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https://www.readbyqxmd.com/read/29329451/epidermal-growth-factor-receptor-signaling-disruption-by-endocrine-and-metabolic-disrupting-chemicals
#1
Josiah E Hardesty, Laila Al-Eryani, Banrida Wahlang, K Cameron Falkner, Hongxue Shi, Jian Jin, Brad Vivace, Brian P Ceresa, Russell A Prough, Matthew C Cave
Background: The purpose of this study is to identify an environmentally relevant shared receptor target for endocrine and metabolism disrupting chemical pollutants. A feature of the tested chemicals was that they induced Cyp2b10 in vivo implicating activation of the constitutive androstane receptor (CAR). Recent studies suggest that these compounds could be indirect CAR activators via epidermal growth factor receptor (EGFR) inhibition. Methods: Assays included a CAR activity reporter assay, EGF endocytosis assay, and EGFR phosphorylation assay...
January 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29329213/a-cross-sectional-study-of-the-association-between-infant-hepatitis-b-vaccine-exposure-in-boys-and-the-risk-of-adverse-effects-as-measured-by-receipt-of-special-education-services
#2
David A Geier, Janet K Kern, Kristin G Homme, Mark R Geier
The National Center for Education Statistics reported that between 1990-2005 the number of children receiving special education services (SES) rose significantly, and then, from 2004-2012, the number declined significantly. This coincided with the introduction of Thimerosal-containing hepatitis B vaccine in 1991, and the subsequent introduction of Thimerosal-reduced hepatitis B vaccine in the early 2000s. This study examined the potential relationship between infant exposure to mercury from three doses of Thimerosal-containing hepatitis B vaccine and the risk of boys being adversely affected (as measured by receipt of SES)...
January 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29325892/added-sugar-intake-among-pregnant-women-in-the-united-states-national-health-and-nutrition-examination-survey-2003-2012
#3
Catherine E Cioffi, Janet Figueroa, Jean A Welsh
BACKGROUND: Despite associations of dietary added sugar with excess weight gain and chronic disease risk, intake among most Americans exceeds the recommended limits (<10% total energy). Maternal diet plays an important role in pregnancy-related outcomes, but little is known about the extent of added sugar intake during pregnancy. OBJECTIVE: To assess intake and identify the top sources of added sugars in the diets of pregnant vs nonpregnant women in the United States...
January 9, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29323406/type-and-timing-of-dietary-acid-intake-and-tooth-wear-among-american-adults
#4
Lynn H Al-Zwaylif, Saoirse O'Toole, Eduardo Bernabé
OBJECTIVES: To explore the interrelationship between type and timing of dietary acid intake and tooth wear among American adults. METHODS: This study used data from 3,586 adults, aged 18 years and older, who participated in the National Health and Nutrition Examination Survey (NHANES) 2003-04. Information on four types of acidic food and beverages (fruits, fruit juices, alcoholic drinks, and soft drinks) and timing of consumption (meals versus snacks, defined according to percentage of total energy intake, self-reported eating occasion, and time of day) was extracted from two 24-hour dietary recalls...
January 11, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29318755/sugar-intake-by-type-added-vs-naturally-occurring-and-physical-form-liquid-vs-solid-and-its-varying-association-with-children-s-body-weight-nhanes-2009-2014
#5
J A Welsh, Y Wang, J Figueroa, C Brumme
BACKGROUND: Sugars and their primary dietary sources (milk, fruits, sweetened foods and beverages) are associated, in different ways, with a range of health outcomes, including obesity. The contribution made to total sugar intake and how the different types and forms of sugar associate with body weight is unclear. OBJECTIVE: To describe sugar consumption and examine its association with weight status among U.S. children by sugar type [added {AS} vs. naturally occurring {NOS}] and form (solid vs...
January 9, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29318033/the-association-of-depression-and-diabetes-across-methods-measures-and-study-contexts
#6
Jaimie C Hunter, Brenda M DeVellis, Joanne M Jordan, M Sue Kirkman, Laura A Linnan, Christine Rini, Edwin B Fisher
Background: Empirical research has revealed a positive relationship between type 2 diabetes mellitus and depression, but questions remain regarding timing of depression measurement, types of instruments used to measure depression, and whether "depression" is defined as clinical depression or depressive symptoms. The present study sought to establish the robustness of the depression-diabetes relationship across depression definition, severity of depressive symptoms, recent depression, and lifetime depression in a nationally representative dataset and a large rural dataset...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29317006/secular-trends-in-regional-differences-in-nutritional-biomarkers-and-self-reported-dietary-intakes-among-american-adults-national-health-and-nutrition-examination-survey-nhanes-1988-1994-to-2009-2010
#7
Ashima K Kant, Barry I Graubard
OBJECTIVE: To understand the contribution of regional differentials in dietary exposures to regional gradients in health, we examined 20-year trends in the association of US census region of residence with nutritional biomarkers and dietary intakes of American adults. DESIGN: Observational. SETTING: The biomarker and 24 h dietary recall data were from the National Health and Nutrition Examination Surveys (NHANES) conducted during 1988-1994 and 1999-2010...
