Vitor Rosetto Muñoz, Renan Fudoli Lins Vieira, Carlos Kiyoshi Katashima, Rafael Calais Gaspar, Marsel Lino, Joice Cristina Dos Santos Trombeta, Renata Garbellini Duft, Ana Paula Azevêdo Macêdo, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle, Leandro Pereira de Moura, Dennys Esper Cintra, Mara Patricia Traina Chacon-Mikahil, Cláudia Regina Cavaglieri, José Rodrigo Pauli
White adipose tissue (WAT) controls energy storage, expenditure and endocrine function. Rho-kinase (ROCK) is related to impaired thermogenesis, downregulation of preadipocyte differentiation, and adipokine production. Furthermore, WAT ROCK responds to metabolic stress from high-fat diets or diabetes. However, ROCK distribution in adipose depots and its response to aging and sex remain unclear. Thus, we aim to investigate ROCK function in adipose tissue of rodent and human in response to aging and sex. We observed specific differences in the ROCK1/2 distribution in inguinal WAT (ingWAT), perigonadal WAT (pgWAT) and brown adipose tissue (BAT) of male and female rodents...
January 10, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences