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https://www.readbyqxmd.com/read/29151069/nitroso-sulfide-coupled-signaling-triggers-specific-vasoactive-effects-in-the-intrarenal-arteries-of-patients-with-arterial-hypertension
#1
S Cacanyiova, A Berenyiova, P Balis, F Kristek, M Grman, K Ondrias, J Breza, J Breza
In normotensive conditions, it has been confirmed that S-nitrosothiols (RSNO), can interact with hydrogen sulfide (H2S) and create new substances with specific vasoactive effects. This interaction could also represent a new regulator signaling pathway in conditions of hypertension. Until now, these effects were studied only in normotensive rats, and they have not been carried out in humans yet. We investigated the vasoactive effects of the products of the H2S/S-nitrosoglutathione (S/GSNO) interaction in lobar arteries (LA) isolated from the nephrectomized kidneys of patients suffering from arterial hypertension and in renal arteries (RA) of spontaneously hypertensive rats (SHR)...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29147599/prevalence-of-dog-erythrocyte-antigen-1-in-7-414-dogs-in-italy
#2
Anyela Andrea Medina Valentin, Alessandra Gavazza, George Lubas
The study aim was to establish the prevalence of DEA 1, the most immunogenic and clinically important blood group in canine blood transfusion, in 7,414 dogs from Italy. The potential sensitization risk following a first transfusion and the acute reaction risk following a second transfusion given without a cross-matching and blood typing test were also calculated. Dogs tested were purebred (4,798) and mongrel (2,616); 38.8% were DEA 1 negative and 61.2% were DEA 1 positive. High prevalence for DEA 1 positive blood type was found in Ariegeois and English Setter, whereas German Shepherd and Boxer had higher DEA 1 negative blood type...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/29141413/single-reference-coupled-cluster-theory-for-multi-reference-problems
#3
Johannes T Margraf, Ajith Perera, Jesse J Lutz, Rodney J Bartlett
Coupled cluster (CC) theory is widely accepted as the most accurate and generally applicable approach in quantum chemistry. CC calculations are usually performed with single Slater-determinant references, e.g., canonical Hartree-Fock (HF) wavefunctions, though any single determinant can be used. This is an attractive feature because typical CC calculations are straightforward to apply, as there is no potentially ambiguous user input required. On the other hand, there can be concern that CC approximations give unreliable results when the reference determinant provides a poor description of the system of interest, i...
November 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29136796/a-multi-purpose-tool-for-food-inspection-simultaneous-determination-of-various-classes-of-preservatives-and-biogenic-amines-in-meat-and-fish-products-by-lc-ms
#4
Luciano Molognoni, Heitor Daguer, Leandro Antunes de Sá Ploêncio, Juliano De Dea Lindner
This paper describes an innovative fast and multipurpose method for the chemical inspection of meat and fish products by liquid chromatography-tandem mass spectrometry. Solid-liquid extraction and low temperature partitioning were applied to 17 analytes, which included large bacteriocins (3.5kDa) and small molecules (organic acids, heterocyclic compounds, polyene macrolides, alkyl esters of the p-hydroxybenzoic acid, aromatic, and aliphatic biogenic amines and polyamines). Chromatographic separation was achieved in 10min, using stationary phase of di-isopropyl-3-aminopropyl silane bound to hydroxylated silica...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136531/long-term-effects-of-contrasting-tillage-on-soil-organic-carbon-nitrous-oxide-and-ammonia-emissions-in-a-mediterranean-vertisol-under-different-crop-sequences
#5
Giuseppe Badagliacca, Emilio Benítez, Gaetano Amato, Luigi Badalucco, Dario Giambalvo, Vito Armando Laudicina, Paolo Ruisi
This 2-year study aimed to verify whether the continuous application of no tillage (NT) for over 20years, in comparison with conventional tillage (CT), affects nitrous oxide (N2O) and ammonia (NH3) emissions from a Vertisol and, if so, whether such an effect varies with crop sequence (continuous wheat, WW and wheat after faba bean, FW). To shed light on the mechanisms involved in determining N-gas emissions, soil bulk density, water filled pore space (WFPS), some carbon (C) and nitrogen (N) pools, denitrifying enzyme activity (DEA), and nitrous oxide reductase gene abundance (nosZ gene) were also assessed at 0-15 and 15-30cm soil depth...
