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controlling blood sugar levels

Amanda Martins Matias, Wagner Müller Estevam, Priscila Murucci Coelho, Douglas Haese, Jéssika Butcovsky Botto Sarter Kobi, Ana Paula Lima-Leopoldo, André Soares Leopoldo
BACKGROUND: Dietary interventions in rodents can induce an excess of adipose tissue and metabolic disorders that resemble human obesity. Nevertheless, these approaches are not standardized, and the phenotypes may vary distinctly among studies. The aim of this study was to investigate the effects of different dietary interventions on nutritional, metabolic, biochemical, hormonal, and cardiovascular profiles, as well as to add to development and characterization of an experimental model of obesity...
August 11, 2018: Nutrients
Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie, Julie Brown
BACKGROUND: Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. OBJECTIVES: To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of the benefits and harms associated with interventions for treating GDM on women and their babies. METHODS: We searched the Cochrane Database of Systematic Reviews (5 January 2018) for reviews of treatment/management for women with GDM...
August 14, 2018: Cochrane Database of Systematic Reviews
Wei-Che Lan, Ching-Yuan Wang, Chia-Der Lin
OBJECTIVES: To compare the efficacy of pentoxifylline with that of conventional steroid therapy in diabetic patients with idiopathic sudden sensorineural hearing loss (ISSNHL) and to compare blood sugar levels during hospitalization. MATERIALS AND METHODS: Medical charts were retrospectively reviewed for all diabetic patients admitted to one institution for ISSNHL between 2000 and 2015. We analyzed 298 cases; 50 patients received pulse steroid treatment (steroid group) and 248 received intravenous administration of pentoxifylline only (pentoxifylline group)...
August 3, 2018: Journal of International Advanced Otology
Vijay Chathoth, Parthasarathy Ramamurthy, Susan Solomon
Clozapine is superior to all other antipsychotics in treatment-resistant schizophrenia. However, metabolic side effects are common while treating patients with clozapine. Administering clozapine in a patient who already is diabetic involves careful weighing of risks and benefits. Here, we report our experience of starting clozapine in a known diabetic patient. Clozapine was started in a patient with treatment-resistant psychosis in view of suicidal risk. Her diabetes mellitus was under good control with oral medications...
July 2018: Indian Journal of Psychological Medicine
Jasmin Steudle, Christiane Schön, Manfred Wargenau, Lioba Pauly, Susann Schwejda-Güttes, Barbara Gaigg, Angelika Kuchinka-Koch, John F Stover
AIM: To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects. METHODS: The study was performed as prospective, randomized, two-part study with 4-way cross-over design with n = 12 in each study arm. Capillary blood glucose levels were determined over a time period of 180 min after intake of a single dose of 10 g or 20 g lactulose provided as crystal or liquid formulation. During the manufacturing process of lactulose, impurities with sugars ( e...
August 7, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
Ya-Feng Zhou, Xiao-Ming Ying, Xiao-Fen He, Sheng-Yun Shou, Jun-Jun Wei, Zhao-Xia Tai, Xiao-Mei Shao, Yi Liang, Fang Fang, Jian-Qiao Fang, Yong-Liang Jiang
Painful diabetic neuropathy (PDN) is a common and troublesome diabetes complication. Protein kinase C (PKC)-mediated dorsal root ganglia (DRG) P2X3 receptor upregulation is one important mechanism underlying PDN. Accumulating evidence demonstrated that electroacupuncture (EA) at low frequency could effectively attenuate neuropathic pain. Our previous study showed that 2-Hz EA could relieve pain well in PDN. The study aimed to investigate whether 2-Hz EA relieves pain in PDN through suppressing PKC-mediated DRG P2X3 receptor upregulation...
August 7, 2018: Purinergic Signalling
Shadman Nemati, Rasool Hassanzadeh, Mojtaba Mehrdad, Sahar Sajedi Kia
Introduction: It seems that diabetes mellitus (DM) can affect the auditory system due to neuropathy, micro-vascular complications, and hearing cell damage during hyperglycemic states. In the current study, we aimed to compare hearing status in patients with type 2 DM (T2DM) according to their blood-sugar control status. Materials and Methods: This cross-sectional study was carried out in 104 patients with T2DM attending the diabetic clinics of Guilan University of Medical Sciences within a period of 1 year (2014-2015)...
