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https://www.readbyqxmd.com/read/27932949/muscle-type-nicotinic-receptor-modulation-by-2-6-dimethylaniline-a-molecule-resembling-the-hydrophobic-moiety-of-lidocaine
#1
Armando Alberola-Die, Gregorio Fernández-Ballester, José M González-Ros, Isabel Ivorra, Andrés Morales
To identify the molecular determinants responsible for lidocaine blockade of muscle-type nAChRs, we have studied the effects on this receptor of 2,6-dimethylaniline (DMA), which resembles lidocaine's hydrophobic moiety. Torpedo marmorata nAChRs were microtransplanted to Xenopus oocytes and currents elicited by ACh (IACh), either alone or co-applied with DMA, were recorded. DMA reversibly blocked IACh and, similarly to lidocaine, exerted a closed-channel blockade, as evidenced by the enhancement of IACh blockade when DMA was pre-applied before its co-application with ACh, and hastened IACh decay...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27918051/detection-of-zn-2-release-in-nitric-oxide-treated-cells-and-proteome-dependence-on-fluorescent-sensor-and-proteomic-sulfhydryl-groups
#2
Mohammad R Karim, David H Petering
Nitric oxide (NO) is both an important regulatory molecule in biological systems and a toxic xenobiotic. Its oxidation products react with sulfhydryl groups and either nitrosylate or oxidize them. The aerobic reaction of NO supplied by diethylamine NONOate (DEA-NO) with pig kidney LLC-PK1 cells and Zn-proteins within the isolated proteome was examined with three fluorescent zinc sensors, zinquin (ZQ), TSQ, and FluoZin-3 (FZ-3). Observations of Zn(2+) labilization from Zn-proteins depended on the specific sensor used...
December 5, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27917003/bilingualism-and-biliteracy-in-down-syndrome-insights-from-a-case-study
#3
REVIEW
Kelly Burgoyne, Fiona J Duff, Dea Nielsen, Anastasia Ulicheva, Margaret J Snowling
We present the case study of MB-a bilingual child with Down syndrome (DS) who speaks Russian (first language [L1]) and English (second language [L2]) and has learned to read in two different alphabets with different symbol systems. We demonstrate that, in terms of oral language, MB is as proficient in Russian as English, with a mild advantage for reading in English, her language of formal instruction. MB's L1 abilities were compared with those of 11 Russian-speaking typically developing monolinguals and her L2 abilities to those of 15 English-speaking typically developing monolinguals and six monolingual English-speaking children with DS; each group achieving the same level of word reading ability as MB...
December 2016: Language Learning
https://www.readbyqxmd.com/read/27916126/general-screening-and-optimization-strategy-for-fast-chiral-separations-in-modern-supercritical-fluid-chromatography
#4
Lucie Nováková, Michal Douša
High throughput general chiral screening method using supercritical fluid chromatography was developed. This method takes an advantage of very fast gradient screening (3 min + 1 min isocratic hold) and generic enantioselectivity of the combined additive formed by 0.1% trifluoroacetic (TFA) acid and 0.1% diethylamine (DEA). The TFA/DEA combined additive was systematically added to organic modifiers methanol and isopropanol. Among five tested polysaccharide-based chiral stationary phases, amylose tris(3,5-dimethylphenylcarbamate) and cellulose tris(3,5-dimethylphenylcarbamate) provided the best enantioseparation success rate...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27914638/planting-richness-affects-the-recovery-of-vegetation-and-soil-processes-in-constructed-wetlands-following-disturbance
#5
Mary M Means, Changwoo Ahn, Gregory B Noe
The resilience of constructed wetland ecosystems to severe disturbance, such as a mass herbivory eat-out or soil disturbance, remains poorly understood. In this study, we use a controlled mesocosm experiment to examine how original planting diversity affects the ability of constructed freshwater wetlands to recover structurally and functionally after a disturbance (i.e., aboveground harvesting and soil coring). We assessed if the planting richness of macrophyte species influences recovery of constructed wetlands one year after a disturbance...
December 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27908613/sparc-interacts-with-actin-in-skeletal-muscle-in%C3%A2-vitro-and-in%C3%A2-vivo
#6
Louise H Jørgensen, Pia Lørup Jepsen, Anders Boysen, Line B Dalgaard, Lars G Hvid, Niels Ørtenblad, Dea Ravn, Jeeva Sellathurai, Jakob Møller-Jensen, Hanns Lochmüller, Henrik D Schrøder
The cytoskeleton is an integral part of skeletal muscle structure, and reorganization of the cytoskeleton occurs during various modes of remodeling. We previously found that the extracellular matrix protein secreted protein acidic and rich in cysteine (SPARC) is up-regulated and expressed intracellularly in developing muscle, during regeneration and in myopathies, which together suggests that SPARC might serve a specific role within muscle cells. Using co-immunoprecipitation combined with mass spectrometry and verified by staining for direct protein-protein interaction, we find that SPARC binds to actin...
