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Electrochemical cancer

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https://www.readbyqxmd.com/read/30514834/epigenetically-reprogrammed-methylation-landscape-drives-the-dna-self-assembly-and-serves-as-a-universal-cancer-biomarker
#1
Abu Ali Ibn Sina, Laura G Carrascosa, Ziyu Liang, Yadveer S Grewal, Andri Wardiana, Muhammad J A Shiddiky, Robert A Gardiner, Hemamali Samaratunga, Maher K Gandhi, Rodney J Scott, Darren Korbie, Matt Trau
Epigenetic reprogramming in cancer genomes creates a distinct methylation landscape encompassing clustered methylation at regulatory regions separated by large intergenic tracks of hypomethylated regions. This methylation landscape that we referred to as Methylscape is displayed by most cancer types, thus may serve as a universal cancer biomarker. To-date most research has focused on the biological consequences of DNA Methylscape changes whereas its impact on DNA physicochemical properties remains unexplored...
December 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/30513307/bioassay-of-saliva-proteins-the-best-alternative-for-conventional-methods-in-non-invasive-diagnosis-of-cancer
#2
REVIEW
Aziz Eftekhari, Mohammad Hasanzadeh, Simin Sharifi, Solmaz Maleki Dizaj, Rovshan Khalilov, Elham Ahmadian
Non-invasive diagnosis of cancer is often the key to effective treatment and patient survival. Saliva as a multi-constituent oral fluid comprises various disease signaling biomarkers, holds great potential for early-stage cancer diagnostics with cost-effective and easy collection, storage, transport and processing. Therefore, detection of biomarkers and proteins in the saliva samples is highly demand. The current review was performed using reliable internet database (mainly PubMed) to provide an overview of the most recent developments on non-invasive diagnosis of cancers in saliva and highlights main challenges and future prospects in sensing of the salivary biomarkers...
December 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30507985/pyrazole-appended-quinoline-bodipy-based-arene-ruthenium-complexes-their-anticancer-activity-and-potential-applications-in-cellular-imaging
#3
Rajendra Prasad Paitandi, Vinay Sharma, Vishwa Deepak Singh, Bhupendra Kumar Dwivedi, Shaikh M Mobin, Daya Shankar Pandey
Synthesis of an entirely new series of arene ruthenium complexes [Ru(η6-C6H6)(L1)Cl]PF6, (1), [Ru(η6-C10H14)(L1)Cl]PF6 (2), [Ru(η6-C6H6)(L2)Cl]PF6 (3) and [Ru(η6-C10H14)(L2)Cl]PF6 (4) involving 5-[2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L1) and 5-[6-methoxy-2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L2) was described. The ligands and complexes were thoroughly characterized by various physicochemical techniques and the structures of L1, 1 and 4 were determined by X-ray single crystal analyses. Photo-/ and electrochemical property, DNA binding, cytotoxicity, cellular uptake and apoptotic studies on 1-4 were performed by various methods, while singlet oxygen-mediated cytotoxicity via photo-irradiation by visible light was supported by 1,3-diphenylisobenzofuran titration studies...
December 3, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30501197/dna-oriented-shaping-of-cell-features-for-the-detection-of-rare-disseminated-tumor-cells
#4
Tao Gao, Lingling Li, Tianshu Chen, Liu Shi, Yang Yang, Genxi Li
Metastasis of tumor is the major cause of death in cancer patients. The efficient detection of disseminated tumor cells (DTCs) is found to be critical for the early warning of tumor metastasis. However, it is technically difficult to identify DTC among circulation tumor cells (CTCs). In this work, we have proposed a DNA-oriented shaping strategy to convert the metastasis-associated feature of CTC into a dominant signature, making DTCs discernible. In detail, by performing the in situ DNA rolling circle amplification, invasive biomarkers at cell surface are specifically labeled with large amount of biotin-incorporated DNA strands...
