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Methimazole

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https://www.readbyqxmd.com/read/27918152/computed-tomographic-characteristics-of-the-thyroid-glands-in-eight-hyperthyroid-cats-pre-and-postmethimazole-treatment-compared-with-seven-euthyroid-cats
#1
Jennifer L Bush, Sarah Nemanic, Jana Gordon, Gerd Bobe
Hyperthyroidism is the most common feline endocrinopathy; thyroid computed tomography (CT) may improve disease detection and methimazole dose selection. Objectives of this experimental pre-post with historical case-control study were to perform thyroid CT imaging in awake or mildly sedated hyperthyroid cats, compare thyroid gland CT appearance in euthyroid and hyperthyroid cats pre- and postmethimazole treatment, and determine whether thyroid size or attenuation correlate with methimazole dose needed for euthyroidism...
December 5, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27915012/intra-laboratory-validated-human-cell-based-in-vitro-vasculogenesis-angiogenesis-test-with-serum-free-medium
#2
T Toimela, O Huttala, E Sabell, M Mannerström, J R Sarkanen, T Ylikomi, T Heinonen
Vasculogenesis and angiogenesis are the processes by which new blood vessels are formed. We have developed a serum-free human adipose stromal cell and umbilical cord vein endothelial cell based vasculogenesis/angiogenesis test. In this study, the test was validated in our GLP laboratory following the OECD Guidance Document 34 [1] using erlotinib, acetylic salicylic acid, levamisole, 2-methoxyestradiol, anti-VEGF, methimazole, and D-mannitol to show its reproducibility, repeatability, and predictivity for humans...
November 30, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27911381/a-novel-approach-for-the-administration-of-medications-and-fluids-in-emergency-scenarios-and-settings
#3
Akilesh Honasoge, Neal Lyons, Kathleen Hesse, Braden Parker, Robert Mokszycki, Kelly Wesselhoff, Rolla Sweis, Erik B Kulstad
The available routes of administration commonly used for medications and fluids in the acute care setting are generally limited to oral, intravenous, or intraosseous routes, but in many patients, particularly in the emergency or critical care settings, these routes are often unavailable or time-consuming to access. A novel device is now available that offers an easy route for administration of medications or fluids via rectal mucosal absorption (also referred to as proctoclysis in the case of fluid administration and subsequent absorption)...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27867675/a-case-of-thyroid-storm-associated-with-cardiomyopathy-and-poststreptococcal-glomerulonephritis
#4
Lisa J Underland, Gerson A Vallencia Villeda, Abhijeet Pal, Leslie Lam
Thyroid storm has a high mortality rate and is often associated with a precipitating factor such as intercurrent illness or infection. It is rare in pediatric patients. Cardiac disease in hyperthyroidism mostly manifests itself as tachycardia but more serious cardiac findings have also been described. A 5-year-old male with recent strep throat infection presented with dilated cardiomyopathy, hematuria, and symptoms and lab findings consistent with severe hyperthyroidism. He was diagnosed with thyroid storm secondary to concurrent Graves' disease and poststreptococcal glomerulonephritis (PSGN)...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27853063/successful-re-administration-of-low-dose-of-methimazole-mmi-in-graves-disease-patients-who-experienced-allergic-cutaneous-reactions-to-mmi-at-initial-treatment-and-had-received-long-term-propylthiouracil-ptu
#5
Sumihisa Kubota
Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis can occur with PTU, especially with long-term use. However, some patients refuse radioiodine therapy and chose PTU. Sometimes PTU treatment may be prolonged. Since the frequency of adverse effects of methimazole (MMI) is dose-related, there is a possibility that we can re-administer a low dose without adverse effects to patients well-controlled with PTU who once experienced an allergic reaction to MMI...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27832996/quercetin-changes-purinergic-enzyme-activities-and-oxidative-profile-in-platelets-of-rats-with-hypothyroidism
#6
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Daniela Zanini, Andréia M Cardoso, Fátima H Abadalla, Gustavo R Thomé, Camila Murussi, Carla R N Polachini, Diéssica P Delenogare, Vania L Loro, Vera M Morsch, Maria R C Schetinger
Diseases related to thyroid hormones have been extensively studied because affect a large number of individuals, and these hormones participate in the regulation of the whole organism homeostasis. However, little is known about the involvement of purinergic signaling related to oxidative stress in hypothyroidism and possible therapeutic adjuncts for treatment of this disorder. Thus, the present study investigates the effects of quercetin on NTPDase, 5'-nucleotidase and adenosine deaminase activities, platelet aggregation and oxidative profile in platelets of rats with methimazole (MMI)-induced hypothyroidism...
