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Nonmelanoma skin cancer

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https://www.readbyqxmd.com/read/28210385/high-dose-rate-electronic-brachytherapy-a-nonsurgical-treatment-alternative-for-nonmelanoma-skin-cancer
#1
REVIEW
Ajay Bhatnagar, Rakesh Patel, William Philip Werschler, Roger I Ceilley, Robert Strimling
The authors summarized data from a group of physicians with experience using high-dose rate electronic brachytherapy for the treatment of nonmelanoma skin cancer. The data have been published or presented in abstract format at national dermatology and radiation oncology meetings. The data included 1,822 treated lesions from 2009 to 2014 in patients ranging in age from 52 to 104 years. Most lesions were basal cell carcinoma (57%) or squamous cell carcinoma (38%) less than 2cm in size (97%). Median follow-up at the various centers ranged from 4 to 16 months, and results yielded an extremely low recurrence rate of less than one percent...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28195845/an-analysis-of-laser-therapy-for-the-treatment-of-nonmelanoma-skin-cancer
#2
Teo Soleymani, Michael Abrouk, Kristen M Kelly
BACKGROUND: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar. OBJECTIVE: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option...
February 9, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28194418/antineoplastic-effects-of-honokiol-on-melanoma
#3
Ruth Guillermo-Lagae, Sreevidya Santha, Milton Thomas, Emily Zoelle, Jonathan Stevens, Radhey S Kaushik, Chandradhar Dwivedi
Honokiol, a plant lignan has been shown to have antineoplastic effects against nonmelanoma skin cancer developments in mice. In this study, antineoplastic effects of honokiol were investigated in malignant melanoma models. In vitro effects of honokiol treatment on SKMEL-2 and UACC-62 melanoma cells were evaluated by measuring the cell viability, proliferation, apoptosis, cell cycle analysis, and expressions of various proteins associated with cell cycle progression and apoptosis. For the in vivo study, male nude mice inoculated with SKMEL-2 or UACC-62 cells received injections of sesame oil or honokiol for two to seven weeks...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28190452/changes-in-the-incidence-of-skin-and-lip-cancer-between-1978-and-2007
#4
E Martín García, S Arias-Santiago, S Serrano-Ortega, A Buendía-Eisman
INTRODUCTION: The aim of this study was to analyze trends in the incidence of skin cancer worldwide, in Europe, and in Spain between 1978 and 2007. MATERIAL AND METHODS: Skin cancer incidence and trends for the period 1978 to 2007 were investigated using the age- and sex-standardized rates (per 100,000 population) published in the Cancer Incidence in Five Continents series. RESULTS: The incidence of cutaneous melanoma increased progressively from 1978 to 2002 but decreased in the last period analyzed (2003-2007)...
February 9, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28162854/malignancy-rates-in-a-large-cohort-of-patients-with-systemically-treated-psoriasis-in-a-managed-care-population
#5
Maryam M Asgari, G Thomas Ray, Jamie L Geier, Charles P Quesenberry
BACKGROUND: Moderate to severe psoriasis often requires treatment with systemic agents, many of which have immunosuppressive properties and could increase cancer risk, including nonmelanoma skin cancer (NMSC). OBJECTIVE: We sought to estimate the overall malignancy rate (excluding NMSC) and NMSC rate among 5889 patients with systemically treated psoriasis. METHODS: We identified a cohort of adult Kaiser Permanente Northern California health plan members with psoriasis diagnosed from 1998 to 2011 and treated with at least 1 systemic antipsoriatic agent and categorized them into ever-biologic or nonbiologic users...
February 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28118455/trends-and-patterns-of-disparities-in-cancer-mortality-among-us-counties-1980-2014
#6
Ali H Mokdad, Laura Dwyer-Lindgren, Christina Fitzmaurice, Rebecca W Stubbs, Amelia Bertozzi-Villa, Chloe Morozoff, Raghid Charara, Christine Allen, Mohsen Naghavi, Christopher J L Murray
Introduction: Cancer is a leading cause of morbidity and mortality in the United States and results in a high economic burden. Objective: To estimate age-standardized mortality rates by US county from 29 cancers. Design and Setting: Deidentified death records from the National Center for Health Statistics (NCHS) and population counts from the Census Bureau, the NCHS, and the Human Mortality Database from 1980 to 2014 were used. Validated small area estimation models were used to estimate county-level mortality rates from 29 cancers: lip and oral cavity; nasopharynx; other pharynx; esophageal; stomach; colon and rectum; liver; gallbladder and biliary; pancreatic; larynx; tracheal, bronchus, and lung; malignant skin melanoma; nonmelanoma skin cancer; breast; cervical; uterine; ovarian; prostate; testicular; kidney; bladder; brain and nervous system; thyroid; mesothelioma; Hodgkin lymphoma; non-Hodgkin lymphoma; multiple myeloma; leukemia; and all other cancers combined...
