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maternal factors

Haruka Takei, Mie Shiraishi, Masayo Matsuzaki, Megumi Haruna
INTRODUCTION: Vegetable intake (VI) is important for both fetal and maternal health. However, VI is insufficient among many pregnant Japanese women. This study aimed to identify the factors related to VI during pregnancy. METHODS: A cross-sectional study was conducted in 2014, at a university hospital in Tokyo, Japan. Dietary intake was assessed using a brief-type self-administered diet history questionnaire. Demographic, physical, and psychological characteristics, dietary habits, and health-related behaviors were investigated using another questionnaire...
August 10, 2018: Appetite
Ryan D Shepard, Shawn Gouty, Haifa Kassis, Aylar Berenji, William Zhu, Brian M Cox, Fereshteh S Nugent
Severe early life stressors increase the probability of developing psychiatric disorders later in life through modifications in neuronal circuits controlling brain monoaminergic signaling. Our previous work demonstrated that 24 h maternal deprivation (MD) in male Sprague Dawley rats modifies dopamine (DA) signaling from the ventral tegmental area (VTA) through changes at GABAergic synapses that were reversible by in vitro histone deacetylase (HDAC) inhibition which led to restoration of the scaffold A-kinase anchoring protein (AKAP150) signaling and subsequently recovered GABAergic plasticity (Authement et al...
August 10, 2018: Experimental Neurology
Maki Kawasaki, Naoko Arata, Yoshihiro Ogawa
PURPOSE OF REVIEW: Type 2 diabetes and obesity during childhood, puberty, and adulthood have become more common. This trend presents a global problem in terms of public health and health economics. Associations between intrauterine exposure to hyperglycemia, obesity, and abnormal glucose tolerance (AGT) in offspring have been reported in populations at high risk of diabetes such as Pima Indians, but these associations have not been established in other groups. In this review, we summarize the evidence on obesity and AGT in the offspring of mothers with diabetes...
August 9, 2018: Current Opinion in Obstetrics & Gynecology
Abby Hunter, Rachael Murray, Laura Asher, Jo Leonardi-Bee
Introduction: The association between cigarette smoking and schizophrenia is well established. However, up to 90% of people with schizophrenia begin smoking before the onset of their illness, thus smoking could be an independent risk factor for schizophrenia. Prenatal exposure to maternal cigarette smoke is also associated with psychiatric problems in adolescence. Therefore, our aim was to undertake a systematic review and meta-analysis to explore the effect of smoking, and prenatal smoke exposure, on risk of schizophrenia...
August 9, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Anisha Parambi, Miranda Davies-Tuck, Kirsten R Palmer
BACKGROUND: Currently, little evidence exists to guide mode of delivery in pregnant women with super obesity. There is a trend toward elective caesarean delivery in this population with little evidence of improved maternal or neonatal outcomes. AIM: Our study compares maternal and neonatal outcomes based on planned mode of delivery and aimed to identify predictors for a successful vaginal delivery. MATERIALS AND METHODS: This retrospective observational study explored maternal and neonatal outcomes of women with a body mass index ≥50 who birthed following a singleton pregnancy at ≥36 weeks gestation over a 10 year period at a single centre in Melbourne, Australia...
August 13, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Omar Karlsson, Jan-Walter De Neve, S V Subramanian
Background: Parental education has been suggested to be an effective instrument for improving child health in low- and middle-income countries. Both education and child health have improved, however, as well as related factors. These changes may have implications for the observed association. Methods: We used Demographic and Health Surveys conducted in 43 countries at two points in time, between 1991 and 2016, to test if the association of parental education with child health has changed over time...
August 7, 2018: International Journal of Epidemiology
Benjamin Anathory Kamala, Andrew Hans Mgaya, Matilda Michael Ngarina, Hussein Lesio Kidanto
Introduction: The global prevalence of low birth weight (LBW) is 16%, representing more than 20 million infants worldwide, of which 96% are born in low-income countries. This study aimed to determine the prevalence, predictors and perinatal outcomes of LBW newborns. Methods: We conducted a retrospective analysis of data obtained from the hospital's obstetric and neonatal database. Descriptive statistics and multivariate logistic regression were performed with 95% confidence intervals (CI)...
