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Valentin Ritschl, Angelika Lackner, Carina Boström, Erika Mosor, Michaela Lehner, Maisa Omara, Romualdo Ramos, Paul Studenic, Josef Sebastian Smolen, Tanja Alexandra Stamm
BACKGROUND: It is estimated that 50-70% of patients with rheumatoid arthritis (RA) are non-adherent to their recommended treatment. Non-adherent patients have a higher risk of not reaching an optimal clinical outcome. We explored factors associated with nonadherence from the patient's perspective. METHODS: Four hundred and fifty-nine RA patients (346 (75.4%) females; mean age 63.0 ± 14.8 years) who failed to attend follow-up visits in two rheumatology centres were eligible to participate in a qualitative interview study...
October 19, 2018: Arthritis Research & Therapy
Sandra Helena Machado, Ricardo M Xavier, Priscila S Lora, Luciana M Kurtz Gonçalves, Luciane R Trindade, Paulo José C Marostica
OBJECTIVE: To evaluate height, sexual maturation, and the difference between final and expected height in girls with juvenile idiopathic arthritis and no glucocorticoid treatment for at least six months, as compared to a group of healthy girls. METHODS: This cross-sectional study involved 44 girls with juvenile idiopathic arthritis, diagnosed according to the International League of Associations for Rheumatology criteria, and 59 healthy controls aged between 8 and 18 (incomplete) years with no comorbid chronic diseases...
October 16, 2018: Jornal de Pediatria
Ciro Romano, Giovanna Cuomo, Roberta Ferrara, Andrea Del Mastro, Sergio Esposito, Ausilia Sellitto, Luigi Elio Adinolfi
Chronic hepatitis C virus (HCV) infection has been associated with myriad extrahepatic manifestations, often resulting from aberrant immune responses. Among the most common immune-mediated manifestations of HCV infection, mixed cryoglobulinemia is the best known extra-hepatic complication. Areas covered: Here we review less common extrahepatic manifestations of HCV infection, with ascertained or presumed immune pathogenesis and the role of the new all oral direct-acting antiviral agents. Rheumatologic, dermatologic, ophthalmologic, renal, pulmonary, hematologic, cardiovascular and neuropsychiatric manifestations of HCV infection have been considered...
October 19, 2018: Expert Review of Clinical Immunology
Ko-Ming Lin, Wei-Ming Chen, Shui-Yi Tung, Kuo-Liang Wei, Chein-Heng Shen, Te-Sheng Chang, Pey-Jium Chang
AIM: In order to increase diagnostic sensitivity for early disease in rheumatoid arthritis (RA), new classification criteria were approved in 2010 by the American College of Rheumatology and the European League Against Rheumatism. One of the criteria, a high-positive rheumatoid factor (RF) or anti-citrullinated protein antibody (ACPA) level, was given a high score of 3. However, the increased prevalence of RF in patients with chronic hepatitis C virus (HCV) infection markedly diminishes the diagnostic specificity of serum RF for RA in these patients...
October 18, 2018: International Journal of Rheumatic Diseases
Prasan Deep Rath, Der-Yuan Chen, Jieruo Gu, Vivian W Y Lee, Nizar Abdulateef Al Ani, Khalid Shirazy, Lyndon Llamado
Although anti-tumor necrosis factor (TNF) agents have greatly improved the management of rheumatic diseases, their cost limits access to many patients throughout the world. As a result, patients and clinicians have turned to biosimilars to provide similar efficacy at a lower cost. Many of the regulatory guidelines in the Asia Pacific region are largely based on those of the European Medicines Agency and the World Health Organization; however, there are variations between countries. Additionally, in some countries, intended copies are available that were approved prior to the development of guidelines and have not fulfilled the requirements of a biosimilar...
October 18, 2018: International Journal of Rheumatic Diseases
Line Raunsbæk Knudsen, Annette de Thurah, Merete Bjerrum
Aim: The aim of this study was to investigate experiences and needs in the transition from child to adult care in an outpatient clinic from the perspective of adolescents with juvenile idiopathic arthritis and their parents focusing on which aspects in the transition could ease the process. Design: A qualitative design with an inductive approach. Methods: Inductive content analysis was used to analyse individual interviews with three parents and three adolescents from a rheumatology clinic in Denmark...