24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28117886/hepatitis-c-virus-infection-and-the-risk-of-cancer-among-elderly-us-adults-a-registry-based-case-control-study
#7
Parag Mahale, Harrys A Torres, Jennifer R Kramer, Lu-Yu Hwang, Ruosha Li, Eric L Brown, Eric A Engels
BACKGROUND: Hepatitis C virus (HCV) infection causes hepatocellular carcinoma (HCC) and subtypes of non-Hodgkin lymphoma (NHL). Associations with other cancers are not established. The authors systematically assessed associations between HCV infection and cancers in the US elderly population. METHODS: This was a registry-based case-control study using Surveillance, Epidemiology, and End Results (SEER)-Medicare data in US adults aged ≥66 years. Cases (n = 1,623,538) were patients who had first cancers identified in SEER registries (1993-2011)...
January 24, 2017: Cancer
https://www.readbyqxmd.com/read/28114205/two-suturing-techniques-for-the-prevention-and-treatment-of-nasal-valve-collapse-after-mohs-micrographic-surgery
#8
Anis Miladi, Joseph W McGowan, Heidi B Donnelly
BACKGROUND: Tumor extirpation of nonmelanoma skin cancer (NMSC) adjacent to the alar groove, using Mohs micrographic surgery (MMS), may risk causing internal nasal valve (INV) collapse, resulting in reduced airflow during inspiration. There are many surgical options described in the literature to repair INV collapse as a postoperative corrective procedure, but few exist as an intra-operative preventative procedure. OBJECTIVE: The authors present 2 distinct methods to prevent and treat INV collapse during the repair of a perialar surgical defect caused by MMS...
January 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28109543/the-risk-of-cancer-in-kidney-transplant-recipients-may-be-reduced-in-those-maintained-on-everolimus-and-reduced-cyclosporine
#9
Wai H Lim, Graeme R Russ, Germaine Wong, Helen Pilmore, John Kanellis, Steven J Chadban
Kidney transplant recipients are at a high risk of developing cancers after transplantation. Switching from calcineurin inhibitors to sirolimus has been shown to prevent secondary nonmelanoma skin cancer but whether everolimus with reduced exposure to calcineurin inhibitors has similar anti-cancer effects remains unknown. Therefore, we compared the risk of incident cancer over seven years of follow-up among kidney transplant recipients randomized to everolimus plus reduced exposure cyclosporine versus mycophenolate sodium and standard exposure cyclosporine...
January 18, 2017: Kidney International
https://www.readbyqxmd.com/read/28099963/low-molecular-weight-hydrophilic-and-lipophilic-antioxidants-in-nonmelanoma-skin-carcinomas-and-adjacent-normal-looking-skin
#10
Konstantina Grammenandi, Maria Kyriazi, Alexandra Katsarou-Katsari, Othon Papadopoulos, Ioanna Anastassopoulou, Georgios T Papaioannou, Alexandros Sagriotis, Michail Rallis, Howard I Maibach
Low-molecular-weight antioxidants are some of the most efficient agents of the skin defense mechanism against environmental factors, such as cosmic rays, smoke, and pollutants. The total skin concentrations of hydrophilic ascorbic and uric acids, as well as lipophilic α-tocopherol, β-carotene, and ubiquinol-10 antioxidants were determined by an HPLC-EC detector from 18 biopsies of human nonmelanoma skin carcinomas and 18 biopsies from skin areas adjacent to carcinomas. No significant differences in the concentrations of lipophilic antioxidants in both carcinomas and normal-looking skin areas adjacent to carcinomas were observed...
2016: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28099531/sarcoidosis-and-squamous-cell-carcinoma-a-connection-documented-in-a-case-series-of-3-patients
#11
Sara A Berg, Roberto A Novoa, Campbell Stewart, Joseph F Sobanko, Christopher J Miller, Misha Rosenbach
Sarcoidosis is a chronic multisystem disease characterized by the formation of noncaseating granulomas in multiple organs, including the skin. An association between multisystem sarcoidosis and an increased risk for malignancy has been established. Dermatologists should be aware of the increased risk for nonmelanoma skin cancers in patients with sarcoidosis. We report a series of 3 patients with primarily cutaneous sarcoidosis who presented with new-onset cutaneous squamous cell carcinoma (SCC). Two patients were black women and 1 patient presented with lesions of cutaneous sarcoidosis arising concurrently with SCCs in the same location, distinguishable only by biopsy...
