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Electro chemical cancer

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https://www.readbyqxmd.com/read/29715330/sensing-ca-15-3-in-point-of-care-by-electropolymerizing-o-phenylenediamine-opda-on-au-screen-printed-electrodes
#1
Rui S Gomes, Felismina T C Moreira, Ruben Fernandes, M Goreti F Sales
This work presents an alternative device for cancer screening in liquid biopsies. It combines a biomimetic film (i) with electrochemical detection (ii). The biomimetic film (i) was obtained by electro-polymerizing amine-substituted benzene rings around a CA 15-3 target. This protein target was previously adsorbed on a gold (Au) support and incubated in charged monomers (4-Styrenesulfonate sodium and 3-Hydroxytyraminium chloride). The protein was further eliminated by enzymatic activity, leaving behind vacant sites for subsequent rebinding...
2018: PloS One
https://www.readbyqxmd.com/read/28335260/a-label-free-microelectrode-array-based-on-one-step-synthesis-of-chitosan-multi-walled-carbon-nanotube-thionine-for-ultrasensitive-detection-of-carcinoembryonic-antigen
#2
Huiren Xu, Yang Wang, Li Wang, Yilin Song, Jinping Luo, Xinxia Cai
Carcinoembryonic antigen (CEA) has been an extensively used tumor marker responsible for clinical early diagnosis of cervical carcinomas, and pancreatic, colorectal, gastric and lung cancer. Combined with micro-electro mechanical system (MEMS) technology, it is important to develop a novel immune microelectrode array (MEA) not only for rapid analysis of serum samples, but also for cell detection in vitro and in vivo. In this work, we depict a simple approach to modify chitosan-multi-walled carbon nanotubes-thionine (CS-MWCNTs-THI) hybrid film through one-step electrochemical deposition and the CS-MWCNTs-THI hybrid films are successfully employed to immobilize anti-CEA for fabricating simple, label-free, and highly sensitive electro-chemical immune MEAs...
July 11, 2016: Nanomaterials
https://www.readbyqxmd.com/read/27296984/a-new-electrolytic-synthesis-method-for-few-layered-mos2-nanosheets-and-their-robust-biointerfacing-with-reduced-antibodies
#3
Manil Kukkar, Satish K Tuteja, Amit L Sharma, Vinod Kumar, Ashok K Paul, Ki-Hyun Kim, Priyanka Sabherwal, Akash Deep
We report an efficient method for the synthesis of few-layered MoS2 nanosheets and demonstrate their application in the label-free detection of the prostate-specific antigen (PSA) cancer marker. As a novel strategy, the electro-dissolution of molybdenum metal sheets in the presence of Na(+) and S(2-) ions led to the formation of Na(+) intercalated MoS2. Further exfoliation by ultrasonication yielded the desired formation of few-layered MoS2 nanosheets. After comprehensive characterization, the synthesized MoS2 nanosheets were channeled in a field-effect transistor (FET) microdevice...
July 6, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26940693/medical-complications-of-tattoos-a-comprehensive-review
#4
REVIEW
Parvez S Islam, Christopher Chang, Carlo Selmi, Elena Generali, Arthur Huntley, Suzanne S Teuber, M Eric Gershwin
Tattoos are defined as the introduction of exogenous pigments into the dermis in order to produce a permanent design. This process may occur unintentional or may be deliberately administered for cosmetic or medical reasons. Tattoos have been around for over 5000 years and over time have evolved to represent a common cosmetic practice worldwide. Currently, adverse reactions are relatively rare and generally unpredictable and predominantly include immune-mediated reactions and skin infections. Along with better healthcare standards and more stringent public health mandates such as the provision of disposable needles, major infectious complications related to hepatitis and human retroviral infections have decreased significantly...
