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Ramón González-Méndez, Peter Watts, David C Howse, Immacolata Procino, Henry McIntyre, Chris A Mayhew
In the present work we present an investigation of the negative ion-molecule chemistry of the anaesthetics isoflurane, ISOF, and enflurane, ENF, in an ion mobility spectrometry/mass spectrometry (IMS/MS), in both air and nitrogen. Hexachloroethane (HCE) was introduced in both air and nitrogen to produce Cl(-) as a reactant ion. This study was undertaken owing to uncertainties in the chemical processes, which lead to the cluster ions reported in other work (Eiceman et al. Anal. Chem. 61, 1093-1099, 1). In particular for ISOF the product ion observed was ISOF...
February 21, 2017: Journal of the American Society for Mass Spectrometry
Alexandre Gauthier, Julien Jaubert, Nicolas Traversier, Jérôme Lemant, Laurent Balu, Dea Garcia-Hermoso, Stephane Welti, Anne Favel, Sandrine Picot, Gautier Hoarau
We describe two serious Trametes polyzona pulmonary infections, which occurred in Réunion Island, in critically ill patients. The identification was performed using sequencing of the internal transcribed spacer region of ribosomal DNA and D1/D2 region of 28S rDNA. In one case, the significance of T. polyzona in the pathological process was certain, proven by histopathological evidence of fungal lung infection. T. polyzona, an emerging filamentous basidiomycete, prevalent in tropical areas, has not been described so far in human infections...
February 16, 2017: Mycoses
Miriam Rolón, Dolores R Serrano, Aikaterini Lalatsa, Esther de Pablo, Juan Jose Torrado, Maria Paloma Ballesteros, Anne Marie Healy, Celeste Vega, Cathia Coronel, Francisco Bolas-Fernández, Maria Auxiliadora Dea-Ayuela
Chagas disease (CD) is a parasitic zoonosis endemic in most mainland countries of Central and South America affecting nearly 10 million people, with 100 million people at high risk of contracting the disease. Treatment is only effective if received at the early stages of the disease. Only two drugs (benznidazole and nifurtimox) have so far been marketed and both share various limitations such as variable efficacy, many side effects and long duration of treatment, thus reducing compliance. The in vitro and in vivo efficacy of poly-aggregated amphotericin B (AmB), encapsulated poly-aggregated AmB in albumin microspheres (AmB-AME) and dimeric AmB - sodium deoxycholate micelles (AmB-NaDC) was evaluated...
February 15, 2017: Molecular Pharmaceutics
Arandel Ludovic, Polay-Espinosa Micaela, Matloka Magdalena, Bazinet Audrey, De Dea Diniz Damily, Naouar Naïra, Rau Frédérique, Jollet Arnaud, Edom-Vovard Frédérique, Mamchaoui Kamel, Tarnopolsky Mark, Puymirat Jack, Battail Christophe, Boland Anne, Deleuze Jean-Francois, Mouly Vincent, Klein F Arnaud, Furling Denis
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant neuromuscular diseases caused by microsatellite expansions and belong to the family of RNA dominant disorders. Availability of cellular models in which the DM mutation is expressed within its natural context is essential to facilitate efforts to identify new therapeutic compounds. Here we generated immortalized DM1 and DM2 human muscle cell lines that display nuclear RNA-aggregates of expanded repeats, a hallmark of myotonic dystrophy. Selected clones of DM1 and DM2 immortalized myoblasts behave as parental primary myoblasts with a reduced fusion capacity of immortalized DM1 myoblasts when compared to control and DM2 cells...
February 10, 2017: Disease Models & Mechanisms
Wei Liu, Zhenyu Tan, Liming Zhang, Christophe Champion
In this work, direct DNA damage induced by low-energy electrons (sub-keV) is simulated using a Monte Carlo method. The characteristics of the present simulation are to consider the new mechanism of DNA damage due to dissociative electron attachment (DEA) and to allow determining damage to specific bases (i.e., adenine, thymine, guanine, or cytosine). The electron track structure in liquid water is generated, based on the dielectric response model for describing electron inelastic scattering and on a free-parameter theoretical model and the NIST database for calculating electron elastic scattering...
February 9, 2017: Radiation and Environmental Biophysics
Ke Wang, Jieming Zhang, Yi-Ming Wei
The trend toward a more fiercely competitive and strictly environmentally regulated electricity market in several countries, including China has led to efforts by both industry and government to develop advanced performance evaluation models that adapt to new evaluation requirements. Traditional operational and environmental efficiency measures do not fully consider the influence of market competition and environmental regulations and, thus, are not sufficient for the thermal power industry to evaluate its operational performance with respect to specific marketing goals (operational effectiveness) and its environmental performance with respect to specific emissions reduction targets (environmental effectiveness)...