October 2018: Nursing Open
Alexia D'Andréa, Damien L Peillet, Christine Serratrice, Pierre-Augute Petignat, Virginie Prendki, Jean-Luc Reny, Jacques Serratrice
RATIONALE: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections. PATIENT CONCERNS: In rare cases, pleural eosinophilia is associated with connective tissue disease. DIAGNOSES: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997...
October 2018: Medicine (Baltimore)
Wan Syamimee Wan Ghazali, Saidatul Manera Mohd Daud, Nurashikin Mohammad, Kah Keng Wong
The aims of this study were to determine damage index in systemic lupus erythematosus (SLE) patients based on Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) and to determine the laboratory and clinico-demographic factors affecting SDI.This is a retrospective cohort study of 94 SLE patients attending rheumatology clinics in 2 local hospitals in Kelantan, Malaysia. The patients were divided into 2 groups based on SDI score assigned by the attending physician, 0 (without damage) or ≥1 (with damage)...
October 2018: Medicine (Baltimore)
Masakazu Kondo, Hisakata Yamada
OBJECTIVES: To assess long-term outcomes for 7 biological disease-modifying antirheumatic drugs (bDMARDs) and one Janus kinase (JAK)-inhibitor in rheumatoid arthritis. METHODS: We retrospectively analyzed data from 801 rheumatoid arthritis patients visiting our rheumatology clinic between 2003 and 2017. We determined drug survival rates, drug discontinuation, and switching rates in these patients. RESULTS: Among the drugs administered to naïve subjects, the drug-survival rate was highest for tocilizumab, at 77...
October 18, 2018: Modern Rheumatology
Tohru Michitsuji, Nozomi Iwanaga, Yoshiro Horai, Yoshika Tsuji, Chieko Kawahara, Yasumori Izumi, Ken Taniguchi, Shinichiro Yoshida, Atsushi Kawakami
AIM: To analyze the clinical course and prognosis in patients diagnosed with polymyalgia rheumatica (PMR) complicated by the presence of malignancies. METHODS: We retrospectively screened the case files of 216 patients hospitalized in our department between 2011 and December 2016 for the results of a thorough physical examination and data on treatment for rheumatic diseases. We identified 53 patients with PMR according to Bird's criteria and 43 patients with 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for PMR, then analyzed the clinical and serologic manifestations of PMR in patients with (n = 6) and without (n = 47 in Bird' criteria, n = 37 in 2012 EULAR/ACR criteria) malignancy...
October 18, 2018: Modern Rheumatology
Jason L Martin, Paraskevi A Vlachou
History A 58-year-old woman was seen in the rheumatology clinic for bilateral wrist and knee pain that was unresponsive to physiotherapy and intra-articular steroid injections. Remote fracture of the left tibia from a motor vehicle collision was reported and was previously treated with conservative management. Serologic work-up for inflammatory disease was negative. The patient reported no prior surgical or medical history. Social history revealed remote immigration from Malaysia. Radiographs of the hands and knees were obtained ( Figs 1 - 4 )...
November 2018: Radiology
Olivier Chatelanat, Christian Van Delden, Dan Adler, Pierre-André Guerne, Mathieu Nendaz, Jacques Serratrice
Pneumocystis jirovecii (formely carinii) pneumonia (PcP) affects immunosuppressed patients. Cotrimoxazole prophylaxis has proven to be effective and its indications in HIV patients are well established. In non-HIV patients, the prognosis is poorer and diagnostic tests are of lower sensitivity. Recommendations for prophylaxis in hematology, oncology and solid organ transplantation are based on expert consensus. In rheumatology, the incidence of PcP is mainly related to the administration of corticosteroids. For some inflammatory diseases, a low CD4 cell count, and the administration of anti-TNFα, rituximab or cyclophosphamide may increase the risk...
