Karthik A Ganapathi, Alina Nicolae, Caoimhe Egan, Huimin Geng, Liqiang Xi, Svetlana D Pack, Jason R McFadden, Mark Raffeld, Elaine S Jaffe, Stefania Pittaluga
Peripheral T-cell lymphomas (PTCL) are morphologically and biologically heterogeneous and a subset expresses CD30, including anaplastic large cell lymphomas (ALCL) and a minority of PTCL, not otherwise specified (PTCL, NOS). ALCL with ALK translocations (ALCL, ALK+) are readily identified by routine diagnostic methods, but differentiating ALCL without ALK translocation (ALCL, ALK-) and PTCL, NOS expressing CD30 (PTCL CD30+) can be challenging. Furthermore, rare PTCL co-express CD30 and CD15 (PTCL CD30+CD15+); some resemble ALCL, ALK- while others resemble classic Hodgkin lymphoma...
April 12, 2024: British Journal of Haematology