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https://www.readbyqxmd.com/read/30515282/evaluation-of-antiproteinuric-and-hepato-renal-protective-activities-of-propolis-in-paracetamol-toxicity-in-rats
#1
Nawal El Menyiy, Noori Al-Waili, Asmae El Ghouizi, Wail Al-Waili, Badiaa Lyoussi
BACKGROUND/OBJECTIVES: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats. MATERIALS AND METHODS: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg...
December 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/30509210/a-novel-model-of-reno-cardiac-syndrome-in-the-c57bl-6-mouse-strain
#2
Julius E Kieswich, Jianmin Chen, Samira Alliouachene, Paul W Caton, Kieran McCafferty, Christoph Thiemermann, Muhammad M Yaqoob
BACKGROUND: The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research improved therapeutic strategies to combat renal cardiac pathologies. Murine in vivo models contribute greatly to such research allowing for specific genetic modification and reduced miscellany, however there is currently no reliable model of reno-cardiac syndrome in the most common genetically modified mouse strain, the C57BL/6...
December 4, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30479486/perioperative-enteral-nutrition-after-left-ventricular-assist-device-implantation
#3
Ryuichiro Abe, Atsuhiro Matsumoto, Ryota Sakaguchi, Koichi Toda, Yoshiki Sawa, Akinori Uchiyama, Yuji Fujino
Objective: We assessed what predicts nutritional adequacy at day 14 following implantation of left ventricular assist device (LVAD). Method: We retrospectively reviewed the cases of 97 adult patients who underwent LVAD implantation at our institution from June 2011 to June 2016. We divided the patients into two groups based on the administered enteral nutrition (EN) calories on post-operative day (POD) 14: the EN calories of group SEN (sufficient enteral nutrition) were >80% of their total target calories, or the EN calories of group IEN (insufficient enteral nutrition) were <80% of their total target calories...
2018: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/30472704/urinary-level-of-liver-type-fatty-acid-binding-protein-reflects-the-degree-of-tubulointerstitial-damage-in-polycystic-kidney-disease
#4
Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori
BACKGROUND/AIMS: Polycystic kidney disease (PKD) is a common, progressive, and heritable type of kidney disease. Although certain imaging modalities are useful for the diagnosis and staging of PKD, they cannot adequately monitor the severity of interstitial inflammation and fibrosis. Therefore, the present study evaluated the urinary level of liver-type fatty acid binding protein (L-FABP) as a marker of interstitial inflammation and fibrosis in PKD. METHODS: Male PCK/CrljCrl-Pkhd1pck/Crl (PCK) rats (n = 34) were used as an animal model of the PKD...
November 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30471912/short-communication-milk-urea-nitrogen-as-a-predictor-of-urinary-nitrogen-and-urea-nitrogen-excretions-of-late-lactation-dairy-cows-fed-nitrogen-limiting-diets
#5
T Barros, K F Reed, J J Olmos Colmenero, M A Wattiaux
Our objectives were to assess the relationships between milk urea N (MUN), serum urea N (SUN), urine N (UN), and urinary urea N (UUN) in late-lactation cows fed N-limiting diets and compare these relationships with those previously established. Data were from a pen-based study in which 128 Holstein cows had been assigned to 1 of 16 pens in a randomized complete block design to assess the effects of diets containing 16.2, 14.4, 13.1, and 11.8% crude protein (CP, dry matter basis) during a 12-wk period. At least half of the cows in each pen were randomly selected to collect pen-level samples of serum and urine in wk 3, 7, and 11, when wk in lactation averaged 35, 39, and 43, respectively...
November 21, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30450935/-the-start-of-the-hungarian-lung-transplantation-program-and-the-first-results
#6
Balázs Gieszer, Péter Radeczky, Áron Ghimessy, Attila Farkas, Kristóf Csende, Levente Bogyó, Levente Fazekas, Nóra Kovács, Ildikó Madurka, Ákos Kocsis, László Agócs, Klára Török, Tibor Bartók, Tamás Dancs, Nóra Schönauer, Krisztina Tóth, József Szabó, Noémi Eszes, Anikó Bohács, Krisztina Czebe, Eszter Csiszér, Sándor Mihály, Lajos Kovács, Veronika Müller, Jenő Elek, Ferenc Rényi-Vámos, György Lang
The first lung transplantation in Hungary was performed on 12th of December, 2015. It was a joint effort of the National Institute of Oncology and the Semmelweis University. Hereby we summarise the results and experiences from the first three years. Until August, 2018, 55 lung transplantations were performed in Hungary. This was a retrospective analysis. All patients were listed according to the recommendation of the Lung Transplantation Committee. All implanted lungs have been procured from brain dead donors...
