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https://www.readbyqxmd.com/read/30537520/diabetes-induced-neuropathic-mechanical-hyperalgesia-depends-on-p2x4-receptor-activation-in-dorsal-root-ganglia
#1
Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Amanda Ferreira Neves, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Catarine Massucato Nishijima, Felipe Hertzing Farias, Jozi Godoi Figueiredo, Victor Hernandez-Olmos, Samer Alshaibani, Cláudia Herrera Tambeli, Christa E Müller, Carlos Amílcar Parada
Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes part in the development of neuropathic pain. However, there is an open question: Is P2X4R activation on dorsal root ganglia (DRG) involved in the development of neuropathic pain? To answer this question, this study verified the involvement of P2X4R expressed in DRG cells on diabetes-induced neuropathic mechanical hyperalgesia in rats...
December 8, 2018: Neuroscience
https://www.readbyqxmd.com/read/30534928/-chikungunya-emerging-disease-in-latin-america-description-of-the-first-cases-in-chile
#2
Cecilia Perret, Cecilia Vizcaya, Thomas Weitzel, Reinaldo Rosas, Jeannette Dabanch, Constanza Martínez
BACKGROUND: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. AIM: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. PATIENTS AND METHODS: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and laboratory results...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/30528171/setting-the-record-straight-the-nosology-of-tardive-syndromes
#3
Daniel D Truong, Karen Frei
We propose the use of the term tardive dyskinesia to refer to the original description of repetitive and complex oral-buccal-lingual (OBL) movements and the analogous repetitive movements of the limbs, trunk, or pelvis. The term tardive syndrome is an umbrella term to be used to refer to the spectrum of all persistent hyperkinetic, hypokinetic, and sensory phenomenologies resulting from chronic dopamine receptor blocking agent (DRBA) exposure. TD is a type of TS. The term tardive dystonia (TDyst) should be used when dystonia is the main feature of TS...
November 28, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30527828/evaluation-of-group-concept-mapping-during-advanced-pharmacy-practice-experiences
#4
S Mimi Mukherjee, Adriana Cabrera, Matthew A Silva
BACKGROUND AND PURPOSE: Concept mapping is an active learning tool associated with meaningful learning. In the pharmacy education literature, most evaluations of concept mapping focused solely on students' perceptions of mapping without evaluating its effectiveness on students' ability to apply the information learned. This article describes an evaluation of the effectiveness of group concept mapping during advanced pharmacy practice experiences (APPEs) by evaluating both application of the knowledge gained and students' reflections on the process...
December 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/30521455/-chronic-pain-after-outpatient-inguinal-hernioplasty-retrospective-cohort-study
#5
Patrícia Oliveira, Ana Duarte, André Guimarães, Armindo Fernandes, Catarina Ferreira, Diana Amorim, Filipa Gouveia, Joana Almeida, Madalena Braga, Mariana Oliveira, Mónica Durães, Rita Pichel, José Romão
INTRODUCTION: Chronic postoperative pain is the most frequent late complication of inguinal hernia repair surgery. The aim of this study is to evaluate the incidence of chronic post-hernioplasty pain in outpatient care at Centro Hospitalar do Porto, describe it, analyse its relation with other variables defined in the literature and study its functional interference. MATERIAL AND METHODS: We performed a retrospective cohort study between February and May 2016, using a structured telephone interview composed of questions from the authors and sections of published questionnaires, two of which are validated for the Portuguese language and culture...
November 30, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/30517969/understanding-secure-messaging-in-the-inpatient-environment-a-new-avenue-for-communication-and-patient-engagement
#6
Cynthia J Sieck, Daniel M Walker, Jennifer L Hefner, Jaclyn Volney, Timothy R Huerta, Ann Scheck McAlearney
BACKGROUND:  Patient portals, and the secure messaging feature in particular, have been studied in the outpatient setting, but research in the inpatient setting is relatively less mature. OBJECTIVE:  To understand the topics discussed in secure messaging in the inpatient environment, we analyzed and categorized messages sent within an inpatient portal. MATERIALS AND METHODS:  This observational study examined the content of all secure messages sent from December 2013 to June 2017 within an inpatient portal at a large Midwestern academic medical center (AMC)...
October 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/30517256/quality-of-life-in-cardiovascular-surgery-elaboration-and-initial-internal-validation-of-a-quality-of-life-questionnaire
#7
Marina Macedo Kuenzer Bond, Jenny Lourdes Rivas de Oliveira, Luiz Carlos Bento de Souza, Pedro Silvio Farsky, Vivian Lerner Amato, Dorival Julio Della Togna, Samira Kaissar Ghorayeb, Magaly Arrais Dos Santos
OBJECTIVE: Elaboration and internal validation of the Quality of Life in Cardiovascular Surgery (QLCS) questionnaire adapted to the reality of Brazilian cardiovascular surgery. METHODS: Cross-sectional pilot study of a prospective cohort included in the Documentation and Surgical Registry Center (CEDREC) for internal validation of the QLCS questionnaire. Four hundred forty-five patients submitted to cardiovascular surgery and who answered a QLCS questionnaire 30 days after hospital discharge were included...
