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https://www.readbyqxmd.com/read/28418777/er-la-opioid-rems-and-accredited-education-survey-results-provide-insight-into-clinical-roles-educational-needs-and-learner-preferences
#1
Cynthia Kear, Tom McKeithen, Sheila Robertson
BACKGROUND: The Collaborative for REMS Education (CO*RE) includes 13 organizations who provide REMS Program Companies (RPC) grant-supported accredited education on extended-release and long-acting (ER/LA) opioid therapy. This report summarizes results of a survey designed to investigate the impact of participant criteria and to better understand the roles and preferences of CME/CE participants. METHODS: In April 2015, we made an online survey available to an estimated 10,000 clinicians who had completed a CO*RE CME/CE activity since 2013...
April 18, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28415014/determination-and-quantification-of-intracellular-fludarabine-triphosphate-cladribine-triphosphate-and-clofarabine-triphosphate-by-lc-ms-ms-in-human-cancer-cells
#2
Jean-Yves Puy, Lars Petter Jordheim, Emeline Cros-Perrial, Charles Dumontet, Suzanne Peyrottes, Isabelle Lefebvre-Tournier
Purine nucleoside analogues are widely used in the treatment of haematological malignancies, and their biological activity is dependent on the intracellular accumulation of their triphosphorylated metabolites. In this context, we developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to study the formation of 5'-triphosphorylated derivatives of cladribine, fludarabine, clofarabine and 2'-deoxyadenosine in human cancer cells. Br-ATP was used as internal standard. Separation was achieved on a hypercarb column...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28413715/brain-serotonin-4-receptor-binding-is-inversely-associated-with%C3%A2-verbal-memory-recall
#3
Dea S Stenbæk, Patrick M Fisher, Brice Ozenne, Emil Andersen, Liv V Hjordt, Brenda McMahon, Steen G Hasselbalch, Vibe G Frokjaer, Gitte M Knudsen
BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall. METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [(11)C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28410671/dog-erythrocyte-antigens-dea-1-4-7-and-suspected-naturally-occurring-anti-dea-7-antibodies-in-italian-corso-dogs
#4
E Spada, D Proverbio, V Priolo, D Ippolito, L Baggiani, R Perego, M G Pennisi
We sought to determine the prevalence of dog erythrocyte antigen (DEA) 1, 4 and 7 and naturally occurring anti-DEA7 antibodies in Italian Corso dogs. In addition, we correlated DEAs with different epidemiologic variables, compared the prevalence of DEAs against other canine populations and assessed the risk of sensitisation and transfusion reactions (TRs) following unmatched transfusion. Blood samples from 100 Corso dogs were evaluated for DEA 1, 4, 7 and naturally occurring anti-DEA 7 antibodies. Seventy-one percent of samples were DEA 1-negative, 100% tested DEA 4-positive, and 95% tested DEA 7-negative...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28409643/economical-doubly-electron-attached-equation-of-motion-coupled-cluster-methods-with-an-active-space-treatment-of-3-particle-1-hole-and-4-particle-2-hole-excitations
#5
Adeayo Olayinka Ajala, Jun Shen, Piotr Piecuch
The previously developed active-space doubly electron-attached (DEA) equation-of-motion (EOM) coupled-cluster (CC) method with up to 4-particle-2-hole (4p-2h) excitations [Shen, J.; Piecuch, P. J. Chem. Phys. 2013, 138, 194102], which utilizes the idea of applying a linear electron-attaching operator to the CC ground state of an (N-2)-electron closed-shell system to generate ground and excited states of the N-electron open-shell species of interest, has been extended to a considerably less expensive model, in which both 3p-1h and 4p-2h terms rather than 4p-2h contributions only are selected using active orbitals...
April 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28406883/characteristics-of-fentanyl-overdose-massachusetts-2014-2016
#6
Nicholas J Somerville, Julie O'Donnell, R Matthew Gladden, Jon E Zibbell, Traci C Green, Morgan Younkin, Sarah Ruiz, Hermik Babakhanlou-Chase, Miranda Chan, Barry P Callis, Janet Kuramoto-Crawford, Henry M Nields, Alexander Y Walley
Opioid overdose deaths in Massachusetts increased 150% from 2012 to 2015 (1). The proportion of opioid overdose deaths in the state involving fentanyl, a synthetic, short-acting opioid with 50-100 times the potency of morphine, increased from 32% during 2013-2014 to 74% in the first half of 2016 (1-3). In April 2015, the Drug Enforcement Agency (DEA) and CDC reported an increase in law enforcement fentanyl seizures in Massachusetts, much of which was believed to be illicitly manufactured fentanyl (IMF) (4)...
April 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28403853/the-application-of-dea-data-envelopment-analysis-window-analysis-in-the-assessment-of-influence-on-operational-efficiencies-after-the-establishment-of-branched-hospitals
#7
Tongying Jia, Huiyun Yuan
BACKGROUND: Many large-scaled public hospitals have established branched hospitals in China. This study is to provide evidence for strategy making on the management and development of multi-branched hospitals by evaluating and comparing the operational efficiencies of different hospitals before and after their establishment of branched hospitals. METHODS: DEA (Data Envelopment Analysis) window analysis was performed on a 7-year data pool from five public hospitals provided by health authorities and institutional surveys...
