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https://www.readbyqxmd.com/read/30113226/antibiotic-utilization-prior-to-endourological-surgery-for-urolithiasis-endourological-society-survey-results
#1
Evan Clayton Carlos, Ramy F Youssef, Adam Geoffrey Kaplan, Daniel Arthur Wollin, Brenton B Winship, Brian H Eisner, Roger L Sur, Glenn M Preminger, Michael Eric Lipkin
INTRODUCTION: Ureteroscopy(URS) and percutaneous nephrolithotomy(PNL) are common procedures performed to treat kidney stones. Despite advances in technology/technique, serious infectious complications can occur. To better understand preoperative antibiotic administration patterns and adherence to guidelines from the American Urological Association(AUA) and the European Association of Urology(EAU), members of the Endourological Society were sent a clinical vignette-based survey to assess antibiotic use in a variety of pre-URS and pre-PNL scenarios...
August 16, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/30111020/-study-on-dryness-effect-of-atractylodis-rhizoma-based-on-theory-of-dry-dry-and-dryness-induced-yin-deficiency
#2
Ling-Hang Qu, Ji-Yuan Tu, Guo-Sheng Cao, Jia-Wen Zhao, Xu-Ling Pan, Yan-Ju Liu
In order to establish a more perfect evaluation system for dryness effect of Atractylodis Rhizoma, determine the main dry parts of Atractylodis Rhizoma,and further define the mechanism of stir-baked Atractylodis Rhizoma in reducing the dryness. The healthy rats were given with different doses of water extract and volatile oil of raw Atractylodis Rhizoma and stir-baked Atractylodis Rhizoma for 21 days. Based on the theory of the dry-dry and dryness-induced Yin deficiency, the amount of drinking water, tissue morphology of submandibular glands, urine volume and the expression of aquaporin 2 (AQP2) in the kidneys, as well as blood rheology, ratio of cAMP/cGMP in serum and the content of Na⁺-K⁺-ATP enzyme were selected as the evaluation indexes...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/30105257/the-incidence-and-risk-factors-of-acute-kidney-disease-after-total-knee-arthroplasty-with-early-postoperative-volume-supplement
#3
Kuan-Ting Wu, Chung-Yang Chen, Bradley Chen, Jun-Wen Wang, Po-Chun Lin, Shih-Hsiang Yen
Background: Etiology of acute kidney disease (AKD) after total knee arthroplasty (TKA) was considered as multifactorial. However, the role of early postoperative volume supplement in AKD rate has not been investigated. The purpose of this study was to evaluate the incidence and risk factors of AKD in patients with early volume supplement following TKA. Methods: This was a retrospective study with 458 patients who underwent unilateral TKA. All the patients received 6% tetrastarch, 7...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30098418/the-trabecular-bone-score-relationships-with-trabecular-and-cortical-microarchitecture-measured-by-hr-pqct-and-histomorphometry-in-patients-with-chronic-kidney-disease
#4
J Ramalho, I D B Marques, Didier Hans, David Dempster, Hua Zhou, Parth Patel, R M R Pereira, V Jorgetti, R M A Moyses, Thomas L Nickolas
The trabecular bone score (TBS) is a novel tool using grayscale variograms of the lumbar spine bone mineral density (BMD) to assess trabecular bone microarchitecture. Studies in patients with chronic kidney disease (CKD) suggest it may be helpful in assessing fracture risk. However, TBS has not been validated as a measure of trabecular architecture against transiliac bone biopsy with histomorphometry in CKD patients. We hypothesized that TBS would reflect trabecular architecture at the iliac crest in CKD patients...
August 8, 2018: Bone
https://www.readbyqxmd.com/read/30097754/age-and-height-adjusted-total-kidney-volume-growth-rate-in-autosomal-dominant-polycystic-kidney-diseases
#5
Eiji Higashihara, Kouji Yamamoto, Shinya Kaname, Takatsugu Okegawa, Mitsuhiro Tanbo, Tsuyoshi Yamaguchi, Kaori Shigemori, Isao Miyazaki, Kenichi Yokoyama, Kikuo Nutahara
BACKGROUND: The Mayo Clinic Image Classification (MIC) was proposed as a renal prognosis prediction model for autosomal dominant polycystic kidney disease (ADPKD). MIC is based on the assumption of exponential constant increase in height-adjusted total kidney volume (HtTKV). HtTKV growth rate is calculated by one-time measurement of HtTKV and age. We named it as an age-adjusted HtTKV growth rate (AHTKV-α). AHTKV-α was compared with HtTKV slope measured by at least two HtTKV values. METHODS: Comparison of repeatability between AHTKV-α and HtTKV slope, correlation of subgroups divided according to baseline AHTKV-α and HtTKV slope with disease manifestations, estimated glomerular filtration rate (eGFR) slope, and renal survival were analyzed in 296 patients with ADPKD...
