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https://www.readbyqxmd.com/read/30327961/aggressive-resuscitation-is-associated-with-the-development-of-acute-kidney-injury-in-acute-pancreatitis
#1
Bo Ye, Wenjian Mao, Yuhui Chen, Zhihui Tong, Gang Li, Jing Zhou, Lu Ke, Weiqin Li
INTRODUCTION: The association between early resuscitation volume and clinical outcomes remains controversial in acute pancreatitis. In the present study, we aimed to identify the association between resuscitation volume and the development of acute kidney injury (AKI) and other clinical outcome metrics. METHODS: Patients admitted to our center with moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP) from January 2009 to December 2013 were reviewed retrospectively...
October 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30326714/peste-des-petits-ruminants-virus-infection-of-black-bengal-goats-showed-altered-haematological-and-serum-biochemical-profiles
#2
Shahana Begum, Mohammed Nooruzzaman, Murshida Parvin, Nijaya Mohanto, Rokshana Parvin, Mohammad R Islam, Emdadul H Chowdhury
In Bangladesh, veterinarians often claim to reduce the mortality of natural peste des petits ruminants (PPR) outbreaks with the help of supportive fluid and electrolyte therapy. Information on haematological and biochemical parameters of PPR-infected goats, which is often altered because of associated tissue damages, is necessary to formulate the appropriate supportive therapy. This study determined the haematological and serum biochemical parameters of Black Bengal goats naturally infected with PPR virus...
October 15, 2018: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/30326148/diabetic-nephropathy-after-kidney-transplantation-in-patients-with-pre-transplantation-type-ii-diabetes-a-retrospective-case-series-study-from-a-high-volume-center-in-the-united-states
#3
Arielle Cimeno, Jennifer Munley, Cinthia Drachenberg, Matthew Weir, Abdolreza Haririan, Jonathan Bromberg, Rolf N Barth, Joseph R Scalea
BACKGROUND: Patients with type II diabetes mellitus (DM) undergoing renal transplantation are at risk of diabetic nephropathy (DN) in the transplanted kidney. The true risk of developing post-transplantation DN is unknown, and post-transplantation DN is poorly characterized in the literature. METHODS: The biopsy database at the University of Maryland Medical Center was queried for kidney transplant biopsies which demonstrated evidence of DN. The time from transplantation to biopsy-proven DN (time to diagnosis, TTD) was calculated and analyzed in the context of demographics, serum creatinine, and onset of diabetes...
October 16, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30322799/impacts-of-diabetes-and-an-sglt2-inhibitor-on-the-glomerular-number-and-volume-in-db-db-mice-as-estimated-by-synchrotron-radiation-micro-ct-at-spring-8
#4
Yumi Takiyama, Toshihiro Sera, Masanori Nakamura, Kanaki Ishizeki, Yasuaki Saijo, Tsuyoshi Yanagimachi, Manami Maeda, Ryoichi Bessho, Takao Takiyama, Hiroya Kitsunai, Hidemitsu Sakagami, Daisuke Fujishiro, Yukihiro Fujita, Yuichi Makino, Atsuko Abiko, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Tsuguhito Ota, Masakazu Haneda
BACKGROUND: Recent large-scale clinical studies demonstrate that sodium-glucose cotransporter 2 (SGLT2) inhibitors protect the diabetic kidney. However, clinical and animal studies have not shown the changes of the total glomeruli in the whole kidney treated with SGLT2 inhibitors. METHODS: We performed computed tomography (CT) imaging on mice using synchrotron radiation to investigate the impact of luseogliflozin, a SGLT2 inhibitor, on the number and volume of glomeruli in the whole kidney...
October 12, 2018: EBioMedicine
https://www.readbyqxmd.com/read/30318563/accuracy-and-reproducibility-of-simplified-qspect-dosimetry-for-personalized-177-lu-octreotate-prrt
#5
Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler, Jean-Mathieu Beauregard
BACKGROUND: Routine dosimetry is essential for personalized 177 Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinical adoption. The aim of this study was to assess the accuracy and inter-observer reproducibility of simplified dosimetry protocols based on quantitative single-photon emission computed tomography (QSPECT) with a limited number of scanning time points. We also updated our personalized injected activity (IA) prescription scheme...
