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https://www.readbyqxmd.com/read/30106636/first-line-trastuzumab-plus-an-aromatase-inhibitor-with-or-without-pertuzumab-in-human-epidermal-growth-factor-receptor-2-positive-and-hormone-receptor-positive-metastatic-or-locally-advanced-breast-cancer-pertain-a-randomized-open-label-phase-ii-trial
#1
Mothaffar Rimawi, Jean-Marc Ferrero, Juan de la Haba-Rodriguez, Christopher Poole, Sabino De Placido, C Kent Osborne, Roberto Hegg, Valerie Easton, Christine Wohlfarth, Grazia Arpino
Purpose To assess pertuzumab plus trastuzumab and an aromatase inhibitor (AI) in patients with human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor-positive metastatic/locally advanced breast cancer (MBC/LABC). Patients and Methods The PERTAIN trial (NCT01491737) is an ongoing randomized, open-label, multicenter-80 sites and eight countries-phase II trial. Patients have HER2-positive, hormone receptor-positive MBC/LABC and no prior systemic therapy with the exception of endocrine. Random assignment was 1:1 to intravenous pertuzumab (840 mg loading dose followed by 420 mg every 3 weeks) plus trastuzumab (8 mg/kg followed by 6 mg/kg every 3 weeks), and oral anastrozole (1 mg every day) or letrozole (2...
August 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/30105234/management-of-hormone-receptor-positive-human-epidermal-receptor-2-negative-advanced-or-metastatic-breast-cancers
#2
REVIEW
Roger K C Ngan
Hormone therapy, rather than chemotherapy, is recommended for hormone-receptor positive (HR+), human epidermal receptor 2 negative (HER2-) advanced or metastatic breast cancer (A/MBC) according to the European Society of Medical Oncology (ESMO), American Society of Clinical Oncology (ASCO) and National Comprehensive Cancer Network (NCCN) guidelines, unless in visceral crisis in which chemotherapy is indicated. Hormonal monotherapy of selective estrogen receptor modulator (SERM) or selective estrogen receptor down-regulator (SERD), aromatase inhibitor (AI), or their combination as doublets, used to be the mainstay options as first-line (1L) therapy for most patients...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30098829/mir-26b-5p-suppresses-proliferation-and-promotes-apoptosis-in-multiple-myeloma-cells-by-targeting-jag1
#3
Chui-Ming Jia, Yu-Yang Tian, Li-Na Quan, Li Jiang, Ai-Chun Liu
BACKGROUND: Though the levels of diagnosis and treatment of multiple myeloma (MM) have been largely improved recent years, the prognosis of these patients remain unacceptable. It is urgent for us to discover the exact mechanism and determine some new indicators for MM. MiRNAs play a critical role in the occurrence and progression of cancers, including MM. MiR-26b-5p has been reported to be closely related to cells proliferation in human pulmonary cancer, hepatocellular carcinoma and so on...
July 27, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30096312/divergent-routes-toward-wnt-and-r-spondin-niche-independency-during-human-gastric-carcinogenesis
#4
Kosaku Nanki, Kohta Toshimitsu, Ai Takano, Masayuki Fujii, Mariko Shimokawa, Yuki Ohta, Mami Matano, Takashi Seino, Shingo Nishikori, Keiko Ishikawa, Kenta Kawasaki, Kazuhiro Togasaki, Sirirat Takahashi, Yasutaka Sukawa, Hiroki Ishida, Shinya Sugimoto, Hirofumi Kawakubo, Jihoon Kim, Yuko Kitagawa, Shigeki Sekine, Bon-Kyoung Koo, Takanori Kanai, Toshiro Sato
Recent sequencing analyses have shed light on heterogeneous patterns of genomic aberrations in human gastric cancers (GCs). To explore how individual genetic events translate into cancer phenotypes, we established a biological library consisting of genetically engineered gastric organoids carrying various GC mutations and 37 patient-derived organoid lines, including rare genomically stable GCs. Phenotype analyses of GC organoids revealed divergent genetic and epigenetic routes to gain Wnt and R-spondin niche independency...
