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Acute Right Heart Failure

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https://www.readbyqxmd.com/read/30103814/unilateral-pulmonary-edema-a-case-report-and-review-of-the-literature
#1
Rangani Handagala, Udaya Ralapanawa, Thilak Jayalath
BACKGROUND: Unilateral pulmonary edema is an uncommon condition and is a rare clinical entity that is often misdiagnosed at the initial stages. In a majority of patients it occurs in the upper lobe of the right lung. There are many causes of unilateral pulmonary edema, but the commonest is the presence of a grade 3 mitral regurgitation. Due to its rare presentation, a high index of suspicion is required, and correct management is necessary to reduce the morbidity and mortality. CASE PRESENTATION: We present a case of right-sided unilateral pulmonary edema in an 86-year-old Sinhalese Sri Lankan woman who presented with acute onset dyspnea with cardiogenic shock due to acute non-ST elevation myocardial infarction, complicated with grade 3 mitral regurgitation...
August 14, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30098019/efficacy-of-treprostinil-in-the-su5416-hypoxia-model-of-severe-pulmonary-arterial-hypertension-hemodynamic-benefits-are-not-associated-with-improvements-in-arterial-remodelling
#2
Ketul R Chaudhary, Yupu Deng, Colin M Suen, Mohamad Taha, Thomas H Petersen, Shirley H J Mei, Duncan J Stewart
BACKGROUND AND PURPOSE: Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure and death. Parenteral prostaglandins, including treprostinil, a prostacyclin analogue, represent the most effective medical treatment for severe PAH. We investigated the effect of treprostinil on established severe PAH and underlying mechanisms using the rat SU5416 (SU, a vascular endothelial growth factor receptor-2 inhibitor)-chronic hypoxia (Hx) model of PAH...
August 11, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30091215/risk-of-heart-failure-in-type-2-diabetes-population-comparison-with-non-diabetes-subjects-with-and-without-coronary-heart-diseases
#3
Hua-Fen Chen, Ching-An Ho, Chung-Yi Li
BACKGROUND: Population-based study comparing age- and sex-specific risk estimates of heart failure (HF) between patients with type 2 diabetes and non-diabetes subjects was limited in number. In addition, the risks of HF in association with type 2 diabetes in people with various coronary heart diseases (CHDs) have rarely been investigated. This study used a nationally representative sample (one-million people) selected from Taiwan's National Health Insurance (NHI) to clarify the above-mentioned research questions...
August 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30075063/distribution-of-alveolar-interstitial-syndrome-in-dogs-and-cats-with-respiratory-distress-as-assessed-by-lung-ultrasound-versus-thoracic-radiographs
#4
Jessica L Ward, Gregory R Lisciandro, Teresa C DeFrancesco
OBJECTIVE: To assess distribution of alveolar-interstitial syndrome (AIS) detected by lung ultrasound (LUS) compared to thoracic radiographs (TXR). DESIGN: Prospective study. SETTING: University teaching hospital. ANIMALS: Seventy-six dogs and 24 cats with acute respiratory distress or tachypnea. INTERVENTIONS: Patients underwent LUS and TXR within 6 hours. Lung ultrasound images were scored for presence and quantity of B-lines in 4 lung quadrants (right cranial, right caudal, left cranial, left caudal)...
August 3, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/30062798/prediction-of-coronary-heart-disease-or-heart-failure-using-high-sensitivity-cardiac-troponin-t-a-pilot-study
#5
Ásthildur Árnadóttir, Kirstine Roll Vestergaard, György Sölétormos, Rolf Steffensen, Jens P Goetze, Kasper Iversen
BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is a good prognostic marker for mortality. However, it is uncertain if hs-cTnT can be used to detect sub-clinical cardiac disease. METHOD: Pilot study in patients without known heart disease and elevated hs-cTnT measured at presentation to the emergency department. Hs-cTnT was measure with Roche Diagnostics. Echocardiography was used to assess structural heart disease and the participants underwent computed tomography angiography for assessment of coronary artery disease and agatston score...
