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Nonmelanoma skin cancer

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https://www.readbyqxmd.com/read/29457484/cryosurgery-5-5-fluorouracil-for-treatment-of-superficial-basal-cell-carcinoma-and-bowen-s-disease
#1
Laura C Soong, Christopher P Keeling
BACKGROUND: Superficial basal cell carcinoma (sBCC) and squamous cell carcinoma in situ (SCCis) are 2 types of nonmelanoma skin cancers (NMSCs) that are amenable to treatment with topical 5-fluorouracil, cryosurgery, or topical imiquimod, among other destructive and surgical modalities. There are few studies examining the effectiveness of combination therapy with 5% 5-fluorouracil and cryosurgery for the treatment of sBCC and SCCis. OBJECTIVES: Our objective was to study the clinical cure rate achieved with the regimen of cryosurgery and a 3-week course of 5% 5-fluorouracil in the treatment of biopsy-proven sBCC and SCCis...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29447639/a-patient-case-highlighting-the-myriad-of-cutaneous-adverse-effects-of-prolonged-use-of-hydroxyurea
#2
Brett Neill, Ted Ryser, John Neill, Daniel Aires, Anand Rajpara
BACKGROUND: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer. CASE PRESENTATION: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29438147/ulcerated-basal-cell-carcinomas-masquerading-as-venous-leg-ulcers
#3
Catherine N Tchanque-Fossuo, Jillian W Millsop, Mary Ann Johnson, Sara E Dahle, R Rivkah Isseroff
BACKGROUND: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies. OBJECTIVE: To report a case series of biopsy-proven BCC from lower-extremity ulcers of patients who presented at a multispecialty wound clinic. METHODS: Four male patients (mean age, 82...
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29419527/nonmelanoma-skin-cancer-in-saudi-arabia-single-center-experience
#4
Sarah Abdullah AlSalman, Tuqa Morad Alkaff, Tariq Alzaid, Yousef Binamer
BACKGROUND: Skin cancer is the most common cancer worldwide; one in every three diagnosed malig.nancies is a skin cancer. However, skin cancer is rarely reported in Saudi Arabia so we conducted this study to highlight these underreported neoplasms. OBJECTIVES: Determine the prevalence and patterns of basal cell carcinoma (BCC) and primary squamous cell carcinoma (SCC), the most common types of nonmelanoma skin cancer (NMSC) with respect to age, sex, and anatomic location and to identify potentially associated risk factors...
January 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29417799/a-synthesis-of-the-world-s-guidelines-on-photodynamic-therapy-for-non-melanoma-skin-cancer
#5
Colin A Morton
Photodynamic therapy (PDT), using topically administered photosensitizing agents, is widely approved as a treatment for certain nonmelanoma skin cancers. As a tissue-sparing non-surgical modality, there is great potential for PDT to enhance the choice of therapies available to treat, and potentially prevent, skin cancer. Treatment-specific guidelines have assessed the evidence for various photosensitizing agents and light sources, dosimetry, and evaluate reported adverse effects. Discomfort is frequently experienced during treatment but no analgesia was required in most pivotal lesion-directed studies...
February 7, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29414904/photodynamic-therapy-activated-by-intense-pulsed-light-in-the-treatment-of-nonmelanoma-skin-cancer
#6
Domenico Piccolo, Dimitra Kostaki
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC)...
February 7, 2018: Biomedicines
https://www.readbyqxmd.com/read/29398593/custom-mold-applicator-high-dose-rate-brachytherapy-for-nonmelanoma-skin-cancer-an-analysis-of-273-lesions
#7
David Olek, Moataz N El-Ghamry, Niloyjyoti Deb, Nitika Thawani, Courtney Shaver, Subhakar Mutyala
PURPOSE: Nonmelanoma skin cancer is the most commonly diagnosed malignancy in the United States. A modern version of surface brachytherapy, "topographic applicator brachytherapy" (TAB), can be used to treat early-stage nonmelanoma skin cancer (ES-NMSC). The purpose of this study was to evaluate the acute toxicity, chronic toxicity, and recurrence rates of patients with ES-NMSC treated with TAB. METHODS AND MATERIALS: From 2010 to 2013, 172 patients with 273 ES-NMSC tumors were consecutively treated with TAB...
February 1, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29392067/defect-reconstruction-of-the-nose-after-surgery-for-nonmelanoma-skin-cancer-our-clinical-experience
#8
İsa Kaya, Mustafa Uslu, Fazıl Apaydın
Objective: This study aimed to investigate reconstruction methods according to nasal subunits in patients who were surgically treated with diagnosis of non-melanoma skin cancer of the nose. Methods: All patients were retrospectively investigated. This study was conducted between April 2004 and December 2010; 180 patients who were surgically treated with diagnoses of skin basal cell carcinoma, squamous cell carcinoma, cancer of skin appendages, and precancerous lesions and 194 lesions were included...
September 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29390104/incidence-of-colorectal-cancer-and-extracolonic-cancers-in-veteran-patients-with-inflammatory-bowel-disease
#9
Christina A Mosher, Geri R Brown, Rick A Weideman, Terri W Crook, Daisha J Cipher, Stuart J Spechler, Linda A Feagins
Background: The risk for colorectal cancer (CRC) and certain extracolonic cancers is thought to be increased in inflammatory bowel disease (IBD), but few recent US studies have evaluated this issue. We aimed to estimate the incidence of CRC and extracolonic cancers in IBD patients. Methods: In this case-control study, cases were all IBD patients treated in our Department of Veterans Affairs (VA) hospital who developed CRC or extracolonic cancers between 1996 and 2015...