November 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30429889/theranostic-pretargeted-radioimmunotherapy-of-internalizing-solid-tumor-antigens-in-human-tumor-xenografts-in-mice-curative-treatment-of-her2-positive-breast-carcinoma
#7
Sarah M Cheal, Hong Xu, Hong-Fen Guo, Mitesh Patel, Blesida Punzalan, Edward K Fung, Sang-Gyu Lee, Meghan Bell, Manisha Singh, Achim A Jungbluth, Pat B Zanzonico, Alessandra Piersigilli, Steven M Larson, Nai-Kong V Cheung
In recent reports, we have shown that optimized pretargeted radioimmunotherapy (PRIT) based on molecularly engineered antibody conjugates and 177 Lu-DOTA chelate (DOTA-PRIT) can be used to cure mice bearing human solid tumor xenografts using antitumor antibodies to minimally internalizing membrane antigens, GPA33 (colon) and GD2 (neuroblastoma). However, many solid tumor membrane antigens are internalized after antibody binding and it is generally believed that internalizing tumor membrane antigens are not suitable targets for PRIT...
2018: Theranostics
https://www.readbyqxmd.com/read/30426716/red-blood-cell-volume-is-not-decreased-in-esa-naive-anemic-chronic-kidney-disease-patients
#8
Carsten Lundby, Belen Ponte, Anne-Kristine Lundby, Paul Robach, Sophie de Seigneux
Anemia is defined according to decreased blood hemoglobin concentration ([Hb]), which is considered a marker of low total red blood cell volume (RBCV). Alterations of plasma volume (PV) may also modify [Hb] without concomitant changes in RBCV. Since anemia and fluid retention are frequent complications of chronic kidney disease (CKD), we hypothesized that anemia during CKD may in part be related to expanded PV without a simultaneous decrease in RBCV. We quantified hemoglobin mass, RBCV, PV, and total blood volume (BV) using an automated carbon monoxide device in 40 consecutive stage 3-5 CKD patients not on dialysis and in seven healthy male controls of the same age range...
November 2018: Physiological Reports
https://www.readbyqxmd.com/read/30410236/acute-oral-toxicity-of-pesticide-combination-acephate-50-and-imidacloprid-1-8-as-active-ingredients-in-sprague-dawley-rats
#9
Rajendra Palkhade, Suresh Yadav, SukhDev Mishra, Jaseer Muhamed
Aim: The aim of this study was to assess the acute toxic interaction and lethal dose (LD50 ) of pesticide combination product (acephate 50% and imidacloprid 1.8% as active ingredients) available in the market in Sprague-Dawley female rats by oral route. Materials and Methods: A total of 10 Sprague-Dawley female rats were divided into two groups, comprising five rats in each dose group. Both groups were identified as control and test groups, respectively. Control group received sterile water as vehicle and test group received pesticide combination (acephate 50% and imidacloprid 1...
September 2018: Veterinary World
https://www.readbyqxmd.com/read/30406512/impact-of-tumor-burden-on-quantitative-68-ga-dotatoc-biodistribution
#10
Rudolf A Werner, Heribert Hänscheid, Jeffrey P Leal, Mehrbod S Javadi, Takahiro Higuchi, Martin A Lodge, Andreas K Buck, Martin G Pomper, Constantin Lapa, Steven P Rowe
PURPOSE: As has been previously reported, the somatostatin receptor (SSTR) imaging agent [68 Ga]-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotate ([68 Ga]DOTATATE) demonstrates lower uptake in normal organs in patients with a high neuroendocrine tumor (NET) burden. Given the higher SSTR affinity of [68 Ga] DOTATATE, we aimed to quantitatively investigate the biodistribution of [68 Ga]-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotide ([68 Ga]DOTATOC) to determine a potential correlation between uptake in normal organs and NET burden...