February 6, 2017: Journal of Environmental Management
Johanna Drewelies, Jenny Wagner, Clemens Tesch-Römer, Jutta Heckhausen, Denis Gerstorf
Perceived control is a key component of successful aging and may serve as a protective factor against age-related declines in central domains of functioning. However, it is a largely open question whether and how perceived control changes from midadulthood to very old age and how such change is shaped by health and social contexts. To examine these questions, we apply growth models to up to 15-year 4-wave longitudinal data from the German Ageing Survey (DEAS; N = 10,081; aged 40-85 years at baseline; 49% women)...
February 2017: Psychology and Aging
Liv V Hjordt, Dea S Stenbæk, Kathrine Skak Madsen, Brenda Mc Mahon, Christian G Jensen, Martin Vestergaard, Ida Hageman, David Meder, Steen G Hasselbalch, Gitte M Knudsen
BACKGROUND: Depressed individuals often exhibit impaired inhibition to negative input and identification of positive stimuli, but it is unclear whether this is a state or trait feature. We here exploited a naturalistic model, namely individuals with seasonal affective disorder (SAD), to study this feature longitudinally. AIM: The goal of this study was to examine seasonal changes in inhibitory control and identification of emotional faces in individuals with SAD...
February 9, 2017: Journal of Abnormal Psychology
Daniela Klaus, Heribert Engstler, Katharina Mahne, Julia K Wolff, Julia Simonson, Susanne Wurm, Clemens Tesch-Römer
No abstract text is available yet for this article.
February 8, 2017: International Journal of Epidemiology
Mirela Verza, Karen Barros Schmid, Regina Bones Barcellos, Natali Linck, Graziele Lima Bello, Daniel Scapin, Rosa Dea Sperhacke, Márcia Susana Nunes Silva, Claudia Wollheim, Martha Gabriela Celle Rivero, Afrânio Lineu Kritski, Leonides Rezende, Martha Maria Oliveira, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti
BACKGROUND: In high tuberculosis (TB) burden countries, there are few data on the performance of new molecular commercialised assays developed locally. OBJECTIVE: To evaluate the performance of a new molecular commercialised assay for TB diagnosis (Detect-TB) in three laboratories. METHODS: A total of 302 sputum samples from an equal number of patients with presumptive diagnosis of pulmonary tuberculosis (PTB) were submitted for routine smear microscopy, culture, and Detect-TB assay at three different sites in Brazil (the cities of Caxias do Sul, São Paulo and Canoas)...
February 2017: Memórias do Instituto Oswaldo Cruz
M Šimek, D Elhottová, M Mench, L Giagnoni, P Nannipieri, G Renella
Phytomanagement of trace element-contaminated soils can reduce the soil toxicity and restore the soil ecological functions, including the soil gas exchange with the atmosphere. We studied the emission rate of the greenhouse gases (GHG) CO2, CH4 and N2O, and the potential CH4 oxidation, denitrification activity (DEA) and glucose mineralization of a Cu-contaminated soil amended with dolomitic limestone and compost, alone or in combination, after a 2 year-phytomanagement with a mixed stand of Populus nigra, Salix viminalis, S...
February 6, 2017: International Journal of Phytoremediation
Xin Dong, Xinyi Zhang, Siyu Zeng
In the context of sustainable development, there has been an increasing requirement for an eco-efficiency assessment of wastewater treatment plants (WWTPs). Data envelopment analysis (DEA), a technique that is widely applied for relative efficiency assessment, is used in combination with the tolerances approach to handle WWTPs' multiple inputs and outputs as well as their uncertainty. The economic cost, energy consumption, contaminant removal, and global warming effect during the treatment processes are integrated to interpret the eco-efficiency of WWTPs...
January 18, 2017: Water Research
Yupeng Fan, Bingyang Bai, Qi Qiao, Peng Kang, Yue Zhang, Jing Guo
China's industrial parks have been playing a crucial role on driving regional economy development, but also been posing threats to local environment due to intensive resource consumption and waste emission. Chinese government facilitated eco-industrial development of industrial park, aiming to output more with less environmental burden. In our study, the eco-efficiency levels of 40 Chinese industrial parks in 2012 were assessed and ranked by Data Envelopment Analysis (DEA). This paper applied indicators relevant to resource, economy, and environment from industrial parks which can well reflect the characteristics of eco-efficiency conforming to the concept of sustainability...
