Pei Yang, Bingbing Xu, Ruirong Zhu, Tao Zhang, Zihan Wang, Qiao Lin, Ming Yan, Zhangsen Yu, Hongjiao Mao, Yun Zhang
Our previous data have revealed TCP particles caused cell death of osteocytes, comprising over 95% of all bone cells, which contribute to periprosthetic osteolysis, joint loosening and implant failure, but its mechanisms are not fully understood. Here, we reported that TCP particles inhibited cell viability of osteocytes MLO-Y4, and caused cell death. TCP particles caused mitochondrial impairment and increased expressions of LC-3 II, Parkin and PINK 1, accompanied by the elevation of autophagy flux and intracellular acidic components, the accumulation of LC-3II, PINK1 and Parkin in damaged mitochondria, and p62 reduction...
September 5, 2023: Toxicology