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https://www.readbyqxmd.com/read/30341970/clinical-impact-of-baseline-chronic-kidney-disease-in-patients-undergoing-transcatheter-or-surgical-aortic-valve-replacement
#1
Andres M Pineda, J Kevin Harrison, Neal S Kleiman, Michael J Reardon, John V Conte, Daniel P O'Hair, Stanley J Chetcuti, Jian Huang, Steven J Yakubov, Jeffrey J Popma, Nirat Beohar
OBJECTIVES: To assess the treatment effect of TAVR versus SAVR on clinical outcomes to 3 years in patients stratified by chronic kidney disease (CKD) by retrospectively studying patients randomized to TAVR or SAVR. BACKGROUND: The impact of CKD on mid-term outcomes of patients undergoing TAVR versus SAVR is unclear. METHODS: Patients randomized to TAVR or SAVR in the CoreValve US Pivotal High Risk Trial were retrospectively stratified by eGFR: none/mild or moderate/severe CKD...
October 20, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30341572/usefulness-of-multidisciplinary-care-to-prevent-worsening-renal-function-in-chronic-kidney-disease
#2
Yoshihiko Imamura, Yasunori Takahashi, Toshihide Hayashi, Masateru Iwamoto, Rie Nakamura, Mikiko Goto, Kazuyo Takeba, Makoto Shinohara, Shun Kubo, Nobuhiko Joki
BACKGROUND: Comprehensive education about lifestyle, nutrition, medications and other types of treatment is important to prevent renal dysfunction in patients with chronic kidney disease (CKD). However, the effectiveness of multidisciplinary care on CKD progression has not been evaluated in detail. We aimed to determine whether multidisciplinary care at our hospital could help prevent worsening renal function associated with CKD. METHODS: A total of 150 pre-dialysis CKD outpatients accompanied (n = 68) or not (n = 82) with diabetes mellitus (DM) were enrolled into this study...
October 19, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/30338870/a-model-for-glomerular-filtration-rate-assessment-in-liver-disease-grail-in-the-presence-of-renal-dysfunction
#3
Sumeet K Asrani, Linda W Jennings, James F Trotter, Josh Levitsky, Mitra K Nadim, W R Kim, Stevan A Gonzalez, Bernard Fischbach, Ranjeeta Bahirwani, Michael Emmett, Goran Klintmalm
Estimation of glomerular filtration rate (eGFR) in patients with liver disease is suboptimal in presence of renal dysfunction. We developed a model for GFR Assessment In Liver disease (GRAIL) before and after liver transplantation (LT). GRAIL was derived using objective variables (creatinine, blood urea nitrogen, age, gender, race, albumin) to estimate GFR based on timing of measurement relative to LT and degree of renal dysfunction. Measured GFR (mGFR) by iothalamate clearance (n=12,122, 1985-2015) at protocol time points before/after LT was used as reference...
October 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30335066/-evaluation-of-nephrocerebral-risk-with-the-use-of-cystatin-c-in-patients-with-chronic-kidney-disease
#4
I T Murkamilov, I S Sabirov, V V Fomin, J A Murkamilova, K A Aitbaev, Z R Rayimzhanov
AIM: To study a role of cystatin C in the nephrocerebral risk in chronic kidney disease at the initial stage of the disease. MATERIAL AND METHODS: One hundred and twenty-eight patients (63 men and 65 women) with chronic kidney disease (CKD) were examined at the pre-dialysis stage of the disease. All patients underwent a complex clinical and laboratory examination with determination of the lipid spectrum, uric acid, fibrinogen, calcium and cystatin C, and subsequent calculation of the glomerular filtration rate (GFR)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30328552/gonadal-hormones-in-the-pathogenesis-and-treatment-of-bone-health-in-patients-with-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#5
REVIEW
Jasna Aleksova, Alexander J Rodriguez, Robert McLachlan, Peter Kerr, Frances Milat, Peter R Ebeling
PURPOSE OF REVIEW: Patients with chronic kidney disease (CKD) have a greatly increased fracture risk compared with the general population. Gonadal hormones have an important influence on bone mineral density (BMD) and fracture risk, and hormone therapies can significantly improve these outcomes. Gonadal dysfunction is a frequent finding in patients with CKD; yet, little is known about the impact of gonadal hormones in the pathogenesis and treatment of bone health in patients with CKD...
October 17, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/30328315/bioactive-compounds-for-the-treatment-of-renal-disease
#6
REVIEW
Kang Su Cho, In Kap Ko, James J Yoo
Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings...
