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https://www.readbyqxmd.com/read/28508651/sugar-breathing-glycopolymersomes-for-regulating-glucose-level
#1
Yufen Xiao, Hui Sun, Jianzhong Du
Diabetes mellitus is a chronic, life-threatening illness that affects people of every age and ethnicity. It is a long-suffering pain for those who are affected and must regulate their blood glucose level by frequent subcutaneous injection of insulin every day. Herein, we propose a non-insulin and antidiabetic-drug-free strategy for regulating blood glucose level by a nano-sized "sugar sponge" which is a lectin-bound glycopolymersome capable of regulating glucose due to the dynamic recognition between the lectin and different carbohydrates...
May 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28502766/anterior-cingulate-serotonin-1b-receptor-binding-is-associated-with-emotional-response-inhibition
#2
Sofi da Cunha-Bang, Liv Vadskjær Hjordt, Vibeke Høyrup Dam, Dea Siggaard Stenbæk, Dorte Sestoft, Gitte M Knudsen
Serotonin has a well-established role in emotional processing and is a key neurotransmitter in impulsive aggression, presumably by facilitating response inhibition and regulating subcortical reactivity to aversive stimuli. In this study 44 men, of whom 19 were violent offenders and 25 were non-offender controls, completed an emotional Go/NoGo task requiring inhibition of prepotent motor responses to emotional facial expressions. We also measured cerebral serotonin 1B receptor (5-HT1BR) binding with [(11)C]AZ10419369 positron emission tomography within regions of the frontal cortex...
May 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28492652/low-energy-electron-induced-decomposition-of-%C3%AE-3-c3h5-ru-co-3br-a-potential-focused-electron-beam-induced-deposition-precursor-with-a-heteroleptic-ligand-set
#3
Rachel M Thorman, Joseph A Brannaka, Lisa McElwee-White, Oddur Ingólfsson
Here we describe in detail low energy electron induced fragmentation of a potential focused electron beam induced deposition (FEBID) precursor, π-allyl ruthenium tricarbonyl bromide, i.e. (η(3)-C3H5)Ru(CO)3Br, specially designed to allow comparison of the effect of different ligands on the efficiency of low energy electron induced fragmentation of FEBID precursors. Specifically, we discuss the efficiency of dissociative electron attachment (DEA) and dissociative ionization (DI) with respect to electron-induced removal of the allyl, bromide and carbonyl ligands...
May 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28490578/investigating-clinical-issues-by-genotyping-of-medically-important-fungi-why-and-how
#4
REVIEW
Alexandre Alanio, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Stéphane Bretagne
Genotyping studies of medically important fungi have addressed elucidation of outbreaks, nosocomial transmissions, infection routes, and genotype-phenotype correlations, of which secondary resistance has been most intensively investigated. Two methods have emerged because of their high discriminatory power and reproducibility: multilocus sequence typing (MLST) and microsatellite length polymorphism (MLP) using short tandem repeat (STR) markers. MLST relies on single-nucleotide polymorphisms within the coding regions of housekeeping genes...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28488061/the-effects-of-environmental-factors-on-the-efficiency-of-clinical-commissioning-groups-in-england-a-data-envelopment-analysis
#5
Rumbidzai Takundwa, Sue Jowett, Hugh McLeod, Maria Cristina Peñaloza-Ramos
Clinical Commissioning Groups (CCGs) were created in 2013 to make the NHS more responsive, efficient and accountable. A large number of different indicators can be used to measure the quality and outcomes of services provided by CCGs, however there is currently no single measure of overall efficiency available. The performance of CCGs may also be confounded by environmental factors such as deprivation, population size and burden of disease. Data Envelopment Analysis (DEA) is a linear programming technique that can be used to measure the relative efficiency of a given set of organisations...
June 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28487006/cost-effectiveness-of-salt-reduction-to-prevent-hypertension-and-cvd-a-systematic-review
#6
Elisabeth Schorling, Dea Niebuhr, Anja Kroke
OBJECTIVE: To analyse and compare the cost-effectiveness of different interventions to reduce salt consumption. DESIGN: A systematic review of published cost-effectiveness analyses (CEA) and cost-utility analyses (CUA) was undertaken in the databases EMBASE, MEDLINE (PubMed), Cochrane and others until July 2016. Study selection was limited to CEA and CUA conducted in member countries of the Organisation for Economic Co-operation and Development (OECD) in English, German or French, without time limit...
May 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28484763/electron-stimulated-desorption-from-condensed-pyrimidine-and-pyridazine
#7
L Ellis-Gibbings, A D Bass, P Cloutier, G García, L Sanche
Low energy electron (LEE) interactions and the formation of transient negative ions play a dominant role in radiation-induced dissociation of condensed-phase biomolecules (e.g. in radiotherapy). Here we present data on the LEE-induced dissociation and desorption of the DNA/RNA-base and radiosensitizing agent analogues pyrimidine and pyridazine. Vapors of each molecule were condensed on either a Pt or Ar substrate to form a multilayer film or a submonolayer molecular target, respectively. These were irradiated with electrons of 0-80 eV and the desorbing anionic and cationic fragments analysed via time of flight mass spectrometry...
