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Columnar cell thyroid

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https://www.readbyqxmd.com/read/30546147/primary-thyroid-biphasic-synovial-sarcoma-and-synchronous-papillary-carcinoma-report-of-a-remarkable-case
#1
M Nicola, M Onorati, G Bertola, P Collini, A I Fascì, F Di Nuovo
Synovial Sarcoma (SS) is the fourth most common soft tissue sarcoma, characterized by translocation t(X;18) (p11.2;q11.2). Although its histological features have been extensively described, this entity is characterized by a wide morphological spectrum so that the recognition can be very challenging at atypical anatomical localization, like the thyroid. We describe a case of a 42-ys-old female patient complaining a cervical swelling due to left intrathyroid nodule, measuring 35 mm in its greatest dimension...
September 2018: Pathologica
https://www.readbyqxmd.com/read/30485710/imprint-cytology-of-strumal-carcinoid-of-the-ovary-a-case-report-with-immunocytochemical-analysis
#2
Mitsuaki Ishida, Tomoko Arimoto, Kaori Sandoh, Kimiaki Okano, Yusuke Ebisu, Hiroko Ito, Mio Matsumoto, Tomomi Mizokami, Masato Kita, Hidetaka Okada, Koji Tsuta
Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo-oophorectomy was performed. The Papanicolaou smear of the imprint cytological specimen of the left ovarian tumor revealed presence of two distinct components. The first component included thyroid follicles, which was composed of flat sheets of polygonal epithelial cells without nuclear groove and intranuclear inclusion...
November 28, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/30376202/aggressive-cribriform-morular-variant-of-papillary-thyroid-carcinoma-report-of-an-unusual-case-with-pulmonary-metastasis-displaying-poorly-differentiated-features
#3
Hiromi Tsuji, Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Takashi Hiroshima, Yasushi Sakamaki, Akira Miyauchi, Masahiko Tsujimoto
The cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity in which metastasis rarely occurs. Until now, only three cases of metastasis by CMV-PTC have been reported. We present a rare sporadic case of CMV-PTC with multiple lung metastases in a 28-year-old female, 3 years after total thyroidectomy. The lung tumor was not encapsulated but well-circumscribed and showed a mixture of cribriform, papillary, and solid patterns of growth with necrosis. The tall columnar carcinoma cells did not display the typical nuclear features of PTC...
October 30, 2018: Pathology International
https://www.readbyqxmd.com/read/30174490/columnar-cell-variant-of-papillary-thyroid-carcinoma-ultrasonographic-and-clinical-differentiation-between-the-indolent-and-aggressive-types
#4
Jooyeon Cho, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh
Objective: To evaluate the ultrasonography (US) features and clinical characteristics of columnar cell variant of papillary thyroid carcinoma (CCV-PTC) that can predict disease progression. Materials and Methods: Six cases of CCV-PTC were identified via surgical pathology analysis at our institution from 1994 to 2016. The histological, architectural, and cytological features met the diagnostic criteria of CCV-PTC. We reviewed the US features and clinicopathological findings in the six cases...
September 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29875289/do-aggressive-variants-of-papillary-thyroid-carcinoma-have-worse-clinical-outcome-than-classic-papillary-thyroid-carcinoma
#5
Eyun Song, Min Ji Jeon, Hye-Seon Oh, Minkyu Han, Yu-Mi Lee, Tae Yong Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong, Dong Eun Song, Won Gu Kim
OBJECTIVE: Evidence for unfavorable outcomes of each type of aggressive variant papillary thyroid carcinoma (AV-PTC) is not clear because most previous studies are focused on tall cell variant (TCV) and did not control for other major confounding factors contributing to clinical outcomes. DESIGN: Retrospective cohort study. METHODS: This study included 763 patients with classical PTC (cPTC) and 144 with AV-PTC, including TCV, columnar cell variant (CCV) and hobnail variants...
September 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29713041/rna-sequencing-of-xp11-translocation-associated-cancers-reveals-novel-gene-fusions-and-distinctive-clinicopathologic-correlations
#6
Xiao-Tong Wang, Qiu-Yuan Xia, Sheng-Bing Ye, Xuan Wang, Rui Li, Ru Fang, Shan-Shan Shi, Ru-Song Zhang, Xiao Tan, Jie-Yu Chen, Ke Sun, Xiao-Dong Teng, Heng-Hui Ma, Zhen-Feng Lu, Xiao-Jun Zhou, Qiu Rao
Both Xp11 translocation renal cell carcinomas and the corresponding mesenchymal neoplasms are characterized by a variety of gene fusions involving TFE3. It has been known that tumors with different gene fusions may have different clinicopathologic features; however, further in-depth investigations of subtyping Xp11 translocation-associated cancers are needed in order to explore more meaningful clinicopathologic correlations. A total of 22 unusual cases of Xp11 translocation-associated cancers were selected for the current study; 20 cases were further analyzed by RNA sequencing to explore their TFE3 gene fusion partners...