2018: Pan African Medical Journal
Alice Goisis, Hanna Remes, Kieron Barclay, Pekka Martikainen, Mikko Myrskylä
BACKGROUND: Based on existing studies, there is no conclusive evidence as to whether and why paternal age matters for birth outcomes. METHODS: We used Finnish population registers on 106 652 children born 1987-2000. We first document the unadjusted association between paternal age and the risk of low birth weight (LBW; <2500 g) and preterm birth (<37 weeks' gestation). Second, we investigate whether the unadjusted association is attenuated on adjustment for child's, maternal and parental socioeconomic characteristics...
August 12, 2018: Journal of Epidemiology and Community Health
Qian-Qian Wang, Yu-Mei Zhang, Xia Zhong, Jian-Wei Li, Xiao-Rong An, Jian Hou
Both developmental pluripotency-associated protein 3 (Dppa3/Stella/PGC7) and dioxygenase ten-eleven translocation 3 (Tet3) are maternal factors that regulate DNA methylation reprogramming during early embryogenesis. In the mouse zygote, dimethylated histone H3 lysine 9 (H3K9me2) attracts Dppa3 to prevent Tet3-mediated oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Here, we addressed the interplay between Dppa3 and Tet3 or H3K9me2 in somatic cells. In mouse NIH3T3 cells, the exogenously expressed Dppa3 preferentially accumulated in the cytoplasm and had no effect on Tet3-mediated 5hmC generation...
August 13, 2018: Reproduction, Fertility, and Development
Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Altankhuu Tungalagsuvd, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara
Infectious, psychological and metabolic stresses in the prenatal and early neonatal period induce long-lasting effects in physiological function and increase the risk of metabolic disorders later in life. We examined the sexual behavior of female rats that were subjected to undernutrition in the prenatal period. Eight pregnant rats were divided into two groups: a maternal normal nutrition group (mNN; n=4) and a maternal undernutrition group (mUN; n=4), which received 50% of the daily food intake amount of the mNN group from gestation day 13 to delivery...
August 9, 2018: General and Comparative Endocrinology
Kari Grethe Hjorthaug Gallaher, Anastasiya Slyepchenko, Benicio N Frey, Kristin Urstad, Signe K Dørheim
Women often experience sleep disturbances and worsening sleep quality throughout pregnancy and postpartum. Circadian rhythms are closely linked to sleep problems and mood disorders. This systematic review provides a summary of studies of circadian rhythms and associated sleep problems and maternal distress, among postpartum women. Articles were idenitfied through a systematic literature search. Circadian rhythm disturbances were strongly correlated with depression, social factors and mothers`s exposure to light postpartum...
September 2018: Sleep Medicine Clinics
Susan Garthus-Niegel, Antje Horsch, Myriam Bickle Graz, Julia Martini, Tilmann von Soest, Kerstin Weidner, Malin Eberhard-Gran
BACKGROUND: The main aim of this study was to examine the prospective impact of maternal postpartum PTSD on several standardized child sleep variables two years postpartum in a large, population-based cohort of mothers. Moreover, we investigated the influence of numerous potential confounding maternal and child factors. Finally, we tested potential reverse temporal associations between child sleep eight weeks postpartum and maternal PTSD symptoms two years postpartum. METHODS: This study is part of the population-based Akershus Birth Cohort, a prospective cohort study at Akershus University Hospital, Norway...
July 24, 2018: Journal of Affective Disorders
Junkun Chen, Liqin Hu, Jingzhen Yang, Ping Liu
OBJECTIVE: To detect numerical chromosomal aberrations and copy number variations (CNVs) in abortus tissue samples with a benchtop semiconductor sequencing platform (SSP). METHODS: One hundred and forty patients with early spontaneous abortions at between 7 and 16 weeks were selected. Following DNA extraction, library preparation, high-throughput sequencing was carried out. RESULTS: Chromosomal anomalies were detected in 82 cases (58.57%), which included 67 aneuploidies and 15 CNVs...
August 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Madeleine Stevens
BACKGROUND: Many childhood risk factors are known to be associated with children's future antisocial and criminal behaviour, including children's conduct disorders and family difficulties such as parental substance abuse. Some families are involved with many different services but little is known about what middle childhood factors moderate the risk of poor outcomes. This paper reports the quantitative component of a mixed methods study investigating what factors can be addressed to help families improve children's outcomes in the longer term...