September 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/30516661/how-common-is-back-pain-and-what-biopsychosocial-factors-are-associated-with-back-pain-in-patients-with-adolescent-idiopathic-scoliosis
#8
Arnold Y L Wong, Dino Samartzis, Prudence W H Cheung, Jason Pui Yin Cheung
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common spine deformity in adolescent patients. Although structural deformity may affect spinal biomechanics of patients with AIS, little is known regarding various period prevalence proportions of back pain and chronic back pain and factors associated with back pain in such patients. QUESTIONS/PURPOSES: (1) What are the period prevalence rates of back pain among teenagers with AIS? (2) Is back pain in patients with AIS associated with curve severity? METHODS: A total of 987 patients with AIS who were treated without surgery were recruited from a single center's scoliosis clinic...
November 13, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/30515646/omitting-the-lower-neck-and-sparing-the-glottic-larynx-in-node-negative-nasopharyngeal-carcinoma-was-safe-and-feasible-and-improved-patient-reported-voice-outcomes
#9
F Xiao, S Dou, Y Li, W Qian, F Liang, L Kong, X Wang, K Wu, C Hu, G Zhu
BACKGROUND: Worsening voice and speech quality was frequently reported in head-and-neck patients after radiotherapy to the neck; omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma (NPC) patients might be safe and feasible, and improve voice and speech outcomes. METHODS: From January 2009 to January 2013, 71 patients were analyzed. All patients received bilateral neck irradiation. Upper group (UG) patients spared the glottic larynx while lower group (LG) patients did not...
December 4, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30514271/stakeholder-expectations-from-the-integration-of-chiropractic-care-into-a-rehabilitation-setting-a-qualitative-study
#10
Zacariah K Shannon, Stacie A Salsbury, Donna Gosselin, Robert D Vining
BACKGROUND: Few studies have investigated patient and provider expectations of chiropractic care, particularly in multidisciplinary settings. This qualitative study explored stakeholder expectations of adding a chiropractor to the healthcare team at a rehabilitation specialty hospital. METHODS: The research methodology was an organizational case study with an inpatient facility for persons recovering from complex neurological conditions serving as the setting. Sixty stakeholders, including patients, families, hospital staff, and administrators, were interviewed or participated in focus groups in June 2015...
December 4, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/30512130/influences-on-primary-care-provider-imaging-for-a-hypothetical-patient-with-low-back-pain
#11
Hai H Le, Matthew DeCamp, Amanda Bertram, Minal Kale, Zackary Berger
OBJECTIVE: How outside factors affect physician decision making remains an open question of vital importance. We sought to investigate the importance of various influences on physician decision making when clinical guidelines differ from patient preference. METHODS: An online survey asking 469 primary care providers (PCPs) across four practice sites whether they would order magnetic resonance imaging for a patient with uncomplicated back pain. Participants were randomized to one of four scenarios: a patient's preference for imaging (control), a patient's preference plus a colleague's opinion against imaging (colleague), a patient's preference plus a professional society's recommendation against imaging (profession), or a patient's preference plus an accountable care organization's quality metric that measures physician use of imaging (ACO)...
December 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/30512126/stress-electrocardiography-vs-radionuclide-myocardial-perfusion-imaging-among-patients-admitted-for-chest-pain-comparison-of-teaching-and-nonteaching-hospital-services
#12
Karishma Samtani, Abdulfatah Issak, Jared Liston, Ronald J Markert, Dean Bricker
OBJECTIVES: The American Board of Internal Medicine Foundation's Choosing Wisely initiative has identified the routine use of stress cardiac imaging among lower-risk patients as an expensive test that should be questioned by both physicians and patients. The objectives of this study were to determine how often patients hospitalized for chest pain are assessed with stress electrocardiography (stress ECG) compared with radionuclide myocardial perfusion imaging (rMPI) and to evaluate whether the cardiac testing guidelines of the American Heart Association and the Choosing Wisely campaign are being followed...
December 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/30509394/acute-and-chronic-suppurative-osteomyelitis-of-the-jaws-a-10-year-review-and-assessment-of-treatment-outcome
#13
Tyler H Haeffs, Christopher A Scott, Tiffany H Campbell, Youbai Chen, Meredith August
PURPOSE: To review cases of suppurative osteomyelitis of the jaws treated at the Massachusetts General Hospital (Boston, MA) over a 10-year period, evaluate specifics of disease presentation, and answer the clinical question: are there identifiable variables associated with treatment outcome? MATERIALS AND METHODS: A retrospective cohort study was completed using patients treated for suppurative osteomyelitis of the jaws at the Massachusetts General Hospital from April 2006 to October 2016...