November 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29132501/low-education-levels-are-associated-with-early-age-of-sexual-debut-drug-use-and-risky-sexual-behaviours-among-young-indigenous-australians
#6
Handan Wand, Joanne Bryant, Heather Worth, Marian Pitts, John M Kaldor, Dea Delaney-Thiele, James Ward
Background: Earlier age at sexual debut is associated with drug and alcohol use, risky sexual behaviours and sexually transmissible infections (STI). Methods: In the present study, 2320 young Indigenous Australians were surveyed. Results: Most study participants had sex for the first time when they were 14 years or younger (79% and 67% for males and females respectively). More than 80% of participants were categorised as being in the high-risk category for the combined sexual risk factors (i.e. not using condoms, drunk or high at last sexual act, or three or more sexual partners in the past year)...
November 14, 2017: Sexual Health
https://www.readbyqxmd.com/read/29110801/enhanced-electrical-field-stimulated-nitrergic-and-purinergic-vasoreactivity-in-distal-vs-proximal-internal-pudendal-arteries
#7
Michael R Odom, Elena S Pak, David A Brown, Johanna L Hannan
BACKGROUND: The internal pudendal arteries (IPAs) supply blood to the penis and are highly susceptible to vascular remodeling in rodent models of diabetes, hypertension, aging, and chronic kidney disease, thus contributing to erectile dysfunction. Interestingly, vascular remodeling primarily occurs in the distal and not in the proximal IPA, suggesting distinct local physiologic signaling differences within the IPA. AIM: To examine the role of purinergic signaling and neurotransmitter release by electrical field stimulation (EFS) in the regulation of proximal and distal IPA vascular tone...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29098593/advanced-scoring-method-of-eco-efficiency-in-european-cities
#8
Victor Moutinho, Mara Madaleno, Margarita Robaina, José Villar
This paper analyzes a set of selected German and French cities' performance in terms of the relative behavior of their eco-efficiencies, computed as the ratio of their gross domestic product (GDP) over their CO2 emissions. For this analysis, eco-efficiency scores of the selected cities are computed using the data envelopment analysis (DEA) technique, taking the eco-efficiencies as outputs, and the inputs being the energy consumption, the population density, the labor productivity, the resource productivity, and the patents per inhabitant...
November 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29097597/multimodal-imaging-in-rat-model-recapitulates-alzheimer-s-disease-biomarkers-abnormalities
#9
Maxime J Parent, Eduardo R Zimmer, Monica Shin, Min Su Kang, Vladimir S Fonov, Axel Mathieu, Antonio Aliaga, Alexey Kostikov, Sonia Do Carmo, Doris Dea, Judes Poirier, Jean-Paul Soucy, Serge Gauthier, A Claudio Cuello, Pedro Rosa-Neto
Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's Disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in AD. Using the McGill-R-Thy1-APP transgenic rat as a model of selective Aβ pathology, we characterized the longitudinal progression of abnormalities in biomarkers commonly used in AD research. Middle-aged (9-11 months) transgenic animals (both male and female) displayed mild spatial memory impairments and disrupted cingulate network connectivity measured by resting-state fMRI, even in the absence of hypometabolism (measured with PET [(18)F]FDG) or detectable fibrillary amyloidosis (measured with PET [(18)F]NAV4694)...
November 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29096502/how-does-methylation-suppress-the-electron-induced-decomposition-of-1-methyl-nitroimidazoles
#10
F Kossoski, M T do N Varella
The efficient decomposition of nitroimidazoles (NIs) by low energy electrons is believed to underlie their radiosensitizing properties. Recent dissociative electron attachment (DEA) measurements showed that methylation at the N1 site unexpectedly suppresses the electron-induced reactions in 4(5)-NI. We report theoretical results that provide a clear interpretation of that astounding finding. Around 1.5 eV, DEA reactions into several fragments are initiated by a π(*) resonance, not considered in previous studies...