July 30, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30061176/cerebral-blood-flow-alteration-following-acute-myocardial-infarction-in-mice
#6
Abdullah Kaplan, Andriy Yabluchanskiy, Rana Ghali, Raffaele Altara, George W Booz, Fouad A Zouein
Heart failure is associated with low cardiac output (CO) and low brain perfusion that imposes a significant risk for accelerated brain aging and Alzheimer disease development. Although clinical heart failure can emerge several years following acute myocardial infarction (AMI), the impact of AMI on cerebral blood flow at early stages and up to 30 days following MI is unknown. 16 months old male mice underwent left anterior descending (LAD) coronary artery ligation. Hemodynamic analysis were performed at baseline and at days 1, 7, and 30 post-MI...
July 30, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30058015/percutaneous-support-of-the-failing-left-and-right-ventricle-recommendations-for-the-use-of-mechanical-device-therapy
#7
REVIEW
Sven Möbius-Winkler, Michael Fritzenwanger, Rüdiger Pfeifer, P Christian Schulze
Patients in cardiogenic shock and acute heart failure show high mortality and morbidity despite aggressive and invasive methods such as percutaneous coronary intervention and the use of mechanical support devices. Percutaneous implantation of active hemodynamic support is often the only option for hemodynamic stabilization of patients in cardiogenic shock. Therefore, current guidelines support the use of these devices. Standardized protocols and clinical algorithms for the use of these support devices decrease mortality in these patients...
July 30, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/30052906/atrioventricular-optimization-in-cardiac-resynchronization-therapy-with-quadripolar-leads-should-we-optimize-every-pacing-configuration-including-multi-point-pacing
#8
Wouter M van Everdingen, Alwin Zweerink, Odette A E Salden, Maarten J Cramer, Pieter A Doevendans, Albert C van Rossum, Frits W Prinzen, Kevin Vernooy, Cornelis P Allaart, Mathias Meine
Aims: This study aims to define an atrioventricular (AV) delay optimization method for cardiac resynchronization therapy (CRT) with a quadripolar left ventricular (LV) lead based on intrinsic conduction intervals. Methods and results: Heart failure patients with a left bundle branch block underwent CRT implantation with a quadripolar LV lead. Invasive LV pressure-volume loops were recorded during four biventricular and three multi-point pacing (MPP) settings, using four patient-specific paced AV delays...
July 24, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/30049892/heterotaxy-syndrome-and-intestinal-rotation-abnormalities
#9
Lindsay M Ryerson, Scott Pharis, Charissa Pockett, Reeni Soni, Deborah Fruitman, Kristine J Guleserian, Melissa Nater, Stephen C Raynor, Andrew S Mackie, Bryan Dicken
BACKGROUND: Infants with heterotaxy syndrome (HS) have abnormal lateralization of organs along the right-left body axis. Intestinal rotation abnormalities (IRAs) are a potential source of morbidity and mortality. For this study, our objective was to prospectively observe a cohort of infants with HS and determine the incidence and natural history of IRA. METHODS: Infants ≤6 months of age with HS were enrolled in this prospective observational study. Exclusion criteria were other congenital abnormalities that necessitated abdominal surgery...
July 26, 2018: Pediatrics
https://www.readbyqxmd.com/read/30043501/best-life-bringing-ecmo-simultion-to-life-how-medical-simulation-improved-regional-ecmo-program
#10
Mateusz Puślecki, Marcin Ligowski, Marek Dąbrowski, Sebastian Stefaniak, Małgorzata Ładzińska, Piotr Ładziński, Aleksander Pawlak, Marcin Zieliński, Agata Dąbrowska, Aniela Artyńska, Mariusz Gezela, Paweł Sobczyński, Łukasz Szarpak, Bartłomiej Perek, Marek Jemielity
BACKGROUND: The implemented "ECMO for Greater Poland" program takes full advantage of the ECMO (extracorporeal membrane oxygenation) perfusion therapy to promote health for 3.5 million inhabitants in the region (Greater Poland). The predominant subjects of implementation are patients with hypothermia, with severe reversible respiratory failure (RRF) and treatment of other critical states leading to heart failure such as sudden cardiac arrest, cardiogenic shock or acute intoxication...