November 28, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27906856/radiation-exposure-and-lung-disease-in-today-s-nuclear-world
#7
Steven D Deas, Nikhil Huprikar, Andrew Skabelund
PURPOSE OF REVIEW: Ionizing radiation poses important health risks. The per capita annual dose rate has increased in the United States and there is increasing concern for the risks posed by low-dose occupational exposure among workers in nuclear industries and healthcare. Recent nuclear accidents and concern for terrorism have heightened concern for catastrophic, high-dose ionizing radiation exposure. This review will highlight recent research into the risks to lung health posed by ionizing radiation exposure and into potential treatments...
November 30, 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27901562/extension-of-the-expiration-date-for-state-disability-examiner-authority-to-make-fully-favorable-quick-disability-determinations-and-compassionate-allowance-determinations-final-rule
#8
(no author information available yet)
We are extending, until December 28, 2018, the expiration date of our disability examiner authority (DEA) rule, which authorizes State agency disability examiners to make fully favorable determinations without the approval of a State agency medical or psychological consultant in claims that we consider under our quick disability determination (QDD) and compassionate allowance (CAL) processes. This is our last extension of this rule because we will phase out the use of DEA during the extension period under section 832 of the Bipartisan Budget Act of 2015 (BBA)...
October 24, 2016: Federal Register
https://www.readbyqxmd.com/read/27901420/is-broader-better
#9
Elizabeth G Epstein, Ashley R Hurst, Dea Mahanes, Mary Faith Marshall, Ann B Hamric
No abstract text is available yet for this article.
December 2016: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/27894789/cardiovascular-event-risk-assessment-in-psoriasis-patients-treated-with-tumor-necrosis-factor-%C3%AE-inhibitors-versus-methotrexate
#10
Jashin J Wu, Annie Guérin, Murali Sundaram, Katherine Dea, Martin Cloutier, Parvez Mulani
BACKGROUND: Psoriasis is associated with increased risk for cardiovascular disease. OBJECTIVE: To compare major cardiovascular event risk in psoriasis patients receiving methotrexate or tumor necrosis factor-α inhibitor (TNFi) and to assess TNFi treatment duration impact on major cardiovascular event risk. METHODS: Adult psoriasis patients with ≥2 TNFi or methotrexate prescriptions in the Truven MarketScan Databases (Q1 2000-Q3 2011) were classified as TNFi or methotrexate users...
October 26, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27875273/sirt2-regulates-nuclear-envelope-reassembly-via-ankle2-deacetylation
#11
Tanja Kaufmann, Eva Kukolj, Andreas Brachner, Etienne Beltzung, Melania Bruno, Sebastian Kostrhon, Susanne Opravil, Otto Hudecz, Karl Mechtler, Graham Warren, Dea Slade
Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here we show that SIRT2 depletion or overexpression causes nuclear envelope reassembly defects. We link this phenotype to the recently identified regulator of nuclear envelope reassembly ANKLE2. ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly...
November 14, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27867545/an-evaluation-study-of-research-efficiency-of-the-guangzhou-institute-of-respiratory-diseases-based-on-malmquist-index
#12
Jian-Feng Liao, Juan Wang, Liang Liang, Yong-Ding Wu, Mei-Juan Huang, Tian-Qiang Liu, Lin Zhou, Xin-Wang Wang
BACKGROUND: This study aimed to analyze the dynamic changes of the scientific research innovation efficiency of Guangzhou Institute of Respiratory Diseases (GIRD) during the year 2009-2013 to explore the reason for these changes and give some suggestions on how to improve the overall efficiency of the Institute. METHODS: The panel data used in this study were taken from 19 research teams of GIRD during 2009 to 2013. Data envelopment analysis (DEA) based on Malmquist index (MI) was used to analyze the performance of each research team in terms of productivity changes over time...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27836870/efficiency-and-productivity-measurement-of-rural-township-hospitals-in-china-a-bootstrapping-data-envelopment-analysis
#13
Zhaohui Cheng, Miao Cai, Hongbing Tao, Zhifei He, Xiaojun Lin, Haifeng Lin, Yuling Zuo
OBJECTIVE: Township hospitals (THs) are important components of the three-tier rural healthcare system of China. However, the efficiency and productivity of THs have been questioned since the healthcare reform was implemented in 2009. The objective of this study is to analyse the efficiency and productivity changes in THs before and after the reform process. SETTING AND PARTICIPANTS: A total of 48 sample THs were selected from the Xiaogan Prefecture in Hubei Province from 2008 to 2014...