August 9, 2018: Cell
https://www.readbyqxmd.com/read/30094551/letrozole-concentration-is-associated-with-cyp2a6-variation-but-not-with-arthralgia-in-patients-with-breast-cancer
#5
Adrienne E Borrie, Rhiannon V Rose, Yun-Hee Choi, Francisco E Perera, Nancy Read, Tracy Sexton, Michael Lock, Theodore A Vandenberg, Karin Hahn, Robert Dinniwell, Jawaid Younus, Diane Logan, Kylea Potvin, Brian Yaremko, Edward Yu, John Lenehan, Stephen Welch, Rachel F Tyndale, Wendy A Teft, Richard B Kim
PURPOSE: The aromatase inhibitor (AI) letrozole is a first-line drug in the adjuvant treatment of breast cancer in postmenopausal women. Adherence to AI therapy, including letrozole, remains problematic due to the development of debilitating AI-induced arthralgia. Letrozole is metabolized in the liver by CYP2A6. It remains unknown if plasma letrozole levels or CYP2A6 genetic variation is associated with the development of arthralgia. METHODS: We enrolled 126 female breast cancer patients initiated on letrozole therapy and prospectively collected blood samples at baseline and two follow-up time points to determine letrozole plasma concentrations and CYP2A6 genotype...
August 9, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30093090/optimizing-adjuvant-endocrine-therapy-for-early-er-breast-cancer-an-update-for-surgeons
#6
REVIEW
Umar Wazir, Leon Mokbel, Ali Wazir, Kefah Mokbel
INTRODUCTION: The optimal duration of adjuvant endocrine therapy in early ER + breast cancer has been controversial. This article aims to provide an overview of the evidence. METHODS: A search of the literature was conducted via MEDLINE using appropriate keywords. Eligible studies were screened and relevant articles were selected for this report. RESULTS: Studies investigating the role of extended adjuvant tamoxifen beyond 5 years have revealed mixed results depending on the proportion of node positivity...
August 3, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/30092342/induction-of-mir-15a-expression-by-tripterygium-glycosides-caused-premature-ovarian-failure-by-suppressing-the-hippo-yap-taz-signaling-effector-lats1
#7
Ai Ai, Ying Xiong, Beiling Wu, Jiajia Lin, Yongyi Huang, Yilin Cao, Te Liu
Tripterygium glycosides (TGs) are chemotherapeutic drugs and immunosuppressant agents for the treatment of cancer and autoimmune diseases. We have previously reported that TGs induces premature ovarian failure (POF) by inducing cytotoxicity in ovarian granulosa cells (OGCs). Hence, we report that TGs suppress the expression of the Hippo-YAP/TAZ pathway in murine OGCs in vitro and in vivo. We found that the expressions of miR-181b, miR-15a, and miR-30d, were elevated significantly in the POF. Luciferase reporter assays confirmed that miR-15a targets Lats1 through a miR-15a binding site in the Lats1 3'UTR...
August 6, 2018: Gene
https://www.readbyqxmd.com/read/30090022/a-case-of-obstructive-jaundice-caused-by-metastasis-of-ovarian-cancer-to-the-duodenal-major-papilla
#8
Yusuke Takasaki, Atsushi Irisawa, Goro Shibukawa, Ai Sato, Yoko Abe, Akane Yamabe, Noriyuki Arakawa, Takumi Maki, Yoshitsugu Yoshida, Ryo Igarashi, Shogo Yamamoto, Tsunehiko Ikeda, Nobutoshi Soeta, Takuro Saito, Hiroshi Hojo
Ovarian cancer often occurs distant metastasis to the peritoneum, liver, lungs, and lymph nodes. However, there has been no reported case of direct metastasis to the duodenal major papilla. We herein reported 72-year-old woman with history of ovarian cancer surgery 11 years ago presenting with obstructive jaundice. Abdominal CT showed a small mass in the distal bile duct. Forceps biopsy from the small mass was done under endoscopic retrograde cholangiography, and histologic examination revealed adenocarcinoma...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/30089600/next-generation-sequencing-reveals-a-novel-alk-g1128a-mutation-resistant-to-crizotinib-in-an-alk-rearranged-nsclc-patient
#9
Xinghao Ai, Xiaomin Niu, Lianpeng Chang, Rongrong Chen, Sai-Hong Ignatius Ou, Shun Lu
OBJECTIVE: Acquired secondary mutations in the anaplastic lymphoma kinase (ALK) gene have been identified in ALK-rearranged non-small cell lung cancer (NSCLC) patients who are resistant to treatment with the ALK inhibitor crizotinib. We sought to uncover novel mutations that contribute to resistance in these patients. MATERIALS AND METHODS: Following clinical diagnosis and development of crizotinib treatment resistance, tissue and ctDNA samples were obtained from the 60-year-old patient and subjected to next-generation sequencing for identification of mutations contributing to drug resistance...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30087712/long-noncoding-rna-snhg1-promotes-cell-proliferation-through-pi3k-akt-signaling-pathway-in-pancreatic-ductal-adenocarcinoma
#10
Yalu Zhang, Rundong Zhang, Guopei Luo, Kaixing Ai
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most common causes of cancer-related death. Recently, long noncoding RNAs (lncRNAs) have emerged as significant regulators in numerous cancers, including PDAC. LncRNA small nucleolar RNA host gene 1 (SNHG1) has been reported in the development of several tumors, but the biological roles of it in PDAC remain to be illuminated. This study aims to investigate the function of lncRNA SNHG1, revealing its molecular mechanism and clinical significance in PDAC...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30081869/prediction-of-three-lipid-derivatives-for-postoperative-gastric-cancer-mortality-the-fujian-prospective-investigation-of-cancer-fiesta-study
#11
Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Guohui Fan, Guodong Xu, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
BACKGROUND: As we previously reported, the presence of preoperative metabolic syndrome can predict the significant risk of gastric cancer mortality. As a further extension, we evaluated the prediction of three lipid derivatives generated from triglycerides (TG), total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDLC and LDLC) at baseline for postoperative gastric cancer mortality by prospectively analysing 3012 patients. The three lipid derivatives included the ratio of TC minus HDLC to HDLC known as atherogenic index (AI), the ratio of TG to HDLC abbreviated as THR and the ratio of LDLC to HDLC abbreviated as LHR...