May 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28443918/ph-responsiveness-of-hydrogels-formed-by-telechelic-polyampholytes
#8
Margarita A Dyakonova, George Gotzamanis, Bart-Jan Niebuur, Natalya S Vishnevetskaya, Konstantinos N Raftopoulos, Zhenyu Di, Sergey K Filippov, Constantinos Tsitsilianis, Christine M Papadakis
We investigate the influence of pH on the rheological and structural properties of hydrogels formed by hydrophobic association of the sticky ends of the triblock terpolymer poly(methyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid)-b-poly(methyl methacrylate) (PMMA-b-P(DEA-co-MAA)-b-PMMA). The middle block is a weak polyampholyte having a pH dependent charge density and sign, which enables tuning of the rheological and structural properties by pH variation. Small-angle neutron scattering (SANS) studies of solutions in D2O at 0...
April 26, 2017: Soft Matter
https://www.readbyqxmd.com/read/28440369/a-variable-stiffness-dielectric-elastomer-actuator-based-on-electrostatic-chucking
#9
Hiroya Imamura, Kevin Kadooka, Minoru Taya
Dielectric elastomer actuators (DEA) are one type of promising artificial muscle; however, applications of bending-type DEA for robotic end-effectors may be limited by their low stiffness and ability to resist external loads without buckling. Unimorph DEA can produce large out-of-plane deformation suitable for use as robotic end effectors; however, design of such actuators for large displacement comes at the cost of low stiffness and blocking force. This work proposes and demonstrates a variable stiffness dielectric elastomer actuator (VSDEA) consisting of a plurality of unimorph DEA units operating in parallel, which can exhibit variable electrostatic chucking to modulate the structure's bending stiffness...
May 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28418777/er-la-opioid-rems-and-accredited-education-survey-results-provide-insight-into-clinical-roles-educational-needs-and-learner-preferences
#10
Cynthia Kear, Tom McKeithen, Sheila Robertson
BACKGROUND: The Collaborative for REMS (Risk Evaluation and Mitigation Strategy) Education (CO*RE) includes 13 organizations that provide REMS Program Companies (RPC) grant-supported accredited education on extended-release and long-acting (ER/LA) opioid therapy. This report summarizes results of a survey designed to investigate the impact of participant criteria and to better understand the roles and preferences of continuing medical education/continuing education (CME/CE) participants...
April 2017: Substance Abuse
https://www.readbyqxmd.com/read/28415014/determination-and-quantification-of-intracellular-fludarabine-triphosphate-cladribine-triphosphate-and-clofarabine-triphosphate-by-lc-ms-ms-in-human-cancer-cells
#11
Jean-Yves Puy, Lars Petter Jordheim, Emeline Cros-Perrial, Charles Dumontet, Suzanne Peyrottes, Isabelle Lefebvre-Tournier
Purine nucleoside analogues are widely used in the treatment of haematological malignancies, and their biological activity is dependent on the intracellular accumulation of their triphosphorylated metabolites. In this context, we developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to study the formation of 5'-triphosphorylated derivatives of cladribine, fludarabine, clofarabine and 2'-deoxyadenosine in human cancer cells. Br-ATP was used as internal standard. Separation was achieved on a hypercarb column...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28413715/brain-serotonin-4-receptor-binding-is-inversely-associated-with%C3%A2-verbal-memory-recall
#12
Dea S Stenbæk, Patrick M Fisher, Brice Ozenne, Emil Andersen, Liv V Hjordt, Brenda McMahon, Steen G Hasselbalch, Vibe G Frokjaer, Gitte M Knudsen
BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall. METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [(11)C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28410671/dog-erythrocyte-antigens-dea-1-4-7-and-suspected-naturally-occurring-anti-dea-7-antibodies-in-italian-corso-dogs
#13
E Spada, D Proverbio, V Priolo, D Ippolito, L Baggiani, R Perego, M G Pennisi
We sought to determine the prevalence of dog erythrocyte antigen (DEA) 1, 4 and 7 and naturally occurring anti-DEA7 antibodies in Italian Corso dogs. In addition, we correlated DEAs with different epidemiologic variables, compared the prevalence of DEAs against other canine populations and assessed the risk of sensitisation and transfusion reactions (TRs) following unmatched transfusion. Blood samples from 100 Corso dogs were evaluated for DEA 1, 4, 7 and naturally occurring anti-DEA 7 antibodies. Seventy-one percent of samples were DEA 1-negative, 100% tested DEA 4-positive, and 95% tested DEA 7-negative...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28409643/economical-doubly-electron-attached-equation-of-motion-coupled-cluster-methods-with-an-active-space-treatment-of-three-particle-one-hole-and-four-particle-two-hole-excitations
#14
Adeayo O Ajala, Jun Shen, Piotr Piecuch
The previously developed active-space doubly electron-attached (DEA) equation-of-motion (EOM) coupled-cluster (CC) method with up to four-particle-two-hole (4p-2h) excitations [Shen, J.; Piecuch, P. J. Chem. Phys. 2013, 138, 194102], which utilizes the idea of applying a linear electron-attaching operator to the CC ground state of an (N - 2)-electron closed-shell system to generate ground and excited states of the N-electron open-shell species of interest, has been extended to a considerably less expensive model, in which both 3p-1h and 4p-2h terms rather than 4p-2h contributions only are selected using active orbitals...