January 30, 2017: Journal of Environmental Management
Liang Xu, Han-Qing Chen, Jiang Zou, Wan-Ting Dong, Guo-Ying Gu, Li-Min Zhu, Xiang-Yang Zhu
Biologically inspired robots with inherent softness and body compliance increasingly attract attention in the field of robotics. Aimed at solving existing problems with soft robots, regarding actuation technology and biological principles, this paper presents a soft bio-inspired annelid robot driven by dielectric elastomer actuators (DEAs) that can advance on flat rigid surfaces. The DEA, a kind of soft functional actuator, is designed and fabricated to mimic the axial elongation and differential friction of a single annelid body segment...
January 31, 2017: Bioinspiration & Biomimetics
Norio Kawamoto, Norio Kamemura, Kido Hiroshi, Toshiyuki Fukao
BACKGROUND: Allergen-specific low-affinity IgE was previously detected in cord blood by a highly sensitive densely carboxylated protein (DCP) chip, but not by ImmunoCAP. Here, we investigated the presence of low-affinity IgE during the early life of infants and observed its relationship with eczema. METHODS: We conducted a birth cohort study, collecting sera at birth and 6 (6M) and 14 months (14M) of age (n=110). We monitored the ovomucoid (OM)- and egg white (EW)-specific-IgE (sIgE) by ImmunoCAP or DCP-chip and analyzed the antigen-affinity of sIgE by binding inhibition assays in the presence or absence of a mild chaotropic agent, diethyl amine (DEA)...
January 31, 2017: Pediatric Allergy and Immunology
Vivien Hakoun, Philippe Orban, Alain Dassargues, Serge Brouyère
Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996-2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6-dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium...
January 27, 2017: Environmental Pollution
Jianbing Wei, Hao Feng, Quanguo Cheng, Shiqian Gao, Haiyan Liu
The objective of this study was to test the hypothesis that environmental regulators of riparian zone soil denitrification potential differ according to spatial scale within a watershed; consequently, a second objective was to provide spatial strategies for conserving and restoring the purification function of runoff in riparian ecosystems. The results show that soil denitrification in riparian zones was more heterogeneous at the profile scale than at the cross-section and landscape scales. At the profile scale, biogeochemical factors (including soil total organic carbon, total nitrogen, and nitrate-nitrogen) were the major direct regulators of the spatial distribution of soil denitrification enzyme activity (DEA)...
February 2017: Environmental Monitoring and Assessment
S Goulet, M C Blais
Since its discovery, the immunogenicity of the Dal blood type has not been further investigated. The aim of this study was to better characterize anti- Dal alloantibodies produced following sensitization of Dal-negative dogs, notably their rate of appearance, the agglutination titer over time, and their immunoglobulin class. A secondary objective was to obtain polyclonal anti- Dal alloantibodies to increase the availability of Dal blood typing. Of 100 healthy laboratory Beagles tested, 2 Dal-negative dogs were identified as recipients...
January 1, 2017: Veterinary Pathology
Dominick Latremouille-Viau, Annie Guerin, Patrick Gagnon-Sanschagrin, Katherine Dea, Benjamin G Cohen, George J Joseph
BACKGROUND: Frequent molecular monitoring (qPCR tests), as recommended by evidence-based monitoring guidelines, is associated with higher adherence to tyrosine kinase inhibitors (TKIs) in the management of chronic myeloid leukemia (CML); both factors have been associated with better clinical and economic outcomes. OBJECTIVES: To (a) estimate the effect of more frequent qPCR tests on health care resource utilization (HRU) and associated costs, including direct (effect of qPCR test frequency on HRU) and indirect (through TKI adherence) effects, and (b) develop an economic model applicable to multiple clinical practice scenarios...
February 2017: Journal of Managed Care & Specialty Pharmacy
Adesola Odunayo, Kayode Garraway, Barton W Rohrbach, Amanda Rainey, Jennifer Stokes
OBJECTIVE To determine the incidence of incompatible crossmatch results in dogs without a history of prior RBC transfusion and to evaluate changes in Hct following RBC administration for transfusion-naïve dogs that did and did not have crossmatching performed. DESIGN Retrospective study. ANIMALS 169 client-owned dogs. PROCEDURES Information obtained from the medical records included signalment, pretransfusion Hct or PCV, and crossmatching results where applicable. Dogs that underwent major crossmatching (n = 149) as part of pretransfusion screening were each crossmatched with 3 potential donors...
February 1, 2017: Journal of the American Veterinary Medical Association
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