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Ptsd And Cancer

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https://www.readbyqxmd.com/read/30098393/rates-and-risk-factors-for-post-traumatic-stress-disorder-symptomatology-among-adult-hematopoietic-cell-transplant-recipients-and-their-informal-caregivers
#1
Jessica Liang, Stephanie J Lee, Barry E Storer, Bronwen E Shaw, Eric J Chow, Mary E Flowers, Elizabeth F Krakow, Merav Bar, Karen L Syrjala, Rachel B Salit, Chareeni E Kurukulasuriya, Heather S L Jim
BACKGROUND: Hematopoietic cell transplant (HCT) can cause significant distress in patients and their informal caregivers. Despite advances in reduced intensity conditioning and supportive care, few recent studies have reported rates of clinically-significant post-traumatic stress disorder symptomatology (hereafter referred to as PTSD). Goals of the current study were to: 1) examine rates of PTSD and distress in patients and caregivers and 2) identify sociodemographic and clinical risk factors for PTSD...
August 8, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29955975/ambivalence-over-emotional-expression-and-physical-functioning-and-limitations-mediating-and-moderating-effects-of-ptsd-symptoms-and-acculturation-among-chinese-breast-cancer-survivors
#2
Ivan H C Wu, Lorna H McNeill, Qian Lu
OBJECTIVE: The psychosocial correlates of physical functioning and limitations are not well-known among Chinese breast cancer survivors. Previous research suggests a link between ambivalence over emotional expression (AEE) and physical functioning. The current study built upon this research by examining post-traumatic stress symptoms (PTSS) as a mechanism. Further, we also examined the moderating effects of mainstream cultural orientation. To this end, we tested study hypotheses using moderated mediation models...
June 29, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29905935/symptoms-of-posttraumatic-stress-disorder-among-hospitalized-patients-with-cancer
#3
Ryan D Nipp, Areej El-Jawahri, Sara M D'Arpino, Andy Chan, Charn-Xin Fuh, P Connor Johnson, Daniel E Lage, Risa L Wong, William F Pirl, Lara Traeger, Barbara J Cashavelly, Vicki A Jackson, David P Ryan, Ephraim P Hochberg, Jennifer S Temel, Joseph A Greer
BACKGROUND: Patients with cancer experience many stressors placing them at risk for posttraumatic stress disorder (PTSD) symptoms, yet little is known about factors associated with PTSD symptoms in this population. This study explored relationships among patients' PTSD symptoms, physical and psychological symptom burden, and risk for hospital readmissions. METHODS: We prospectively enrolled patients with cancer admitted for an unplanned hospitalization from August 2015-April 2017...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29901408/pain-is-associated-with-continuing-depression-in-cancer-survivors
#4
Patricia M Bamonti, Jennifer Moye, Aanand D Naik
Depression is common but under-diagnosed in cancer survivors. This study characterized depressive symptoms over one year in cancer survivors and examined disease-related and psychosocial predictors of depression severity. Participants (n = 122; Mage 65.33, SD = 9.17, 98.4% male) with head and neck, esophageal, gastric, or colorectal cancers were recruited through tumor registries at two regional Veterans Administration Medical Centers. Self-report measures assessing depressive symptoms (PHQ-9), combat-related PTSD symptoms (PC-PTSD), and health-related quality of life (PROMIS) were administered at six, twelve, and eighteen months after diagnosis...
June 14, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29863965/psychosocial-factors-associated-with-posttraumatic-stress-and-growth-in-australian-women-with-ovarian-cancer
#5
Lyndel K Shand, Joanne E Brooker, Sue Burney, Jane Fletcher, Lina A Ricciardelli
The study examined psychosocial factors (quality of life, depression, anxiety, optimism, coping, and social support) in relation to symptoms of posttraumatic stress disorder (PTSD) and posttraumatic growth (PTG) in 108 women diagnosed with ovarian cancer. Canonical correlational analysis showed that both PTSD and PTG were related to poorer quality of life, lack of social supports, and avoidant coping styles. However, higher PTG was also associated with the use of meaning and social support to cope with their experience...
June 4, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29674970/hypothesis-the-psychedelic-ayahuasca-heals-traumatic-memories-via-a-sigma-1-receptor-mediated-epigenetic-mnemonic-process
#6
Antonio Inserra
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N -Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29628046/mechanisms-underlying-the-effects-of-n-3-polyunsaturated-fatty-acids-on-fear-memory-processing-and-their-hypothetical-effects-on-fear-of-cancer-recurrence-in-cancer-survivors
#7
REVIEW
R Okubo, C Chen, M Sekiguchi, K Hamazaki, Y J Matsuoka
The relationship of n-3 polyunsaturated fatty acids (PUFAs) and gut microbiota with brain function has been extensively reported. Here, we review how n-3 polyunsaturated fatty acids affect fear memory processing. n-3 PUFAs may improve dysfunctional fear memory processing via immunomodulation/anti-inflammation, increased BDNF, upregulated adult neurogenesis, modulated signal transduction, and microbiota-gut-brain axis normalization. We emphasize how n-3 PUFAs affect this axis and also focus on the hypothetical effects of PUFAs in fear of cancer recurrence (FCR), the primary psychological unmet need of cancer survivors...
