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https://www.readbyqxmd.com/read/28937941/the-scheduling-of-kratom-and-selective-use-of-data
#1
O Hayden Griffin, Megan E Webb
Kratom is a traditional drug from Southeast Asia that has been an emerging new substance in the United States. On August 30, 2016, the DEA announced the intention to emergency schedule kratom into Schedule I. To support this decision, the DEA cited an increase in drug seizures of kratom and an increase in calls to poison control concerning kratom. However, a short time later, on October 12, 2016, the DEA withdrew the intent to schedule kratom after public and congressional backlash. The withdrawal by the DEA was somewhat unprecedented...
September 22, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28936697/reactive-oxygen-species-and-glutathione-antioxidants-in-the-testis-of-the-soil-biosentinel-podarcis-sicula-rafinesque-1810
#2
Giulia Guerriero, Gerardino D'Errico, Rossella Di Giaimo, Dea Rabbito, Oladokun Sulaiman Olanrewaju, Gaetano Ciarcia
Important toxicological achievements have been made during the last decades using reptiles. We focus our investigation on gonadal reproductive health of the soil biosentinel Podarcis sicula which is very sensitive to endocrine-disrupting chemicals. The aim of this study is to quantitatively detect, by sensitive microassays, reactive oxygen species and the glutathione antioxidants in the testis and investigate if they are differentially expressed before and after remediation of a site of the "Land of Fires" (Campania, Italy) subject to illicit dumping of unknown material...
September 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28934471/a-novel-non-canonical-pip-box-mediates-parg-interaction-with-pcna
#3
Tanja Kaufmann, Irina Grishkovskaya, Anton A Polyansky, Sebastian Kostrhon, Eva Kukolj, Karin M Olek, Sebastien Herbert, Etienne Beltzung, Karl Mechtler, Thomas Peterbauer, Josef Gotzmann, Lijuan Zhang, Markus Hartl, Bojan Zagrovic, Kareem Elsayad, Kristina Djinovic-Carugo, Dea Slade
Poly(ADP-ribose) glycohydrolase (PARG) regulates cellular poly(ADP-ribose) (PAR) levels by rapidly cleaving glycosidic bonds between ADP-ribose units. PARG interacts with proliferating cell nuclear antigen (PCNA) and is strongly recruited to DNA damage sites in a PAR- and PCNA-dependent fashion. Here we identified PARG acetylation site K409 that is essential for its interaction with PCNA, its localization within replication foci and its recruitment to DNA damage sites. We found K409 to be part of a non-canonical PIP-box within the PARG disordered regulatory region...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28918279/seasonal-variation-of-chloro-s-triazines-in-the-hartbeespoort-dam-catchment-south-africa
#4
Cornelius Rimayi, David Odusanya, Jana M Weiss, Jacob de Boer, Luke Chimuka
Seasonal variation of eight chloro-s-triazine herbicides and seven major atrazine and terbuthylazine degradation products was monitored in the Hartbeespoort Dam catchment using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS/MS). Lake, river and groundwater were sampled from the Hartbeespoort Dam catchment over four seasons and the downstream Jukskei River was monitored during the winter season. Triazine herbicide concentrations in the Hartbeespoort Dam were in the order atrazine>simazine>propazine>ametryn>prometryn throughout the four seasons sampled...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28916535/spinal-cord-perfusion-pressure-predicts-neurologic-recovery-in-acute-spinal-cord-injury
#5
Jordan W Squair, Lise M Bélanger, Angela Tsang, Leanna Ritchie, Jean-Marc Mac-Thiong, Stefan Parent, Sean Christie, Christopher Bailey, Sanjay Dhall, John Street, Tamir Ailon, Scott Paquette, Nicolas Dea, Charles G Fisher, Marcel F Dvorak, Christopher R West, Brian K Kwon
OBJECTIVE: To determine whether spinal cord perfusion pressure (SCPP) as measured with a lumbar intrathecal catheter is a more predictive measure of neurologic outcome than the conventionally measured mean arterial pressure (MAP). METHODS: A total of 92 individuals with acute spinal cord injury were enrolled in this multicenter prospective observational clinical trial. MAP and CSF pressure (CSFP) were monitored during the first week postinjury. Neurologic impairment was assessed at baseline and at 6 months postinjury...