April 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26903367/antiproliferative-activity-of-a-series-of-cisplatin-based-pt-iv-acetylamido-carboxylato-prodrugs
#5
Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Federico Fregonese, Giorgio Pelosi, James A Platts, Domenico Osella
We report studies of a novel series of Pt(IV) complexes exhibiting an asymmetric combination of acetylamido and carboxylato ligands in the axial positions. We demonstrate efficient synthesis of a series of analogues, differing in the alkyl chain length and hence lipophilicity, from a stable acetylamido/hydroxido complex formed by reaction of cisplatin with peroxyacetimidic acid (PAIA). NMR spectroscopy and X-ray crystallography confirm the identity of the resulting complexes, and highlight subtle differences in the structure and stability of acetylamido complexes compared to the equivalent acetato complexes...
March 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/26519798/transformation-products-and-pathways-of-chlorophenols-via-electro-enzymatic-catalysis-how-to-control-toxic-intermediate-products
#6
Penghui Du, He Zhao, Haitao Li, Di Zhang, Ching-Hua Huang, Manfeng Deng, Chenming Liu, Hongbin Cao
Chlorophenols can be easily oxidized into chlorobenzoquinones (CBQs), which are highly toxic and have been linked to bladder cancer risk. Herein, we report the transformation, products, and pathways of 2,4-dichlorophenol (DCP) by horseradish peroxidase (HRP) and electro-generated hydrogen peroxide (H2O2) and suggest methods to control the formation of toxic intermediate products. After a 10-min electroenzymatic process, 99.7% DCP removal may be achieved under optimal conditions. A total of 16 reaction products, most of which are subsequently verified as DCP polymers and related quinone derivatives, are identified by using ultra-performance liquid chromatography-time-of-flight mass spectrometry (UPLC-TOF-MS)...
February 2016: Chemosphere
https://www.readbyqxmd.com/read/25530535/cuo-induced-signal-amplification-strategy-for-multiplexed-photoelectrochemical-immunosensing-using-cds-sensitized-zno-nanotubes-arrays-as-photoactive-material-and-aupd-alloy-nanoparticles-as-electron-sink
#7
Guoqiang Sun, Yan Zhang, Qingkun Kong, Xiaoxiao Zheng, Jinghua Yu, Xianrang Song
In this work, multiplexed photoelectrochemical (PEC) immunoassays are introduced into an indium tin oxide (ITO) device. Firstly, the ITO device is fabricated using a simple acid etch treatment method. Secondly, AuPd alloy nanoparticles are electro-deposited on ITO working electrodes as electron sink to construct the immunosensor platform. After that, ZnO nanotubes (ZNTs) arrays are synthesized via chemical etching of ZnO nanorods that are grown on AuPd surface by electrochemical deposition method. Subsequently, CdS is electro-deposited on ZNTs arrays and used as photoactive material...
April 15, 2015: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/25465796/development-and-application-of-a-new-electronic-nose-instrument-for-the-detection-of-colorectal-cancer
#8
E Westenbrink, R P Arasaradnam, N O'Connell, C Bailey, C Nwokolo, K D Bardhan, J A Covington
Colorectal cancer is a leading cause of cancer death in the USA and Europe with symptoms that mimick other far more common lower gastrointestinal (GI) disorders. This difficulty in separating colorectal cancer from these other diseases has driven researchers to search for an effective, non-invasive screening technique. Current state-of-the-art method of Faecal Immunochemical Testing achieving sensitivity ~90%, unfortunately the take-up in the western world is low due to the low patient acceptability of stool samples...
May 15, 2015: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/25379101/a-novel-miniature-dynamic-microfluidic-cell-culture-platform-using-electro-osmosis-diode-pumping
#9
Jen-Yung Chang, Shuo Wang, Jeffrey S Allen, Seong Hyuk Lee, Suk Tai Chang, Young-Ki Choi, Craig Friedrich, Chang Kyoung Choi
An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface mount diodes were embedded along the sidewalls of a microchannel to rectify externally applied alternating current into pulsed direct current power across the diodes in order to generate EOS flows...
