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Hypertension And Gestational

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https://www.readbyqxmd.com/read/30513528/the-tubular-damage-markers-neutrophil-gelatinase-associated-lipocalin-and-kidney-injury-molecule-1-in-newborns-with-intrauterine-growth-restriction
#1
Monika Kamianowska, Marek Szczepański, Elżbieta Ewa Kulikowska, Barbara Bebko, Anna Wasilewska
BACKGROUND: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. OBJECTIVES: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1)...
December 4, 2018: Neonatology
https://www.readbyqxmd.com/read/30513036/neonatal-morbidity-and-mortality-among-growth-discordant-dichorionic-twins-classified-according-to-birth-weight-of-the-smaller-twin-a-population-based-cohort-study
#2
Katja Ražem, Lea Bombač, Natasa Tul, Isaac Blickstein
OBJECTIVE: To examine the outcomes among discordant dichorionic (DC) twins, where the smaller twin is small for gestational age (SGA) or non-SGA. MATERIALS AND METHODS: We used the national perinatal registry to compare the relationship between selected maternal characteristics (age, parity, body mass index, gestational diabetes, hypertensive disorders, and gestational age at delivery) and neonatal outcomes in discordant > 25% DC twins. Chorionicity was established by standard ultrasound criteria and confirmed postpartum...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30504523/placental-thickness-on-ultrasound-and-neonatal-birthweight
#3
Odessa P Hamidi, Avi Hameroff, Allen Kunselman, William M Curtin, Risha Sinha, Serdar H Ural
Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. The relationship between placental thickness and neonatal birthweight was assessed using Pearson's correlation coefficient (r) with 95% confidence interval (CI)...
December 3, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/30502314/health-physical-growth-and-neurodevelopmental-outcomes-in-preterm-infants-of-women-with-hypertensive-disorders-of-pregnancy
#4
Forgive Avorgbedor, Susan Silva, Elizabeth Merwin, James A Blumenthal, Diane Holditch-Davis
OBJECTIVE: To compare the health, physical growth, and developmental outcomes in preterm infants of women with and without hypertensive disorders of pregnancy (HDP). DESIGN: Cross-sectional analysis of health outcomes; physical growth (head circumference, height, and weight) collected at birth and 2 months, corrected for prematurity; and cognitive, language, and motor skills of preterm infants of women with and without HDP. SETTING: Four NICUs in the United States...
November 28, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/30501941/the-effect-of-body-mass-index-bmi-and-gestational-weight-gain-on-adverse-obstetrical-outcomes-in-pregnancies-following-assisted-reproductive-technology-as-compared-to-spontaneously-conceived-pregnancies
#5
Dvora Frankenthal, Galit Hirsh-Yechezkel, Valentina Boyko, Raoul Orvieto, Raphael Ron-El, Liat Lerner-Geva, Adel Farhi
OBJECTIVE: To compare the effect of pre-pregnancy body mass index (BMI) and inappropriate gestational weight gain (GWG) on adverse obstetrical outcomes among women undergoing assisted reproductive technology (ART) treatments as compared to spontaneously-conceived (SC) pregnancies. METHODS: This prospective cohort study included 1058 pregnant women from two medical centres; 504 women who conceived following ART treatments and 554 who conceived spontaneously. The women were recruited at 8 weeks of gestation and follow-up telephone interviews were conducted 6 weeks after delivery...
November 27, 2018: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/30501623/are-cytokines-il-6-crp-and-adiponectin-associated-with-bone-mineral-density-in-a-young-adult-birth-cohort
#6
Ana Maria Baptista Menezes, Paula Duarte Oliveira, Helen Gonçalves, Isabel O Oliveira, Maria Cecilia F Assunção, Luciana Tovo-Rodrigues, Gustavo Dias Ferreira, Fernando César Wehrmeister
BACKGROUND: Studies have shown that cytokines play a role in bone remodeling. METHODS: In 1993, all hospital births occurred in Pelotas (Brazil) were identified and a total of 5249 newborns were included in the present cohort. Sub-samples of this cohort were visited during childhood and all members were traced at 11, 15, 18 and 22 years old. At 18 and 22 years the following biomarkers were measured: IL-6, CRP and adiponectin (the last one in a sub-sample) and bone mineral density (BMD-mg/cm2 ) was evaluated at 22 years...
November 30, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30501553/serum-endocan-concentration-and-its-correlation-with-severity-of-hypertensive-disorders-in-pregnancy
#7
Agata Szpera-Goździewicz, Katarzyna Kosicka, Tomasz Goździewicz, Mariola Krzyścin, Przemysław Wirstlein, Anna Siemiątkowska, Franciszek K Główka, Ewa Wender-Ożegowska, Wiesław Markwitz, Grzegorz H Bręborowicz
INTRODUCTION: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis. OBJECTIVE: The aim of this study was to investigate the relationship between endocan serum levels and various types of hypertensive disorders in pregnant women. PATIENTS AND METHODS: We created three study groups (preeclampsia [n = 60], chronic hypertension [n = 39], gestational hypertension [n = 58]) and the control group consisting of 59 healthy pregnant women...