October 15, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30317531/human-adipose-tissue-derived-stromal-cells-attenuate-the-multiple-organ-injuries-induced-by-sepsis-and-mechanical-ventilation-in-mice
#6
Shuya Mei, Shuang Wang, Shuqing Jin, Xiang Zhao, Zhenzhen Shao, Renlingzi Zhang, Xiangsheng Yu, Yao Tong, Shibiao Chen, Zhixia Chen, Quan Li
Mechanical ventilation (MV) can augment sepsis-induced organ injury. Previous studies indicate that human mesenchymal stem cells (hMSCs) have immune-modulatory effect. We hypothesize that human adipose tissue-derived stromal cells (hADSCs) could attenuate MV and sepsis-induced organ injury. Male C57BL/6 mice were randomized to five groups: Sham group; MV group; cecal ligation and puncture (CLP) group; CLP + MV group; and CLP + MV + hADSC group. Anesthetized mice were subjected to cecal ligation and puncture surgery...
October 13, 2018: Inflammation
https://www.readbyqxmd.com/read/30316941/heart-failure-outcomes-with-volume-guided-management
#7
John E Strobeck, Jonathan Feldschuh, Wayne L Miller
OBJECTIVES: This study performed a retrospective outcome analyses of a large cohort of mixed ejection fraction patients admitted for acute heart failure (HF), whose inpatient care was guided by individual quantitative blood volume analysis (BVA) results. BACKGROUND: Decongestion strategies in patients hospitalized for HF are based on clinical assessment of volume and have not integrated a quantitative intravascular volume metric. METHODS: Propensity score control matching analysis was performed in 245 consecutive HF admissions to a community hospital (September 2007 to April 2014; 78 ± 10 years of age; 50% with HF with reduced ejection fraction [HFrEF]; and 30% with Stage 4 chronic kidney disease)...
October 4, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/30315631/clinical-implication-of-renal-allograft-volume-to-recipient-body-surface-area-ratio-in-pediatric-renal-transplant
#8
Michael E Chua, Jin Kyu Kim, Michele Gnech, Jessica M Ming, Bisma Amir, Nicolas Fernandez, Armando J Lorenzo, Walid A Farhat, Diane Hebert, Joana Dos Santos, Martin A Koyle
Our study aims to assess the clinical implication of RAV/rBSA ratio in PRT as a predictor for attained renal function at 1 year post-transplantation and its association with surgical complications. A retrospective cohort was performed for PRT cases from January 2000 to December 2015 in our institution. Extracted clinical information includes the recipient's demographics, donor type, renal allograft characteristics, arterial, venous and ureteral anastomoses, vascular anastomosis time while kidney off ice, overall operative time, and estimated blood loss...
October 12, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/30312449/con-tolvaptan-for-autosomal-dominant-polycystic-kidney-disease-do-we-know-all-the-answers
#9
Peter Gross, Holger Schirutschke, Alexander Paliege
According to recent literature, tolvaptan ameliorates the natural decline of renal function in autosomal dominant polycystic kidney disease. Tolvaptan is an orally available vasopressin V2 receptor antagonist. We describe herein the remaining questions and problems: it is unclear from the published work what influence tolvaptan has on total kidney volume. The consequences of hepatotoxicity for the subsequent dosing of tolvaptan have not been reported. A vasopressin V2 antagonist will cause polyuria and polydipsia and tolvaptan may influence quality of life (QOL), however, there are no QOL data...
October 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30311649/antidiabetic-antihyperlipidemic-and-antioxidant-activities-of-mulberry-lees-fermented-products-in-diabetic-mice
#10
JeanYu Hwang, Den-En Shieh, Yung-Shin Shyu, Cheng-Kuang Hsu, Chuan-Wang Lin
Mulberry lees are the sediment in the bottom of the barrel, which can be obtained from the processing of mulberry wine, and they are considered as low-value byproducts. In this study, mulberry lees were extracted with ethanol, and then fermented with Monascus pilosus to obtain fermented products (M × M). Male ICR mice were diabetes induced by STZ, and then oral administration of fermented products. The results showed that fermented products could reduce 31.9% to 47.9% plasma glucose, 25.8% to 48.2% total cholesterol, and 16...