July 25, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30035809/va-ecmo-for-cardiogenic-shock-in-the-contemporary-era-of-heart-transplantation-which-patients-should-be-urgently-transplanted
#11
Marlena V Habal, Lauren Truby, Masahiko Ando, Hirohisa Ikegami, Arthur R Garan, Veli K Topkara, Paolo Colombo, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Maryjane A Farr
With the impending United Network for Organ Sharing (UNOS) heart allocation policy giving VA-ECMO supported heart transplant (HT) candidates highest priority status (Tier 1), identifying patients in cardiogenic shock (CS) with severe and irreversible heart failure (HF) appropriate for urgent HT, is critically important. In a centre where wait times currently preclude this approach, we retrospectively reviewed 119 patients (ages 18-72) with CS from 1/2014 - 12/2016 who required VA-ECMO for > 24h. Underlying aetiologies included postcardiotomy shock (45), acute coronary syndromes (33), and acute on chronic HF (16)...
July 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30033081/%C3%AE-blockers-after-inotropes-in-acute-heart-failure-when-is-the-right-time
#12
EDITORIAL
Jennifer E Ho
No abstract text is available yet for this article.
June 5, 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/30014565/randomized-controlled-trial-of-an-oral-appliance-somnodent-%C3%A2-for-sleep-disordered-breathing-and-cardiac-function-in-patients-with-heart-failure
#13
Hiroki Matsumoto, Takatoshi Kasai, Shoko Suda, Shoichiro Yatsu, Jun Shitara, Azusa Murata, Takao Kato, Masaru Hiki, Naotake Yanagisawa, Kazutoshi Fujibayashi, Shuko Nojiri, Yuji Nishizaki, Mitsuyo Shinohara, Hiroyuki Daida
BACKGROUND: In patients with heart failure (HF), sleep-disordered breathing (SDB) is a common comorbidity and a risk factor for poor clinical outcomes. SDB can be ameliorated by continuous positive airway pressure; however, inadequate adherence remains a major cause of treatment failure. On the other hand, the efficacy of oral appliance (OA) has been proved in orthodontics and otolaryngology, although the efficacy of OA in patients with HF remains to be elucidated. AIM: This trial aims to determine the efficacy of OA for SDB in patients with HF...
July 16, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30012103/fatal-heart-failure-caused-by-severe-pulmonary-regurgitation-tricuspid-regurgitation-and-late-onset-mitral-stenosis-in-an-adult-patient-with-noonan-syndrome-a-case-report
#14
Yoshito Kadoya, Tsuneaki Kenzaka, Yohei Oda, Satoaki Matoba
BACKGROUND: In patients with Noonan syndrome (NS), cardiac disorders such as pulmonary valve stenosis (PS) or hypertrophic cardiomyopathy (HCM) are common. While some patients can develop heart failure associated with HCM, the long-term outcome of adult patients with NS is reported to be good. Fatal outcomes of heart failure in patients with NS but without HCM are rare. CASE PRESENTATION: We report a 25-year-old Japanese woman diagnosed with NS in adulthood. She exhibited short stature and minor facial dysmorphism and was diagnosed with PS at 1 year of age...