December 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30497841/psychopharmacological-prescribing-practices-in-pregnancy-for-women-with-severe-mental-illness-a-multicentre-study
#8
Megan Galbally, Jacqueline Frayne, Stuart J Watson, Martien Snellen
There is little known about real world psychopharmacological prescribing practices in managing pregnant women with severe mental illness (SMI). This study utilised a sample of 535 women with a SMI across two hospitals in Australia. This included women with psychotic disorders, bipolar disorder and a range of non-psychotic disorders. The majority of women with a SMI in pregnancy were prescribed psychotropic medication as part of their management. Furthermore, more than one class of agent was prescribed for 31% of women with psychotic disorders and 30% of women with bipolar disorder...
November 26, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30496724/association-between-endoglin-transforming-growth-factor-beta-receptors-1-2-gene-polymorphisms-and-the-level-of-soluble-endoglin-with-preeclampsia-in-egyptian-women
#9
Asmaa A ElMonier, Noha A El-Boghdady, Mohamed A Abdelaziz, Amira A Shaheen
INTRODUCTION: Preeclampsia (PE) is a pregnancy-specific hypertensive disease whose etiopathogenesis remains unclear. OBJECTIVES: This study was designed to assess association between PE and 3 single nucleotide polymorphisms (SNPs): ENG(G/A) rs11792480, TGFβR1(A/C) rs10739778 and TGFβR2(G/A) rs6550005, beside circulating soluble endoglin (sENG), oxidative stress biomarkers and nitric oxide (NO) in Egyptian women. METHODS: The study included 75 preeclamptic women stratified into 4 clinical subgroups and 50 normotensive pregnant women...
November 26, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30489356/the-risk-for-childhood-malignancies-in-the-offspring-of-mothers-with-previous-gestational-diabetes-mellitus-a-population-based-cohort-study
#10
Roy Kessous, Tamar Wainstock, Asnat Walfisch, Eyal Sheiner
The hyperglycemic intrauterine environment has been shown to have long-term effects on offspring. We aimed to evaluate its effect on the long-term risk of childhood malignancies. This was a population-based cohort analysis comparing the risk for long-term childhood malignancies (≤18 years) in children born to mothers with and without gestational diabetes mellitus (GDM). Childhood malignancies were diagnosed by physicians and recorded in hospital medical files according to predefined codes based on ICD-9. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center...
November 26, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30485648/association-of-chorioamnionitis-and-its-duration-with-adverse-maternal-outcomes-by-mode-of-delivery-a-cohort-study
#11
Kartik K Venkatesh, Angelica Glover, Catherine J Vladutiu, David M Stamilio
OBJECTIVE: To investigate the association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery. DESIGN: A retrospective cohort study. SETTING: Data from the Consortium on Safe Labor Study (CSL) in the USA (2002-2008). POPULATION: Singleton deliveries at ≥23 weeks of gestation (221,274 assessed deliveries, 62,331 by cesarean). METHODS: The association of chorioamnionitis, and secondarily the duration of chorioamnionitis estimated from intrapartum antibiotic use, with adverse maternal outcomes was analyzed using logistic regression with generalized estimating equations, adjusting for age, parity, race, pre-gestational diabetes, chronic hypertension, gestational age at delivery, study site, and delivery year...
November 28, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/30482067/fetal-abdominal-circumference-in-the-second-trimester-and-prediction-of-small-for-gestational-age-at-birth
#12
Georgios Doulaveris, Patience Gallagher, Elizabeth Romney, Michael Richley, Juliana Gebb, Mara Rosner, Dar M D Pe'er
BACKGROUND: Infants that are small for gestational age (SGA) at birth are at increased risk for morbidity and mortality. Unfortunately, the antenatal prediction of SGA is suboptimal. OBJECTIVES: We sought to: 1. examine the association between second trimester fetal abdominal circumference < 10% (2T-AClag) with SGA and other gestational and neonatal adverse outcomes; 2. assess 2T-AClag as a predictor of SGA. STUDY DESIGN: Retrospective study of 212 singleton gestations with 2T-AClag on routine ultrasound between 18-24 weeks...
