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Cancer Ai

You-Ping Liu, Hao Li, Rui You, Ji-Bin Li, Xue-Kui Liu, An-Kui Yang, Xiang Guo, Ming Song, Quan Zhang, Zhu-Ming Guo, Wen-Kuan Chen, Wei-Wei Liu, Xiong Zou, Yi-Jun Hua, Qi Yang, Yi-Nuan Zhang, Rui Sun, Hao-Yuan Mo, Ling Guo, Ai-Hua Lin, Hai-Qiang Mai, Chao-Nan Qian, Ming-Yuan Chen
OBJECTIVE: To compare survival effects of comprehensive neck dissection (CND) and selective neck dissection (SND) for patients with nasopharyngeal carcinoma (NPC) with only regional failure. METHODS: A total of 294 recurrent T0N1-3M0 NPC patients who underwent neck dissection in Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China, between January 1984 and February 2014, were enrolled in the survival and interaction analyses. Using propensity scores to adjust for potential prognostic factors, an additional well-balanced cohort of 210 patients was constructed by matching each patient who received SND with one patient who underwent CND (1:1); the differences were then compared between SND and CND in terms of overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS)...
October 16, 2018: Laryngoscope
Ashley Mooneyham, Yoshie Iizuka, Qing Yang, Courtney Coombes, Mark McClellan, Vijayalakshmi Shridhar, Edith Emmings, Mihir Shetty, Liqiang Chen, Teng Ai, Joyce Meints, Michael K Lee, Melissa Gardner, Martina Bazzaro
UNC-45A, a highly conserved member of the UCS (UNC45A/CRO1/SHE4P) protein family of co-chaperones, plays an important role in regulating cytoskeletal-associated functions in invertebrates and mammalian cells including cytokinesis, exocytosis, cell motility, and neuronal development. Here, for the first time UNC-45A is demonstrated to function as a mitotic-spindle-associated protein that destabilizes microtubules (MTs) activity. Using in vitro biophysical reconstitution and total internal reflection fluorescence (TIRF) microscopy analysis, reveal that UNC-45A directly binds to taxol-stabilized MTs in the absence of any additional cellular co-factors or other microtubule-associated proteins (MAPs) and acts as an ATP-independent microtubule destabilizer...
October 15, 2018: Molecular Cancer Research: MCR
Naomi R Lee, Rachel L Winer, Steven Cherne, Carolyn J Noonan, Lonnie Nelson, Angela A Gonzales, Jason G Umans, Dedra Buchwald
Background: High-risk human papillomavirus (HrHPV) causes cervical cancer. In the U.S., approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian women are insufficiently sampled to permit a population-specific estimate of HrHPV prevalence. Methods: Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains...
October 15, 2018: Journal of Infectious Diseases
Kamila Pires de Carvalho, Mariana Tavares Miranda Lima, Fernanda Silva Mazzutti, Isis Danyelle Dias Custódio, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
PURPOSE: To study the use of functional capacity (FC) level and duration of aromatase inhibitor (AI) therapy with adiposity parameters in women with breast cancer. PATIENTS AND METHODS: FC was evaluated through the Health Assessment Questionnaire, which was assessed by classification and divided into 3 groups: G1 = mild to moderate difficulty, G2 = moderate to severe disability, and G3 = severe or very severe disability. Body mass, height, and waist circumference (WC) were measured, and body mass index (BMI) was calculated...
September 13, 2018: Clinical Breast Cancer
Li Li, Bingmei Chang, Xiaoyue Jiang, Xueke Fan, Yingrui Li, Teng Li, Shanshan Wu, Jun Zhang, Seyed Kariminia, Qin Li
BACKGROUND: Adjuvant endocrine therapy undoubtedly prolongs the time to recurrence for patients with hormone-positive early breast cancer. Extended endocrine therapy to 10 years or longer has been expected to bring a greater clinical advantage. However, the related research conclusions are controversial. METHODS: Tamoxifen (TAM), Aromatase Inhibitor (AI), Exemestane, letrozole (LET) and anastrozole were used as key words in the literature search. After the patients completed 5 years of adjuvant endocrine treatment, they were allocated to continue endocrine treatment for 5 years or receive placebo/observation for 5 years...
October 12, 2018: BMC Cancer
Lu-Lu Zhang, Guo-Hong Li, Yi-Yang Li, Zhen-Yu Qi, Ai-Hua Lin, Ying Sun
Purpose: The incidence, risk factors and survival impact of secondary primary malignancies (SPMs) among survivors of nasopharyngeal carcinoma (NPC) treated with definitive intensity-modulated radiation therapy (IMRT) with or without chemotherapy are poorly characterized. Methods and Materials: Consecutive patients (n=6,377) from the big-data intelligence platform at Sun Yat-Sen University Cancer Center, China (in a high-incidence area) with newly diagnosed non-metastatic pathologically proven non-keratinizing undifferentiated NPC treated with IMRT±chemotherapy between January 2003 and June 2013 were retrospectively analyzed...