November 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27824612/effects-of-altered-thyroid-states-on-oxidative-stress-parameters-in-rats
#7
Sehkar Oktay, Lebriz Uslu, Nesrin Emekli
BACKGROUND: Thyroid hormones are effective on oxidant-antioxidant balance by leading basal metabolic rate. In this study, the effects of altered thyroid states on low density lipoprotein (LDL) oxidation and oxidative stress parameters were investigated in an experimental animal model. METHODS: Thirty female Wistar Albino rats were equally divided into 3 groups as follows: control group; hypothyroid group (methimazole (75 mg/100 g was added to diet); hyperthyroid group [L-thyroxine (0...
November 8, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27819113/serum-immunoglobulin-g4-levels-and-graves-disease-phenotype
#8
Carmen Sorina Martin, Anca Elena Sirbu, Minodora Andreea Betivoiu, Suzana Florea, Carmen Gabriela Barbu, Simona Vasilica Fica
PURPOSE: We investigated, at diagnosis, the relationship between serum immunoglobulin G4 levels and the main characteristics of Graves' disease: hyperthyroidism severity, goiter size, presence of active Graves' ophthalmopathy, antithyroid antibodies status, and titer. METHODS: This prospective study included 80 newly diagnosed Graves' disease patients. The main parameters measured at diagnosis: thyroid-stimulating hormone, free thyroxine, free triiodothyronine, total triiodothyronine, thyroglobulin, antithyroid peroxidase antibodies, anti-thyroglobulin antibodies, thyroid-stimulating hormone receptor antibodies, immunoglobulin G4...
November 7, 2016: Endocrine
https://www.readbyqxmd.com/read/27809623/onset-of-graves-disease-during-pregnancy-in-a-woman-with-established-hypothyroidism
#9
María Alberiche, Rosa María Sánchez-Hernández, Xabier López Mérida, Ana María Wägner
BACKGROUND: Pregnancy strongly influences the thyroid gland and its function. Thyroid guidelines recommend a 30 to 50% increase of the preconceptional levothyroxine dose in women with hypothyroidism, when pregnancy is diagnosed. CASE: A 33 year-old, 8-week pregnant woman with hypothyroidism, presents with a 2-week history of palpitations, sweating, nervousness and fatigue. Physical examination shows tachycardia (108 bpm), distal tremors and diffuse goiter. After biochemical confirmation of hyperthyroidism, her levothyroxine dose is reduced and finally interrupted...
November 4, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27804243/low-cardiac-output-thyroid-storm-in-a-girl-with-graves-disease
#10
Marut Chantra, Alisa Limsuwan, Pat Mahachoklertwattana
A 15-year-old girl with Graves' disease presented with hypotension after methimazole and propranolol were re-started for hyperthyroidism. She was found to have pulmonary artery hypertension resulting in obstructive shock. Thyroid storm was diagnosed according to Burch and Wartofsky score. She was promptly treated with anti-thyroid drugs, inorganic iodide, corticosteroid, and respiratory support. Pulmonary hypertension was treated with inhaled nitric oxide until the clinical status improved. Propranolol was withdrawn due to poor cardiac function...
October 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27784851/postpartum-hypothalamic-adrenal-insufficiency-with-remission-a-rare-case
#11
Yuko Akehi, Yoko Hashimoto, Junko Meren, Makito Tanabe, Takashi Nomiyama, Toshihiko Yanase
A 37-year-old female patient was hospitalized because of general fatigue and loss of axillary and pubic hair after massive bleeding at delivery of her third child. The basal levels of both plasma adrenocorticotropin hormone (ACTH) and serum cortisol were very low, 5.2 pg/mL and 1.9 μg/dL, respectively. Based on the fact that ACTH showed a low response to insulin tolerance test and a normal response to corticotropin-releasing hormone (CRH), she was diagnosed with hypothalamic adrenal insufficiency. No organic lesions were found in the hypothalamic-pituitary region by pituitary MRI and hydrocortisone therapy was instituted...
October 25, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27766920/assessment-of-liver-slices-for-research-on-metabolic-drug-drug-interactions-in-cattle
#12
Paula Viviani, Adrian Lifschitz, Jorge García, María Laura Maté, Miguel Angel Quiroga, Carlos Lanusse, Guillermo Virkel
1. Precision-cut liver slices (PCLS) from food-producing animals have not been extensively used to study xenobiotic metabolism, and thus information on this field of research is sparse. 2. The aims of the present work were to further validate the technique of production and culture of bovine PCLS and to characterize the metabolic interaction between the anthelmintic albendazole (ABZ) and the flavin-monooxygenase (FMO) inhibitor methimazole (MTZ). 3. Nine (9) steers were used as donors. PCLS were produced and incubated under two methods, a dynamic organ culture (DOC) incubator and a well-plate (WP) system...