October 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29096487/systematic-design-of-active-spaces-for-multi-reference-calculations-of-singlet-triplet-gaps-of-organic-diradicals-with-benchmarks-against-doubly-electron-attached-coupled-cluster-data
#11
Samuel J Stoneburner, Jun Shen, Adeayo O Ajala, Piotr Piecuch, Donald G Truhlar, Laura Gagliardi
Singlet-triplet gaps in diradical organic π-systems are of interest in many applications. In this study, we calculate them in a series of molecules, including cyclobutadiene and its derivatives and cyclopentadienyl cation, by using correlated participating orbitals within the complete active space (CAS) and restricted active space (RAS) self-consistent field frameworks, followed by second-order perturbation theory (CASPT2 and RASPT2). These calculations are evaluated by comparison with the results of doubly electron-attached (DEA) equation-of-motion (EOM) coupled-cluster (CC) calculations with up to 4-particle-2-hole (4p-2h) excitations...
October 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29092503/assessing-the-degradation-of-compliant-electrodes-for-soft-actuators
#12
Samuel Rosset, Christine de Saint-Aubin, Alexandre Poulin, Herbert R Shea
We present an automated system to measure the degradation of compliant electrodes used in dielectric elastomer actuators (DEAs) over millions of cycles. Electrodes for DEAs generally experience biaxial linear strains of more than 10%. The decrease in electrode conductivity induced by this repeated fast mechanical deformation impacts the bandwidth of the actuator and its strain homogeneity. Changes in the electrode mechanical properties lead to reduced actuation strain. Rather than using an external actuator to periodically deform the electrodes, our measurement method consists of measuring the properties of an electrode in an expanding circle DEA...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29081042/frog-pelophylax-bergeri-g%C3%A3-nther-1986-endocrine-disruption-assessment-characterization-and-role-of-skin-poly-adp-ribose-polymerases
#13
Giulia Guerriero, Maria Violetta Brundo, Sofiane Labar, Anna Rita Bianchi, Samantha Trocchia, Dea Rabbito, Giancarlo Palumbo, Fagr Kh Abdel-Gawad, Anna De Maio
Model of the our research was the adult male amphibian anura, Pelophylax bergeri, poikilotherm species not considered threatened by the IUCN, sampled in representative sites at different degree. In the first phase, a biochemical characterization of the ADP-ribosylation on the skin of barcoded amphibian anura collected from Matese Lake (clean reference site in CE, Italy) was carried out. Two PARP isoforms were evidence: the first of 66 kDa is localized into nucleus and activated by DNA damage; the second of 150 kDa is in cytoplasm, as demonstrated by biochemical and immunohistochemical analysis...
October 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29080209/association-between-serum-amiodarone-and-n-desethylamiodarone-concentrations-and-development-of-thyroid-dysfunction
#14
Mikie Yamato, Kyoichi Wada, Tomohiro Hayashi, Mai Fujimoto, Kouichi Hosomi, Akira Oita, Mitsutaka Takada
OBJECTIVE: This retrospective cohort study was performed to examine the association between serum amiodarone (AMD) and N-desethylamiodarone (DEA) concentrations and the development of thyroid dysfunction. METHODS: Patients treated with AMD from January 2012 to April 2016 were identified from the computerized hospital information system database at the National Cerebral and Cardiovascular Center. Only patients whose serum AMD and DEA concentrations had been determined at least once were included in the study...
October 27, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29079609/investigation-of-the-international-comparability-of-population-based-routine-hospital-data-set-derived-comorbidity-scores-for-patients-with-lung-cancer
#15
Margreet Lüchtenborg, Eva J A Morris, Daniela Tataru, Victoria H Coupland, Andrew Smith, Roger L Milne, Luc Te Marvelde, Deborah Baker, Jane Young, Donna Turner, Diane Nishri, Craig Earle, Lorraine Shack, Anna Gavin, Deirdre Fitzpatrick, Conan Donnelly, Yulan Lin, Bjorn Moller, David H Brewster, Andrew Deas, Dyfed W Huws, Ceri White, Janet Warlow, Jem Rashbass, Michael D Peake
INTRODUCTION: The International Cancer Benchmarking Partnership (ICBP) identified significant international differences in lung cancer survival. Differing levels of comorbid disease across ICBP countries has been suggested as a potential explanation of this variation but, to date, no studies have quantified its impact. This study investigated whether comparable, robust comorbidity scores can be derived from the different routine population-based cancer data sets available in the ICBP jurisdictions and, if so, use them to quantify international variation in comorbidity and determine its influence on outcome...