November 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/30328166/heart-rate-variability-as-a-predictor-of-rapid-renal-function-deterioration-in-chronic-kidney-disease-patients
#7
Yu-Hsiang Chou, Wei-Lieh Huang, Chin-Hao Chang, Cheryl C H Yang, Terry B J Kuo, Shuei-Liong Lin, Wen-Chih Chiang, Tzong-Shinn Chu
AIM: Autonomic dysfunction contributes to cardiovascular morbidity/mortality and can be evaluated with heart rate variability (HRV). This study is to evaluate the prognostic significance of HRV on renal function in non-dialysis chronic kidney disease (CKD) patients. METHODS: We enrolled 326 non-dialysis CKD patients in this prospective observational study. The median follow-up period was 2.02 years. Five-minutes of electrocardiography recordings obtained at enrollment were reprocessed to assess HRV...
October 17, 2018: Nephrology
https://www.readbyqxmd.com/read/30327720/educational-support-around-dialysis-modality-decision-making-in-patients-with-chronic-kidney-disease-qualitative-study
#8
Brendan P Cassidy, Lori Harwood, Leah E Getchell, Michael Smith, Shannon L Sibbald, Louise M Moist
Background: Patients with chronic kidney disease (CKD) are asked to choose a renal replacement therapy or conservative management. Education and knowledge transfer play key roles in this decision-making process, yet they remain a partially met need. Objective: We sought to understand the dialysis modality decision-making process through exploration of the predialysis patient experience to better inform the educational process. Design: Qualitative descriptive study...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/30325973/plasma-neutrophil-gelatinase-associated-lipocalin-is-independently-associated-with-left-ventricular-hypertrophy-and-diastolic-dysfunction-in-patients-with-chronic-kidney-disease
#9
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are known as predictors of CVD in these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. Recently, elevated NGAL levels have been reported in patients with CVD. This study aimed to evaluate the association between plasma NGAL levels and LVH/LVDD in patients with CKD...
2018: PloS One
https://www.readbyqxmd.com/read/30325191/clinical-outcomes-and-healthcare-use-associated-with-optimal-esrd-starts
#10
Peter W Crooks, Christopher O Thomas, Amy Compton-Phillips, Wendy Leith, Alvina Sundang, Yi Yvonne Zhou, Linda Radler
OBJECTIVES: To assess the association between optimal end-stage renal disease (ESRD) starts and clinical and utilization outcomes in an integrated healthcare delivery system. STUDY DESIGN: Retrospective observational cohort study in 6 regions of an integrated healthcare delivery system, 2011-2013. METHODS: Propensity score techniques were used to match 1826 patients who experienced an optimal start of renal replacement therapy (initial therapy of hemodialysis via an arteriovenous fistula or graft, peritoneal dialysis, or pre-emptive transplant) to 1826 patients who experienced a nonoptimal start (hemodialysis via a central venous catheter)...
October 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/30321257/obesity-and-risk-of-end-stage-renal-disease-in-patients-with-chronic-kidney-disease-a-cohort-study
#11
Ting-Yun Lin, Jia-Sin Liu, Szu-Chun Hung
Background: Obesity is a risk factor for de novo chronic kidney disease (CKD) in the general population. Obesity has been increasingly prevalent in patients with CKD and may lead to further progression of pre-existing CKD. However, whether obesity is associated with the development of end-stage renal disease (ESRD) in patients with CKD is not well understood. Objective: We investigated the impact of obesity on ESRD (needing chronic dialysis treatment or pre-emptive renal transplantation) or all-cause mortality in patients with moderate to advanced CKD...
October 13, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30320621/sex-hormones-and-their-influence-on-chronic-kidney-disease
#12
José Manuel Valdivielso, Conxita Jacobs-Cachá, María José Soler
PURPOSE OF REVIEW: The majority of end-stage renal disease including dialysis and kidney transplant patients are men. In contrast, the incidence of chronic kidney disease (CKD) is higher in women compared with men. In this review, we dissect the sex hormone levels and its effects on experimental models and patients with CKD. RECENT FINDINGS: Sex hormones are clearly involved in CKD progression to end-stage renal disease (ESRD). A significant reduction in lipid peroxidation as a mechanism of renoprotection has been observed in kidneys of streptozotocin (STZ)-diabetic ovariectomized rats after estradiol administration...
October 12, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/30320542/thrombophilic-genetic-anomalies-and-their-association-with-dialysis-initiation-age-in-a-cohort-of-lebanese-hemodialysis-patients
#13
Antoine Barbari, Aline Milane, Pascale Salameh, Jennifer Abi Younis, Abir El Houjairy, Katia Safi, Ikram Sabaa Ayoun, Mahassen Jaafar, Line Bou Khalil, Ali Bachir, Nadine Bassil, Hussein Karnib, Nina Morad, Sylvana Rizk, Marwan Masri
OBJECTIVES: The relationship between chronic kidney disease and cardiovascular disease is complex and bidirectional. This relationship may be partially linked to thrombophilic genetic anomalies that may predispose to the progression of both diseases. MATERIALS AND METHODS: We analyzed blood samples from 102 Lebanese patients with end-stage renal disease and undergoing hemodialysis and 20 randomly selected healthy volunteers for frequencies of 12 cardiovascular disease gene mutations and traditional risk factors...