November 27, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30477627/-persistent-hypertension-for-two-months-in-a-preterm-infant
#13
Yun-Feng Liu, Tong-Yan Han, Xiao-Mei Tong, Jing Wang, Ya-Nan Tang, Li-Gang Cui, Xiao-Hui Zhu, Mei-Hua Piao, Qing-Qing Wang, Hui Wu
A boy aged 2 months (born at 36 weeks of gestation) was admitted due to cough and dyspnea. After admission, he was found to have persistent hypertension, proteinuria, and persistent convulsion, and imaging examination showed extensive calcification of the aorta and major branches and stenosis of local lumens of the abdominal aorta and the right renal artery with increased blood flow velocity. The boy was admitted during the neonatal period due to wet lung and pulmonary arterial hypertension and was found to have hypertension and proteinuria...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30477618/-clinical-features-and-prognosis-of-bronchopulmonary-dysplasia-complicated-by-pulmonary-hypertension-in-preterm-infants
#14
Chen-Hong Wang, Li-Ping Shi, Xiao-Lu Ma, Li-Zhong DU
OBJECTIVE: To study the clinical features and prognosis of bronchopulmonary dysplasia (BPD) complicated by pulmonary hypertension (PH) in preterm infants. METHODS: A retrospective analysis was performed on the clinical data of 191 preterm infants with BPD. RESULTS: In the 191 preterm infants with BPD, 37 (19.4%), all with moderate or severe BPD, developed PH beyond 36 weeks' corrected age. The incidence rates of PH in infants with moderate and severe BPD were 5...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30477033/maternal-hypothyroidism-during-pregnancy-and-the-risk-of-pediatric-endocrine-morbidity-in-the-offspring
#15
Tamar Eshkoli, Tamar Wainstock, Eyal Sheiner, Ofer Beharier, Merav Fraenkel, Asnat Walfisch
OBJECTIVE:  Previous studies suggested maternal hypothyroidism during pregnancy to be associated with cognitive impairment of the offspring. Scarce data exist regarding long-term endocrine health of the offspring. This study was aimed to assess whether children born to mothers with hypothyroidism during pregnancy are at an increased risk for long-term endocrine morbidity. STUDY DESIGN:  A retrospective population-based cohort study compared long-term endocrine morbidity of children born between the years 1991 and 2014 to mothers with and without hypothyroidism...
November 26, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30472740/risk-of-adverse-maternal-and-fetal-outcomes-during-pregnancy-in-living-kidney-donors-a-matched-cohort-study
#16
Scott Davis, James Dylewski, Pratik B Shah, John Holmen, Zhiying You, Michel Chonchol, Jessica Kendrick
BACKGROUND: We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls. METHODS: Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery < 37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital > 3 days, infant death/transfer to acute facility and low birth weight (<2,500 gm)...
November 25, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30470272/stroke-in-pregnancy-an-update
#17
REVIEW
Erica C Camargo, Steven K Feske, Aneesh B Singhal
Pregnancy confers a substantially increased risk of stroke in women. The period of highest risk of stroke is the peripartum/postpartum phase, coinciding with the highest risk for hypertensive disorders of pregnancy and peak gestational hypercoagulability. Hemorrhagic stroke is the most common type of obstetric stroke. Hypertensive disorders of pregnancy are important contributors to obstetric stroke and predispose women to premature cardiovascular disease. The rate of stroke associated with hypertensive disorders of pregnancy has increased in the United States...
February 2019: Neurologic Clinics
https://www.readbyqxmd.com/read/30463851/neonatal-outcomes-of-very-preterm-or-very-low-birth-weight-triplets
#18
Prakesh S Shah, Satoshi Kusuda, Stellan Håkansson, Brian Reichman, Kei Lui, Liisa Lehtonen, Neena Modi, Maximo Vento, Mark Adams, Franca Rusconi, Mikael Norman, Brian A Darlow, Abhay Lodha, Junmin Yang, Dirk Bassler, Kjell K Helenius, Tetsuya Isayama, Shoo K Lee
OBJECTIVES: To compare the neonatal outcomes of very preterm triplets with those of matched singletons using a large international cohort. METHODS: A retrospective matched-cohort study of preterm triplets and singletons born between 2007 and 2013 in the International Network for Evaluation of Outcomes in neonates database countries and matched by gestational age, sex, and country of birth was conducted. The primary outcome was a composite of mortality or severe neonatal morbidity (severe neurologic injury, treated retinopathy of prematurity, and bronchopulmonary dysplasia)...
November 21, 2018: Pediatrics
https://www.readbyqxmd.com/read/30461154/addressing-knowledge-gaps-in-long-term-outcomes-following-embryo-freezing
#19
Alice R Rumbold, Vivienne M Moore, Michael J Davies
Cryopreservation of embryos following in vitro fertilisation (IVF) has been a major advance in assisted reproductive technology (ART), facilitating single embryo transfer and thereby reducing multiple births. Compared with fresh embryo cycles, cryopreservation is also associated with improved pregnancy rates and reductions in preterm birth, small for gestational age and low birth weight (Maheshwari et al Hum Reprod Update 2018;24(1):35-58). However, emerging adverse health impacts include increased risks of hypertensive disease in pregnancy and macrosomia (Maheshwari et al Hum Reprod Update 2018;24(1):35-58)...
November 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/30459092/a-retrospective-population-based-cohort-study-to-evaluate-the-impact-of-an-older-sibling-with-undescended-testis-and-hypospadias-on-the-known-maternal-and-fetal-risk-factors-for-undescended-testis-and-hypospadias-in-ontario-canada-1997-2007
#20
S Dave, K Liu, R Clark, A X Garg, S Z Shariff
INTRODUCTION: There are several reported risk factors for undescended testis (UDT) and hypospadias (HYP). Also, a family history of UDT or HYP has not been accounted for in prior studies, and doing so may influence these independent risk estimates. STUDY DESIGN: A population-based retrospective cohort study was conducted using linked administrative databases in Ontario, Canada, to identify all live male newborns born between 1997 and 2007, and it was determined whether they underwent an orchidopexy or HYP repair within 5 years of birth...
October 10, 2018: Journal of Pediatric Urology
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