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T3cDM

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https://www.readbyqxmd.com/read/28902790/impact-of-treatments-on-diabetic-control-and-gastrointestinal-symptoms-after-total-pancreatectomy
#1
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman
OBJECTIVES: The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS: Thirty-nine patients with T3cDM (18 CSII patients vs 21 MDI patients) who underwent TP between 2000 and 2016 at 3 Harvard-affiliated hospitals and the University of Minnesota returned prospectively obtained questionnaires examining quality of life and both endocrine and exocrine pancreatic functions...
October 2017: Pancreas
https://www.readbyqxmd.com/read/27406162/the-nutritional-management-of-type-3c-pancreatogenic-diabetes-in-chronic-pancreatitis
#2
REVIEW
S N Duggan, N Ewald, L Kelleher, O Griffin, J Gibney, K C Conlon
Type 3c diabetes mellitus (T3cDM), also known as pancreatogenic diabetes, refers to diabetes caused by disease of the exocrine pancreas. T3cDM is not commonly recognised by clinicians and frequently it is misclassified as T1DM, or more commonly, T2DM. T3cDM can be difficult to distinguish from T1DM and T2DM, and it often co-exists with the latter. The aim of this review is to describe T3cDM, along with its complications, diagnosis and management. We focus on the nutritional implications of T3cDM for those with chronic pancreatitis, and provide a practical guide to the nutritional management of this condition...
January 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/25561813/pancreatic-exocrine-insufficiency-diabetes-mellitus-and-serum-nutritional-markers-after-acute-pancreatitis
#3
Miroslav Vujasinovic, Bojan Tepes, Jana Makuc, Sasa Rudolf, Jelka Zaletel, Tjasa Vidmar, Maja Seruga, Bostjan Birsa
AIM: To investigate impairment and clinical significance of exocrine and endocrine pancreatic function in patients after acute pancreatitis (AP). METHODS: Patients with AP were invited to participate in the study. Severity of AP was determined by the Atlanta classification and definitions revised in 2012. Pancreatic exocrine insufficiency (PEI) was diagnosed by the concentration of fecal elastase-1. An additional work-up, including laboratory testing of serum nutritional markers for determination of malnutrition, was offered to all patients with low levels of fecal elastase-1 FE...
December 28, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24974302/clinical-signature-and-pathogenetic-factors-of-diabetes-associated-with-pancreas-disease-t3cdm-a-prospective-observational-study-in-surgical-patients
#4
Gianpaolo Balzano, Erica Dugnani, Valentina Pasquale, Giovanni Capretti, Maria Grazia Radaelli, Tania Garito, Gregorio Stratta, Alessandro Nini, Raffaele Di Fenza, Renato Castoldi, Carlo Staudacher, Michele Reni, Marina Scavini, Claudio Doglioni, Lorenzo Piemonti
To characterize the clinical signature and etiopathogenetic factors of diabetes associated with pancreas disease [type 3 diabetes mellitus (T3cDM)]. To estimate incidence and identify predictors of both diabetes onset and remission after pancreatic surgery. A prospective observational study was conducted. From January 2008 to December 2012, patients (n = 651) with new diagnosis of pancreatic disease admitted to the Pancreatic Surgery Unit of the San Raffaele Scientific Institute were evaluated. Hospital and/or outpatient medical records were reviewed...
October 2014: Acta Diabetologica
https://www.readbyqxmd.com/read/23375619/diabetes-mellitus-secondary-to-pancreatic-diseases-type-3c-are-we-neglecting-an-important-disease
#5
REVIEW
Nils Ewald, Reinhard G Bretzel
Type 3c diabetes mellitus (T3cDM) is a clinically relevant condition with a prevalence of 5-10% among all diabetic subjects in Western populations. Its prevalence and clinical importance have been underestimated and underappreciated so far. In contrast to the management of type 1 or type 2 diabetes, the endocrinopathy in T3cDM is very complex and complicated by additional present comorbidities such as maldigestion and concommitant qualitative malnutrition. The failure to correctly diagnose T3cDM leads to failure to implement an appropriate medical therapy of these patients...
April 2013: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/22843556/diabetes-and-pancreatic-cancer
#6
REVIEW
YunFeng Cui, Dana K Andersen
Epidemiological studies clearly indicate that the risk of pancreatic cancer (PC) is increased in diabetic patients, but most studies focus on overall diabetes or type 2 diabetes mellitus (T2DM), and there are few studies on the risks of type 1 and type 3c (secondary) diabetes. Possible mechanisms for increased cancer risk in diabetes include cellular proliferative effects of hyperglycemia, hyperinsulinemia, and abnormalities in insulin/IGF receptor pathways. Recently, insulin and insulin secretagogues have been observed to increase the PC risk, while metformin treatment reduces the cancer risk in diabetic subjects...
October 2012: Endocrine-related Cancer
https://www.readbyqxmd.com/read/22226275/pancreatic-polypeptide-administration-enhances-insulin-sensitivity-and-reduces-the-insulin-requirement-of-patients-on-insulin-pump-therapy
#7
RANDOMIZED CONTROLLED TRIAL
Atoosa Rabiee, Panagis Galiatsatos, Rocio Salas-Carrillo, Michael J Thompson, Dana K Andersen, Dariush Elahi
INTRODUCTION: The effects of pancreatic polypeptide (PP) infusion were examined in patients on insulin pump therapy to determine whether PP administration can reduce insulin requirements in patients with type 1 diabetes mellitus (T1DM) or type 3c diabetes mellitus (T3cDM; pancreatogenic). METHODS: Ten subjects with long-standing T1DM (n = 7) or T3cDM (n = 3) on insulin pump treatment received a 72 h subcutaneous infusion of 2 pmol/kg/min bovine PP or saline by portable infusion pump in a single-blinded, randomized, crossover design...
November 1, 2011: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/21757968/pancreatogenic-diabetes-special-considerations-for-management
#8
REVIEW
Yunfeng Cui, Dana K Andersen
BACKGROUND/AIMS: Pancreatogenic, or type 3c, diabetes (T3cDM) occurs due to inherited or acquired pancreatic disease or resection. Although similar to the more prevalent type 1 and type 2 diabetes, pancreatogenic diabetes has a unique pattern of hormonal and metabolic characteristics and a high incidence of pancreatic carcinoma in the majority of patients with T3cDM. Despite these differences, no guidelines for therapy have been described. METHODS: Published studies on the prevalence, pathophysiology, and cancer associations of T3cDM were reviewed...
2011: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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