October 15, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/30318504/case-of-serotonin-syndrome-initially-presenting-as-diffuse-body-pain
#14
Michael H Guo, Reesa L Monir, Ashleigh Wright, Neal P Holland
BACKGROUND Serotonin syndrome is a common yet potentially life-threatening condition caused by increased serotonergic activity, usually from serotonergic pharmaceutical agents. Primary features of serotonin syndrome include mental status changes, autonomic hyperactivity, and neuromuscular abnormalities. However, the presentation of serotonin syndrome is often quite variable, leading to its under-diagnosis. CASE REPORT A 50-year-old female with chronic kidney disease on peritoneal dialysis presented to the Emergency Department with severe, diffuse body pain...
October 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/30316311/urologic-evaluation-and-management-of-pediatric-kidney-transplant-patients
#15
REVIEW
Blake Palmer, Brad Kropp
Urologic causes of end-stage renal disease are estimated between 25% and 40% of causes. The goal of renal transplantation in chronic kidney disease patients is to provide renal replacement therapy with less morbidity, better quality of life, and improved overall survival compared with dialysis. A patient's urologic history can be a significant source of problems related to infections, recurrence of disease, and surgical complications. Many of the urologic risks are modifiable. Proper evaluation and management can mitigate the potential problems after transplantation, and these patients with complex urologic problems are seen to have similar graft function outcomes...
November 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/30312430/fibroblast-growth-factor-23-is-associated-with-fractional-excretion-of-sodium-in-patients-with-chronic-kidney-disease
#16
Hong Xu, Ali Hashem, Anna Witasp, Rik Mencke, David Goldsmith, Peter Barany, Annette Bruchfeld, Annika Wernerson, Juan-Jesus Carrero, Hannes Olauson
Background: Recent studies suggest that the phosphaturic hormone fibroblast growth factor 23 (FGF23) is involved in regulation of renal sodium excretion and blood pressure. There is evidence of both direct effects via regulation of the sodium-chloride symporter (NCC) in the distal tubule, and indirect effects through interactions with the renin-angiotensin-aldosterone system. However, clinical data on the association between FGF23 and renal sodium regulation is lacking. Herein, we investigated the associations of FGF23 with renal sodium handling and blood pressure in non-dialysis CKD patients...
October 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30309449/relationships-between-abdominal-aortic-calcification-glomerular-filtration-rate-and-cardiovascular-risk-factors-in-patients-with-non-dialysis-dependent-chronic-kidney-disease
#17
Yunan Zhou, Matthias Hellberg, Evangelia Kouidi, Asterios Deligiannis, Peter Höglund, Naomi Clyne
BACKGROUND: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. MATERIALS AND METHODS: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22...
October 12, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30305308/broadening-our-perspectives-ckd-care-and-the-dialysis-transition
#18
EDITORIAL
Thomas Hostetter, Josie P Briggs
No abstract text is available yet for this article.
October 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30305038/prevalence-socio-demographic-characteristics-and-comorbid-health-conditions-in-pre-dialysis-chronic-kidney-disease-results-from-the-manitoba-chronic-kidney-disease-cohort
#19
Mariette J Chartier, Navdeep Tangri, Paul Komenda, Randy Walld, Ina Koseva, Charles Burchill, Kari-Lynne McGowan, Allison Dart
BACKGROUND: Chronic Kidney Disease (CKD) is common and its prevalence has increased steadily over several decades. Monitoring of rates and severity of CKD across populations is critical for policy development and resource planning. Administrative health data alone has insufficient sensitivity for this purpose, therefore utilizing population level laboratory data and novel methodology is required for population-based surveillance. The aims of this study include a) develop the Manitoba CKD Cohort, b) estimate CKD prevalence, c) identify individuals at high risk of progression to kidney failure and d) determine rates of comorbid health conditions...
October 10, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30305035/diagnosis-and-management-of-non-dialysis-chronic-kidney-disease-in-ambulatory-care-a-systematic-review-of-clinical-practice-guidelines
#20
Gesine F C Weckmann, Sylvia Stracke, Annekathrin Haase, Jacob Spallek, Fabian Ludwig, Aniela Angelow, Jetske M Emmelkamp, Maria Mahner, Jean-François Chenot
BACKGROUND: Chronic kidney disease (CKD) is age-dependent and has a high prevalence in the general population. Most patients are managed in ambulatory care. This systematic review provides an updated overview of quality and content of international clinical practice guidelines for diagnosis and management of non-dialysis CKD relevant to patients in ambulatory care. METHODS: We identified guidelines published from 2012-to March 2018 in guideline portals, databases and by manual search...
October 11, 2018: BMC Nephrology
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