December 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30509216/protocol-for-the-development-of-a-core-outcome-set-for-pelvic-girdle-pain-including-methods-for-measuring-the-outcomes-the-pgp-cos-study
#14
Francesca Wuytack, Annelie Gutke, Britt Stuge, Siv Mørkved, Christina Olsson, Hilde Stendal Robinson, Nina K Vøllestad, Birgitta Öberg, Lena Nilsson Wikmar, Juan Jose Saldaña Mena, Valerie Smith
BACKGROUND: Pelvic Girdle Pain (PGP) is an important cause of disability and economic cost worldwide. There is a need for effective preventative and management strategies. Emerging studies measure a variety of outcomes rendering synthesis and translation to clinical practice difficult. A Core Outcome Set (COS) can address this problem by ensuring that data are relevant, useful and usable for making well-informed healthcare choices. The aim of this study is to develop a consensus-based PGP-COS, including agreement on methods (e...
December 3, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/30508186/can-postoperative-massage-therapy-reduce-pain-and-anxiety-in-cardiac-surgery-patients
#15
Ciaran Grafton-Clarke, Laura Grace, Neil Roberts, Amer Harky
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, 'In patients undergoing cardiac surgery, is postoperative massage therapy effective in reducing pain, anxiety and physiological parameters?'. Altogether, 287 papers were found using the reported search, of which 7 papers represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and the results of these papers are tabulated...
December 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/30508181/music-therapy-following-cardiac-surgery-is-it-an-effective-method-to-reduce-pain-and-anxiety
#16
Ciaran Grafton-Clarke, Laura Grace, Amer Harky
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: In patients undergoing cardiac surgery, is postoperative music therapy effective in reducing pain and anxiety? Altogether, 153 papers were found using the reported search method, of which 7 represented the best evidence to answer the clinical question. Six of the included studies were randomized trials, with 1 further non-randomized trial. The specific music protocols utilized widely varied, ranging from 1 short session on day 1 postoperatively to multiple sessions per day over a 72-h period...
December 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/30504341/balancing-exercise-risk-and-benefits-lessons-learned-from-sickle-cell-trait-and-sickle-cell-anemia
#17
REVIEW
Robert I Liem
Development of exercise guidelines for individuals with sickle cell trait (SCT) and sickle cell anemia (SCA) is hampered by the need to weigh the benefits against risks of exercise in these populations. In SCT, concern for exercise collapse associated with sickle cell trait has resulted in controversial screening of student athletes for SCT. In SCA, there exists unsubstantiated concerns that high-intensity exercise may result in pain and other complications. In both, finding the "right dose" of exercise remains a challenge for patients and their providers...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30503333/influence-of-preoperative-opioid-use-on-postoperative-outcomes-and-opioid-use-after-arthroscopic-rotator-cuff-repair
#18
Brady T Williams, Nathan J Redlich, Dara J Mickschl, Steven I Grindel
BACKGROUND: Recent orthopedic research has questioned the effect of opioid use on surgical outcomes. This study investigated this in the context of arthroscopic rotator cuff repair. We hypothesized that preoperative opioid use would be associated with inferior outcomes and greater postoperative opioid requirements. METHODS: A database query identified adult patients with full-thickness or partial-thickness supraspinatus tears surgically treated between 2011 and 2015...
November 29, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/30502644/exploring-cannabis-use-by-patients-with-multiple-sclerosis-in-a-state-where-cannabis-is-legal
#19
Laura Weinkle, Christopher H Domen, Ian Shelton, Stefan Sillau, Kavita Nair, Enrique Alvarez
BACKGROUND: Studies suggest cannabis may improve symptoms like pain and muscle spasticity in patients with multiple sclerosis (PwMS). Despite cannabis' new-found legality and availability, few studies have explored the profile of PwMS cannabis users and characteristics of their use, particularly in a state where cannabis is legal both for recreational and medicinal use. The purpose of the current study was to evaluate cannabis use among PwMS at a large academic multiple sclerosis (MS) clinic, specifically: (1) prevalence, (2) products used (e...
November 20, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30500720/management-of-thoracic-spine-pain-and-dysfunction-a-survey-of-clinical-practice-in-the-uk
#20
Nicola R Heneghan, S Gormley, C Hallam, Alison Rushton
BACKGROUND: The thoracic spine (TS) is relatively under-researched compared to the neck and low back. As the challenge of managing spinal pain persists, understanding current physiotherapy clinical practice for TS pain and dysfunction is necessary to inform future research in this area. OBJECTIVE: To investigate physiotherapy practice for managing thoracic spine pain and dysfunction (TSPD) in the UK, with a secondary focus on examining differences across settings and expertise...
November 22, 2018: Musculoskeletal Science & Practice
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