November 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30402970/high-sodium-intake-increases-blood-pressure-and-risk-of-kidney-disease-from-the-science-of-salt-a-regularly-updated-systematic-review-of-salt-and-health-outcomes-august-2016-to-march-2017
#11
Daniela Malta, Kristina S Petersen, Claire Johnson, Kathy Trieu, Sarah Rae, Katherine Jefferson, Joseph Alvin Santos, Michelle M Y Wong, Thout Sudhir Raj, Jacqui Webster, Norm R C Campbell, JoAnne Arcand
The purpose of this review was to identify, summarize, and critically appraise studies on dietary salt and health outcomes that were published from August 2016 to March 2017. The search strategy was adapted from a previous systematic review on dietary salt and health. Studies that meet standards for methodological quality criteria and eligible health outcomes are reported in detailed critical appraisals. Overall, 47 studies were identified and are summarized in this review. Two studies assessed all-cause or disease-specific mortality outcomes, eight studies assessed morbidity reduction-related outcomes, three studies assessed outcomes related to symptoms/quality of life/functional status, 25 studies assessed blood pressure (BP) outcomes and other clinically relevant surrogate outcomes, and nine studies assessed physiologic surrogate outcomes...
November 7, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30402202/effects-of-concurrent-chloroquine-and-ethanol-administration-on-the-rat-kidney-morphology
#12
Abdurrahman Abdulkadir, Ejikeme Felix Mbajiorgu, Trust Nyirenda
Introduction: The use of antimalarial chloroquine in malaria-endemic regions of Africa is rampant and it is not uncommon to find individuals taken the drug concurrent with alcohol. Effects of anti-malarial drug chloroquine (Chq) and ethanol (Et) combination on kidney volume and function using rat model was investigated. Methods: 32 adult male rats were randomly distributed into four groups of 8 rats each. Group C serve as control and received vehicle only, while Q is Chq treated only, E is Et treated and QE is Et and Chq treated...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30384394/assessment-of-postoperative-renal-function-after-adrenalectomy-in-patients-with-primary-aldosteronism
#13
Tadashi Onohara, Toshio Takagi, Kazuhiko Yoshida, Junpei Iizuka, Masayoshi Okumi, Tsunenori Kondo, Hideki Ishida, Kazunari Tanabe
OBJECTIVE: To investigate kidney function change during adrenalectomy in patients with primary aldosteronism and assess predictors of kidney function decline. METHODS: The present study included 90 patients who underwent adrenalectomy for primary aldosteronism between 2004 and 2017. Kidney function was evaluated 1 month after surgery. Predictors associated with a ≥10% decline in the estimated glomerular filtration rate were investigated. Kidney parenchymal volume was compared before and after surgery in 10 patients using volumetric studies...
November 1, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/30374529/biodistribution-and-radiation-dose-estimates-for-68-ga-dota-jr11-in-patients-with-metastatic-neuroendocrine-tumors
#14
Simone Krebs, Neeta Pandit-Taskar, Diane Reidy, Bradley J Beattie, Serge K Lyashchenko, Jason S Lewis, Lisa Bodei, Wolfgang A Weber, Joseph A O'Donoghue
PURPOSE: Somatostatin receptor antagonists have shown promise for imaging neuroendocrine tumors (NETs) in preclinical studies, but clinical data is still very limited. In this study, we assess the feasibility of using the novel somatostatin antagonist 68 Ga-DOTA-JR11 for PET imaging of NETs. METHODS: Twenty patients with advanced NETs underwent whole-body PET/CT imaging 60 min after injection of 169 MBq (median) 68 Ga-DOTA-JR11 as part of a prospective study. Volumes of interest were drawn around up to four 68 Ga-DOTA-JR11-avid lesions per patient (with uptake greater than liver) and standardized uptake values were estimated...
October 29, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30369399/individual-renal-unit-urine-sampling-to-identify-unilateral-metabolic-defects
#15
Justin B Ziemba, Rishab Gurnani, Wesley W Ludwig, Michael A Gorin, John Asplin, Brian R Matlaga
AIMS: Preventing kidney stone recurrence relies on detecting and modifying urine chemistry abnormalities. The assumption is that an abnormality is due to a global metabolic defect present in both kidneys. However, we hypothesize that clinically significant unilateral defects may exist. We aimed to identify these patients by sampling urine from each renal unit. MATERIALS AND METHODS: Adults undergoing retrograde upper urinary tract surgery were eligible for inclusion...
