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GRADE system AND meta-analysis

Shenghan Lou, Houchen Lv, Zhirui Li, Peifu Tang, Yansong Wang
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is a common adjunct used to promote bone healing for fresh fractures and non-unions, but its efficacy for bone distraction osteogenesis remains uncertain. This study aims to determine whether LIPUS can effectively and safely reduce the associated treatment time for patients undergoing distraction osteogenesis. METHODS: MEDLINE, EMBASE, and the Cochrane Library were searched until May 1, 2018, without language restriction...
August 17, 2018: Journal of Orthopaedic Surgery and Research
Rishad Khan, Joanne Plahouras, Bradley C Johnston, Michael A Scaffidi, Samir C Grover, Catharine M Walsh
BACKGROUND: Endoscopy has traditionally been taught with novices practicing on real patients under the supervision of experienced endoscopists. Recently, the growing awareness of the need for patient safety has brought simulation training to the forefront. Simulation training can provide trainees with the chance to practice their skills in a learner-centred, risk-free environment. It is important to ensure that skills gained through simulation positively transfer to the clinical environment...
August 17, 2018: Cochrane Database of Systematic Reviews
Jatin K Jain, Rajesh Sethuraman, Sameer Chauhan, Piyush Javiya, Shreya Srivastava, Rutvik Patel, Bhagyashri Bhalani
Purpose: This systematic review aimed to evaluate retention failures in cement- and screw-retained fixed restorations on dental implants in partially edentulous arches. Methods: The relevant articles were retrieved from MEDLINE (PubMed), Cochrane Library, and EBSCO electronic databases for articles published from January 1995 to January 2016 and were restricted to randomized controlled trials and retrospective and prospective studies on human subjects that were reported in English...
July 2018: Journal of Indian Prosthodontic Society
Carlotta Caramia, Diego Torricelli, Maurizio Schmid, Adriana Munoz, Jose Gonzalez, Francisco Grandas, Jose Pons
Inertial Measurement Units (IMUs) have a long-lasting popularity in a variety of industrial applications, from navigation systems, to guidance and robotics. Their use in clinical practice is now becoming more common thanks to miniaturization and the ability to integrate on-board computational and decision-support features. IMU-based gait analysis is a paradigm of this evolving process, and in this study its use for the assessment of Parkinson's Disease (PD) is comprehensively analyzed. Data coming from 25 individuals with different levels of PD symptoms severity and an equal number of age-matched healthy individuals were included into a set of 6 different machine learning (ML) techniques, processing 18 different configurations of gait parameters taken from 8 IMU sensors...
August 13, 2018: IEEE Journal of Biomedical and Health Informatics
Jia-Long Nong, Zhen-Xue Long, Chun-Xian Lu
OBJECTIVE: To compare clinical efficacy of complete and incomplete radical debridement for spinal tuberculosis by Meta-analysis. METHODS: The literatures of RCT or non-RCT with complete and incomplete radical debridement for spinal tuberculosis from Medline, EMBASE, Cochrane Library, Web of Science, CBM, CNKI and Wanfang were searched from the time of creating database to July, 2017. Two independent reviewers identified eligible studies, extracted data and evaluated risk of bias of included studies...
July 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Rosa Camila Lucchetta, Barbara Paes Miglioli da Mata, Patricia Carvalho Mastroianni
STUDY OBJECTIVE: Divergent opinions exist on the use of benzodiazepines and the development of dementia, with studies indicating that benzodiazepines could be either a protective factor or a risk factor for dementia, or that there may be an absence of an association between the two. The objective of this study was to identify whether an association exists between the use of benzodiazepines and the development of dementia. DESIGN: Systematic review and meta-analysis of 12 prospective and retrospective cohort studies and case-control studies...
August 11, 2018: Pharmacotherapy
Sara Juliana de A de Vasconcellos, Edmundo M do Nascimento-Júnior, Marcel Vinícius de Aguiar Menezes, Mário Luis Tavares Mendes, Rafael de Souza Dantas, Paulo Ricardo Saquete Martins-Filho
Importance: Evidence has emerged on the efficacy of tranexamic acid to control blood loss and postoperative complications after rhinoplasty. Objective: To investigate the results of tranexamic acid use to reduce intraoperative bleeding, postoperative eyelid edema, and periorbital ecchymosis in rhinoplasty. Data Sources and Study Selection: For this systematic review of randomized clinical trials, searches were performed in PubMed, Cochrane Central Register of Controlled Trials, Web of Science, SCOPUS, Science Direct, Google Scholar, OpenThesis, and ClinicalTrials...