October 11, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Coby Basal, Emily Vertosick, Theresa A Gillis, Qing Li, Ting Bao, Andrew Vickers, Jun J Mao
PURPOSE: Arthralgia is common among women with breast cancer on adjuvant aromatase inhibitor (AI) therapy. Pain is associated with falls in the general population; however, little is known about the relationship between arthralgia and falls among AI users. Our objective was to determine whether joint pain severity and interference predict future falls. METHODS: We conducted a prospective cohort study of postmenopausal women with stage I-III estrogen receptor-positive breast cancer who were prescribed a third-generation AI...
October 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Huanan Wang, Guangxu Deng, Meiling Ai, Zhijun Xu, Tingyu Mou, Jiang Yu, Hao Liu, Shuang Wang, Guoxin Li
Hsp90ab1 is upregulated in numerous solid tumors, which is thought to induce the angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) has not been exhibited. In this study, Hsp90ab1 was demonstrated to be overexpressed and correlated with the poor prognosis, proliferation and invasion of GC. Ectopic expression of Hsp90ab1 promoted the proliferation and metastasis of GC cells both in vitro in cell line models of GC and in vivo using two different xenograft mouse models, while opposite effects were observed in Hsp90ab1 silenced cells...
October 10, 2018: Oncogene
Chi Xu, Daosheng Ai, Shengbao Suo, Xingwei Chen, Yizhen Yan, Yaqiang Cao, Na Sun, Weizhong Chen, Joseph McDermott, Shiqiang Zhang, Yingying Zeng, Jing-Dong Jackie Han
Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of single gene mutations' non-tissue-specific "core transcriptome signatures" (CSs) of 8,476 genes generated from the TCGA database. We developed the core-signature drug-to-gene (csD2G) software to scan 3,546 drug treatment profiles against the reference signatures...
October 9, 2018: Cell Reports
Kivanc Görgülü, Kalliope N Diakopoulos, Jiaoyu Ai, Benjamin Schoeps, Derya Kabacaoglu, Angeliki-Faidra Karpathaki, Katrin J Ciecielski, Ezgi Kaya-Aksoy, Dietrich A Ruess, Alexandra Berninger, Marlena Kowalska, Marija Stevanovic, Sonja M Wörmann, Thomas Wartmann, Yue Zhao, Walter Halangk, Svetlana Voronina, Alexey Tepikin, Anna Melissa Schlitter, Katja Steiger, Anna Artati, Jerzy Adamski, Michaela Aichler, Axel Walch, Martin Jastroch, Götz Hartleben, Christos S Mantzoros, Wilko Weichert, Roland M Schmid, Stephan Herzig, Achim Krüger, Bruno Sainz, Marina Lesina, Hana Algül
BACKGROUND AND AIMS: Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences of varying levels of the autophagy related 5 (Atg5) protein on pancreatic tumor formation and progression. METHODS: We generated mice that express oncogenic Kras in primary pancreatic cancer cells and have homozygous disruption of Atg5 (A5;Kras) or heterozygous disruption of Atg5 (A5+/-;Kras), and compared them with mice with only oncogenic Kras (controls)...
October 5, 2018: Gastroenterology
N Martínez, M Herrera, L Frías, M Provencio, R Pérez-Carrión, V Díaz, Michael Morse, M C Crespo
PURPOSE: Breast cancer patients receiving hormonal therapies face risks of relapse, increased rates of cardiovascular events, and toxicities of therapy such as aromatase inhibitor (AI)-associated musculoskeletal symptoms (AIMSS). C-reactive protein (CRP), a marker for inflammation, is associated with breast cancer outcomes. We evaluated whether the olive-derived polyphenol hydroxytyrosol combined with omega-3 fatty acids and curcumin would reduce CRP and musculoskeletal symptoms in breast cancer patients receiving adjuvant hormonal therapies...
October 6, 2018: Clinical & Translational Oncology
Chen Ai, Lei Kong
Gene set enrichment (GSE) analyses play an important role in the interpretation of large-scale transcriptome datasets. Multiple GSE tools can be integrated into a single method as obtaining optimal results is challenging due to the plethora of GSE tools and their discrepant performances. Several existing ensemble methods lead to different scores in sorting pathways as integrated results; furthermore, it is difficult for users to choose a single ensemble score to obtain optimal final results. Here, we develop an ensemble method using a machine learning approach called Combined Gene set analysis incorporating Prioritization and Sensitivity (CGPS) that integrates the results provided by nine prominent GSE tools into a single ensemble score (R score) to sort pathways as integrated results...
