary-level-care-hospital-during-2014-2016
#6
Ana Estela Gamiño-Arroyo, José Luis Sánchez-Huerta, Alicia Elhaín de la Garza-López, Israel Parra-Ortega, Noé Escobar-Escamilla, Edgar Mendieta-Condado, Fabiola Garcés-Ayala, Gisela Barrera-Badillo, José Ernesto Ramírez-González, José Alberto Díaz-Quiñonez, Daniela de la Rosa-Zamboni
Background: The reemergence of enterovirus D68 (EV-D68) infections in the United States was reported from August-October 2014 (691 cases). In Mexico, an outbreak at the National Institute of Respiratory Diseases was reported (24 cases). The results of epidemiological surveillance of Enterovirus sp. (EV) and other respiratory viruses in a national pediatric tertiary care level hospital are presented. Methods: Following the alert issued by the reemergence of EV-D68 in 2014, epidemiological surveillance -which only detected respiratory viruses by PCR in patients with influenza-like illness using nasopharyngeal swabs- expanded to include children with asthma exacerbation or acute respiratory distress...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29642713/house-dust-mite-sublingual-immunotherapy-for-pediatric-patients-with-allergic-asthma
#7
Jessika R Richards, Janice L Stumpf
OBJECTIVE: To review the published literature evaluating administration of house dust mite (HDM) sublingual immunotherapy (SLIT) in pediatric patients with allergic asthma. DATA SOURCES: PubMed database search (1966 to November 2017) using the search terms allergy, allergic rhinitis, asthma, allergic asthma, house dust mite, allergen immunotherapy, subcutaneous immunotherapy, sublingual immunotherapy, MK-8237, children, and pediatric. Package labeling and references from identified articles were also reviewed...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29629847/understanding-the-cognitive-and-affective-mechanisms-that-underlie-proxy-risk-perceptions-among-caregivers-of-asthmatic-children
#8
James A Shepperd, Nikolette P Lipsey, Thorsten Pachur, Erika A Waters
OBJECTIVE: Medical decisions made on behalf of another person-particularly those made by adult caregivers for their minor children-are often informed by the decision maker's beliefs about the treatment's risks and benefits. However, we know little about the cognitive and affective mechanisms influencing such "proxy" risk perceptions and about how proxy risk perceptions are related to prominent judgment phenomena. METHODS: Adult caregivers of minor children with asthma ( N = 132) completed an online, cross-sectional survey assessing 1) cognitions and affects that form the basis of the availability, representativeness, and affect heuristics; 2) endorsement of the absent-exempt and the better-than-average effect; and 3) proxy perceived risk and unrealistic comparative optimism of an asthma exacerbation...
April 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29626164/neighborhood-child-opportunity-and-individual-level-pediatric-acute-care-use-and-diagnoses
#9
Ellen E Kersten, Nancy E Adler, Laura Gottlieb, Douglas P Jutte, Sarah Robinson, Katrina Roundfield, Kaja Z LeWinn
: media-1vid110.1542/5751513300001PEDS-VA_2017-2309 Video Abstract OBJECTIVES: Although health care providers and systems are increasingly interested in patients' nonmedical needs as a means to improve health, little is known about neighborhood conditions that contribute to child health problems. We sought to determine if a novel, publicly available measure of neighborhood context, the Child Opportunity Index, was associated with pediatric acute care visit frequency and diagnoses. METHODS: This cross-sectional study included San Francisco residents <18 years of age with an emergency department and/or urgent care visit to any of 3 medical systems ( N = 47 175) between 2007 and 2011...
April 6, 2018: Pediatrics
https://www.readbyqxmd.com/read/29625664/challenges-in-the-treatment-of-asthma-in-children-and-adolescents
#10
REVIEW
Stanley J Szefler, Bradley Chipps
OBJECTIVE: Despite the availability of effective treatments, asthma control in children and adolescents remains inadequate and rates of health care use are high. This follow-up to a recent review (O'Byrne et al, Eur Respir J. 2017;50[3]) examines a number of challenges in current pediatric asthma management compared with that of an adult perspective and discusses possible alternative strategies that might improve pediatric asthma management and control. DATA SOURCES: The evidence base for this review is limited because, historically, much of the research has been performed in adults...