November 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27834890/measurement-of-low-carbon-economy-efficiency-with-a-three-stage-data-envelopment-analysis-a-comparison-of-the-largest-twenty-co%C3%A2-emitting-countries
#14
Xiang Liu, Jia Liu
This paper employs a three-stage approach to estimate low carbon economy efficiency in the largest twenty CO₂ emitting countries from 2000 to 2012. The approach includes the following three stages: (1) use of a data envelopment analysis (DEA) model with undesirable output to estimate the low carbon economy efficiency and calculate the input and output slacks; (2) use of a stochastic frontier approach to eliminate the impacts of external environment variables on these slacks; (3) re-estimation of the efficiency with adjusted inputs and outputs to reflect the capacity of the government to develop a low carbon economy...
November 9, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27806504/measuring-the-effect-of-size-on-technical-efficiency-of-the-united-arab-emirates-hospitals
#15
Ashraf Mahate, Samer Hamidi, Fevzi Akinci
OBJECTIVE: The main purpose of this study is to estimate the technical efficiency of the United Arab Emirates (UAE) hospitals and examine the effect of hospital size on estimated technical efficiency scores. METHODS: Using 2012 data from Ministry of Health, Dubai Health Authority, and Health Authority in Abu Dhabi, we employed a nonparametric method, data envelopment analysis (DEA), to estimate the technical efficiency of 96 private and governmental hospitals in the UAE...
July 12, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27802417/blood-pressure-lowering-effect-of-orally-ingested-nitrite-is-abolished-by-a-proton-pump-inhibitor
#16
Marcelo F Montenegro, Michaela L Sundqvist, Filip J Larsen, Zhengbing Zhuge, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg
Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we tested the effects of a proton pump inhibitor on the acute cardiovascular effects of nitrite. Fifteen healthy nonsmoking, normotensive subjects, aged 19 to 39 years, were pretreated with placebo or esomeprazole (3×40 mg) before ingesting sodium nitrite (0...
October 31, 2016: Hypertension
https://www.readbyqxmd.com/read/27802110/base-release-and-modification-in-solid-phase-dna-exposed-to-low-energy-electrons
#17
Surakarn Choofong, Pierre Cloutier, Léon Sanche, J Richard Wagner
Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approximately 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a glass substrate or X rays combined with extra LEEs (average energy of 5.8 eV) emitted from a tantalum (Ta) substrate under an atmosphere of N2 and standard ambient conditions of temperature and pressure...
November 1, 2016: Radiation Research
https://www.readbyqxmd.com/read/27796108/a-study-on-the-prevalence-of-dog-erythrocyte-antigen-1-1-and-detection-of-canine-babesia-by-polymerase-chain-reaction-from-apparently-healthy-dogs-in-a-selected-rural-community-in-zimbabwe
#18
Solomon Dhliwayo, Tariro A Makonese, Belinda Whittall, Silvester M Chikerema, Davies M Pfukenyi, Musavenga T Tivapasi
A study was carried out to determine the prevalence of blood group antigen dog erythrocyte antigen (DEA) 1.1 in mixed breed dogs in rural Chinamhora, Zimbabwe. DEA 1.1 is clinically the most important canine blood group as it is the most antigenic blood type; hence, DEA 1.1 antibodies are capable of causing acute haemolytic, potentially life-threatening transfusion reactions. In this study, blood samples were collected from 100 dogs in Chinamhora, and blood typing was carried out using standardised DEA 1.1 typing strips with monoclonal anti-DEA 1...
October 26, 2016: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/27792946/method-for-selection-of-optimal-road-safety-composite-index-with-examples-from-dea-and-topsis-method
#19
Miroslav Rosić, Dalibor Pešić, Dragoslav Kukić, Boris Antić, Milan Božović
Concept of composite road safety index is a popular and relatively new concept among road safety experts around the world. As there is a constant need for comparison among different units (countries, municipalities, roads, etc.) there is need to choose an adequate method which will make comparison fair to all compared units. Usually comparisons using one specific indicator (parameter which describes safety or unsafety) can end up with totally different ranking of compared units which is quite complicated for decision maker to determine "real best performers"...
October 25, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27791205/intracellular-sting-inactivation-sensitizes-breast-cancer-cells-to-genotoxic-agents
#20
Julie Gaston, Laura Cheradame, Vanessa Yvonnet, Olivier Deas, Marie-France Poupon, Jean-Gabriel Judde, Stefano Cairo, Vincent Goffin
Activation of the IFN/STAT1 pathway is closely associated with drug response and recurrence of breast cancer treated by chemotherapy. The aim of the current study was to elucidate the molecular mechanisms involved upstream and downstream of this pathway in order to identify distinct entities that might be manipulated to improve treatment efficacy. Four breast cancer cell lines (T-47D, MCF7, MDA-MB-231 and HBCx-19 established from the eponymous PDX) were treated in vitro with mafosfamide, a DNA damage inducer...
October 24, 2016: Oncotarget
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