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https://www.readbyqxmd.com/read/25197009/endocrine-function-and-bone-disease-during-long-term-chelation-therapy-with-deferasirox-in-patients-with-%C3%AE-thalassemia-major
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MULTICENTER STUDY
Maddalena Casale, Serena Citarella, Aldo Filosa, Elisa De Michele, Francesco Palmieri, Alfonso Ragozzino, Giovanni Amendola, Umberto Pugliese, Immacolata Tartaglione, Filomena Della Rocca, Patrizia Cinque, Bruno Nobili, Silverio Perrotta
Iron overload in β-thalassemia major (TM) typically results in iron-induced cardiomyopathy, liver disease, and endocrine complications. We examined the incidence and progression of endocrine disorders (hypothyroidism, diabetes, hypoparathyroidism, hypogonadism), growth and pubertal delay, and bone metabolism disease during long-term deferasirox chelation therapy in a real clinical practice setting. We report a multicenter retrospective cohort study of 86 transfusion-dependent patients with TM treated with once daily deferasirox for a median duration of 6...
December 2014: American Journal of Hematology
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