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29625590/guideline-on-management-of-the-acute-asthma-attack-in-children-by-italian-society-of-pediatrics
#11
REVIEW
Luciana Indinnimeo, Elena Chiappini, Michele Miraglia Del Giudice
BACKGROUND: Acute asthma attack is a frequent condition in children. It is one of the most common reasons for emergency department (ED) visit and hospitalization. Appropriate care is fundamental, considering both the high prevalence of asthma in children, and its life-threatening risks. Italian Society of Pediatrics recently issued a guideline on the management of acute asthma attack in children over age 2, in ambulatory and emergency department settings. METHODS: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology was adopted...
April 6, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29622722/inpatient-quality-improvement-interventions-for-asthma-a-meta-analysis
#12
REVIEW
Kavita Parikh, Susan Keller, Shawn Ralston
CONTEXT: Despite the availability of evidence-based guidelines for the management of pediatric asthma, health care utilization remains high. OBJECTIVE: Systematically review the inpatient literature on asthma quality improvement (QI) and synthesize impact on subsequent health care utilization. DATA SOURCES: Medline and Cumulative Index to Nursing and Allied Health Literature (January 1, 1991-November 16, 2016) and bibliographies of retrieved articles...
April 5, 2018: Pediatrics
https://www.readbyqxmd.com/read/29622002/does-specialist-physician-supply-affect-pediatric-asthma-health-outcomes
#13
Guido Filler, Tom Kovesi, Erik Bourdon, Sarah Ann Jones, Laurentiu Givelichian, Cheryl Rockman-Greenberg, Jason Gilliland, Marion Williams, Elaine Orrbine, Bruno Piedboeuf
BACKGROUND: Pediatrician and pediatric subspecialist density varies substantially among the various Canadian provinces, as well as among various states in the US. It is unknown whether this variability impacts health outcomes. To study this knowledge gap, we evaluated pediatric asthma admission rates within the 2 Canadian provinces of Manitoba and Saskatchewan, which have similarly sized pediatric populations and substantially different physician densities. METHODS: This was a retrospective cross-sectional cohort study...
April 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29617470/applicability-of-a-generic-questionnaire-for-quality-of-life-assessment-for-asthmatic-children
#14
Ana Aline Marcelino da Silva, Álvaro Campos Cavalcanti Maciel, Priscilla Rique Furtado, Renata Ramos Tomaz, Thalita Medeiros Fernandes de Macêdo, Karla Morganna Pereira Pinto de Mendonça
OBJECTIVE: To determine the applicability of the generic instrument Pediatric Quality of Life Inventory (PedsQL 4.0) to assess health-related quality of life of asthmatic children compared to the specific instrument Pediatric Asthma Quality of Life Questionnaire (PAQLQ). METHODS: This research involved the evaluation of 30 children aged seven to eleven years, who had been diagnosed with asthma for at least six months prior to research. Both quality of life questionnaires were applied to children by an interviewer over the period of one day...
March 29, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29615379/doxycycline-suppresses-chlamydia-pneumoniae-induced-interferon-gamma-responses-in-peripheral-blood-mononuclear-cells-in-children-with-allergic-asthma
#15
Tamar A Smith-Norowitz, Diana Weaver, Yitzchok M Norowitz, Margaret R Hammerschlag, Rauno Joks, Helen G Durkin, Stephan Kohlhoff
Persistent respiratory infections caused by Chlamydia pneumoniae have been implicated in the pathogenesis of chronic diseases (e.g. asthma). Antibiotics are used to treat C. pneumoniae respiratory infections; however, the use of antibiotics as anti-inflammatory agents in treatment of asthma remains controversial. The current study investigated whether ciprofloxacin, azithromycin, or doxycycline can suppress C. pneumoniae-induced production of immunoglobulin (Ig) E or cytokines in peripheral blood mononuclear cells (PBMC) obtained from asthmatic children...