October 12, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/30309449/relationships-between-abdominal-aortic-calcification-glomerular-filtration-rate-and-cardiovascular-risk-factors-in-patients-with-non-dialysis-dependent-chronic-kidney-disease
#11
Yunan Zhou, Matthias Hellberg, Evangelia Kouidi, Asterios Deligiannis, Peter Höglund, Naomi Clyne
BACKGROUND: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. MATERIALS AND METHODS: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22...
October 12, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30306364/estimation-of-sodium-and-chloride-storage-in-critically-ill-patients-a-balance-study
#12
Lara Hessels, Annemieke Oude Lansink-Hartgring, Miriam Zeillemaker-Hoekstra, Maarten W Nijsten
BACKGROUND: Nonosmotic sodium storage has been reported in animals, healthy individuals and patients with hypertension, hyperaldosteronism and end-stage kidney disease. Sodium storage has not been studied in ICU patients, who frequently receive large amounts of sodium chloride-containing fluids. The objective of our study was to estimate sodium that cannot be accounted for by balance studies in critically ill patients. Chloride was also studied. We used multiple scenarios and assumptions for estimating sodium and chloride balances...
October 11, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/30301693/three-dimensional-image-fusion-is-associated-with-lower-radiation-exposure-and-shorter-time-to-carotid-cannulation-during-carotid-artery-stenting
#13
Nicholas J Swerdlow, Douglas W Jones, Alexander B Pothof, Thomas F X O'Donnell, Patric Liang, Chun Li, Mark C Wyers, Marc L Schermerhorn
OBJECTIVE: Three-dimensional (3D) image fusion is associated with lower radiation exposure, contrast agent dose, and operative time during endovascular abdominal aortic aneurysm repair. Therefore, we evaluated the impact of this technology on carotid artery stenting (CAS). METHODS: We identified consecutive CAS procedures from 2009 to 2017 and compared those performed with and without 3D image fusion. For image fusion, we created a 3D reconstruction of the aortic arch anatomy based on preoperative computed tomography or magnetic resonance angiography that we merged with two-dimensional fluoroscopy, allowing 3D image overlay...
October 6, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30299374/perfusion-of-porcine-kidneys-with-macromolecular-heparin-reduces-early-ischemia-reperfusion-injury
#14
Amir Sedigh, Sofia Nordling, Fredrik Carlsson, Erik Larsson, Bo Norlin, Norbert Lübenow, Fredrik Lennmyr, Gunnar Tufveson, Peetra U Magnusson, Tomas Lorant
BACKGROUND: Previously we have been able to demonstrate the possibility of coating the inner surface of the renal arteries in porcine kidneys with a heparin conjugate during hypothermic machine perfusion (HMP). The purpose of this study was to assess the efficacy of this treatment in reducing early ischemia-reperfusion injury. METHOD: Brain death was induced in male landrace pigs by stepwise volume expansion of an epidural balloon catheter until negative cerebral perfusion pressure was obtained...
October 6, 2018: Transplantation
https://www.readbyqxmd.com/read/30293657/chronic-kidney-disease-as-a-possible-predictor-of-left-atrial-thrombogenic-milieu-among-patients-with-nonvalvular-atrial-fibrillation
#15
Shun Kizawa, Takahide Ito, Kanako Akamatsu, Noboru Ichihara, Shimpei Nogi, Masatoshi Miyamura, Yumiko Kanzaki, Koichi Sohmiya, Masaaki Hoshiga
Patients with chronic kidney disease (CKD) experiencing atrial arrhythmia are hypothesized to have elevated CHADS2 and CHA2 DS2 -VASc scores, thereby predisposed to left atrial (LA) thrombus formation and subsequent thromboembolism. We examined possible association of LA thrombogenic milieu (TM) with CKD in patients with nonvalvular atrial fibrillation. A total of 581 patients (181 women; mean age, 67 years) who underwent transesophageal echocardiography were examined. Patients were divided into 4 groups based on the estimated glomerular filtration rate (eGFR) (ml/min/1...