April 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28394598/low-energy-electron-interaction-with-melatonin-and-related-compounds
#8
Stanislav A Pshenichnyuk, Alberto Modelli, Derek Jones, Eleonora F Lazneva, Alexei S Komolov
The electron attaching properties and fragmentation of temporary negative ions of melatonin and its biosynthetic precursor tryptophan are studied in vacuo using dissociative electron attachment (DEA) spectroscopy. The experimental findings are interpreted in silico with the support of Hartree-Fock and density functional theory calculations of empty orbital energies and symmetries, and evaluation of the electron affinities of the indolic molecules under investigation. The only fragment anions formed by DEA to melatonin at incident electron energies below 2 eV are associated with the elimination of a hydrogen atom (energetically favored from the NH site of the pyrrole ring, leaving the ring intact) or a CH3(·) radical from the temporary molecular negative ion...
April 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28379959/unraveling-chagas-disease-transmission-through-the-oral-route-gateways-to-trypanosoma-cruzi-infection-and-target-tissues
#9
Danielle Silva-Dos-Santos, Juliana Barreto-de-Albuquerque, Bárbara Guerra, Otacilio C Moreira, Luiz Ricardo Berbert, Mariana Tavares Ramos, Barbara Angelica S Mascarenhas, Constança Britto, Alexandre Morrot, Déa M Serra Villa-Verde, Luciana Ribeiro Garzoni, Wilson Savino, Vinícius Cotta-de-Almeida, Juliana de Meis
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed the importance of parasite contact with oral cavity to induce a highly severe acute disease in mice. However, it remains uncertain the primary site of parasite entry and multiplication due to an oral infection. Here, we evaluated the presence of T...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28361805/hospital-efficiency-how-to-spend-less-maintaining-quality
#10
Paolo Campanella, Elena Azzolini, Alessio Izzi, Ferruccio Pelone, Concetta De Meo, Daniele La Milia, Maria Lucia Specchia, Walter Ricciardi
INTRODUCTION: The recent global economic crisis is pushing governments worldwide to obtain a more explicit and urgent rationing of resources. The purpose of this study is to provide, through Data Envelopment Analysis (DEA), a methodological framework useful for investigating technical efficiency of hospital care. METHODS: To validate such framework, we compared 50 Italian public hospital trusts (AOs) to identify relative efficient using inputs and outputs from national databases...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28355049/schedules-of-controlled-substances-placement-of-fda-approved-products-of-oral-solutions-containing-dronabinol-delta-9-transtetrahydrocannabinol-delta-9-thc-in-schedule-ii-interim-final-rule-with-request-for-comments
#11
(no author information available yet)
On July 1, 2016, the U.S. Food and Drug Administration (FDA) approved a new drug application for Syndros, a drug product consisting of dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] oral solution. Thereafter, the Department of Health and Human Services (HHS) provided the Drug Enforcement Administration (DEA) with a scheduling recommendation that would result in Syndros (and other oral solutions containing dronabinol) being placed in schedule II of the Controlled Substances Act (CSA). In accordance with the CSA, as revised by the Improving Regulatory Transparency for New Medical Therapies Act, DEA is hereby issuing an interim final rule placing FDA-approved products of oral solutions containing dronabinol in schedule II of the CSA...
March 23, 2017: Federal Register
https://www.readbyqxmd.com/read/28350941/spine-oncology-primary-spine-tumors
#12
Nicolas Dea, Ziya Gokaslan, David Choi, Charles Fisher
Primary tumors originating from the spine are very complex and challenging entities to treat. Due to their rarity, a multicenter collaborative network is essential to shepherd the best research and contribute to the dissemination of the best evidence possible. Over the last few years, several advances have occurred in many different fields. Surgery is still the cornerstone of treatment in most cases. The occasional suboptimal outcomes and high morbidity of surgical treatment have however encouraged professionals caring for these patients to explore safer treatment options and alternatives or adjuncts to surgical treatment...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28345746/an-analysis-of-errors-discrepancies-and-variation-in-opioid-prescriptions-for-adult-outpatients-at-a-teaching-hospital
#13
Mark C Bicket, Deepa Kattail, Myron Yaster, Christopher L Wu, Peter Pronovost
OBJECTIVE: To determine opioid-prescribing patterns and rate of three types of errors, discrepancies, and variation from ideal practice. DESIGN: Retrospective review of opioid prescriptions processed at an outpatient pharmacy. SETTING: Tertiary institutional medical center. PATIENTS: We examined 510 consecutive opioid medication prescriptions for adult patients processed at an institutional outpatient pharmacy in June 2016 for patient, provider, and prescription characteristics...