July 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/30011073/identification-of-potential-pathogenic-viruses-in-patients-with-acute-myocarditis-using-next-generation-sequencing
#15
Suguru Takeuchi, Jun-Ichi Kawada, Yusuke Okuno, Kazuhiro Horiba, Takako Suzuki, Yuka Torii, Kazushi Yasuda, Atsushi Numaguchi, Taichi Kato, Yoshiyuki Takahashi, Yoshinori Ito
Myocarditis is an inflammatory disease of the myocardium, leading to cardiac dysfunction and heart failure. Although viral infections are considered to be the most common etiology of myocarditis, identification of the causative virus is still challenging. Recently, next-generation sequencing (NGS) has been applied in the diagnosis of infectious diseases. The aim of the present study was to comprehensively analyze potential pathogenic microorganisms using NGS in sera of patients with myocarditis. Twelve pediatric and five adult patients hospitalized for acute myocarditis were included...
July 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/30010659/real-time-pressure-volume-analysis-of-acute-myocardial-infarction-in-mice
#16
Lars Michel, Pia Stock, Christos Rammos, Matthias Totzeck, Tienush Rassaf, Ulrike B Hendgen-Cotta
Acute myocardial infarction can lead to acute heart failure and cardiogenic shock. The evaluation of hemodynamics is critical for the evaluation of any potential therapeutic approach directed against acute left ventricular (LV) dysfunction. Current imaging modalities (e.g., echocardiography and magnetic resonance imaging) have several limitations since data on LV pressure cannot directly be measured. LV catheterization in mice undergoing coronary artery occlusion could serve as a novel method for a real-time evaluation of LV function...
July 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30003641/hot-off-the-press-a-novel-algorithm-to-decrease-unnecessary-hospitalizations-in-patients-with-atrial-fibrillation
#17
Justin Morgenstern, Corey Heitz, Chris Bond, William K Milne
No abstract text is available yet for this article.
July 12, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29996663/relationship-between-cha2ds2-vasc-score-and-right-ventricular-dysfunction-in-patients-with-acute-pulmonary-thromboembolism
#18
Murat Gök, Alparslan Kurtul, Murat Harman, Meryem Kara, Muhammed Süleymanoglu, Ender Ornek
In this study, the association between the right ventricular dysfunction (RVD) and CHA2DS2-VASc (C: congestive heart failure or left ventricular systolic dysfunction, H: hypertension, A: age of ≥ 75 years, D: diabetes mellitus, S: previous stroke, V: vascular disease, A: age between 65 and 74 years, Sc: female gender) scores was investigated in patients with acute pulmonary thromboembolism (PTE). The patients have been assigned to 3 subgroups as massive, submassive, and nonmassive PTE. The CHA2DS2-VASc scores were calculated for all of the patients, and the scores have been classified into 3 groups as the scores between 0 and 1, the scores of 2, and the scores of 3 and over...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29987833/large-porcine-model-of-profound-acute-ischemic-cardiogenic-shock
#19
Ole K Møller-Helgestad, Hanne B Ravn, Jacob E Møller
Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29984912/rationale-and-design-of-the-randomized-multicentre-his-optimized-pacing-evaluated-for-heart-failure-hope-hf-trial
#20
Daniel Keene, Ahran Arnold, Matthew J Shun-Shin, James P Howard, Sm Afzal Sohaib, Philip Moore, Mark Tanner, Norman Quereshi, Amal Muthumala, Badrinathan Chandresekeran, Paul Foley, Francisco Leyva, Shaumik Adhya, Emanuela Falaschetti, Hilda Tsang, Pugal Vijayaraman, John G F Cleland, Berthold Stegemann, Darrel P Francis, Zachary I Whinnett
AIMS: In patients with heart failure and a pathologically prolonged PR interval, left ventricular (LV) filling can be improved by shortening atrioventricular delay using His-bundle pacing. His-bundle pacing delivers physiological ventricular activation and has been shown to improve acute haemodynamic function in this group of patients. In the HOPE-HF (His Optimized Pacing Evaluated for Heart Failure) trial, we are investigating whether these acute haemodynamic improvements translate into improvements in exercise capacity and heart failure symptoms...
July 9, 2018: ESC Heart Failure
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