August 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30066211/hamdb-a-database-of-human-autophagy-modulators-with-specific-pathway-and-disease-information
#12
Ning-Ning Wang, Jie Dong, Lin Zhang, Defang Ouyang, Yan Cheng, Alex F Chen, Ai-Ping Lu, Dong-Sheng Cao
Autophagy is an important homeostatic cellular recycling mechanism responsible for degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells. In addition to its vital homeostatic role, this degradation pathway also involves in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. Therefore, the comprehensive understanding of autophagy process, autophagy-related modulators and corresponding pathway and disease information will be of great help for identifying the new autophagy modulators, potential drug candidates, new diagnostic and therapeutic targets...
July 31, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/30065049/canonical-wnt-signaling-remodels-lipid-metabolism-in-zebrafish-hepatocytes-following-ras-oncogenic-insult
#13
Yuxiao Yao, Shaoyang Sun, Jingjing Wang, Fei Fei, Zhaoru Dong, Ai-Wu Ke, Ruoyu He, Lei Wang, Lili Zhang, Min-Biao Ji, Qiang Li, Min Yu, Guo-Ming Shi, Jia Fan, Zhiyuan Gong, Xu Wang
There is limited understanding of the effects of major oncogenic pathways and their combinatorial actions on lipid composition and transformation during hepatic tumorigenesis. Here we report a negative correlation of Wnt/Myc activity with steatosis in human hepatocellular carcinoma (HCC) and perform in vivo functional studies using three conditional transgenic zebrafish models. Double-transgenic zebrafish larvae conditionally expressing human CTNNB1mt and zebrafish tcf7l2 or murine Myc together with krasv12 in hepatocytes led to severe hepatomegaly and significantly attenuated accumulation of lipid droplets and cell senescence triggered by krasv12 expression alone...
July 31, 2018: Cancer Research
https://www.readbyqxmd.com/read/30061637/differential-regulation-of-the-sphere-formation-and-maintenance-of-cancer-initiating-cells-of-malignant-mesothelioma-via-cd44-and-alk4-signaling-pathways
#14
Yoshiya Ohno, Serina Shingyoku, Sakina Miyake, Aya Tanaka, Sena Fudesaka, Yuta Shimizu, Ai Yoshifuji, Yuki Yamawaki, Sachiyo Yoshida, Saya Tanaka, Kazuma Sakura, Toshiyuki Tanaka
Malignant mesothelioma (MM) has a poor prognosis and is largely resistant to standard treatments, so it is important to seek novel therapeutic strategies for this disease. Cancer-initiating cells (CICs) were previously identified in MM using stem cell-associated markers in combination with spheroid cultures. However, the mechanisms underlying the induction and maintenance of CICs in MM remain to be fully explored. Here we showed that the CICs, which had high aldehyde dehydrogenase levels (ALDHbright ) and stem cell-associated genes, were expanded in MM cells cultured under sphere-forming conditions...
July 30, 2018: Oncogene
https://www.readbyqxmd.com/read/30061525/multimodal-3d-densenet-for-idh-genotype-prediction-in-gliomas
#15
Sen Liang, Rongguo Zhang, Dayang Liang, Tianci Song, Tao Ai, Chen Xia, Liming Xia, Yan Wang
Non-invasive prediction of isocitrate dehydrogenase ( IDH ) genotype plays an important role in tumor glioma diagnosis and prognosis. Recently, research has shown that radiology images can be a potential tool for genotype prediction, and fusion of multi-modality data by deep learning methods can further provide complementary information to enhance prediction accuracy. However, it still does not have an effective deep learning architecture to predict IDH genotype with three-dimensional (3D) multimodal medical images...