October 17, 2018: Revue Médicale Suisse
Susana Seca, Miguel Patrício, Sebastian Kirch, Giovanna Franconi, António S Cabrita, Henry J Greten
BACKGROUND: Rheumatoid arthritis (RA) is characterized by pain, functional disability, poor quality of life (QoL), high socioeconomic impact, and annual costs of over $56 billion in the United States. Acupuncture (AC) is widely in use; however, studies show severe methodological shortcomings, did not consider the functional diagnosis for the allocation of acupoints and their results showed no differences between verum and control groups. OBJECTIVE: The authors aimed to objectively assess the safety and efficacy of AC treatments for RA...
October 16, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Raju Khubchandani
No abstract text is available yet for this article.
October 16, 2018: Indian Journal of Pediatrics
Reem Hamdy A Mohammed, Hanan Kotb, Marian Amir, Andrea Di Matteo
PURPOSE: This study aimed at investigating the prevalence of crystal deposits with knee osteoarthritis (OA) by ultrasonography and measure the inflammatory burden associated with crystal deposits in OA using WOMAC score. METHODS: Adult patients with primary knee OA diagnosed according to the American College of Rheumatology criteria were included. Participants were subjected to history taking, clinical examination, knee US, and plain radiography. The EULAR and the OMERACT ultrasonography definitions and scanning protocols were used...
October 16, 2018: Journal of Medical Ultrasonics
L Bause
The introduction of biologics has led to a great improvement in the treatment options for inflammatory rheumatic diseases. Nevertheless, surgical interventions are still necessary in many patients but a change in surgical indications could be observed. The previously predominant synovectomy of inflamed rheumatic joints is now reduced to a few so-called rebellious joints with persistent inflammation. Joint-preservation and tenoplasty are standard surgical procedures requiring a specific approach including potential complications...
October 16, 2018: Der Orthopäde
Giorgio Tamborrini, André Leumann
No abstract text is available yet for this article.
2018: Praxis
Sarah Skeoch, Nicholas Weatherley, Andrew J Swift, Alexander Oldroyd, Christopher Johns, Conal Hayton, Alessandro Giollo, James M Wild, John C Waterton, Maya Buch, Kim Linton, Ian N Bruce, Colm Leonard, Stephen Bianchi, Nazia Chaudhuri
BACKGROUND: Drug-induced interstitial lung disease (DIILD) occurs as a result of numerous agents, but the risk often only becomes apparent after the marketing authorisation of such agents. METHODS: In this PRISMA-compliant systematic review, we aimed to evaluate and synthesise the current literature on DIILD. RESULTS: Following a quality assessment, 156 full-text papers describing more than 6000 DIILD cases were included in the review. However, the majority of the papers were of low or very low quality in relation to the review question (78%)...
October 15, 2018: Journal of Clinical Medicine
Seung Min Jung, Seung-Ki Kwok, Ji Hyeon Ju, Sang-Won Lee, Jason Jungsik Song, Chong-Hyeon Yoon, Yong-Beom Park, Sung-Hwan Park
OBJECTIVE: The proportion of elderly patients with rheumatoid arthritis (RA) is continuously growing as a result of the increasing aging population. We compared disease activity between different age groups, and evaluated the clinical factors associated with high disease activity. METHODS: This cross-sectional study analyzed the data of RA patients enrolled in the Korean College of Rheumatology Biologics registry (KOBIO-RA) between 2012 and 2014. Disease activity between elderly (age ≥ 65 years) and non-elderly patients (age < 65 years) was compared, and the association of clinical factors with high disease activity was assessed using a multivariate logistic regression model...
2018: PloS One
Dhia Kaffel, Emira Ben Hamida
INTRODUCTION: The CIAP (Clarification, Illustration, Application, Participation) teaching, was adopted by our faculty since 1988. It allows a pedagogical approach favoring teacher / student contact. It puts the disciple in the center of the work. However, this method has been initiated for a long time, its actual place in our teaching is not yet well established and not all teachers adhere to it because it has never been evaluated before. AIM: To evaluate the CIAP teaching in rheumatology in abarticular shoulder pathology in DCEM1 students...
February 2018: La Tunisie Médicale
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