August 10, 2018: BMC Psychology
Xi Gong, Yan Lin, Michelle L Bell, F Benjamin Zhan
BACKGROUND: Most previous studies examining associations between maternal exposures to air pollutants during pregnancy and low birth weight (LBW) in offspring focused on criteria air pollutants (PM2.5 , PM10 , O3 , NO2 , SO2 , CO, and Pb). The relationship between non-criteria air pollutants and LBW is understudied and requires greater coverage. OBJECTIVES: This study investigated associations between maternal residential exposure to industrial air pollutants during pregnancy and LBW in offspring...
August 7, 2018: Environment International
Madhuri Sudan, Laura Ellen Birks, Juan J Aurrekoetxea, Amparo Ferrero, Mara Gallastegi, Mònica Guxens, Mina Ha, Hyungryul Lim, Jorn Olsen, Llúcia González-Safont, Martine Vrijheid, Leeka Kheifets
BACKGROUND: There have been few studies of children's cognitive development in relation to mothers' cell phone use, and most were limited to outcomes at age 3 years or younger. We examined the relationship between maternal cell phone use during pregnancy and cognitive performance in 5-year old children. METHODS: This study included data from 3 birth cohorts: the Danish National Birth Cohort (DNBC) (n = 1209), Spanish Environment and Childhood Project (INMA) (n = 1383), and Korean Mothers and Children's Environment Health Study (MOCEH) (n = 497)...
August 7, 2018: Environment International
Aaron B Bogutz, Rosemary Oh-McGinnis, Karen J Jacob, Rita Ho-Lau, Ting Gu, Marina Gertsenstein, Andras Nagy, Louis Lefebvre
The basic helix-loop-helix (bHLH) transcription factor ASCL2 plays essential roles in diploid multipotent trophoblast progenitors, intestinal stem cells, follicular T-helper cells, as well as during epidermal development and myogenesis. During early development, Ascl2 expression is regulated by genomic imprinting and only the maternally inherited allele is transcriptionally active in trophoblast. The paternal allele-specific silencing of Ascl2 requires expression of the long non-coding RNA Kcnq1ot1 in cis and the deposition of repressive histone marks...
August 10, 2018: PLoS Genetics
Sonnet S Jonker, Samantha Louey, Charles E Roselli
Polycystic ovary syndrome (PCOS) is a complex and common disorder in women, and those affected experience an increased burden of cardiovascular disease. It is an intergenerational syndrome, as affected women with high androgen levels during pregnancy "program" fetal development, leading to a similar phenotype in their female offspring. The effect of excess maternal testosterone exposure on fetal cardiomyocyte growth and maturation is unknown. METHODS Pregnant ewes received biweekly injections of vehicle (Control) or 100 mg testosterone propionate between 30-59 days of gestation (dGA; Early T) or 60-90 dGA (Late T)...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Jin-Tian Hu, Qi Chen, Hui-Ying Song, Yi-Lin Cao, Yong-Biao Zhang, Xu Zhou, Tun Liu, Qing-Guo Zhang
BACKGROUND: Seasonality of congenital birth defect could help to identify environmental risk factors. Data concerning the seasonality of the prevalence of microtia are little. This article aims to determine whether births of microtia follow a certain pattern. METHODS: Data were obtained from 2669 patients with microtia who were admitted to Second Ear Reconstruction Center of Plastic Surgery Hospital, Chinese Academy of Medical Science from January 2007 to December 2013...
August 7, 2018: Journal of Craniofacial Surgery
Margaret McCallister, Rosalinda Medrano, Janet Wojcicki
BACKGROUND: Previous studies showed that youths who are obese are more likely to have asthma; however, some studies found important sex differences in the risk for asthma. METHODS: We retrospectively assessed the asthma incidence in a Latino cohort of children recruited from birth and followed up until 9 years of age. We subsequently assessed risk factors for asthma and for an early asthma (defined as <4 years of age) diagnosis in relation to obesity. Asthma was assessed via maternal reports and medical records review of the children at 9 years of age...
July 1, 2018: Allergy and Asthma Proceedings:
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