March 31, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29605205/caregiver-and-pediatric-provider-perspectives-on-symptom-based-inhaled-corticosteroid-therapy-in-asthma
#16
Tiffany Dy, Ericka M Lewis, Vithya Murugan, Sarah Gehlert, Juanita Taylor, Jane Garbutt, Leonard B Bacharier, Mario Castro, Kaharu Sumino
OBJECTIVES: Guidelines recommend that healthcare providers adjust the dose of inhaled corticosteroids (ICS) in asthma patients based on the degree of symptom severity and control. Symptom-based, intermittent ICS therapy (use of ICS together with short acting bronchodilators- symptom-based adjustment: SBA) has been demonstrated to be comparable to guideline-based management by providers in controlled clinical trials. We sought input from African American caregivers and pediatricians on the acceptability and barriers for this alternative management strategy...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29597240/maternal-asthma-is-an-independent-risk-factor-for-long-term-respiratory-morbidity-of-the-offspring
#17
E Spiegel, I Shoham-Vardi, A Goldbart, R Sergienko, E Sheiner
OBJECTIVE:  The objective of this study was to investigate whether maternal bronchial asthma increases the risk for long-term respiratory morbidity of the offspring. STUDY DESIGN:  A population-based cohort study compared the incidence of long-term pediatric hospitalizations due to respiratory disease of the offspring of mothers with and without bronchial asthma. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center. Congenital malformations as well as multiple pregnancies were excluded...
March 29, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29592540/reported-problems-and-adherence-in-using-asthma-medications-among-adolescents-and-their-caregivers
#18
Betsy Sleath, Daniel Gratie, Delesha Carpenter, Scott A Davis, Charles Lee, Ceila E Loughlin, Nacire Garcia, Daniel S Reuland, Gail Tudor
BACKGROUND: Many factors affect youth adherence to asthma medications. Better understanding of the relationship between problems reported by youth in using asthma medications, self-efficacy, outcome expectations, and adherence is needed. OBJECTIVE: The study examined the relationship between youth and caregiver problems in using asthma medications, asthma management self-efficacy, outcome expectations, and youth- and caregiver-reported adherence to asthma controller medications...
March 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29590651/the-frequency-of-nonsteroidal-anti-inflammatory-drug-hypersensitivity-in-children-with-asthma
#19
Hakan Guvenir, Emine Dibek Misirlioglu, Murat Capanoglu, Betul Buyuktiryaki, Zeynep Reyhan Onay, Tayfur Ginis, Muge Toyran, Ersoy Civelek, Can Naci Kocabas
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the second-most frequent drug type to cause hypersensitivity reactions in children. Asthma is one of the risk factors for NSAID hypersensitivity (NSAID-H) in adult patients. There are limited number of studies evaluating NSAID-H among children with asthma. Our aim was to assess the frequency of confirmed NSAID-H and evaluate the classification of NSAID-H in children with asthma. METHODS: Patients followed with a diagnosis of asthma in our Pediatric Allergy Clinic were evaluated for NSAID-H...
March 28, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29575773/non-invasive-ventilation-practices-in-children-across-europe
#20
Juan Mayordomo-Colunga, Martí Pons-Òdena, Alberto Medina, Corsino Rey, Christophe Milesi, Merja Kallio, Andrea Wolfler, Mireia García-Cuscó, Demet Demirkol, Milagros García-López, Peter Rimensberger
OBJECTIVES: To describe the diversity in practice in non-invasive ventilation (NIV) in European pediatric intensive care units (PICUs). WORKING HYPOTHESIS: No information about the use of NIV in Pediatrics across Europe is currently available, and there might be a wide variability regarding the approach. STUDY DESIGN: Cross-sectional electronic survey. METHODOLOGY: The survey was distributed to the ESPNIC mailing list and to researchers in different European centers...
March 24, 2018: Pediatric Pulmonology
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