July 2014: Biomicrofluidics
https://www.readbyqxmd.com/read/25058796/influence-of-electrotaxis-on-cell-behaviour
#10
REVIEW
Barbara Cortese, Ilaria Elena Palamà, Stefania D'Amone, Giuseppe Gigli
Understanding the mechanism of cell migration and interaction with the microenvironment is not only of critical significance to the function and biology of cells, but also has extreme relevance and impact on physiological processes and diseases such as morphogenesis, wound healing, neuron guidance, and cancer metastasis. External guidance factors such as topography and physical cues of the microenvironment promote directional migration and can target specific changes in cell motility and signalling mechanisms...
September 2014: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/24510818/electroporation-mediated-sirna-delivery-into-tumors
#11
Yoshifumi Takei
Electroporation-mediated gene transfer (electro-transfection) is a powerful tool to introduce nucleic acid compounds such as plasmid DNAs, antisense oligonucleotides, and short interfering RNAs (siRNAs) into the cells. Electro-transfection is a physical gene transfer method that utilizes an electrostatic field generated with an electroporator apparatus. Here, we demonstrate a practical protocol for electro-transfection (electro-delivery) of siRNA into cells in vivo and further demonstrate the application of the method to cancer therapy...
2014: Methods in Molecular Biology
https://www.readbyqxmd.com/read/24201003/highly-sensitive-and-label-free-electrochemical-detection-of-micrornas-based-on-triple-signal-amplification-of-multifunctional-gold-nanoparticles-enzymes-and-redox-cycling-reaction
#12
Lin Liu, Ning Xia, Huiping Liu, Xiaojing Kang, Xiaoshuan Liu, Chan Xue, Xiaoling He
MicroRNAs (miRNAs) are believed to be important for cancer diagnosis and prognosis, serving as reliable molecular biomarkers. In this work, we presented a label-free and highly sensitive electrochemical genosensor for miRNAs detection with the triple signal amplification of gold nanoparticles (AuNPs), alkaline phosphatase (ALP) and p-aminophenol (p-AP) redox cycling. The label-free strategy is based on the difference in the structures of RNA and DNA. Specifically, miRNAs were first captured by the pre-immobilized DNA probes on a gold electrode...
March 15, 2014: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/24011711/a-5-fluorouracil-loaded-polydioxanone-weft-knitted-stent-for-the-treatment-of-colorectal-cancer
#13
Gang Li, Yufeng Chen, Jun Hu, Xiaojian Wu, Junyan Hu, Xiaowen He, Jiashen Li, Zheng Zhao, Zexian Chen, Yuling Li, Hong Hu, Yi Li, Ping Lan
In-stents restenosis caused by tumour ingrowth is a major problem for patients undergoing stent displacement because the conventional stents often lack a sustained anti-tumour capability. The aim of this paper was to develop a weft-knitted polydioxanone stent which can slow release 5-fluorouracil (5-FU). In order to determine the most suitable drug concentration, the 5-FU safe concentration in vivo and appropriate loading percentage in the membranes were investigated, and then 5-FU-loaded poly-l-lactide membranes at concentration of 3...
December 2013: Biomaterials
https://www.readbyqxmd.com/read/20803328/endoscopic-tissue-characterization-by-frequency-domain-fluorescence-lifetime-imaging-fd-flim
#14
J Mizeret, G Wagnières, T Stepinac, H Van Den Bergh
Tissue characterization by endoscopic fluorescence imaging of endogenous or exogenous fluorochromes is a promising method for early cancer detection. However, the steady-state fluorescence contrast between healthy tissue and lesions such as early-stage carcinomas is generally poor. The authors propose to improve this contrast by using the additional information contained in the fluorescence lifetime (FLT). The FLT of several fluorochromes is sensitive to their physico-chemical environment.The FLT can be measured by frequency-domain methods...
October 1997: Lasers in Medical Science
https://www.readbyqxmd.com/read/17954236/identification-of-intact-lipid-peroxides-by-ag-coordination-ion-spray-mass-spectrometry-cis-ms
#15
Huiyong Yin, Ned A Porter
Free radical-induced autoxidation of lipids containing polyunsaturated fatty acids (PUFA) has been implicated in numerous human diseases including atherosclerosis, neurodegenerative diseases, and cancer. Autoxidation of PUFAs generates hydroperoxides as primary oxidation products and further oxidation leads to cyclic peroxides as secondary oxidation products. It is challenging to identify these peroxides by conventional electro-spray ionization (ESI) mass spectrometry (MS) method because of their thermal and chemical instability under most analytical conditions...