September 13, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
Peile Wang, Jing Yang, Zhenfeng Zhu, Xiaojian Zhang
The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Nowadays, the extract of Marsdenia tenacissima, under the trademark of "Xiao-ai-ping", is widely used in clinic for the treatment of different cancers in China. To date, approximately 196 chemical ingredients covering steroids, triterpenes and organic acids have been identified from different parts of this plant...
October 4, 2018: American Journal of Chinese Medicine
H Ai, W Xie, A-H Xiu, N Li, S-T Zhang, Y-L Zhang, X-O Xue
OBJECTIVE: Long intergenic non-coding RNA 1088 (LINC01088) has been suggested to act as a tumor suppressor in epithelial ovarian cancer (EOC); however, the prognostic role of LINC01088 has not been evaluated in cancer patients. This study aimed to investigate the expression of LINC01088 in EOC, along with evaluating its clinical-pathological and prognostic importance. PATIENTS AND METHODS: A bioinformatics tool (GEPIA) was used to screen the dysregulated lncRNAs...
September 2018: European Review for Medical and Pharmacological Sciences
Zhongping Ai, Xiaolan Gao, Silin Zheng, Changbi Lu
Variability and factors influencing quality of life (QOL) in breast cancer patients having chemotherapy were examined in a longitudinal prospective cohort study in two teaching hospitals in China. Physical, mental, social/family, and functional QOL changed significantly over time with varying patterns. In addition, various factors influenced the QOL of breast cancer patients at each chemotherapy cycle. Health professionals should focus on critical time periods during chemotherapy, particularly at baseline and during the fourth and fifth cycles when the QOL in our sample was at the lowest point, and they should provide additional support to patients to ensure that chemotherapy is delivered in an optimal fashion...
October 3, 2018: Clinical Nursing Research
Yangfan Du, Na Li, Xin Jiao, Kai Li, Shunchao Yan
Purpose: The predictive ability of plasma ESR1 mutations for outcomes among patients with advanced breast cancer undergoing endocrine therapy (ET) remains disputable. We performed a comprehensive meta-analysis of published studies to clarify the impact of plasma ESR1 mutations on clinical outcomes for patients after subsequent ET. Materials and methods: An electronic search was performed to identify eligible studies. Studies analyzing progression-free survival (PFS) and/or overall survival (OS) according to plasma ESR1 mutation status after subsequent ET were included...
2018: OncoTargets and Therapy
Nalinee Kanth Kadiyala, Badal Kumar Mandal, Shivendu Ranjan, Nandita Dasgupta
The development of novel functionalized reduced graphene oxide nanocomposite materials keeping in mind environmental and health perspectives via green approaches is currently gaining enormous research interest in the field of nanoscience and nanotechnology. Herein, we report a bio-inspired green synthesis approach for gold nanoparticles decorated reduced graphene oxide nanocomposite in which Syzygium cumini seed extract (SCSE) is applied as natural reducing and stabilizing agent for the simultaneous reduction of chloroauric acid and graphene oxide (GO)...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Kamlesh K Yadav
Annually, approximately 20 million men are prostate-specific-antigen screened, and 1.3 million undergo an invasive biopsy to diagnose roughly 200,000 new cases, 50% of which end up being indolent. Approximately 30,000 men die of prostate cancer (PCa) yearly. Importantly, an estimated US$8 billion is spent on unnecessary biopsies. Thus, an integrative analysis and predictive model of prognosis is needed to help identify only lethal and aggressive forms of the disease.
September 2018: IEEE Pulse
Yiming Liang, Enliang Li, Jiaqi Min, Chengwu Gong, Jun Gao, Jiyuan Ai, Wenjun Liao, Linquan Wu
The interferon-induced transmembrane protein 3 (IFITM3, also called 1‑8U) gene represents dysregulated expression in various tumors and is involved in tumorigenesis and progression. However, the role of IFITM3 and its underlying mechanism in hepatocellular carcinoma (HCC) are still far from elucidated. MicroRNAs (miRNAs), a class of endogenous (approximately 22 nucleotides) small noncoding RNAs, can post‑transcriptionally regulate gene expression by repressing protein translation or silencing the expression of target genes that play critical roles in various cancers...
September 28, 2018: Oncology Reports
Samir Gupta, Li Tao, James D Murphy, M Constanza Camargo, Eyal Oren, Mark A Valasek, Scarlett Lin Gomez, Maria Elena Martinez
Anatomic-subsite risk factors for gastric cancer differ substantially, and subsite-specific distribution of risk factors (such as Helicobacter pylori) may vary by race/ethnicity and neighborhood socioeconomic status (nSES). We examined differences in gastric cancer incidence by subsite, stratified by race/ethnicity and nSES utilizing Surveillance Epidemiology and End Results Program 2000-2014 data for 77,881 incident gastric cancer cases (n=23,651 cardia, n=35,825 non-cardia; n=18,405 overlapping/unspecified)...
September 26, 2018: Gastroenterology
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