July 26, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/30096903/relative-validity-of-a-beverage-frequency-questionnaire-used-to-assess-fluid-intake-in-the-autosomal-dominant-polycystic-kidney-disease-population
#6
Carly Mannix, Anna Rangan, Annette Wong, Jennifer Zhang, Margaret Allman-Farinelli, Gopala Rangan
Maintaining hydration sufficient to reduce levels of arginine vasopressin has been hypothesised to slow kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). The semi-quantitative beverage frequency questionnaire (BFQ) was designed to measure usual fluid intake over the past month. The aim of this study was to assess the validity and reliability of the BFQ compared with the 24-h urine biomarkers. Participants with ADPKD (18⁻67 years; estimated glomerular filtration rate (eGFR) ≥ 30 mL/min1...
August 9, 2018: Nutrients
https://www.readbyqxmd.com/read/30089153/serum-leptin-level-is-associated-with-phase-angle-in-ckd5-patients-not-undergoing-dialysis
#7
Jun Young Lee, Jae-Seok Kim, Jae-Won Yang, Seung Ok Choi, Joon Hyung Sohn, Byoung-Geun Han
OBJECTIVE: Malnutrition is very complex in patients with end-stage renal disease (ESRD) and is associated with poor prognosis. This is because hemodynamic changes, hormonal changes, persistent inflammatory reactions, and fluid overloads are more complicated as uremia is worsening. Bio-impedance spectroscopy (BIS) is a useful method to estimate fluid balance (Overhydration/ extracellular water, OH/ECW) and nutritional status (Phase angle, PhA). We aimed to evaluate the volume and nutritional status by BIS and to investigate the relationship between the appetite regulating hormones and the parameters of BIS in patients with stage 5 chronic kidney disease not undergoing dialysis (CKD5-ND)...
2018: PloS One
https://www.readbyqxmd.com/read/30072297/renal-artery-orientation-influences-the-renal-outcome-in-endovascular-thoraco-abdominal-aortic-aneurysm-repair
#8
Enrico Gallitto, Gianluca Faggioli, Rodolfo Pini, Chiara Mascoli, Stefano Ancetti, Mohammad Abualhin, Andrea Stella, Mauro Gargiulo
OBJECTIVE: To evaluate the impact of renal artery (RA) anatomy on the renal outcome of fenestrated-branched endografts (FB-EVAR) for thoraco-abdominal aortic aneurysms (TAAA). METHODS: Between 2010 and 2016, all patients undergoing FB-EVAR for TAAA were prospectively collected. Anatomical, procedural, and post-operative data were retrospectively analysed. RA anatomy was assessed on volume rendering, multi planar and centre line reconstructions by dedicated software (3Mensio)...
July 30, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/30066121/characterization-of-11-c-pxt012253-as-a-pet-radioligand-for-mglu-4-allosteric-modulators-in-nonhuman-primates
#9
Akihiro Takano, Sangram Nag, Zhisheng Jia, Mahabuba Jahan, Anton Forsberg, Ryosuke Arakawa, Per Grybäck, Guillaume Duvey, Christer Halldin, Delphine Charvin
PURPOSE: Modulation of presynaptic metabotropic glutamate receptor 4 (mGlu4 ) by an allosteric ligand has been proposed as a promising therapeutic target in Parkinson's disease and levodopa-induced dyskinesia. A positron emission tomography (PET) ligand for an allosteric site of mGlu4 may provide evidence that a clinical drug candidate reaches and binds the target. A carbon-11-labeled PET radioligand binding an allosteric site of mGlu4 , [11 C]PXT012253, has been recently developed. Here, we describe the detailed characterization of this novel radiolabeled mGlu4 ligand in nonhuman primates...