July 2018: Iranian Journal of Otorhinolaryngology
Tasnuva Sharmin, Md Shahidur Rahman, Habiba Mohammadi
BACKGROUND: Lagerstroemia speciosa (L.) Pers. (Family: Lythraceae) is used in traditional medicine in the treatment of diarrhea, diabetes and other diseases. The study was performed to conduct antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial, peripheral and central analgesic and hypoglycemic activity assays and phenobarbitone sodium-induced sleeping time test using crude methanol extract of flowers of L. speciosa and its different partitionates. METHOD: The antioxidant potential was evaluated by determining the ability of the samples to scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical...
August 6, 2018: BMC Complementary and Alternative Medicine
Alwaleed Aljohar, Khalid F Alhabib, Tarek Kashour, Ahmad Hersi, Waleed Al Habeeb, Anhar Ullah, Abdelfatah Elasfar, Ali Almasood, Abdullah Ghabashi, Layth Mimish, Saleh Alghamdi, Ahmed Abuosa, Asif Malik, Gamal Abdin Hussein, Mushabab Al-Murayeh, Hussam AlFaleh
Background: The prognostic impact of hyperglycemia (HG) in acute heart failure (AHF) is controversial. Our aim is to examine the impact of HG on short- and long-term survival in AHF patients. Methods: Data from the Heart Function Assessment Registry Trial in Saudi Arabia (HEARTS) for patients who had available random blood sugar (RBS) were analyzed. The enrollment period was from October 2009 to December 2010. Comparisons were performed according to the RBS levels on admission as either <11...
October 2018: Journal of the Saudi Heart Association
Maryam Eskandari Mehrabadi, Zahra Salemi, Saeid Babaie, Mitra Panahi
OBJECTIVES: Without proper medication for the treatment of diabetic retinopathy, retinal cells become malnourished and degenerate, which results in damage to vision cells and can lead to blindness. Flavonoids such as biochanin A (BCA) can directly target various facets of angiogenesis. We assessed the effect of administrating BCA on angiogenic and inflammatory markers in the retina of rats with diabetes. METHODS: We randomly selected 2 groups from 30 male Wistar rats...
April 3, 2018: Canadian Journal of Diabetes
Lin Chen, Minzeng Sun, Hui Liu, Lihui Ma, Tiansong Wang, Peiqiong Li, Mingqin Lin, Haifeng Lin, Penghuan Chang, Yueli Liu
BACKGROUND: Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China. METHODS: A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles...
July 27, 2018: Lipids in Health and Disease
Kendra M Seckinger, Vishnu P Rao, Nicole E Snell, Allison E Mancini, Michele L Markwardt, M A Rizzo
The release of insulin from the pancreas is tightly controlled by glucokinase (GCK) activity that couples β-cell metabolism to changes in blood sugar. Despite having only a single glucose-binding site, GCK displays positive glucose cooperativity. Ex vivo structural studies have identified several potential protein conformations with varying levels of enzymatic activity, yet it is unclear how living cells regulate GCK cooperativity. To better understand the cellular regulation of GCK activation, we developed a homotransfer Förster resonance energy transfer (FRET) GCK biosensor and used polarization microscopy to eliminate fluorescence crosstalk from FRET quantification and improve the signal-to-noise ratio...
August 10, 2018: Biochemistry
Fahimeh Yarigholi, Ali Zare Mehrjardi, Zahra Azizi, Massoud Baghai Wadji
Introduction: The activation of hypothalamic-pituitary-adrenal (HPA) axis through severe diseases and stress courses leads to a rise in circulatory cortisol for an adequate response to stress. This axis is one of the important systems that involve in neuroendocrine response to the surgical stress. Hepatoadrenal syndrome that is a manifestation of adrenal insufficiency (AI) in the course of liver disease is described as insufficient production of steroid hormones mainly cortisol due to primary dysfunction of the adrenal gland or secondary malfunction of the HPA axis to provoke the adrenal gland leading to severe illness and increased mortality...
2018: Surgery Research and Practice
Dong Wook Shin, Beomseok Suh, Youngmin Park, Hyunsun Lim, Yun-Suhk Suh, Jae Moon Yun, BeLong Cho, Han-Kwang Yang
BACKGROUND: Small studies suggest improvement of cardiovascular risk profiles and reduced cardiovascular mortality after gastrectomy for gastric cancer. In our study using national health insurance data, we investigated coronary heart disease (CHD) and ischemic stroke incidence among gastric cancer patients who received gastrectomy compared with general population controls. METHODS: A total of 98,936 gastric cancer patients were included in the study and matched to non-cancer controls via 1:1 propensity score matching...