December 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30499292/versatile-electroanalytical-bioplatforms-for-simultaneous-determination-of-cancer-related-dna-5-methyl-and-5-hydroxymethyl-cytosines-at-global-and-gene-specific-levels-in-human-serum-and-tissues
#5
Eloy Povedano, Víctor Ruiz-Valdepeñas Montiel, Alejandro Valverde, Fernando Navarro-Villoslada, Paloma Yanez-Sedeno, María Pedrero, Ana Montero-Calle, Rodrigo Barderas, Alberto Peláez-García, Marta Mendiola, David Hardisson, Jaime Feliú, Jordi Camps, Elisabet Rodríguez-Tomàs, Jorge Joven, Meritxell Arenas, Susana Campuzano, José M Pingarrón
This paper reports the preparation of versatile electrochemical biosensing platforms for the simple, rapid and PCR-independent detection of the most frequent DNA methylation marks (5-methylcytosine, 5-mC, and/or 5-hydroximethylcytosine, 5-hmC) both at global and gene-specific levels. The implemented strategies, relying on the smart coupling of immuno-magnetic beads (MBs), specific DNA probes and amperometric detection at screen-printed carbon electrodes (SPCEs), provided sensitive and selective determination of the target methylated DNAs in less than 90 min with a great reproducibility and demonstrated feasibility for the simultaneous detection of the same or different cytosine epimarks both at global level and in different loci of the same gene or in different genes...
November 30, 2018: ACS Sensors
https://www.readbyqxmd.com/read/30496635/early-detection-of-cervical-cancer-based-on-high-risk-hpv-dna-based-genosensors-a-systematic-review
#6
REVIEW
Pegah Mahmoodi, Mona Fani, Majid Rezayi, Amir Avan, Zahra Pasdar, Ehsan Karimi, Iraj S Amiri, Majid Ghayour-Mobarhan
Human papillomavirus type (HPV) is a common cause of sexually transmitted disease (STD) in humans. HPV types 16 and 18 as the highest risk types are related with gynecologic malignancy and cervical cancer (CC) among women worldwide. Recently, considerable development of genosensors, which allows dynamic monitoring of hybridization events for HPV-16 and 18, has been a topic of focus by many researchers. In this systematic review, we highlight the route of development of DNA-based genosensory detection methods for diagnosis of high risk of HPV precancer...
November 29, 2018: BioFactors
https://www.readbyqxmd.com/read/30486941/electrochemical-synthesis-and-magnetic-properties-of-mfe%C3%A2-o%C3%A2-m-fe-mn-co-ni-nanoparticles-for-potential-biomedical-applications
#7
J G Ovejero, A Mayoral, M Cañete, M García, A Hernando, P Herrasti
In this study, we evaluate the magnetic properties and cytotoxic effect of magnetic nanoparticles (MNPs) based on magnetite and Mn, Co and Ni ferrites, obtained by electrochemical synthesis. These nanoparticles have almost spherical shape and an mode size of 9±1 nm. The electrochemical synthesis produces a single crystallographic phase with a spinel-like structure in all cases. Magnetization saturation at room temperature varies with the composition of the ferrites from M S (Fe₃O₄) > M S (MnFe₂O₄) > M S (CoFe₂O₄) > M S (NiFe₂O₄)...
April 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30482306/platinum-loaded-mesoporous-nickel-phosphonate-and-its-electrochemical-application-for-sarcosine-detection
#8
Qia Wang, Chun Yang, Qingui Yang, Shenghao Yu, Haipeng Yang
In 2009, Sreekumar found that sarcosine, as an effective biomarker, can be used to identify prostate cancer. However, it is difficult to detect sarcosine in urine or plasma because of its low concentration. In this work, we describe a simple strategy for the preparation of sarcosine biosensor based on platinum-loaded mesoporous nickel phosphonate (Pt/MNP) and subsequently apply it to detect sarcosine. Mesoporous structure could increase the active sites on the MNP surface, which makes the Pt/MNP have excellent electrochemical performance for detecting hydrogen peroxide, one of the enzymatic products, and the sarcosine biosensor exhibited a superior electrochemical performance...