January 10, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29304819/heavy-metal-exposure-and-nasal-staphylococcus-aureus-colonization-analysis-of-the-national-health-and-nutrition-examination-survey-nhanes
#8
Shoshannah Eggers, Nasia Safdar, Kristen Mc Malecki
BACKGROUND: Heavy metals including lead and cadmium can disrupt the immune system and the human microbiota. and are increasingly of concern with respect to the propogation of antibiotic-resistence. Infection by methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of global morbidity and mortality. Heavy metal exposure may be associated with increased MRSA colonization and infection, and a decrease in methicillin-susceptible Staphylococcus aureus (MSSA) through co-selection mechanisms and natural selection of antibiotic resistance in the presence of heavy metals...
January 5, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29298711/the-relationship-between-sitting-height-sitting-height-to-height-ratio-with-blood-pressure-among-polokwane-private-school-children-aged-6-13%C3%A2-years
#9
Nthai E Ramoshaba, Kotsedi D Monyeki, Joyce Mpya, Mafolwa S Monyeki
BACKGROUND: It is notable that sitting height (SH) correlates with blood pressure (BP) in children and adolescents of developed countries. However, little is known about the relationships between SH and SH to height ratio (SH/H) with BP in South African children from middle and upper socio-economic groups. The purpose of this study was to compare SH and SH/H of private school attending children in the Polokwane area with National Health and Nutrition Examination Survey III (NHANES III) reference population and to determine the relationship between SH, SH/H with BP among private school attending children...
January 4, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29297435/validation-of-spirometry-prediction-equations-in-western-kenya
#10
D W Paul, D K Lagat, N MacIntyre, J R Egger, D M Murdoch, L G Que, P S Kussin
SETTING: Community of Eldoret, Kenya. OBJECTIVE: To test the performance of three commonly used spirometry prediction equations in a healthy Kenyan population. DESIGN: Cross-sectional assessment of healthy adults in Eldoret. RESULTS: Of the 331 subjects enrolled in the study, 282 subjects aged 18-85 years (45% males, 55% females) produced high-quality spirograms. Lung function predictions were made using the Global Lung Initiative 2012 (GLI 2012) prediction equations for African Americans, the National Health and Nutrition Examination Survey III (NHANES III) prediction equations for African Americans, and the Crapo prediction equation...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29291571/pfoa-is-associated-with-diabetes-and-metabolic-alteration-in-us-men-national-health-and-nutrition-examination-survey-2003-2012
#11
Xiaowei He, Yuanxin Liu, Bo Xu, Liubao Gu, Wei Tang
Exposure to perfluoroalkyl substances (PFAS) is associated with a range of adverse health effects. However, it remains unclear whether PFAS at environmentally relevant exposure levels are related to diabetes and metabolite concentrations in adults. Using cross-sectional data from 7904 adults (age≥20years) in the 2003-2012 National Health and Nutrition Examination Survey (NHANES), we examined the association of PFAS with the prevalence of diabetes and metabolite concentrations. A multivariate logistic regression was applied to investigate the associations of diabetes prevalence with serum perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS) and perfluorononanoate (PFNA) levels...
December 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29287676/nonalcoholic-fatty-liver-disease-and-sarcopenia-in-a-western-population-nhanes-iii-the-importance-of-sarcopenia-definition
#12
Tao-Chun Peng, Li-Wei Wu, Wei-Liang Chen, Fang-Yih Liaw, Yaw-Wen Chang, Tung-Wei Kao
BACKGROUND: Recent epidemiological studies have shown that sarcopenia is associated with non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis in an Asian population. We investigated whether NAFLD is associated with a higher risk of sarcopenia using a different definition in elderly patients. METHODS: A population-based cross-sectional survey of US patients was conducted, involving 2551 participants aged 60-75 years. NAFLD was measured by ultrasound. Sarcopenia was defined by both a low muscle mass and poor muscle function...
December 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29283283/epidemiology-of-objectively-measured-bedtime-and-chronotype-in-us-adolescents-and-adults-nhanes-2003-2006
#13
Jacek K Urbanek, Adam P Spira, Junrui Di, Andrew Leroux, Ciprian Crainiceanu, Vadim Zipunnikov
BACKGROUND: We propose a method for estimating the timing of in-bed intervals using objective data in a large representative US sample, and quantify the association between these intervals and age, sex, and day of the week. METHODS: The study included 11,951 participants 6 years and older from the National Health and Nutrition Examination Survey (NHANES) 2003-2006, who wore accelerometers to measure physical activity for seven consecutive days. Participants were instructed to remove the device just before the nighttime sleep period and put it back on immediately after...
December 28, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29282129/dietary-patterns-plasma-vitamins-and-trans-fatty-acids-are-associated-with-peripheral-artery-disease
#14
Mohsen Mazidi, Nathan D Wong, Niki Katsiki, Dimitri P Mikhailidis, Maciej Banach
BACKGROUND: To investigate the association between dietary patterns (DP), plasma vitamins and trans fatty acids (TFAs) with the likelihood of peripheral artery disease (PAD). METHODS: National Health and Nutrition Examination Survey (NHANES) data for the years 1999-2002 were used. PAD was diagnosed by ankle brachial index assessment. Plasma concentrations of vitamins were measured using high performance liquid chromatography. Vitamin D levels were measured by radioimmunoassay...