January 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28344756/measuring-efficiency-of-knowledge-production-in-health-research-centers-using-data-envelopment-analysis-dea-a-case-study-in-iran
#14
Mohammad Meskarpour Amiri, Taha Nasiri, Seyed Hassan Saadat, Hosein Amini Anabad, Payman Mahboobi Ardakan
INTRODUCTION: Efficiency analysis is necessary in order to avoid waste of materials, energy, effort, money, and time during scientific research. Therefore, analyzing efficiency of knowledge production in health areas is necessary, especially for developing and in-transition countries. As the first step in this field, the aim of this study was the analysis of selected health research center efficiency using data envelopment analysis (DEA). METHODS: This retrospective and applied study was conducted in 2015 using input and output data of 16 health research centers affiliated with a health sciences university in Iran during 2010-2014...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28342416/joint-carbon-footprint-assessment-and-data-envelopment-analysis-for-the-reduction-of-greenhouse-gas-emissions-in-agriculture-production
#15
Ricardo Rebolledo-Leiva, Lidia Angulo-Meza, Alfredo Iriarte, Marcela C González-Araya
Operations management tools are critical in the process of evaluating and implementing action towards a low carbon production. Currently, a sustainable production implies both an efficient resource use and the obligation to meet targets for reducing greenhouse gas (GHG) emissions. The carbon footprint (CF) tool allows estimating the overall amount of GHG emissions associated with a product or activity throughout its life cycle. In this paper, we propose a four-step method for a joint use of CF assessment and Data Envelopment Analysis (DEA)...
March 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342048/assessing-knowledge-performance-and-efficiency-for-hospital-waste-management-a-comparison-of-government-and-private-hospitals-in-pakistan
#16
Mustafa Ali, Wenping Wang, Nawaz Chaudhry, Yong Geng, Uzma Ashraf
Proper management of healthcare waste is a critical concern in many countries of the world. Rapid urbanization and population growth rates pose serious challenges to healthcare waste management infrastructure in such countries. This study was aimed at assessing the situation of hospital waste management in a major city of Pakistan. Simple random sampling was used to select 12 government and private hospitals in the city. Field visits, physical measurements, and questionnaire survey method were used for data collection...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28334144/the-effects-of-plant-nutritional-strategy-on-soil-microbial-denitrification-activity-through-rhizosphere-primary-metabolites
#17
Julien P Guyonnet, Florian Vautrin, Guillaume Meiffren, Clément Labois, Amélie A M Cantarel, Serge Michalet, Gilles Comte, Feth El Zahar Haichar
The aim of this study was to determine (i) whether plant nutritional strategy affects the composition of primary metabolites exuded into the rhizosphere and (ii) the impact of exuded metabolites on denitrification activity in soil. We answered this question by analysing primary metabolite content extracted from the root-adhering soil (RAS) and the roots of three grasses representing different nutrient management strategies: conservative (Festuca paniculata), intermediate (Bromus erectus) and exploitative (Dactylis glomerata)...
April 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28329732/performance-analysis-of-different-rice-based-cropping-systems-in-tropical-region-of-nepal
#18
Anil Pokhrel, Peeyush Soni
Energy inputs, environmental impacts and economic outputs are the main concerns in today's agricultural production systems. The current study investigated the energy, environmental and financial performances of different rice-based cropping systems (CSs). The CSs studied were: Rice-Wheat-Fallow (R-W-F), Rice-Wheat-Maize (R-W-M), Rice-Wheat-Mungbean (R-W-Mu), Rice-Lentil-Maize (R-L-M), Rice-Lentil-Mungbean (R-L-Mu), Rice-Garlic (R-G) and Rice-Onion (R-O). Primary data were collected from 210 randomly selected farms by using structured questionnaire...
March 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28326182/birt-hogg-dub%C3%A3-syndrome-a-case-report-and-a-review-of-the-literature
#19
REVIEW
Dea Kejlberg Jensen, Anders Villumsen, Anne-Bine Skytte, Mia Gebauer Madsen, Mette Sommerlund, Elisabeth Bendstrup
Background: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant inherited syndrome caused by mutations in the folliculin coding gene (FLCN). The clinical manifestations of the syndrome involve the skin, lungs, and kidneys. Because of the rarity of the syndrome, guidelines for diagnosis and management of the patients with BHDS are lacking. Objective: To present a case story and a review of the literature on BHDS in order to give an update on genetics, clinical manifestations, diagnosis, treatment, prognosis and follow-up strategies...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28318606/on-the-role-of-environmental-corruption-in-healthcare-infrastructures-an-empirical-assessment-for-italy-using-dea-with-truncated-regression-approach
#20
Marina Cavalieri, Calogero Guccio, Ilde Rizzo
OBJECTIVES: This paper investigates empirically whether the institutional features of the contracting authority as well as the level of 'environmental' corruption in the area where the work is localised affect the efficient execution of public contracts for healthcare infrastructures. METHODS: A two-stage Data Envelopment Analysis (DEA) is carried out based on a sample of Italian public contracts for healthcare infrastructures during the period 2000-2005. First, a smoothed bootstrapped DEA estimator is used to assess the relative efficiency in the implementation of each single infrastructure contract...
February 27, 2017: Health Policy
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