May 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28406883/characteristics-of-fentanyl-overdose-massachusetts-2014-2016
#15
Nicholas J Somerville, Julie O'Donnell, R Matthew Gladden, Jon E Zibbell, Traci C Green, Morgan Younkin, Sarah Ruiz, Hermik Babakhanlou-Chase, Miranda Chan, Barry P Callis, Janet Kuramoto-Crawford, Henry M Nields, Alexander Y Walley
Opioid overdose deaths in Massachusetts increased 150% from 2012 to 2015 (1). The proportion of opioid overdose deaths in the state involving fentanyl, a synthetic, short-acting opioid with 50-100 times the potency of morphine, increased from 32% during 2013-2014 to 74% in the first half of 2016 (1-3). In April 2015, the Drug Enforcement Agency (DEA) and CDC reported an increase in law enforcement fentanyl seizures in Massachusetts, much of which was believed to be illicitly manufactured fentanyl (IMF) (4)...
April 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28403853/the-application-of-dea-data-envelopment-analysis-window-analysis-in-the-assessment-of-influence-on-operational-efficiencies-after-the-establishment-of-branched-hospitals
#16
Tongying Jia, Huiyun Yuan
BACKGROUND: Many large-scaled public hospitals have established branched hospitals in China. This study is to provide evidence for strategy making on the management and development of multi-branched hospitals by evaluating and comparing the operational efficiencies of different hospitals before and after their establishment of branched hospitals. METHODS: DEA (Data Envelopment Analysis) window analysis was performed on a 7-year data pool from five public hospitals provided by health authorities and institutional surveys...
April 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28394598/low-energy-electron-interaction-with-melatonin-and-related-compounds
#17
Stanislav A Pshenichnyuk, Alberto Modelli, Derek Jones, Eleonora F Lazneva, Alexei S Komolov
The electron attaching properties and fragmentation of temporary negative ions of melatonin and its biosynthetic precursor tryptophan are studied in vacuo using dissociative electron attachment (DEA) spectroscopy. The experimental findings are interpreted in silico with the support of Hartree-Fock and density functional theory calculations of empty orbital energies and symmetries, and evaluation of the electron affinities of the indolic molecules under investigation. The only fragment anions formed by DEA to melatonin at incident electron energies below 2 eV are associated with the elimination of a hydrogen atom (energetically favored from the NH site of the pyrrole ring, leaving the ring intact) or a CH3(·) radical from the temporary molecular negative ion...
April 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28379959/unraveling-chagas-disease-transmission-through-the-oral-route-gateways-to-trypanosoma-cruzi-infection-and-target-tissues
#18
Danielle Silva-Dos-Santos, Juliana Barreto-de-Albuquerque, Bárbara Guerra, Otacilio C Moreira, Luiz Ricardo Berbert, Mariana Tavares Ramos, Barbara Angelica S Mascarenhas, Constança Britto, Alexandre Morrot, Déa M Serra Villa-Verde, Luciana Ribeiro Garzoni, Wilson Savino, Vinícius Cotta-de-Almeida, Juliana de Meis
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed the importance of parasite contact with oral cavity to induce a highly severe acute disease in mice. However, it remains uncertain the primary site of parasite entry and multiplication due to an oral infection. Here, we evaluated the presence of T...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28361805/hospital-efficiency-how-to-spend-less-maintaining-quality
#19
Paolo Campanella, Elena Azzolini, Alessio Izzi, Ferruccio Pelone, Concetta De Meo, Daniele La Milia, Maria Lucia Specchia, Walter Ricciardi
INTRODUCTION: The recent global economic crisis is pushing governments worldwide to obtain a more explicit and urgent rationing of resources. The purpose of this study is to provide, through Data Envelopment Analysis (DEA), a methodological framework useful for investigating technical efficiency of hospital care. METHODS: To validate such framework, we compared 50 Italian public hospital trusts (AOs) to identify relative efficient using inputs and outputs from national databases...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28355049/schedules-of-controlled-substances-placement-of-fda-approved-products-of-oral-solutions-containing-dronabinol-delta-9-transtetrahydrocannabinol-delta-9-thc-in-schedule-ii-interim-final-rule-with-request-for-comments
#20
(no author information available yet)
On July 1, 2016, the U.S. Food and Drug Administration (FDA) approved a new drug application for Syndros, a drug product consisting of dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] oral solution. Thereafter, the Department of Health and Human Services (HHS) provided the Drug Enforcement Administration (DEA) with a scheduling recommendation that would result in Syndros (and other oral solutions containing dronabinol) being placed in schedule II of the Controlled Substances Act (CSA). In accordance with the CSA, as revised by the Improving Regulatory Transparency for New Medical Therapies Act, DEA is hereby issuing an interim final rule placing FDA-approved products of oral solutions containing dronabinol in schedule II of the CSA...
March 23, 2017: Federal Register
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