July 24, 2018: Annals of Surgical Oncology
Abdel Aal M Elkamshoushi, Eman M Hassan, Amr M El Abd, Seham Z Hassan, Amer A Maher
Endothelial dysfunction is reported in erectile dysfunction (ED) and cardiovascular disease (CVD). Endocan is a serum marker in some endothelial-related disorders. Thirty patients with erectile dysfunction (Group A) and 15 controls (Group B) were enrolled in the study. Group A is subdivided into Group AI including 15 diabetic patients with ED and group AII including 15 nondiabetic patients with ED. The erectile function was assessed in all subjects using International Index of Erectile Function (IIEF-5) score...
July 23, 2018: Andrologia
Millad Ramazani, Durdi Qujeq, Zoleika Moazezi
OBJECTIVES: This study is essentially a correlative study that examines the potential of reduced levels of L-carnitine (LC) when combined with the pathophysiology of type 2 diabetes. The aim of the study was to assess the levels of LC, total antioxidant capacity (TAOC), fasting blood sugar (FBS), triglycerides and cholesterol in people with newly diagnosed and long-standing type 2 diabetes and in healthy controls. METHODS: The study was done in 90 adult subjects, including 30 with newly diagnosed diabetes, 30 with long-standing type 2 diabetes and 30 healthy controls...
March 29, 2018: Canadian Journal of Diabetes
Chaowanee Chupeerach, Cholathip Yothakulsiri, Rungrat Chamchan, Uthaiwan Suttisansanee, Kitti Sranacharoenpong, Anchalee Tungtrongchitr, Nattira On-Nom
Coconut jelly is a popular dessert among Asian people. However, it contains high levels of sugar. The recent patents on steviol glycoside (WO2015014969A1), steviol glycoside compositions for oral ingestion or use (WO2017095932A1) and sweetener composition for preventing and improving obesity, containing glycolysis inhibitor ingredient (EP2756764B1) [3] help to select the sweetener for development of coconut jelly. OBJECTIVE: Therefore, the purposes of this study were to develop a healthier coconut jelly formula by using stevia as a natural sweetener as well as to investigate the short-term effects of modified coconut jelly (MCJ) compared to control formula (CCJ) consumption on glycemic and insulin responses in twelve healthy participants...
July 17, 2018: Recent Patents on Food, Nutrition & Agriculture
Jiao Nie, Chang-Ping Li, Jue-Hong Li, Xia Chen, Xiaoling Zhong
The prevalence of non-alcoholic fatty liver disease (NAFLD) has been increasing in recent years. Previous studies have suggested that micro (mi)RNAs may be involved in the pathogenesis of NAFLD. To investigate the role of miRNAs in rat NAFLD, a total of 16 male Sprague Dawley rats were randomly divided into a control group and a model group. Rats in the control group were fed a normal diet for 12 weeks, whereas the rats in the model group were fed a high‑fat and high‑sugar diet for 12 weeks. Following this, the animals were sacrificed and liver tissues were rapidly removed to investigate the severity of NAFLD...
September 2018: Molecular Medicine Reports
Maryam Saghafi-Asl, Elnaz Vaghef-Mehrabany
BACKGROUND & AIMS: Only a limited number of studies have compared nursing home and community residing elderly in terms of health-related issues. The present study aimed to compare nutritional status and its associated factors between nursing home residents and community-dwelling seniors. METHODS: In this case-control, age- and gender-matched study in Tabriz (East Azarbaijan, Iran), elderly subjects aged 65 years and older were recruited from nursing homes (n = 76) and community (n = 88)...
October 2017: Clinical Nutrition ESPEN
Kun-Hong Li, Yen-Tze Liu, Yu-Wen Yang, Ying-Li Lin, Min-Ling Hung, I-Ching Lin
This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood sugar and HbA1c. PURPOSE: This study was undertaken to assess the effect of blood glucose on BMD and possible interactions with age, sex, and BMI in a Taiwanese population...
July 16, 2018: Archives of Osteoporosis
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