September 15, 2017: Neurology
https://www.readbyqxmd.com/read/28915811/strategies-for-the-quality-assessment-of-the-health-care-service-providers-in-the-treatment-of-gastric-cancer-in-colombia
#6
María Del Pilar Villamil, David Barrera, Nubia Velasco, Oscar Bernal, Esteban Fajardo, Carlos Urango, Sebastian Buitrago
BACKGROUND: While, at its inception in 1993, the health care system in Colombia was publicized as a paradigm to be copied across the developing world, numerous problems in its implementation have led to, what is now, an inefficient and crisis-ridden health system. Furthermore, as a result of inappropriate tools to measure the quality of the health service providers, several corruption scandals have arisen in the country. This study attempts to tackle this situation by proposing a strategy for the quality assessment of the health service providers (Entidades Promotoras de Salud, EPS) in the Colombian health system...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28905625/oral-ingestion-and-intraventricular-injection-of-curcumin-attenuates-the-effort-related-effects-of-the-vmat-2-inhibitor-tetrabenazine-implications-for-motivational-symptoms-of-depression
#7
Samantha E Yohn, Dea Gorka, Anisha Mistry, Samantha Collins, Emily Qian, Merce Correa, Arushi Manchanda, Robin H Bogner, John D Salamone
Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0-160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2...
September 14, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28892718/insight-into-the-effects-of-modifying-chromophores-on-the-performance-of-quinoline-based-dye-sensitized-solar-cells
#8
Mao Mao, Jian-Bo Wang, Xiu-Lin Liu, Guo-Hua Wu, Xia-Qin Fang, Qin-Hua Song
A series of organic dyes based on quinoline as an electron-deficient π-linker, were designed and synthesized for dye sensitized solar cells (DSSC) application. These push-pull conjugated dyes, sharing same anchoring group with distinctive electron-rich donating groups such as N,N-diethyl (DEA-Q), 3,6-dimethoxy carbazole (CBZ-Q), bis(4-butoxyphenyl)amine (BPA-Q), were synthesized by Riley oxidation of CH3 followed by Knoevenagel condensation of the corresponding aldehyde precursors 2a-c with cyanoacrylic acid...
September 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28891686/innovative-processes-and-technologies-for-modified-atmosphere-packaging-of-fresh-and-fresh-cut-fruits-and-vegetables-a-review
#9
Matthew Deas Wilson, Roger A Stanley, Alieta Eyles, Tom Ross
Modified atmosphere packaging (MAP) technology has been commercially viable since the 1970s. Currently, MAP is extensively used worldwide to preserve the quality and extend the shelf-life of whole fresh fruits and vegetables, but is also increasingly used to extend the shelf-life of minimally processed fresh fruit and vegetables. This review discusses new processes and technologies that can be used to improve quality preservation and consumer acceptability of minimally processed produce where high respiration rates and challenging degradation processes operate...
September 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28888430/vacuum-facilitated-infusion-of-bioactives-into-yeast-microcarriers-evaluation-of-a-novel-encapsulation-approach
#10
Stephen Young, Sharleen Dea, Nitin Nitin
Encapsulation into yeast microcarriers provides an appealing alternative to biomimetic systems by employing natural, pre-formed vehicles for the stabilization and delivery of bioactives compounds. However, current (diffusion-limited) methods of encapsulation using yeast require long time scales and heating which lead to poor encapsulation efficiencies and yields. This study evaluates the usage of vacuum infusion to encapsulate two model bioactives, curcumin and fisetin, into yeast and yeast cell wall particles and the physical parameters, e...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28886714/the-oxylipin-and-endocannabidome-responses-in-acute-phase-plasmodium-falciparum-malaria-in-children
#11
Izabella Surowiec, Sandra Gouveia-Figueira, Judy Orikiiriza, Elisabeth Lindquist, Mari Bonde, Jimmy Magambo, Charles Muhinda, Sven Bergström, Johan Normark, Johan Trygg
BACKGROUND: Oxylipins and endocannabinoids are low molecular weight bioactive lipids that are crucial for initiation and resolution of inflammation during microbial infections. Metabolic complications in malaria are recognized contributors to severe and fatal malaria, but the impact of malaria infection on the production of small lipid derived signalling molecules is unknown. Knowledge of immunoregulatory patterns of these molecules in malaria is of great value for better understanding of the disease and improvement of treatment regimes, since the action of these classes of molecules is directly connected to the inflammatory response of the organism...