January 10, 2019: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30480095/superhydrophobic-lab-on-chip-measures-secretome-protonation-state-and-provides-a-personalized-risk-assessment-of-sporadic-tumour
#9
N Malara, F Gentile, N Coppedè, M L Coluccio, P Candeloro, G Perozziello, L Ferrara, M Giannetto, M Careri, A Castellini, C Mignogna, I Presta, C K Pirrone, D Maisano, A Donato, G Donato, M Greco, D Scumaci, G Cuda, F Casale, E Ferraro, S Bonacci, V Trunzo, V Mollace, V Onesto, R Majewska, F Amato, M Renne, N Innaro, G Sena, R Sacco, F Givigliano, C Voci, G Volpentesta, G Guzzi, A Lavano, E Scali, U Bottoni, E Di Fabrizio
Secretome of primary cultures is an accessible source of biological markers compared to more complex and less decipherable mixtures such as serum or plasma. The protonation state (PS) of secretome reflects the metabolism of cells and can be used for cancer early detection. Here, we demonstrate a superhydrophobic organic electrochemical device that measures PS in a drop of secretome derived from liquid biopsies. Using data from the sensor and principal component analysis (PCA), we developed algorithms able to efficiently discriminate tumour patients from non-tumour patients...
2018: NPJ Precision Oncology
https://www.readbyqxmd.com/read/30472220/a-molecularly-imprinted-electrochemical-nanobiosensor-for-prostate-specific-antigen-determination
#10
Z Yazdani, H Yadegari, H Heli
Prostate Specific Antigen (PSA) is a biomarker employed for detection of prostate cancer. An electrochemical nanobiosensor is designed and fabricated using a molecularly imprinted polymer for the simple and fast PSA detection. The imprinted polymer served as a PSA artificial receptor fabricated by electrochemical polymerization of pyrrole on screen-printed gold electrode in the presence of PSA. PSA was a molecular template for the polymer. The fabricated nanobiosensor was evaluated by differential pulse voltammetry and using K3 [Fe(CN)6 ]/K4 [Fe(CN)6 ] as an electrochemical marker...
November 22, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/30467539/big-potential-from-silicon-based-porous-nanomaterials-in-field-of-energy-storage-and-sensors
#11
REVIEW
Rana Zafar Abbas Manj, Xinqi Chen, Waheed Ur Rehman, Guanjia Zhu, Wei Luo, Jianping Yang
Silicon nanoparticles (SiNPs) are the promising materials in the various applications due to their unique properties like large surface area, biocompatibility, stability, excellent optical and electrical properties. Surface, optical and electrical properties are highly dependent on particle size, doping of different materials and so on. Porous structures in silicon nanomaterials not only improve the specific surface area, adsorption, and photoluminescence efficiency but also provide numbers of voids as well as the high surface to volume ratio and enhance the adsorption ability...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/30461262/a-sample-to-targeted-gene-analysis-biochip-for-nanofluidic-manipulation-of-solid-phase-circulating-tumor-nucleic-acid-amplification-in-liquid-biopsies
#12
Kevin Maisheng Koo, Shuvashis Dey, Matt Trau
The use of circulating tumor nucleic acids (ctNA) in patient liquid biopsies for targeted genetic analysis is rapidly increasing in clinical oncology. Still, the call for an integrated methodology that is both rapid and sensitive for analyzing trace ctNA amount in liquid biopsies, has unfortunately not been fully realized. Herein, we performed complex liquid biopsy sample-to-targeted genetic analysis on a biochip with 50 copies-detection limit within 30 min. Our biochip uniquely integrated: 1) electrical lysis and release of cellular targets with minimal processing; 2) nanofluidic manipulation to accelerate molecular kinetics of solid-phase isothermal amplification; 3) single-step capture and amplification of multiple NA targets prior to nanozyme-mediated electrochemical detection...