December 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28088996/a-systematic-review-of-comorbidity-indices-used-in-the-nonmelanoma-skin-cancer-population
#12
Karen L Connolly, Jiyeon M Jeong, Christopher A Barker, Marisol Hernandez, Erica H Lee
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28074526/risk-factors-for-nonmelanoma-skin-cancer-in-renal-transplant-recipients-a-case-control-study-from-a-reference-outpatient-clinic-in-southeast-brazil
#13
Flávia R Ferreira, Marilia M Ogawa, Luiz F C Nascimento, Jane Tomimori
BACKGROUND: Nonmelanoma skin cancer (NMSC) is the most common tumor in humans, and its incidence increases among renal transplant recipients (RTRs). The aims of this study were to characterize the RTRs with NMSC, to identify risk factors, and to calculate the probability of this tumor in this population. METHODS: This was a hospital-based case-control study. Epidemiological and clinical variables were evaluated. Hierarchical logistic regression was used, and a mathematical model was built...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28063524/switching-from-conventional-photodynamic-therapy-to-daylight-photodynamic-therapy-for-actinic-keratoses-systematic-review-and-meta-analysis
#14
A Tomás-Velázquez, P Redondo
Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28040691/ultraviolet-radiation-and-kaposi-sarcoma-incidence-in-a-nationwide-us-cohort-of-hiv-infected-men
#15
Elizabeth K Cahoon, Eric A Engels, D Michal Freedman, Mary Norval, Ruth M Pfeiffer
BACKGROUND: Although ultraviolet radiation (UVR) is established as both an inducer of herpes simplex virus reactivation and as the primary risk factor for many common skin cancers, its relationship with human herpes virus 8 (HHV8) infection or risk of Kaposi sarcoma (KS) is unknown. METHODS: Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for the association between ambient UVR, history of nonmelanoma skin cancer (NMSC; as a biomarker of personal cumulative UVR dose), and incidence of first primary KS in a nationwide US cohort of white and African American male veterans infected with HIV between 1986 and 1996 (prior to the widespread availability of treatment) using Cox regression...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28030717/pathologic-evaluation-of-skin-tumors-with-ex-vivo-dermoscopy-with-derm-dotting
#16
Marc Haspeslagh, Isabelle Hoorens, Nele Degryse, Ine De Wispelaere, Annemarie Degroote, Sarah Van Belle, Jan Verboven, Katrien Vossaert, Fabio Facchetti, Jo Van Dorpe, Sofie De Schepper, Lieve Brochez
Importance: Ex vivo dermoscopy (EVD) with derm dotting (DD) improves clinicopathologic correlation and the quality of diagnosis in skin tumors. Objective: To compare the diagnostic performance of the standard method of skin biopsy processing with the practice of EVD with DD. Design, Setting, and Participants: This retrospective study compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a standard method of processing with 8584 biopsy specimens examined in 2015 with EVD and DD...
December 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/28028856/british-association-of-dermatologists-national-audit-on-nonmelanoma-skin-cancer-excision-2014
#17
D J Keith, D A R de Berker, A P Bray, S T Cheung, A Brain, M F Mohd Mustapa
BACKGROUND: Diagnosis and management of nonmelanoma skin cancer (NMSC) represents a large part of the dermatology workload, and complete excision is a required surgical standard for treatment. AIM: To conduct an audit of the surgical practice for the treatment of NMSC by dermatologists in the UK. METHODS: Data on 10 consecutive nonmicrographic excisions of nonmelanoma skin cancer by UK dermatologists. Data collected included site, preoperative diagnosis, histological diagnosis, proximity to previous scars, and histological deep and peripheral margins...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28027254/evidence-based-medicine-cutaneous-facial-malignancies-nonmelanoma-skin-cancer
#18
Karen L Connolly, Kishwer S Nehal, Joseph J Disa
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma. SUMMARY: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28027201/incidence-and-clinical-features-of-rare-cutaneous-malignancies-in-olmsted-county-minnesota-2000-to-2010
#19
Stanislav N Tolkachjov, Adam R Schmitt, John G Muzic, Amy L Weaver, Christian L Baum
BACKGROUND: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. OBJECTIVE: To determine the incidence of several rare nonmelanoma skin cancers. MATERIALS AND METHODS: The authors conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven nonmelanoma skin cancer-excluding basal cell carcinoma and squamous cell carcinoma-were included in this study...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28002834/cost-effectiveness-and-budget-effect-analysis-of-a-population-based-skin-cancer-screening
#20
Lore Pil, Isabelle Hoorens, Katrien Vossaert, Vibeke Kruse, Isabelle Tromme, Niko Speybroeck, Lieven Annemans, Lieve Brochez
Importance: Several epidemiological studies show an alarming global increase in incidence of melanoma and nonmelanoma skin cancer. Objectives: To examine the cost-effectiveness of 2 population-based skin cancer screening methods and to assess their budget effect and the influence on skin cancer epidemiological findings. Design, Setting, and Participants: A Markov model with a latent period of 20 years and a time horizon of 50 years was used to analyze the cost-effectiveness (societal perspective) and budget effect (public health care payer perspective) of 2 population-based skin cancer screening programs in Belgium compared with the absence of a screening program...
December 14, 2016: JAMA Dermatology
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