September 8, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28886087/hong-kong-hospital-authority-resource-efficiency-evaluation-via-a-novel-dea-malmquist-model-and-tobit-regression-model
#12
Hainan Guo, Yang Zhao, Tie Niu, Kwok-Leung Tsui
The Hospital Authority (HA) is a statutory body managing all the public hospitals and institutes in Hong Kong (HK). In recent decades, Hong Kong Hospital Authority (HKHA) has been making efforts to improve the healthcare services, but there still exist some problems like unfair resource allocation and poor management, as reported by the Hong Kong medical legislative committee. One critical consequence of these problems is low healthcare efficiency of hospitals, leading to low satisfaction among patients. Moreover, HKHA also suffers from the conflict between limited resource and growing demand...
2017: PloS One
https://www.readbyqxmd.com/read/28880910/no-evidence-for-a-role-of-the-serotonin-4-receptor-in-five-factor-personality-traits-a-positron-emission-tomography-brain-study
#13
Dea Siggaard Stenbæk, Vibeke Høyrup Dam, Patrick MacDonald Fisher, Nanna Hansen, Liv Vadskjær Hjordt, Vibe Gedsoe Frokjaer
Serotonin (5-HT) brain architecture appears to be implicated in normal personality traits as supported by genetic associations and studies using molecular brain imaging. However, so far, no studies have addressed potential contributions to variation in normal personality traits from in vivo serotonin 4 receptor (5-HT4R) brain availability, which has recently become possible to image with Positron Emission Tomography (PET). This is particularly relevant since availability of 5-HT4R has been shown to adapt to synaptic levels of 5-HT and thus offers information about serotonergic tone in the healthy brain...
2017: PloS One
https://www.readbyqxmd.com/read/28874139/the-association-of-falls-with-loneliness-and-social-exclusion-evidence-from-the-deas-german-ageing-survey
#14
André Hajek, Hans-Helmut König
BACKGROUND: It remains an open question whether falls are related with social relations, covering subjective (e.g., perceived loneliness) and more objective dimensions (e.g., number of important individuals in regular contact). Consequently, we aimed at examining the association between falls and social ties comprehensively, including loneliness, social exclusion and the number of important people in regular contact. METHODS: Cross-sectional data were used from a population-based sample of community-dwelling individuals aged 40 and over (n = 7808) in Germany...
September 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28868554/highly-flexible-and-transparent-dielectric-elastomer-actuators-using-silver-nanowire-and-carbon-nanotube-hybrid-electrodes
#15
Ye Rim Lee, Hyungho Kwon, Do Hoon Lee, Byung Yang Lee
We demonstrate a dielectric elastomer actuator (DEA) with a high areal strain value of 146% using hybrid electrodes of silver nanowires (AgNWs) and single-walled carbon nanotubes (SWCNTs). The addition of a very small amount of SWCNTs (∼35 ng mm(-2)) to a highly resistive AgNW network resulted in a remarkable reduction of the electrode sheet resistance by three orders, increasing the breakdown field by 183% and maximum strain, while maintaining the reduction of optical transmittance within 11%. The DEA based on our transparent and stretchable hybrid electrodes can be easily fabricated by a simple vacuum filtration and transfer process of the electrode film on a pre-strained dielectric elastomer membrane...