July 30, 2018: Genes
https://www.readbyqxmd.com/read/30061179/in-vivo-and-in-vitro-effects-of-hyperplasia-suppressor-gene-on-the-proliferation-and-apoptosis-of-lung-adenocarcinoma-a549-cells
#16
Zhen-Qing Sun, Gang Chen, Qiang Guo, He-Fei Li, Zhou Wang
Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). Hyperplasia suppressor gene (HSG) has been reported to inhibit cell proliferation, migration and remodeling in cardiovascular diseases. However, there lacks systematic researches on the effect of HSG on the apoptosis and proliferation of lung adenocarcinoma A549 cells and data of in vivo experiments. This study aims to investigate the effects of HSG gene silencing on proliferation and apoptosis of lung adenocarcinoma A549 cells...
July 30, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30057847/successful-pregnancy-following-myomectomy-accompanied-with-abdominal-radical-trachelectomy-for-an-infertile-woman-with-early-cervical-cancer-a-case-report-and-literature-review
#17
Yuji Kamei, Ai Miyoshi, Nao Wakui, Takeya Hara, Serika Kanao, Hirokazu Naoi, Hirofumi Otsuka, Takeshi Yokoi
Women in the reproductive age group diagnosed with cervical cancer can receive radical trachelectomy in case they wish to preserve fertility. However, the indication for this procedure in infertile women with cervical cancer is controversial depending on the underlying cause of infertility. Here, we present a case of a successful pregnancy following myomectomy accompanied with abdominal radical trachelectomy for an infertile woman with early cervical cancer. The patient was a 38-year-old nulliparous woman with a significant past medical history of infertility of unknown origin...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/30056184/piperidine-alkaloids-and-xanthone-from-the-roots-of-caulophyllum-robustum-maxim
#18
Hui-Xiang Yang, Wei Li, Qian Li, Hong-Lian Ai, Zheng-Hui Li, Rong Huang, Tao Feng, Ji-Kai Liu
Two undescribed piperidine racemates, (±)-caulophines A and B (1 and 2), a new N-containing xanthone derivative (3), together with six known piperidines, were isolated from the roots of Caulophyllum robustum Maxim. Their structures were determined by extensive spectroscopic techniques. Compounds 3 and 7 exhibited weak cytotoxicities against human palace cancer hela cell line with inhibitory rates of 32.2% and 39.7%, respectively, at the concentration of 40 μM.
July 26, 2018: Fitoterapia
https://www.readbyqxmd.com/read/30056008/association-between-gait-speed-with-mortality-cardiovascular-disease-and-cancer-a-systematic-review-and-meta-analysis-of-prospective-cohort-studies
#19
Nicola Veronese, Brendon Stubbs, Stefano Volpato, Giovanni Zuliani, Stefania Maggi, Matteo Cesari, Darren M Lipnicki, Lee Smith, Patricia Schofield, Joseph Firth, Davy Vancampfort, Ai Koyanagi, Alberto Pilotto, Emanuele Cereda
OBJECTIVES: Slow gait speed may be associated with premature mortality, cardiovascular disease (CVD), and cancer, although a comprehensive meta-analysis is lacking. In this systematic review and meta-analysis, we explored potential associations between gait speed and mortality, incident CVD, and cancer. DESIGN: A systematic search in major databases was undertaken from inception until March 15, 2018 for prospective cohort studies reporting data on gait speed and mortality, incident CVD, and cancer...
July 25, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/30054909/cers6-regulates-cisplatin-resistance-in-oral-squamous-cell-carcinoma-by-altering-mitochondrial-fission-and-autophagy
#20
Shengjiao Li, Yangou Wu, Yunpeng Ding, Miao Yu, Zexin Ai
Chemoresistance remains a challenge in the effective treatment of solid tumors, including oral squamous cell carcinoma (OSCC). Mitochondrial dynamics and autophagy have recently been implicated in the chemoresistance of cancer cells. The neutralization of ceramide is also associated with multidrug resistance, and ceramide synthase 6 (CerS6) is known to induce apoptosis. However, whether CerS6 regulates chemoresistance in OSCC is not clearly understood. Therefore, we investigated the role of CerS6 in the susceptibility of OSCC cells to cisplatin...
July 27, 2018: Journal of Cellular Physiology
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