April 30, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29668629/asymptomatic-intrathyroidal-pyriform-sinus-fistula-mimicking-thyroid-cancer-a-case-report-and-literature-review
#7
Soo Chin Kim, Ji-Hoon Kim, Jae-Kyung Won, Eun Jae Chung
RATIONALE: There have been many reports of non-thyroidal lesions which can be mistaken for thyroidal lesions on ultrasound (US) examination. However, it is not known that pyriform sinus fistula (PSF) can manifest as an incidental thyroid nodule and cause serious complication on fine-needle aspiration (FNA). PATIENT CONCERNS: We present a 34-year-old man with PSF incidentally detected on US. US examination showed hypoechoic nodule with several bright echogenic spots at the uppermost part of left thyroid gland...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29563836/clinical-behaviors-of-rare-variants-of-papillary-thyroid-carcinoma-are-associated-with-survival-a-population-level-analysis
#8
Chenghao Jiang, Tong Cheng, Xucai Zheng, Shikai Hong, Song Liu, Jianjun Liu, Jing Wang, Shengying Wang
Objective: This study was to evaluate the risk factors of survival in patients with columnar cell variant (CCV) and encapsulated variant (ECV). Materials and methods: The Surveillance, Epidemiology, and End Results database (1988-2013) was used to compare the characteristics of CCV and ECV with those of classic papillary thyroid carcinoma (PTC). Survival was analyzed by the Kaplan-Meier method, the log-rank test, and Cox multivariate regression. Multivariate logistic regression was used to further analyze lymph node metastases and distant metastasis...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29494399/clinicopathologic-characteristics-of-thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-a-case-report
#9
Liang Li, Fengjuan Zhou, Fanzhong Lin, Cuihong Han
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm. It morphologically resembles papillary thyroid carcinoma and is immunochemically positive for thyroid transcription factor 1. Herein, we reported a case of TL-LGNPPA in a female patient of 35 years old. She felt pharyngeal foreign body sensation of unknown cause and subsequently developed dyspnea after activities. Nasopharyngeal plain computerized tomography showed no abnormalities, but laryngoscopy showed a peanut-sized smooth neoplasm with a pedicel at the posterior edge of the nasal septum...
February 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29482989/clinicopathological-features-of-low-grade-malignant-endolymphatic-sac-tumors
#10
Hong-Qun Wang, Li Jie, Huai-Yin Shi
BACKGROUND: Low-grade malignant endolymphatic sac tumor (ELST) is a rare neoplasm, occurring in the inner ear and invading the temporal bone. This study aims to investigate the clinicopathological features of low-grade malignant ELSTs. METHODS: The clinicopathological data of 21 patients with low-grade malignant ELSTs were collected and analyzed. RESULTS: The patients were aged 16-71 years, with an average age of 40.3 years and a median age of 39 years, and the male to female ratio was 1:1...
March 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29446856/thyroid-carcinoma-producing-%C3%AE-human-chorionic-gonadotropin-shows-different-clinical-behavior
#11
Haiyan Gu, Shaofeng Sui, Xiujie Cui, Bo Han, Chunyan Zhang, Mei Qi, Congcong Li, Zhiyan Liu
Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β-hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses...
April 2018: Pathology International
https://www.readbyqxmd.com/read/29351089/aggressive-variants-of-papillary-thyroid-carcinoma-hobnail-tall-cell-columnar-and-solid
#12
REVIEW
Meryl C Nath, Lori A Erickson
Papillary thyroid carcinomas are the most common endocrine cancer and are usually associated with good survival. However, some variants of papillary thyroid carcinomas may behave more aggressively than classic papillary thyroid carcinomas. The tall cell variant of papillary thyroid carcinoma is the most common aggressive variant of papillary thyroid carcinoma. The aggressive behavior has been ascribed to the histologic subtype and/or to the clinicopathologic features, an issue that remains controversial. The columnar variant of papillary thyroid carcinoma can be aggressive, particularly in older patients, with larger tumors showing a diffusely infiltrative growth pattern and extrathyroidal extension...
May 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29239042/special-types-of-thyroid-carcinoma
#13
REVIEW
Zubair W Baloch, Virginia A LiVolsi
This article reviews the small percentage of thyroid tumours that are not classified as classic papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma. It includes subtypes of papillary thyroid carcinoma, including, tall-cell, hobnail/micropapillary, columnar cell, diffuse sclerosing and solid variants. Poorly differentiated carcinoma, high-grade carcinoma and anaplastic thyroid carcinoma are reviewed. Also discussed are entities that are unusual but need to be recognized as primary thyroid neoplasms, i...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29160552/cotton-rats-sigmodon-hispidus-possess-pharyngeal-pouch-remnants-originating-from-different-primordia
#14
Teppei Nakamura, Osamu Ichii, Takao Irie, Tatsuya Mizoguchi, Akio Shinohara, Hirokazu Kouguchi, Yuji Sunden, Saori Otsuka-Kanazawa, Yaser Hosny Ali Elewa, Chihiro Koshimoto, Ken-Ichi Nagasaki, Yasuhiro Kon
Pharyngeal pouches in mammals develop into specific derivatives. If the differentiation of the pharyngeal pouches is anomalous, their remnants can result in cysts, sinuses, and fistulae in the differentiated organs or around the neck. In the present study, we found several pharyngeal pouch remnants, such as cystic structures in thymus and parathyroid gland and fossulae extended from the piriform fossa, in the inbred cotton rats maintained at Hokkaido Institute of Public Health (HIS/Hiph) and University of Miyazaki (HIS/Mz)...