October 26, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30369309/increased-muscle-mass-protects-against-hypertension-and-renal-injury-in-obesity
#16
Joshua T Butcher, James D Mintz, Sebastian Larion, Shuiqing Qiu, Ling Ruan, David J Fulton, David W Stepp
Background Obesity compromises cardiometabolic function and is associated with hypertension and chronic kidney disease. Exercise ameliorates these conditions, even without weight loss. Although the mechanisms of exercise's benefits remain unclear, augmented lean body mass is a suspected mechanism. Myostatin is a potent negative regulator of skeletal muscle mass that is upregulated in obesity and downregulated with exercise. The current study tested the hypothesis that deletion of myostatin would increase muscle mass and reduce blood pressure and kidney injury in obesity...
August 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30368514/co-inheritance-of-autosomal-dominant-polycystic-kidney-disease-and-naevoid-basal-cell-carcinoma-syndrome-effects-on-renal-progression
#17
Maria Florencia Martínez, Luis Daniel Mazzuoccolo, Elisabet Mónica Oddo, Paula Virginia Iscoff, Carolina Muchnik, Hartmut P H Neumann, Rodolfo Santiago Martin, Adriana Raquel Fraga, Pablo Javier Azurmendi
The calcium signalling and hedgehog (HH) signalling pathways operate in the primary cilium. Abnormalities in these pathways cause autosomal dominant polycystic kidney disease (ADPKD) and naevoid basal cell carcinoma syndrome (NBCCS) respectively. Several reports have proposed that hyperactivation of the HH pathway in animal models of polycystic kidney disease affects normal renal development and renal cyst phenotype. A family with 2 cases (a proband and her sister) of ADPKD and NBCCS coinheritance led us to investigate whether interactions may be present in the 2 pathways...
October 26, 2018: Nephron
https://www.readbyqxmd.com/read/30357715/tolvaptan-in-japanese-patients-with-later-stage-autosomal-dominant-polycystic-kidney-disease
#18
Masahiko Oguro, Yuta Kogure, Junichi Hoshino, Yoshifumi Ubara, Hiroki Mizuno, Akinari Sekine, Masahiro Kawada, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Naoki Sawa, Kenmei Takaichi
BACKGROUND: A recent study demonstrated that tolvaptan slowed estimated glomerular filtration rate (eGFR) decline in later-stage autosomal dominant polycystic kidney disease (ADPKD) patients. However, Japanese patients were not included in that trial, therefore tolvaptan's efficacy in Japanese patients with advanced chronic kidney disease (CKD) has remained unknown. METHODS: In this prospective cohort study, 54 patients with ADPKD who had eGFR ≥ 15 ml/min/1...
December 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/30350455/female-preterm-indigenous-australian-infants-have-lower-renal-volumes-than-males-a-predisposing-factor-for-end-stage-renal-disease
#19
Yogavijayan Kandasamy, Donna Rudd, Eugenie R Lumbers, Roger Smith
AIM: Indigenous Australians have an increased risk of developing Chronic Kidney Disease (CKD). Indigenous women have a higher rate of CKD than men. In a cohort of Indigenous and non-Indigenous preterm neonates, we assessed total renal volume (TRV) (a proxy indicator for nephron number). We hypothesised that there would be no difference in renal volume between these two groups at term corrected (37 weeks gestation). METHODS: Normally grown preterm neonates less than 32 weeks of gestation were recruited and at term corrected dates, the neonates underwent renal ultrasonography (TRV measurements), urine microalbumin-creatinine ratio (ACR) and serum analysis for Cystatin C measurement for eGFR calculation...
October 23, 2018: Nephrology
https://www.readbyqxmd.com/read/30348100/low-birth-weight-associates-with-glomerular-area-in-young-male-iga-nephropathy-patients
#20
Paschal Ruggajo, Sabine Leh, Einar Svarstad, Hans-Peter Marti, Bjørn Egil Vikse
BACKGROUND: In a recent study we demonstrated that low birth weight (LBW) was associated with increased risk of progressive IgA nephropathy (IgAN). In the present study we investigate whether this could be explained by differences in glomerular morphological parameters. METHODS: The Medical Birth Registry of Norway has registered all births since 1967 and the Norwegian Kidney Biopsy Registry has registered all kidney biopsies since 1988. Patients diagnosed with IgAN, registered birth weight and estimated glomerular filtration rate above 60 ml/min/1...
October 22, 2018: BMC Nephrology
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