August 9, 2018: JAMA Otolaryngology—Head & Neck Surgery
Alexander Schnabel, Sylvia U Reichl, Stephanie Weibel, Peter Kranke, Peter K Zahn, Esther M Pogatzki-Zahn, Christine H Meyer-Frießem
BACKGROUND: The duration of analgesia provided by nerve blocks is limited if local anaesthetics are administered alone. Therefore, several additives, including dexmedetomidine (DEX), have been investigated in order to prolong postoperative analgesia following single-shot regional anaesthesia. OBJECTIVES: The aim of this meta-analysis was to assess the efficacy and safety of the addition of perineural DEX to local anaesthetics compared with local anaesthetics alone or local anaesthetics combined with systemic administration of DEX...
August 7, 2018: European Journal of Anaesthesiology
Anita Aminoshariae, James C Kulild, Ashraf F Fouad
INTRODUCTION: The purpose of this systematic review was to determine whether endodontic infections had an impact on the pathogenesis of systemic disease. METHODS: Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies, gray literature of all relevant articles, and textbooks were manually searched. There was no disagreement between the 2 reviewers...
August 2, 2018: Journal of Endodontics
Lei Li, Weizhen Liu, Huishan Tao, Hengyu Chen, Wenrong Li, Tao Huang, Ende Zhao
BACKGROUND: To evaluate whether negative pressure drainage has advantage over natural drainage in effectiveness and safety for patients with thyroid disease after thyroid surgery. METHOD: We performed intensive literature search and followed the standards described in preferred reporting items for systematic review and meta-analysis (PRISMA) statement to conduct this systematic review. Risk of bias was assessed using the Cochrane Risk of bias tool. We used Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to evaluate the quality of evidence body...
August 2018: Medicine (Baltimore)
Asma Salari-Moghaddam, Parvane Saneei, Bagher Larijani, Ahmad Esmaillzadeh
BACKGROUND/OBJECTIVES: Although several studies have investigated the association between dietary Glycemic Index (GI), glycemic load (GL) and depression, results are inconsistent. This systematic review and meta-analysis was performed to summarize earlier evidence on the association between dietary GI, GL, and depression. SUBJECTS/METHODS: We searched in PubMed/Medline, ISI Web of Knowledge, Scopus, EMBASE, and Google Scholar to identify related articles published until April 2018...
July 27, 2018: European Journal of Clinical Nutrition
Hassan Mir, Reed Alexander C Siemieniuk, Long Cruz Ge, Farid Foroutan, Michael Fralick, Talha Syed, Luciane Cruz Lopes, Ton Kuijpers, Jean-Louis Mas, Per O Vandvik, Thomas Agoritsas, Gordon H Guyatt
OBJECTIVE: To examine the relative impact of three management options in patients aged <60 years with cryptogenic stroke and a patent foramen ovale (PFO): PFO closure plus antiplatelet therapy, antiplatelet therapy alone and anticoagulation alone. DESIGN: Systematic review and network meta-analysis (NMA) supported by complementary external evidence. DATA SOURCES: Medline, EMBASE and Cochrane CENTRAL. STUDY SELECTION: Randomised controlled trials (RCTs) addressing PFO closure and/or medical therapies in patients with PFO and cryptogenic stroke...
July 25, 2018: BMJ Open
Francisco J García Bacete, Inmaculada Sureda-García, Victoria Muñoz-Tinoco, Irene Jiménez-Lagares, Ghislaine Marande Perrin, Jesús F Rosel
Aim: The aim of this study was to identify which adverse peer experiences better predict perceived negative peer relationships among elementary school first graders according to sex. The peer experiences examined were peer rejection, peer victimization, and mutual antipathy; the interpersonal perceptions studied were perceived peer victimization, dyadic meta-perception of peer disliking, and loneliness. Methods: The participants were 809 children ( M age = 6.4 years, SD = 0.32; n girls = 412, 50.9%) enrolled in 35 first-grade classes from 15 schools in 4 Spanish regions: Valencia, n = 276, 34...