November 21, 2018: ACS Sensors
https://www.readbyqxmd.com/read/30460466/synthesis-biological-evaluation-and-corrosion-inhibition-studies-of-transition-metal-complexes-of-schiff-base
#13
Shubham Kashyap, Sanjiv Kumar, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Hari Om, Balasubramanian Narasimhan
BACKGROUND: The transition metal complexes formed from Schiff base is regarded as leading molecules in medicinal chemistry. Because of the preparative availability and diversity in the structure of central group, the transition metals are important in coordination chemistry. In the present work, we have designed and prepared Schiff base and its metal complexes (MC1 -MC4 ) and screened them for antimicrobial, anticancer and corrosion inhibitory properties. METHODOLOGY: The synthesized metal complexes were characterized by physicochemical and spectral investigation (UV, IR, 1 H and 13 C-NMR) and were further evaluated for their antimicrobial (tube dilution) and anticancer (SRB assay) activities...
November 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30458111/ferrous-supply-regeneration-nanoengineering-for-cancer-cell-specific-ferroptosis-in-combination-with-imaging-guided-photodynamic-therapy
#14
Tao Liu, Wenlong Liu, Mingkang Zhang, Wuyang Yu, Fan Gao, Chuxin Li, Shi-Bo Wang, Jun Feng, Xian-Zheng Zhang
Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the inevitable biocarriers of traditional apoptotic therapeutic means. Inspired by industrial electro-Fenton technology featured with electrochemical iron cycling, we construct ferrous-supply-regeneration nanoengineering to intervene tumorous iron metabolism for enhanced ferroptosis. Fe3+ ion and naturally derived tannic acid (TA) spontaneously form a network-like corona onto sorafenib (SRF) nanocores. The formed SRF@FeIII TA nanoparticles can respond to a lysosomal acid environment with corona dissociation, permitting SRF release to inhibit GPX4 enzyme for ferroptosis initiation...
November 26, 2018: ACS Nano
https://www.readbyqxmd.com/read/30454575/catalytic-hairpin-assembly-programmed-formation-of-clickable-nucleic-acids-for-electrochemical-detection-of-liver-cancer-related-short-gene
#15
Meiwen Wang, Yingying Tang, Yaoyao Chen, Ya Cao, Guifang Chen
DNA amplification usually takes place in an aqueous system to facilitate a highly efficient reaction. Therefore, it is a challenge to connect the DNA amplification with popular dry chemical methods, whose signal outputs usually come from a solid-liquid interface. Here, by linking catalytic hairpin assembly (CHA) with electrochemical biosensors through clickable nucleic acids, we develop a facile method for the detection of liver cancer related short gene MXR7. On one hand, the method maintains the advantages of CHA especially its high efficiency by performing the whole process of CHA in aqueous phase...
January 3, 2019: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30451486/an-immuno-biochip-selectively-captures-tumor-derived-exosomes-and-detects-exosomal-rna-for-cancer-diagnosis
#16
Yunchen Yang, Eric Kannisto, Guan Yu, Mary Reid, Santosh Patnaik, Yun Wu
Tumor-derived exosomes (TEXs) play instrumental roles in tumor growth, angiogenesis, immune modulation, metastasis and drug resistance. TEX RNAs are a new class of non-invasive biomarkers for cancer. Neither current techniques such as qRT-PCR and next generation sequencing nor new ones such as electrochemical or surface plasmon resonance-based biosensors are able to selectively capture and separate TEXs from normal cell-derived exosomes, making TEX RNAs potentially less sensitive biomarkers. We developed an immuno-biochip that selectively captures TEXs using antibodies against tumor-associated proteins and quantifies in situ TEX RNAs using cationic lipoplexes containing molecular beacons...