2007: Methods in Enzymology
https://www.readbyqxmd.com/read/17256022/-exposure-to-polychlorinated-biphenyls-pcbs-in-food-and-cancer-risk-recent-advances
#16
REVIEW
Anna Maria Roveda, Licia Veronesi, Roberta Zoni, Maria Eugenia Colucci, Giuliano Sansebastiano
Polychlorinated Biphenyls are synthetic chlorinated hydrocarbon compounds whose commercial production started in the thirties and that have been widely used in the electro-technical industry. Although their production was stopped over 25 years ago, the Stockholm Convention included these compounds among the list of Persistent Organic Pollutants (POPs). In fact, humans continue to be exposed to the toxic effects of PCBs because of their resistance to chemical and biological decomposition, their capacity of bio-accumulation and their long half-life...
November 2006: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/16843042/human-cancer-from-environmental-pollutants-the-epidemiological-evidence
#17
REVIEW
Paolo Boffetta
An increased risk of mesothelioma has been reported among individuals experiencing residential exposure to asbestos, while results for lung cancer are less consistent. Several studies have reported an increased risk of lung cancer risk from outdoor air pollution: on the basis of the results of the largest study, the proportion of lung cancers attributable to urban air pollution in Europe can be as high as 10.7%. A causal association has been established between second-hand tobacco smoking and lung cancer, which may be responsible for 1...
September 28, 2006: Mutation Research
https://www.readbyqxmd.com/read/15203457/high-levels-of-oxidative-dna-damage-in-lymphocyte-dna-of-premenopausal-breast-cancer-patients-from-egypt
#18
Amr S Soliman, Suryanarayana V Vulimiri, Heather E Kleiner, Jianjun Shen, Saad Eissa, Magda Morad, Hala Taha, Farzana Lukmanji, Donghui Li, Dennis A Johnston, Herng-Hsang Lo, Serrine Lau, John Digiovanni, Melissa L Bondy
Egypt shows a parallel increase in premenopausal breast cancer and environmental pollution. The purpose of this study is to explore a possible relationship between oxidative DNA damage, urinary estrogen metabolites and breast cancer in Egyptian premenopausal women. We conducted a pilot study of Egyptian breast cancer involving 29 cases and 32 controls and analysed lymphocyte DNA levels of 7,8-dihydro-8-oxo-2'-deoxyguanine (8-oxo-dG), a measure of oxidative DNA damage using high performance liquid chromatography with electro-chemical detection (HPLC-ECD) method...
April 2004: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/15096708/near-infrared-fluorescence-optical-imaging-and-tomography
#19
Michael Gurfinkel, Shi Ke, Xiaoxia Wen, Chun Li, Eva M Sevick-Muraca
The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises selective and specific molecular targeting of diseased tissues. As an example of one area of the field, recent work focusing on pharmacokinetic analysis of fluorophores targeting the epidermal growth factor receptor (EGFR) is presented in a human breast cancer xenograft mouse model to demonstrate specificity of molecularly targeted contrast agents...
0: Disease Markers
https://www.readbyqxmd.com/read/12807948/chapter-10-cervical-cancer-screening-using-visualization-techniques
#20
REVIEW
Thomas C Wright
There is a resurgence of interest in the use of visual techniques to identify cervical intraepithelial neoplasia (CIN). These visual techniques can be divided into two general categories. One is the simple visual screening method, such as direct visual inspection (DVI), during which the cervix is visualized with either the naked eye or a low-power magnification device after the application of a solution of 3% to 5% acetic acid that is used as a chemical contrast agent to highlight regions of CIN. DVI has been evaluated in a number of large clinical trials and is considered by some to be a possible alternative to cervical cytology for primary cervical cancer screening in low-resource settings...
2003: Journal of the National Cancer Institute. Monographs
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