April 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29590473/disability-rating-age-at-death-and-cause-of-death-in-u-s-veterans-with-service-connected-conditions
#8
Charles Maynard, Ranak Trivedi, Karin Nelson, Stephan D Fihn
Introduction: The association between disability and cause of death in Veterans with service-connected disabilities has not been studied. The objective of this study was to compare age at death, military service and disability characteristics, including disability rating, and cause of death by year of birth. We also examined cause of death for specific service-connected conditions. Materials and methods: This study used information from the VETSNET file, which is a snapshot of selected items from the Veterans Benefits Administration corporate database...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29546528/post-traumatic-stress-in-head-and-neck-cancer-survivors-and-their-partners
#9
Elisavet Moschopoulou, Iain Hutchison, Kamaldeep Bhui, Ania Korszun
PURPOSE: Head and neck cancer (HNC) diagnosis and treatment are distressing and have immediate detrimental impacts on functioning and quality of life (QoL). Nevertheless, little is known about long-term psychosocial effects. The aim of this study was to determine the prevalence and correlates of clinical post-traumatic stress disorder (PTSD) and subclinical post-traumatic stress symptoms (PTSS) in HNC patients surviving more than 2 years since treatment and in their partners. METHODS: HNC survivors identified from the cancer registry of a London hospital and their partners completed measures of PTSS, depression and anxiety, fear of cancer recurrence, social support, appearance concerns and health-related QoL...
March 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29532498/posttraumatic-stress-disorder-and-mortality-in-va-patients-with-implantable-cardioverter-defibrillators
#10
Peter Ofman, Peter Hoffmeister, Danny G Kaloupek, David R Gagnon, Adelqui Peralta, Luc Djousse, J Michael Gaziano, Catherine R Rahilly-Tierney
BACKGROUND: The association between posttraumatic stress disorder (PTSD) and mortality in patients undergoing implantable cardioverter-defibrillator (ICD) placement has not been evaluated in US veterans. HYPOTHESIS: PTSD in veterans with ICD is associated with increased mortality. METHODS: We studied a retrospective cohort of 25 678 veterans who underwent ICD implantation between September 30, 2002, and December 31, 2011. Of these subjects, 3280 carried the diagnosis of PTSD prior to ICD implantation...
May 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29492967/the-solace-of-an-uncertain-future-acute-illness-the-self-and-self-care
#11
Kaethe Weingarten, Miranda Worthen
"Take care of yourself" may be one of the most ubiquitous phrases spoken to people who are ill or to their caretakers. Yet few people who offer it as a balm consider what the self experience is of the person to whom the injunction is offered. We unravel some of the paradoxes inherent in the phrase, illustrating complexities that arise in the context of a life-threatening diagnosis. To illustrate the relational nature of the self, we analyze a partial transcript of an interview conducted in 1988 with the authors-a family therapist mother who had recently undergone surgery for breast cancer and her then 9-year-old daughter...
June 2018: Family Process
https://www.readbyqxmd.com/read/29427193/knowledge-and-perceptions-of-infertility-in-female-cancer-survivors-and-their-parents
#12
Taryn Sandheinrich, Sarah B Wondmeneh, Caroline Mohrmann, Katie Gettinger, Jennifer Henry, Robert J Hayashi
PURPOSE: The purpose of this study was to assess knowledge and perceptions of infertility, reproductive concerns, quality of life, and emotional burden of fertility concerns in adolescent female cancer survivors and their parents. METHODS: A cross-sectional design was used to investigate reproductive knowledge and concerns among female childhood cancer survivors and their parents. The instruments administered at a single, routine visit were the 13-item knowledge instrument, Adolescent Fertility Values Clarification Tool (VCT), Impact of Event Scale (IES), and Pediatrics Quality of Life Assessment (PedsQL)...
July 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29152719/course-and-predictors-of-post-traumatic-stress-disorder-in-a-cohort-of-psychologically-distressed-patients-with-cancer-a-4-year-follow-up-study
#13
Caryn Mei Hsien Chan, Chong Guan Ng, Nur Aishah Taib, Lei Hum Wee, Edward Krupat, Fremonta Meyer
BACKGROUND: Scant evidence exists on the long-term course of cancer-related post-traumatic stress disorder (PTSD). This is among the few studies worldwide, and the first in the South-East Asian region, to prospectively evaluate PTSD in patients with cancer using gold-standard clinical interviews. The objective of the study was to assess the course and predictors of PTSD in adult patients with cancer in a South-East Asian population. METHODS: A prospective, longitudinal study was conducted in a cohort of 469 consecutively recruited patients (aged ≥18 years) with various cancer types within 1 month of diagnosis at a single oncology referral center...