November 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30445301/aptamer-dna-concatamer-quantum-dots-based-electrochemical-biosensing-strategy-for-green-and-ultrasensitive-detection-of-tumor-cells-via-mercury-free-anodic-stripping-voltammetry
#17
Yue Zheng, Xiaoyu Wang, Shengquan He, Zehua Gao, Ya Di, Kunling Lu, Kun Li, Jidong Wang
A electrochemical biosensing strategy was developed for green and ultrasensitive detection of tumor cells by combining aptamer-DNA concatamer-CdTe quantum dots (QDs) signal amplification probe with mercury-free anodic stripping voltammetry (ASV). First, aptamer-DNA concatamer- CdTe QDs probes were designed by DNA hybridization and covalent assembling, which contained specific recognition of aptamer and signal amplification incorporating the DNA concatamer with QDs. Meanwhile, the capture electrode, glassy carbon electrode (GCE)/Graphene oxide (GO)/Polyaniline (PANI) / Glutaraldehyde (GA) / concanavalin A (Con A) was fabricated by a layer-by-layer assembling technique...
September 21, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30439624/electrochemical-immunosensor-for-cdh22-biomarker-based-on-benzaldehyde-substituted-poly-phosphazene-modified-disposable-ito-electrode-a-new-fabrication-strategy-for-biosensors
#18
Muhammet Aydın, Elif Burcu Aydın, Mustafa Kemal Sezgintürk
A novel label-free impedimetric immunosensor was fabricated for rapid, selective and sensitive detection and quantification of Cadherin-like protein 22 (CDH22), a cancer marker, in human serum by using easy and quickly prepared disposable ITO immunoelectrode. cancer marker, in human serum by using easy and quickly prepared disposable ITO immunoelectrode. The biosensing approach implied the use of ITO electrode coated with poly(phosphazene) polymer including benzaldehyde groups attached with CDH22 antibody and CDH22 antigens...
November 2, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30428987/swcnts-gqds-composites-as-nanocarriers-for-enzyme-free-dual-signal-amplification-electrochemical-immunoassay-of-cancer-biomarker
#19
Yanan Luo, Yuxin Wang, Hongye Yan, Yu Wu, Chengzhou Zhu, Dan Du, Yuehe Lin
Carcinoembryonic antigen (CEA) as a typical biomarker plays a remarkable role in various human physiological processes. A sensitive and rapid method should be developed to realize the precise diagnosis of cancer at its early stage. In this work, we successfully synthesized the peroxidase-like graphene quantum dots (GQDs) and utilized it to fabricate an enzyme-free electrochemical immunosensor towards CEA by forming a single-wall carbon nanotubes@GQDs (SWCNTs@GQDs) composite. In addition to the SWCNTs@GQDs, reduced graphene oxide-Au nanoparticles (rGO-Au NPs) with the huge specific surface area and excellent conductivity were employed to modify the electrodes, leading to a dual-signal amplification result...
December 26, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30428986/genomagnetic-lamp-based-electrochemical-test-for-determination-of-high-risk-hpv16-and-hpv18-in-clinical-samples
#20
Martin Bartosik, Ludmila Jirakova, Milan Anton, Borivoj Vojtesek, Roman Hrstka
Major cause of cervical cancer is a persistent infection with high-risk types of human papillomaviruses (HPV). For that reason, HPV testing is now becoming an important addition to standard cytological screening of cervical malignancies in women (known as Pap test). New methods are sought which could offer rapid and inexpensive detection schemes, such as those based on electrochemical (EC) readout. Here, we developed an assay for parallel detection of two most oncogenic high-risk HPV types, HPV16 and HPV18, by combining loop-mediated amplification (LAMP) of template DNA, its separation using magnetic beads and detection with amperometry at carbon-based electrode chips...
December 26, 2018: Analytica Chimica Acta
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