January 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29377079/incidence-of-diseases-primarily-affecting-the-skin-by-age-group-population-based-epidemiologic-study-in-olmsted-county-minnesota-and-comparison-with-age-specific-incidence-rates-worldwide
#10
REVIEW
Laurel L Wessman, Louise K Andersen, Mark D P Davis
Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature...
January 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29368863/antihypertensive-drugs-and-risk-of-skin-cancer
#11
Nicoletta Cassano, Alessandro DI Stefani, Gino A Vena, Ketty Peris
The potential carcinogenic risk of antihypertensive drugs has been examined in several studies that reported controversial results. The association between treatment with antihypertensives and risk of skin cancer has also been questioned, considering the longterm administration of such drugs and the ability of some agents to cause photosensitive reactions. In fact, experimental and epidemiologic findings suggest a link between druginduced photosensitivity and skin cancer, possibly through the induction of DNA damage in predisposed individuals...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29355917/radiotherapy-regimens-in-patients-with-nonmelanoma-head-and-neck-skin-cancers
#12
Yusuf Dundar, Richard B Cannon, Jason P Hunt, Marcus Monroe, Gita Suneja, Ying J Hitchcock
BACKGROUND: To assess the effectiveness and outcomes of adjuvant radiotherapy regimens for nonmelanoma skin cancers (NMSC) of the head and neck, particularly for elderly patients. METHODS: A retrospective review of patients with head and neck NMSC was conducted. Radiotherapy dose per fraction regimens included ≤200, 240-250, 300-400, and 500-600 cGy. Demographics, tumor characteristics, local control (LC), regional control (RC), and survival outcomes were analyzed...
January 22, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29352565/quality-of-life-in-nonmelanoma-skin-cancer
#13
P García-Montero, M V de Gálvez-Aranda, M de Troya Martín
No abstract text is available yet for this article.
January 15, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29335541/modulation-of-uvb-induced-carcinogenesis-by-activation-of-alternative-dna-repair-pathways
#14
Yan Sha, Vladimir Vartanian, Nichole Owen, Stephanie J Mengden Koon, Marcus J Calkins, Courtney S Thompson, Zahra Mirafzali, Sara Mir, Lisa E Goldsmith, Huaping He, Chun Luo, Scott M Brown, Paul W Doetsch, Andy Kaempf, Jeong Y Lim, Amanda K McCullough, R Stephen Lloyd
The molecular basis for ultraviolet (UV) light-induced nonmelanoma and melanoma skin cancers centers on cumulative genomic instability caused by inefficient DNA repair of dipyrimidine photoproducts. Inefficient DNA repair and subsequent translesion replication past these DNA lesions generate distinct molecular signatures of tandem CC to TT and C to T transitions at dipyrimidine sites. Since previous efforts to develop experimental strategies to enhance the repair capacity of basal keratinocytes have been limited, we have engineered the N-terminally truncated form (Δ228) UV endonuclease (UVDE) from Schizosaccharomyces pombe to include a TAT cell-penetrating peptide sequence with or without a nuclear localization signal (NLS): UVDE-TAT and UVDE-NLS-TAT...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315147/nonmelanoma-skin-cancer-risk-in-patients-with-inflammatory-bowel-disease-undergoing-thiopurine-therapy-a-systematic-review-of-the-literature
#15
Joshua W Hagen, Melissa A Pugliano-Mauro
BACKGROUND: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD. OBJECTIVE: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29309338/treatment-of-nonmelanoma-skin-cancers-using-laser-assisted-drug-delivery
#16
Faisal R Ali, Firas Al-Niaimi
No abstract text is available yet for this article.
January 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29288096/comorbidity-scores-associated-with-limited-life-expectancy-in-the-very-elderly-with-nonmelanoma-skin-cancer
#17
Emma M Rogers, Karen L Connolly, Kishwer S Nehal, Stephen W Dusza, Anthony M Rossi, Erica Lee
BACKGROUND: There is controversy regarding nonmelanoma skin cancer (NMSC) treatment in the very elderly, with some suggesting that this population may not live long enough to benefit from invasive treatments. Tools to assess limited life expectancy (LLE) exist, but performance in the very elderly NMSC population has not been well-defined. OBJECTIVE: Define comorbidity scores associated with LLE in the very elderly presenting for management of NMSC. METHODS: A retrospective review of 488 patients aged 85 or older presenting for NMSC management between July 1999 through December 2014 was performed...
December 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29262420/neoplastic-multifocal-skin-lesions-biology-etiology-and-targeted-therapies-for-nonmelanoma-skin-cancers
#18
Ana R Fernandes, Ana C Santos, Elena Sanchez-Lopez, Andjekla B Kovačević, Marta Espina, Ana C Calpena, Francisco J Veiga, Maria L Garcia, Eliana B Souto
Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs...
December 21, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29261825/age-at-diagnosis-as-a-relative-contraindication-for-intervention-in-facial-nonmelanoma-skin-cancer
#19
Ruvi Chauhan, Brook N Munger, Michael W Chu, Imtiaz Munshi, Adam C Cohen, William A Wooden, Sunil S Tholpady
No abstract text is available yet for this article.
December 20, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29243817/association-between-atopic-dermatitis-and-squamous-cell-carcinoma-a-case-control-study
#20
Janice M Cho, Dawn Marie R Davis, David A Wetter, Adam C Bartley, Jerry D Brewer
BACKGROUND: Conflicting data have been published on whether an association exists between atopic dermatitis (AD) and nonmelanoma skin cancer. This study aimed to determine whether individuals with AD had an increased risk of squamous cell carcinoma (SCC) development. METHODS: We conducted a retrospective, case-control study of patients residing in Olmsted County, Minnesota. Cases were selected from patients seen at Mayo Clinic (Rochester, Minnesota) who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010...
December 15, 2017: International Journal of Dermatology
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