September 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30276919/renal-perfusion-parameters-measured-by-contrast-enhanced-ultrasound-in-healthy-dogs-demonstrate-a-wide-range-of-variability-in-the-long-term
#16
Daisy J X Liu, Myriam Hesta, Emmelie Stock, Evelien Bogaerts, Bart J G Broeckx, Jimmy H Saunders, Katrien Vanderperren
Contrast-enhanced ultrasound may be helpful for detecting early renal microvascular damage and dysfunction in dogs. However, before this noninvasive imaging method can be tested as an early-stage screening tool in clinical patients, an improved understanding of long-term variation in healthy animals is needed. In this prospective, secondary, longitudinal, serial measurements study, variability of contrast-enhanced ultrasound renal perfusion parameters was described for eight healthy dogs, using seven time points and a period of 83 weeks...
October 1, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/30274753/impact-of-vascular-access-on-the-development-of-contrast-induced-nephropathy-in-patients-undergoing-coronary-angiography-and-or-percutaneous-coronary-intervention
#17
Lucia Barbieri, Monica Verdoia, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Contrast induced nephropathy (CIN) is a common complication of procedures that foresee the use of contrast media. Several risk factors have been identified as independent predictors of CIN, but, to date, no definitive data are available about the association between the angiographic approach and its development. METHODS AND RESULTS: Our population included 4199 patients undergoing coronary angiography and/or PCI. CIN was defined as an absolute ≥0.5 mg/dl or a relative ≥25% increase in creatinine level at 24-48 h after the procedure without another clear cause for the acute kidney injury...
August 10, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30269828/recanalization-of-chronic-total-occlusions-in-patients-with-vs-without-chronic-kidney-disease-the-impact-of-contrast-induced-acute-kidney-injury
#18
Lorenzo Azzalini, Soledad Ojeda, Ozan M Demir, Joseph Dens, Masaki Tanabe, Alessio La Manna, Susanna Benincasa, Barbara Bellini, Enrico Poletti, Davide Maccagni, Francisco Hidalgo, Jorge Chavarría, Joren Maeremans, Giacomo Gravina, Eligio Miccichè, Guido D'Agosta, Giuseppe Venuti, Corrado Tamburino, Manuel Pan, Mauro Carlino, Antonio Colombo
BACKGROUND: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is associated with high contrast volumes, which can be particularly deleterious in patients with chronic kidney disease (CKD). We aimed to study the outcomes of CTO PCI in subjects with vs without CKD, and the impact of contrast-induced acute kidney injury (CI-AKI). METHODS: This multicentre registry included patients who underwent CTO PCI at 5 centres. CI-AKI was defined as an increase in serum creatinine ≥0...
October 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/30260084/dosing-recommendations-based-on-population-pharmacokinetics-of-tacrolimus-in-mexican-adult-patients-with-kidney-transplant
#19
Reséndiz-Galván Juan Eduardo, Medellín-Garibay Susanna Edith, Milán-Segovia Rosa Del Carmen, Niño-Moreno Perla Del Carmen, Isordia-Segovia Javier, Romano-Moreno Silvia
The aim of this study was to perform a population pharmacokinetic analysis of tacrolimus in adult Mexican kidney transplant to analyse the influence of clinical and genetic covariates to propose a dosage regimen. Kidney transplant patients (>18 years old) receiving oral tacrolimus treatment were included in the current study. The population pharmacokinetic model was built using a one-compartment model and the First-Order Conditional method with Interaction (FOCEI via NONMEM (v.7.3). A total of 600 tacrolimus trough blood concentrations from 52 kidney transplant patients were analysed...
September 27, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/30255600/volume-of-urea-cleared-as-a-therapy-dosing-guide-for-more-frequent-hemodialysis
#20
John K Leypoldt, Eric D Weinhandl, Allan J Collins
With dialysis delivery systems that operate at low dialysate flow rates, prescriptions for more frequent hemodialysis (HD) employ dialysate volume as the primary parameter for small solute removal rather than blood-side urea dialyzer clearance (K). Such delivery systems, however, yield dialysate concentrations that almost completely saturate with blood (water), suggesting that the volume of urea cleared (the product of K and treatment time or Kt) can be readily estimated from the prescribed dialysate volume to target small solute removal...
September 25, 2018: Hemodialysis International
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