October 27, 2017: Thorax
https://www.readbyqxmd.com/read/29071756/novel-electrophysiological-criteria-for-septal-ventricular-outflow-tract-tachycardias-requiring-a-sequential-bilateral-ablation
#16
Chin-Yu Lin, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Yao-Ting Chang, Yun-Yu Chen, Abigail Louise D Te, Shinya Yamada, Ling Kuo, Jennifer Jeanne B Vicera, Ting-Yung Chang, Hoang Quang Minh, Simon Salim, Ting-Chung Huang, Shih-Ann Chen
BACKGROUND: Septal ventricular outflow tract ventricular arrhythmias (OT-VAs) are defined as septal origin VAs from the right ventricular or left ventricular OT. Patients with septal OT-VAs may require a sequential bilateral OT ablation. This study aimed to evaluate the electrophysiological characteristics and ablation outcome in patients with septal OT-VAs. METHODS: We retrospectively analyzed the electrocardiography and electrophysiological parameters in 96 patients (mean age 49 ± 15 years, 49 male) undergoing bilateral activation mapping before catheter ablation of idiopathic septal OT-VAs...
October 26, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29065673/evaluating-the-relationship-between-productivity-and-quality-in-emergency-departments
#17
Hyojung Kang, Nathaniel D Bastian, John P Riordan
BACKGROUND: In the United States, emergency departments (EDs) are constantly pressured to improve operational efficiency and quality in order to gain financial benefits and maintain a positive reputation. OBJECTIVES: The first objective is to evaluate how efficiently EDs transform their input resources into quality outputs. The second objective is to investigate the relationship between the efficiency and quality performance of EDs and the factors affecting this relationship...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29064357/retention-throughout-the-hiv-care-and-treatment-cascade-from-diagnosis-to-antiretroviral-treatment-of-adults-and-children-living-with-hiv-haiti-1985-2015
#18
Andrew F Auld, Valerie Pelletier, Ermane G Robin, Ray W Shiraishi, Jacob Dee, Mayer Antoine, Yrvel Desir, Gracia Desforges, Chris Delcher, Nirva Duval, Nadjy Joseph, Kesner Francois, Mark Griswold, Jean Wysler Domercant, Yves Anthony Patrice Joseph, Joelle Deas Van Onacker, Varough Deyde, David W Lowrance, And The Groupe d'Analyses Salvh
Monitoring retention of people living with HIV (PLHIV) in the HIV care and treatment cascade is essential to guide program strategy and evaluate progress toward globally-endorsed 90-90-90 targets (i.e., 90% of PLHIV diagnosed, 81% on sustained antiretroviral therapy (ART), and 73% virally suppressed). We describe national retention from diagnosis throughout the cascade for patients receiving HIV services in Haiti during 1985-2015, with a focus on those receiving HIV services during 2008-2015. Among the 266,256 newly diagnosed PLHIV during 1985-2015, 49% were linked-to-care, 30% started ART, and 18% were retained on ART by the time of database closure...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29058280/bootstrapping-data-envelopment-analysis-of-efficiency-and-productivity-of-county-public-hospitals-in-eastern-central-and-western-china-after-the-public-hospital-reform
#19
Man-Li Wang, Hai-Qing Fang, Hong-Bing Tao, Zhao-Hui Cheng, Xiao-Jun Lin, Miao Cai, Chang Xu, Shuai Jiang
China implemented the public hospital reform in 2012. This study utilized bootstrapping data envelopment analysis (DEA) to evaluate the technical efficiency (TE) and productivity of county public hospitals in Eastern, Central, and Western China after the 2012 public hospital reform. Data from 127 county public hospitals (39, 45, and 43 in Eastern, Central, and Western China, respectively) were collected during 2012-2015. Changes of TE and productivity over time were estimated by bootstrapping DEA and bootstrapping Malmquist...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29049113/the-us-opioid-crisis-current-federal-and-state-legal-issues
#20
REVIEW
Cobin D Soelberg, Raeford E Brown, Derick Du Vivier, John E Meyer, Banu K Ramachandran
The United States is in the midst of a devastating opioid misuse epidemic leading to over 33,000 deaths per year from both prescription and illegal opioids. Roughly half of these deaths are attributable to prescription opioids. Federal and state governments have only recently begun to grasp the magnitude of this public health crisis. In 2016, the Centers for Disease Control and Prevention released their Guidelines for Prescribing Opioids for Chronic Pain. While not comprehensive in scope, these guidelines attempt to control and regulate opioid prescribing...
November 2017: Anesthesia and Analgesia
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