July 31, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30064370/off-clamp-partial-nephrectomy-has-a-positive-impact-on-short-and-long-term-renal-function-a-systematic-review-and-meta-analysis
#10
Wen Deng, Xiaoqiang Liu, Jieping Hu, Luyao Chen, Bin Fu
BACKGROUND: Ongoing efforts are focused on shortening ischemia intervals as much as possible during partial nephrectomy to preserve renal function. Off-clamp partial nephrectomy (off-PN) has been a common strategy for to avoid ischemia in small renal tumors. Although studies comparing the advantages between off-PN with conventional on-clamp partial nephrectomy (on-PN) have been reported, the impact on short- and especially long-term renal function of the two surgical methods has not been discussed seriously and remained unclear...
July 31, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30063488/the-use-of-bioimpedance-spectroscopy-to-guide-fluid-management-in-patients-receiving-dialysis
#11
Matthew Tabinor, Simon J Davies
PURPOSE OF REVIEW: To summarize the findings of recent trials and meta-analyses designed to determine whether bioimpedance spectroscopy adds value to the clinical assessment of fluid status in dialysis patients so as to achieve a normally hydrated weight and put these in a contemporary context. RECENT FINDINGS: Eight trials (published 2010-2018) and two meta-analyses (2017) are reviewed. Both haemodialysis and peritoneal dialysis modalities are represented. Despite considerable heterogeneity in intervention, all are open-label randomized comparisons of a bioimpedance intervention with normal clinical practice in which clinicians were blinded to bioimpedance data...
July 30, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/30062395/first-evaluation-of-pet-based-human-biodistribution-and-radiation-dosimetry-of-11-c-bu99008-a-tracer-for-imaging-the-imidazoline-2-binding-site
#12
Ashwin V Venkataraman, Nicholas Keat, James F Myers, Samuel Turton, Inge Mick, Roger N Gunn, Eugenii A Rabiner, Jan Passchier, Christine A Parker, Robin J Tyacke, David J Nutt
BACKGROUND: We measured whole body distribution of 11 C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site. The purpose of this phase I study was to evaluate the biodistribution and radiation dosimetry of 11 C-BU99008 in healthy human subjects. METHODS: A single bolus injection of 11 C-BU99008 (296 ± 10.5 MBq) was administered to four healthy subjects who underwent whole-body PET/CT over 120 min from the cranial vertex to the mid-thigh...
July 30, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/30049849/recent-advances-in-the-management-of-autosomal-dominant-polycystic-kidney-disease
#13
REVIEW
Fouad T Chebib, Vicente E Torres
Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic cause of ESKD, is characterized by relentless development of kidney cysts, hypertension, and destruction of the kidney parenchyma. Over the past few years, major advancements in diagnosing, prognosticating, and understanding the pathogenesis and natural course of the disease have been made. Currently, no kidney disease is more suitable for nephron-protective strategies. Early nephrology referral and implementation of these strategies may have a substantial effect...
July 26, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30049484/laparoscopic-total-nephrectomy-for-wilms-tumor-towards-new-standards-of-care
#14
REVIEW
Paula Flores, Martín Cadario, Yvonne Lenz, Walter Cacciavillano, Laura Galluzzo, Enrique Guillermo Nestor Paz, Juan Pablo Corbetta, Pedro Zubizarreta
INTRODUCTION: Laparoscopic total nephrectomy (LN) in malignant pediatric tumors remains controversial. For selected patients undergoing pre-operative chemotherapy in referral centers, LN has so far shown comparable results to the standard open technique. PURPOSE: To describe the inclusion criteria and preliminary results of laparoscopic nephrectomies (LN) for the treatment of unilateral Wilms tumors (WT). MATERIAL AND METHODS: Between November 2010 and January 2016, a retrospective study of patients with WT and undergoing pre-operative chemotherapy was performed...