2018: Frontiers in Psychology
R L Nelson, A Kravets, R Khateeb, M Raza, M Siddiqui, I Taha, A Tummala, R Epple, S Huang, M Wen
BACKGROUND: Among the techniques investigated to reduce the risk of surgical wound infection or surgical space infection (SSI) in patients having colorectal surgery are topical application of antimicrobials (antibiotics and antiseptics) to the open wound or immediately after closure. The aim of the present study was to perform a systematic review of the literature on those treatments, with the exception of antibiotic ointments applied to closed skin, which are adequately assessed elsewhere, and a meta-analysis...
July 17, 2018: Techniques in Coloproctology
Peng Chen, Fuchao Chen, Benhong Zhou
Background: Recent clinical studies have shown that initial therapy with combined cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade and granulocyte-macrophage colony-stimulating factor (GM-CSF)-based immunotherapies can enhance the antitumor efficacy of this approach. A key unanswered question is whether systemic GM-CSF enhances CTLA-4 blockade. Thus, the objective of this study was taking a meta-analysis of randomized controlled trials to compare the effect of ipilimumab plus GM-CSF versus ipilimumab alone on overall response, overall survival, and progression-free survival, as well as the risk of adverse events (AEs) in patients with cancer...
2018: Drug Design, Development and Therapy
R Thompson, R Hornigold, L Page, T Waite
OBJECTIVES: The objective of this study was to describe the mental health effects of high ambient temperatures and heat waves, determine whether heat-related morbidity and mortality are increased among people with known mental disorders and identify knowledge gaps to inform targeting of future research. STUDY DESIGN: Systematic literature review and narrative synthesis. METHODS: A systematic review of published literature using MEDLINE, Embase and PsycINFO without geographical or temporal limits was conducted...
August 2018: Public Health
Fernanda Márcia Rodrigues Martins Ferreira, Maria Emília Abreu Chaves, Vinícius Cunha Oliveira, Adriana Maria Valladão Novais Van Petten, Claysson Bruno Santos Vimieiro
Robot-Assisted Therapy (RT) is an innovative approach to neurological rehabilitation that uses intensive, repetitive, interactive, and individualized practice. This systematic review aimed to investigate the effectiveness of RT on the body function and structure of people with upper limb impairments (PROSPERO registration: CRD42017054982). A search strategy conducted on seven databases identified randomized controlled studies. Methodological quality was assessed using the PEDro scale. When possible, the data were pooled, the strength of evidence was assessed using the GRADE system, and the effect sizes were assessed using Cohen coefficient...
2018: PloS One
Farid Foroutan, Barbara S Doumouras, Heather Ross, Ana C Alba
The ISHLT's 2016 Guidelines on the selection of heart transplant (HT) candidates recommends weight loss prior to listing for persons with body mass (BMI) index greater than 35 kg/m2 . We conducted a systematic review to assess the impact of BMI on all-cause mortality. We searched to identify eligible observational studies that followed HT recipients. We used the GRADE system to quantify absolute effects and quality of evidence, and meta-analyzed survival curves to assess post-transplant mortality across BMI categories...
July 10, 2018: Clinical Transplantation
Bo Yang, Ruili Yu, Lili Cai, Bin Guo, Hongfei Chen, Haomin Zhang, Peifeng He, Xuechun Lu
We compared the safety and efficacy of haploidentical stem cell transplantation (haplo-SCT) to matched donor SCT (matched-SCT) in treating hematological malignancies. The Medline, Cochrane, EMBASE, and Google Scholar databases were searched through 21 June 2017 using the search term "(hematological disease) AND matched AND (haploidentical OR haplo-identical OR haplo identical OR haplo transplantation OR haplo transplant OR haplo-SCT OR haplo-HSCT OR haplo-HCT)." Twenty-five studies enrolling 11,359 patients (haplo-SCT: 2677; matched-SCT: 8682) were included...
July 9, 2018: Bone Marrow Transplantation
Xin Shu, Qing-Qing Mai, Markus Blatz, Richard Price, Xiao-Dong Wang, Ke Zhao
PURPOSE: The primary objective of this systematic review was to compare treatment outcomes of direct and indirect permanent restorations in endodontically treated teeth, and provide clinical suggestions for restoring teeth after endodontic treatment. MATERIALS AND METHODS: Electronic databases (Medline, EMBASE, CENTRAL) and gray literature were screened for articles in English that reported on prospective and retrospective clinical studies of direct or indirect restorations after endodontic treatment with an observation period of at least 3 years...
2018: Journal of Adhesive Dentistry
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