September 4, 2017: Soft Matter
https://www.readbyqxmd.com/read/28864776/a-histone-mimicking-interdomain-linker-in-a-multi-domain-protein-modulates-multivalent-histone-binding
#16
Sebastian Kostrhon, Georg Kontaxis, Tanja Kaufmann, Erika Schirghuber, Stefan Kubicek, Robert Konrat, Dea Slade
N-terminal histone tails are subject to many posttranslational modifications that are recognized by and interact with designated reader domains in histone-binding proteins. BROMO domain adjacent to zinc finger 2B (BAZ2B) is a multi-domain histone-binding protein that contains two histone reader modules, a plant homeodomain (PHD) and a bromodomain (BRD), linked by a largely disordered linker. While previous studies have reported a specificity of the PHD domain for the unmodified N-terminus of histone H3 and of the BRD domain for H3 acetylated at Lys-14 (H3K14ac), the exact mode of H3 binding by BAZ2B and its regulation are underexplored...
September 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28863055/the-last-state-to-grant-nurse-practitioners-dea-licensure-an-education-improvement-initiative-on-the-florida-prescription-drug-monitoring-program
#17
Joni R Kellams, John P Maye
Nurse practitioners (NPs) now have prescriptive authority for controlled substances in all 50 states in the United States. Florida, the last state to grant NPs DEA licensure, has been wrought with prescription diversion practices for a number of years as pill mills, doctor shopping, and overprescribing proliferated. Prescription Drug Monitoring Programs (PDMPs) help curb drug diversion activity and play a key role in reducing the abuse of controlled substances. The primary objective of this education improvement initiative was to increase knowledge of actively licensed NPs in the state of Florida regarding the state's PDMP...
July 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/28859052/trends-in-deaths-involving-heroin-and-synthetic-opioids-excluding-methadone-and-law-enforcement-drug-product-reports-by-census-region-united-states-2006-2015
#18
Julie K O'Donnell, R Matthew Gladden, Puja Seth
Opioid overdose deaths quadrupled from 8,050 in 1999 to 33,091 in 2015 and accounted for 63% of drug overdose deaths in the United States in 2015. During 2010-2015, heroin overdose deaths quadrupled from 3,036 to 12,989 (1). Sharp increases in the supply of heroin and illicitly manufactured fentanyl (IMF) are likely contributing to increased deaths (2-6). CDC examined trends in unintentional and undetermined deaths involving heroin or synthetic opioids excluding methadone (i.e., synthetic opioids)* by the four U...
September 1, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28843872/does-grandchild-care-influence-grandparents-self-rated-health-evidence-from-a-fixed-effects-approach
#19
Merih Ates
The present study aims to identify, whether and how supplementary grandchild care is causally related to grandparents' self-rated health (SRH). Based on longitudinal data drawn from the German Aging Survey (DEAS; 2008-2014), I compare the results of pooled OLS, pooled OLS with lagged dependant variables (POLS-LD), random and fixed effects (RE, FE) panel regression. The results show that there is a positive but small association between supplementary grandchild care and SRH in POLS, POLS-LD, and RE models. However, the fixed effects model shows that the intrapersonal change in grandchild care does not cause a change in grandparents' SRH...
August 19, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28806649/firm-performance-and-the-role-of-environmental-management
#20
Tommy Lundgren, Wenchao Zhou
This paper analyzes the interactions between three dimensions of firm performance - productivity, energy efficiency, and environmental performance - and especially sheds light on the role of environmental management. In this context, environmental management is investments to reduce environmental impact, which may also affect firm competitiveness, in terms of change in productivity, and spur more (or less) efficient use of energy. We apply data envelopment analysis (DEA) technique to calculate the Malmquist firm performance indexes, and a panel vector auto-regression (VAR) methodology is utilized to investigate the dynamic and causal relationship between the three dimensions of firm performance and environmental investment...
August 11, 2017: Journal of Environmental Management
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