December 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29250813/using-threshold-regression-to-analyze-survival-data-from-complex-surveys-with-application-to-mortality-linked-nhanes-iii-phase-ii-genetic-data
#15
Yan Li, Tao Xiao, Dandan Liao, Mei-Ling Ting Lee
The Cox proportional hazards (PH) model is a common statistical technique used for analyzing time-to-event data. The assumption of PH, however, is not always appropriate in real applications. In cases where the assumption is not tenable, threshold regression (TR) and other survival methods, which do not require the PH assumption, are available and widely used. These alternative methods generally assume that the study data constitute simple random samples. In particular, TR has not been studied in the setting of complex surveys that involve (1) differential selection probabilities of study subjects and (2) intracluster correlations induced by multistage cluster sampling...
December 18, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29250608/the-effect-of-the-environmental-protection-agency-maximum-contaminant-level-on-arsenic-exposure-in-the-usa-from-2003-to-2014-an-analysis-of-the-national-health-and-nutrition-examination-survey-nhanes
#16
Anne E Nigra, Tiffany R Sanchez, Keeve E Nachman, David Harvey, Steven N Chillrud, Joseph H Graziano, Ana Navas-Acien
Background: The current US Environmental Protection Agency (EPA) maximum contaminant level (MCL) for arsenic in public water systems (10 µg/L) took effect in 2006. Arsenic is not federally regulated in private wells. The impact of the 2006 MCL on arsenic exposure in the US, as confirmed through biomarkers, is presently unknown. We evaluated national trends in water arsenic exposure in the US, hypothesizing that urinary arsenic levels would decrease over time among participants using public water systems but not among those using well water...
November 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/29248354/sleep-and-other-correlates-of-high-level-health-in-older-adults
#17
Eileen R Chasens, Kyeongra Yang, Lynn M Baniak, JiYeon Choi, Christopher C Imes
A large sample (N = 1139) of adults ≥75 years from the 2011-2014 NHANES cohorts was used to examine predictors of high-level health. Analyses were done with SAS to control for sample weights and allow results to be reported as population parameters. The majority of participants described their health as high-level (73.6%). Logistic regression found a longer sleep duration, minority status, decreased income, multiple medications, low physical activity, and late stage memory impairment were significant predictors of low-level health (p < ...
December 13, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29247408/associations-between-total-mercury-and-methyl-mercury-exposure-and-cardiovascular-risk-factors-in-us-adolescents
#18
Yuxi Zhang, Cheng Xu, Zhi Fu, Yaqin Shu, Jie Zhang, Changgui Lu, Xuming Mo
Low levels of chronic heavy metal exposure are associated with a range of adverse health effects. However, whether total blood mercury (Hg) and methyl mercury (MeHg) exposure affect risk factors for cardiovascular disease (CVD) in adolescents remains unclear. The associations between CVD risk factors and total blood Hg and MeHg in adolescents were evaluated using data from the National Health and Nutrition Examination Survey (NHANES), 2011-2012. Data for 1129 adolescents (age 12-19 years) who participated in the US NHANES 2011-2012 were analyzed...
December 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29246432/adolescents-exposed-to-the-world-trade-center-collapse-have-elevated-serum-dioxin-and-furan-concentrations-more-than-12years-later
#19
Linda G Kahn, Xiaoxia Han, Tony T Koshy, Yongzhao Shao, Dinh Binh Chu, Kurunthachalam Kannan, Leonardo Trasande
BACKGROUND: The collapse of the World Trade Center (WTC) on September 11, 2001 released a dust cloud containing numerous environmental contaminants, including polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans (PCDD/Fs). PCDD/Fs are toxic and are associated with numerous adverse health outcomes including cancer, diabetes, and impaired reproductive and immunologic function. Prior studies have found adults exposed to the WTC disaster to have elevated levels of PCDD/Fs...
December 2, 2017: Environment International
https://www.readbyqxmd.com/read/29243293/the-association-between-celiac-disease-and-periodontitis-results-from-nhanes-2009-2012
#20
Thomas Spinell, Francesco DeMayo, Matthew Cato, Ashley Thai, Eva J Helmerhorst, Peter H R Green, Benjamin Lebwohl, Ryan T Demmer
AIM: To investigate whether celiac disease (CD) was associated with periodontitis among a nationally representative sample of U.S. adults. MATERIALS AND METHODS: The National Health and Nutrition Examination Survey (NHANES) 2009-2012 enrolled 6,661 subjects with full-mouth periodontal examination and serological testing for anti-tissue transglutaminase (tTg) and anti-endomysial (EMA) antibodies. CD was defined as i) self-reported physician diagnosis while on a gluten-free diet; ii) or tTg levels>10...
December 15, 2017: Journal of Clinical Periodontology
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