January 15, 2018: Cancer
https://www.readbyqxmd.com/read/29147881/childhood-cancer-and-brain-tumor-late-effects-relationships-with-family-burden-and-survivor-psychological-outcomes
#14
Melissa K Cousino, Rebecca Hazen, Katherine Leigh Josie, Kelly Laschinger, Peter de Blank, H Gerry Taylor
This study examines illness-specific family burden as a mediator of the association between late effects of childhood cancer and survivors' emotional and behavioral outcomes. Childhood cancer survivors (n = 65; ages 10-17) two or more years off-treatment completed measures assessing internalizing and PTSD symptoms. Parents reported on illness-specific family burden, late effects severity, and survivor internalizing/externalizing problems. Providers documented the number of late effects. Illness-specific family burden was correlated with provider-reported late effects (r = ...
December 2017: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29101712/posttraumatic-stress-related-psychological-functioning-in-adult-survivors-of-childhood-cancer
#15
Jennifer Allen, Victoria W Willard, James L Klosky, Chenghong Li, D Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Sean Phipps
PURPOSE: The majority of research examining posttraumatic stress symptoms/disorder (PTSS/PTSD) among adult survivors of childhood cancer has been oriented to cancer, assuming that cancer has been the most traumatic experience in their lives. Whether that assumption is valid, and how it might impact assessment of PTSS, is unknown. METHODS: Survivors in the St. Jude Lifetime Cohort study completed an assessment of PTSS without cancer orientation, global psychological functioning, perceived stress, and cancer-related anxiety...
April 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29042341/pain-self-management-for-veterans-development-and-pilot-test-of-a-stage-based-mobile-optimized-intervention
#16
Sara S Johnson, Deborah A Levesque, Lynne E Broderick, Dustin G Bailey, Robert D Kerns
BACKGROUND: Chronic pain is a significant public health burden affecting more Americans than cardiovascular disease, diabetes, and cancer combined. Veterans are disproportionately affected by chronic pain. Among previously deployed soldiers and veterans, the prevalence of chronic pain is estimated between 44% and 60%. OBJECTIVE: The objective of this research was to develop and pilot-test Health eRide: Your Journey to Managing Pain, a mobile pain self-management program for chronic musculoskeletal pain for veterans...
October 17, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29030020/the-trajectory-of-positive-psychological-change-in-a-head-and-neck-cancer-population
#17
S A Harding
A stressful event may be sufficient to challenge a strongly held set of assumptions about the world and the self. In some people this may lead to post-traumatic stress disorder (PTSD) and in others to positive psychological change (PPC), whereby a person's reactions to the challenge are beneficial. Little research has investigated PPC in people who have had head and neck cancer (HNC). The aim of this study was to identify demographic, clinical, and psychological factors associated with PPC over time. A cross-sequential study collected data over 5 years...
May 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28966544/posttraumatic-symptoms-quality-of-life-and-survival-among-lung-cancer-patients
#18
Angela Liegey Dougall, Jeffrey Swanson, Yasushi Kyutoku, Chandra P Belani, Andrew Baum
PURPOSE: This longitudinal study characterized psychological adjustment in a sample of lung cancer patients by examining the occurrence of posttraumatic stress and growth and their relationships with mental and physical health quality of life and survival over time. METHODS: Two waves of consecutive cohort samples, totaling 115 participants diagnosed with lung cancer, were identified from outpatient oncology clinics. Of these, 93 consented and completed the first of three assessments, and 57 completed the study...
September 2017: Journal of Applied Biobehavioral Research
https://www.readbyqxmd.com/read/28926288/effect-of-inpatient-palliative-care-during-hematopoietic-stem-cell-transplant-on-psychological-distress-6-months-after-transplant-results-of-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Areej El-Jawahri, Lara Traeger, Joseph A Greer, Harry VanDusen, Sarah R Fishman, Thomas W LeBlanc, William F Pirl, Vicki A Jackson, Jason Telles, Alison Rhodes, Zhigang Li, Thomas R Spitzer, Steven McAfee, Yi-Bin A Chen, Jennifer S Temel
Purpose Inpatient palliative care integrated with transplant care improves patients' quality of life (QOL) and symptom burden during hematopoietic stem-cell transplant (HCT). We assessed patients' mood, post-traumatic stress disorder (PTSD) symptoms, and QOL 6 months post-transplant. Methods We randomly assigned 160 patients with hematologic malignancies who underwent autologous or allogeneic HCT to inpatient palliative care integrated with transplant care (n = 81) or transplant care alone (n = 79). At baseline and 6 months post-transplant, we assessed mood, PTSD symptoms, and QOL with the Hospital Anxiety and Depression Scale and Patient Health Questionnaire, PTSD checklist, and Functional Assessment of Cancer Therapy-Bone Marrow Transplant...
November 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28884427/effect-of-oleuropein-on-cognitive-deficits-and-changes-in-hippocampal-brain-derived-neurotrophic-factor-and-cytokine-expression-in-a-rat-model-of-post-traumatic-stress-disorder
#20
Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm
Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. This psychopathological response to traumatic stressors induces learning and memory deficits in rats. Oleuropein (OLE), a major compound in olive leaves, has been reported to possess several pharmacological properties, including anti-cancer, anti-diabetic, anti-atherosclerotic and neuroprotective activities. However, the cognitive effects of OLE and its mechanism of action have remained unclear in PTSD...
January 2018: Journal of Natural Medicines
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