October 21, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27749745/frosted-branch-angiitis-in-methimazole-induced-antineutrophil-cytoplasmic-antibody-positive-vasculitis
#13
Kenzo J Koike, Jeffrey P Blice, Jan A Kylstra, Jonathan S Ralston, Sally E Self, Natasha M Ruth, Lucian V Del Priore
PURPOSE: To describe an unusual case of frosted branch angiitis that developed in a patient with acute onset systemic vasculitis possibly triggered by the antithyroid medication methimazole. METHODS: We conducted a thorough review of the medical records of a 16-year-old female patient who presented with frosted branch angiitis. During the initial hospital admission, the patient underwent an extensive systemic workup to determine the etiology of her disease and ophthalmologic testing including fundus photographs and fluorescein angiography...
October 5, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27741549/management-of-hyperthyroidism-during-the-preconception-phase-pregnancy-and-the-postpartum-period
#14
Sudipa Sarkar, Lindsay A Bischoff
Hyperthyroidism can occur during pregnancy and the postpartum period, and the treatment of hyperthyroidism should be considered in the preconception phase. Pregnancy has multiple normal physiologic effects on thyroid hormone, which is a separate process distinct from syndromes such as transient hyperthyroidism of hyperemesis gravidarum. The rationale regarding antithyroid drug use during different stages of pregnancy is reviewed, including the literature regarding adverse neonatal outcomes such as aplasia cutis and methimazole embryopathy in the setting of first trimester maternal methimazole use...
November 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27734699/-thyroid-hormones-and-cardiovascular-system
#15
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27734319/effects-of-selenium-on-short-term-control-of-hyperthyroidism-due-to-graves-disease-treated-with-methimazole-results-of-a-randomized-clinical-trial
#16
M Leo, L Bartalena, G Rotondo Dottore, E Piantanida, P Premoli, I Ionni, M Di Cera, E Masiello, L Sassi, M L Tanda, F Latrofa, P Vitti, C Marcocci, M Marinò
OBJECTIVE: In spite of previous conflicting results, an adjuvant role of selenium in the treatment of Graves' disease (GD) hyperthyroidism has been proposed. To address this issue, a randomized clinical trial was carried out aimed at investigating whether selenium is beneficial on the short-term control of GD hyperthyroidism treated with methimazole (MMI). METHODS: Thirty newly diagnosed hyperthyroid GD patients were randomly assigned to treatment with: (i) MMI or (ii) MMI plus selenium...
October 12, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27732097/variables-affecting-the-long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoid-pulse-therapy-in-patients-not-treated-with-orbital-radiotherapy
#17
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVE: Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves orbitopathy (GO), but factors affecting GO outcome are poorly understood. We performed a retrospective study to investigate the variables affecting GO after ivGC. METHODS: We evaluated 83 consecutive GO patients treated with ivGC but not orbital radiotherapy (ORT) and re-examined them after a median of 47 months. The endpoints were the relationships between GO outcome or additional treatments with age, sex, smoking habits, thyroid volume, thyroid treatment, time since thyroid treatment, antithyroid-stimulating hormone receptor antibodies (TRAb), GO duration, GO features, and follow-up time...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27721890/dual-directional-immunomodulatory-effects-of-corbrin-capsule-on-autoimmune-thyroid-diseases
#18
Tianyi He, Ruxing Zhao, Yiran Lu, Wenjuan Li, Xinguo Hou, Yu Sun, Ming Dong, Li Chen
Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves's disease (GD) and 56 patients with Hashimoto's thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27707971/thyroid-hormone-acts-locally-to-increase-neurogenesis-neuronal-differentiation-and-dendritic-arbor-elaboration-in-the-tadpole-visual-system
#19
Christopher K Thompson, Hollis T Cline
: Thyroid hormone (TH) regulates many cellular events underlying perinatal brain development in vertebrates. Whether and how TH regulates brain development when neural circuits are first forming is less clear. Furthermore, although the molecular mechanisms that impose spatiotemporal constraints on TH action in the brain have been described, the effects of local TH signaling are poorly understood. We determined the effects of manipulating TH signaling on development of the optic tectum in stage 46-49 Xenopus laevis tadpoles...
October 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27701715/hypothyroidism-induces-a-moderate-steatohepatitis-accompanied-by-liver-regeneration-mast-cells-infiltration-and-changes-in-the-expression-of-the-farnesoid-x-receptor
#20
J Rodríguez-Castelán, A Corona-Pérez, L Nicolás-Toledo, M Martínez-Gómez, F Castelán, E Cuevas-Romero
Hypothyroidism is associated with the development of non-alcoholic steatohepatitis, but cellular mechanisms have been scarcely analyzed. Thyroid hormones regulate the synthesis and secretion of bile acids that are endogenous ligands of the farnesoid receptor (FXRα), which have been involved in the development of non-alcoholic steatohepatitis. However, the relationship between thyroid hormones and FXRα expression in the liver is yet unknown. Control (n=6) and methimazole-induced hypothyroid (n=6) female rabbits were used to evaluate the amount of lipids and glycogen, vascularization, hepatocytes proliferation, immune cells infiltration, and expression of FXRα...
October 4, 2016: Experimental and Clinical Endocrinology & Diabetes
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