Sergio Matarraz, Julia Almeida, Juan Flores-Montero, Quentin Lécrevisse, Valentina Guerri, Antonio López, Susana Bárrena, Vincent H J Van Der Velden, Jeroen G Te Marvelde, Jacques J M Van Dongen, Alberto Orfao
Despite diagnostic criteria are currently available for the distinct subtypes of monocytic-lineage neoplasias, a number of partially overlapping features still remain evident, which may hamper their differential diagnosis. An accurate identification and characterization of monocytic cells is of major relevance for the diagnosis and classification of these neoplasias. In this regard, as compared to other conventional techniques, flow cytometry has shown the highest sensitivity for detection of early monocytic commitment of (normal and neoplastic) bone marrow CD34+ hematopoietic precursors as well as of monocytic aberrations and maturation blockades, which are frequently associated with clonal myeloid disorders...
May 2017: Cytometry. Part B, Clinical Cytometry