July 23, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/30046330/interstitial-nephritis-caused-by-anorexia-nervosa-in-young-male-a-case-report-and-literature-review
#15
Ji Wook Choi, Soon Kil Kwon, Sun Moon Kim, Hyunjeong Cho, Ho-Chang Lee, Hye-Young Kim
Severe eating disorders characterized by repetitive episodes of purging and vomiting can occasionally trigger acute kidney injury. However, interstitial nephritis induced by episodes of repeated vomiting has rarely been reported, and the pathophysiology of this entity remains unknown. A 26-year-old man was admitted to our hospital because of known hypokalemia. His serum electrolyte profile showed: sodium 133 mEq/L, potassium 2.6 mEq/L, chloride 72 mEq/L, total carbon dioxide 50 mEq/L, blood urea nitrogen/creatinine ratio (BUN/Cr) 21...
June 2018: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/30045680/cognitive-impairments-and-dysexecutive-behavioral-disorders-in-chronic-kidney-disease
#16
Laurent Puy, Jean-Marc Bugnicourt, Sophie Liabeuf, Lucie Desjardins, Martine Roussel, Momar Diouf, Jean Marc Chillon, Gabriel Choukroun, Ziad A Massy, Olivier Godefroy
The purpose of this study was to characterize cognitive impairments and behavioral disorders in a sample of patients with chronic kidney disease (CKD). A total of 52 patients with CKD were prospectively recruited over a 344-day period. Cognitive functions (memory, action speed, executive function, and language) and behavioral characteristics were assessed with a standardized comprehensive battery. The patients' performances were interpreted with a validated method on the basis of normative data from 1,003 healthy control subjects...
July 26, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30043487/magnetic-resonance-imaging-3t-and-total-fibrotic-volume-in-autosomal-dominant-polycystic-kidney-disease
#17
S Lai, D Mastroluca, C Letizia, L Petramala, A Perrotta, A DiGaeta, L Ferrigno, M Ciccariello, A R D'Angelo, A DiGaeta
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD. The aim of this study was to identify and quantify in ADPKD, through a novel MR protocol with 3 Tesla (MRI 3Tesla), the presence of parenchymal fibrotic tissue at early stage of disease, able to correlate the glomerular filtrate and to predict the loss of the function renal...
July 24, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/30041290/evaluation-of-renal-injury-caused-by-acute-volume-replacement-with-hydroxyethyl-starch-130-0-4-or-ringer-s-lactate-solution-in-pigs
#18
David A Ferreira, Rita Cruz, Carlos Venâncio, Ana I Faustino-Rocha, Aura Silva, João R Mesquita, Ana Liza Ortiz, Helena Vala
This work aimed to evaluate the effects on renal tissue integrity after Hydroxyethyl starch (HES) 130/0.4 and Ringer's lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 ( n =11) received RL solution (25 mL/kg) and Group 2 ( n =11) received HES 130/0.4 solution (20 mL/kg). An additional Group 3 ( n =6) was not submitted to bleeding or volume replacement...
July 20, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/30041198/current-perspectives-on-sudden-cardiac-death-in-hemodialysis-patients
#19
Nobuhiko Joki, Masanori Tokumoto, Nobuyuki Takahashi, Masato Nishimura
BACKGROUND: Recent lines of evidence suggest that, as in other countries, sudden cardiac death (SCD) is more common in the Japanese dialysis clinical setting than we previously thought. SUMMARY: Three specific important findings may underlie the increased incidence of SCD in dialysis patients. Even after successful coronary revascularization, hemodialysis (HD) patients continue to have a higher incidence of SCD than the general population. Second, about 70% or more of end-stage kidney disease patients have concentric and eccentric left ventricular hypertrophy, which predisposes many dialysis patients to interstitial fibrosis, decreased coronary perfusion reserve, and decreased ischemia tolerance...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/30037680/open-repair-of-thoracoabdominal-aortic-aneurysms-in-experienced-centers
#20
REVIEW
Konstantinos G Moulakakis, Georgios Karaolanis, Constantine N Antonopoulos, John Kakisis, Christos Klonaris, Ourania Preventza, Joseph S Coselli, George Geroulakos
OBJECTIVE: We performed a systematic review and meta-analysis aiming to assess the mortality and morbidity of all published case series on thoracoabdominal aortic aneurysms (TAAAs) in experienced centers treated with open repair. METHODS: A systematic search of the literature published until April 2017 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Separate meta-analyses were conducted for overall in-hospital mortality for TAAA, mortality according to the type of TAAA, spinal cord ischemia, paraplegia and paraparesis, cardiac events, stroke, acute kidney failure, and bowel ischemia...
August 2018: Journal of Vascular Surgery
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