June 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29118471/cytomorphologic-diversity-of-papillary-thyroid-carcinoma
#15
Vidya Monappa, Ranjini Kudva
Introduction: Cytologic features of papillary thyroid carcinoma (PTC) have been extensively documented in literature. However, PTC variants can prove to be diagnostically challenging on fine needle aspiration cytology (FNAC). Aims: To study the FNAC features of PTC and its variants and explore the causes for misdiagnosis. Materials and Methods: This is a retrospective study. All cases of histopathologically (HP) confirmed cases of PTC during a 2-year period (January 2012 to December 2013) with presurgical FNAC were included...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29019044/hobnail-variant-of-papillary-thyroid-carcinoma-a-literature-review
#16
REVIEW
Francesca Ambrosi, Alberto Righi, Costantino Ricci, Lori A Erickson, Ricardo V Lloyd, Sofia Asioli
Papillary thyroid carcinoma is the most common thyroid malignancy and it is usually associated with a good prognosis. However, recurrence, metastases, and cancer death may occur in 10 to 15% of patients with more aggressive types of papillary thyroid carcinoma, such as tall cell, columnar cell, solid variant, or the more recently described hobnail variant of papillary thyroid carcinoma. Papillary thyroid carcinoma with a prominent hobnail pattern is a moderately differentiated papillary thyroid carcinoma variant with aggressive clinical behavior and significant mortality...
December 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28601658/thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-with-squamous-differentiation-a-novel-histological-finding
#17
Takashi Oide, Osamu Kadosono, Jun Matsushima, Di Wu, Hiroaki Nagashima, Hideto Saigusa, Atsuko Masunaga, Yukio Nakatani, Kenzo Hiroshima
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm originating from the nasopharyngeal surface epithelium. Histopathologically, TL-LGNPPA is characterized by cuboidal/columnar tumor cells forming papillary fronds and thyroid transcription factor-1 (TTF-1) expression resembling papillary thyroid carcinoma. To date, the recorded histological features of TL-LGNPPA have been almost uniform, and the range of histological variations in this tumor type has not been sufficiently understood...
December 2017: Human Pathology
https://www.readbyqxmd.com/read/28552827/metastatic-thyroid-carcinoma-without-identifiable-primary-tumor-within-the-thyroid-gland-a-retrospective-study-of-a-rare-phenomenon
#18
Bin Xu, Theresa Scognamiglio, Perry R Cohen, Manju L Prasad, Adnan Hasanovic, Robert Michael Tuttle, Nora Katabi, Ronald A Ghossein
Metastatic papillary thyroid carcinoma (PTC) without an identifiable primary tumor despite extensive microscopic examination of the thyroid gland is a rare but true phenomenon.We retrieved 7 of such cases and described in detail the clinical and pathologic features of these tumors. BRAF V600E immunohistochemistry and Sequenom molecular profile were conducted in selected cases. All patients harbored metastatic disease in the central (n=3), lateral (n=3), or both neck compartments (n=1). The histotype of the metastatic disease was PTC (n=5), poorly differentiated thyroid carcinoma in association with a PTC columnar variant (n=1), and anaplastic thyroid carcinoma in association with a PTC tall cell variant (n=1)...
July 2017: Human Pathology
https://www.readbyqxmd.com/read/28529577/aggressiveness-of-the-tall-cell-variant-of-papillary-thyroid-carcinoma-is-independent-of-the-tumor-size-and-patient-age
#19
Rocío Villar-Taibo, Diego Peteiro-González, José Manuel Cabezas-Agrícola, Elvin Aliyev, Francisco Barreiro-Morandeira, Clara Ruiz-Ponte, José M Cameselle-Teijeiro
The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width. TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC. The current study compared TCV with the classical and follicular variants (CaFVs) of PTC to determine if, irrespective of the age at diagnosis and tumor size, TCV is more aggressive than its classical and follicular counterparts...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28419762/hobnail-variant-of-papillary-thyroid-carcinoma-a-case-with-an-unusual-presentation
#20
Mohammed T Lilo, Justin A Bishop, Syed Z Ali
Variants of papillary thyroid carcinoma (PTC) account for up to 25% of the cases, some of which are proven to be associated with aggressive clinical behavior such as tall cell and columnar cell variants. Hobnail variant of PTC (HVPTC) is recently described as a rare and aggressive variant of PTC. Herein, we are reporting a case of HVPTC in a patient who presented with hemoptysis and an intratracheal blood clot that was aspirated and submitted for cytopathological examination. Cytomorphology displayed neoplastic cells with profound micropapillary architecture, elongated nuclei, and prominent hobnail configuration...
August 2017: Diagnostic Cytopathology
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