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Hypertension And Gestational

Teofana O Bizerea, Stefana G Dezsi, Otilia Marginean, Ramona Stroescu, Alexandru Rogobete, Otilia Bizerea-Spiridon, Constantin Ilie
BACKGROUND: The first line of defence against oxidative stress (OS) are the endogenous antioxidants, such as the Se containing compounds. During pregnancy, OS is caused by the intense growth activity of the fetus; therefore, the placenta is a key place for the activity of many seleno-compounds such as glutathione-peroxidase and thioredoxinreductase. METHODS: This review aims to establish the link between the type of selenium compounds, their concentration, their metabolic pathways, and their role in both physiologic and pathologic processes during pregnancy...
October 1, 2018: Clinical Laboratory
Anne S Siegmund, Marlies A M Kampman, Martijn A Oudijk, Barbara J M Mulder, Gertjan Tj Sieswerda, Steven V Koenen, Yoran M Hummel, Monique W M de Laat, Krystyna M Sollie-Szarynska, Henk Groen, Arie P J van Dijk, Dirk J van Veldhuisen, Caterina M Bilardo, Petronella G Pieper
OBJECTIVE: Pregnant women with congenital heart disease (CHD) have an increased chance of abnormal uteroplacental flow (UPF) measured from second trimester onwards. This is related to pregnancy complications affecting mother and baby. Maternal right ventricular (RV) dysfunction has been suggested as predisposing factor. First trimester UPF screening, followed by therapeutic strategies, is effective in preventing pregnancy complications. The study aim was to relate first trimester UPF measurements to pre-pregnancy maternal cardiac function and pregnancy complications...
October 17, 2018: Ultrasound in Obstetrics & Gynecology
X Gong, A Liu, Y Li, H Sun, Y Li, C Li, X Yu, C Fan, Z Shan, W Teng
OBJECTIVES: To explore the effect of isolated maternal hypothyroxinemia (IMH) during the first and second trimester of gestation on pregnancy outcomes. To explore whether levothyroxine (L-T4) treatment of women who had IMH identified in the first trimester improves pregnancy outcomes. METHODS: Women in the early pregnancy in the iodine-sufficient area (n = 3398) were recruited to this prospective cohort study (ChiCTR-TRC-12002326). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were detected...
October 17, 2018: Journal of Endocrinological Investigation
Barbara Luke, Morton B Brown, Ethan Wantman, David B Seifer, Amy T Sparks, Paul C Lin, Kevin J Doody, Bradley J Van Voorhis, Logan G Spector
PURPOSE: To evaluate the risk of prematurity and infant mortality by maternal fertility status, and for in vitro fertilization (IVF) pregnancies, by oocyte source and embryo state combinations. METHODS: Women in 14 States who had IVF-conceived live births during 2004-13 were linked to their infant's birth and death certificates; a 10:1 sample of non-IVF births was selected for comparison; those with an indication of infertility treatment on the birth certificate were categorized as subfertile, all others were categorized as fertile...
October 17, 2018: Journal of Assisted Reproduction and Genetics
Denice S Feig, Rosa Corcoy, Lois E Donovan, Kellie E Murphy, Jon F R Barrett, J Johanna Sanchez, Tim Wysocki, Katrina Ruedy, Craig Kollman, George Tomlinson, Helen R Murphy
OBJECTIVE: To compare glycemic control, quality of life, and pregnancy outcomes of women using insulin pumps and multiple daily injection therapy (MDI) during the Continuous Glucose Monitoring in Type 1 Diabetes Pregnancy Trial (CONCEPTT). RESEARCH DESIGN AND METHODS: This was a prespecified analysis of CONCEPTT involving 248 pregnant women from 31 centers. Randomization was stratified for pump versus MDI and HbA1c . The primary outcome was change in HbA1c from randomization to 34 weeks' gestation...
October 16, 2018: Diabetes Care
Bassam Haddad, Guillaume Lefèvre, Alexandra Rousseau, Thomas Robert, Samir Saheb, Cedric Rafat, Marie Bornes, Camille Petit-Hoang, Frédéric Richard, Edouard Lecarpentier, Vassilis Tsatsaris, Jean Guibourdenche, Anthony Corchia, Eric Rondeau, Tabassome Simon, Alexandre Hertig
OBJECTIVE: Severe preeclampsia may require the delivery of the placenta to avoid life-threatening complications for the mother. Before 26 weeks of gestation, this often results in perinatal death. A decrease in soluble fms-like tyrosine kinase 1 (sFlt1), an anti-angiogenic factor central to the pathophysiology of the maternal syndrome, has been reported after LDL- apheresis. The present study tested whether LDL-apheresis could be used to allow women with early and severe preeclampsia to reach a gestational age where the baby had a viable chance of survival...
September 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
M S Vieira-Rocha, P Rodriguez-Rodriguez, J B Sousa, M C Gonzalez, S M Arribas, A L Lopez de Pablo, C Diniz
Fetal stress increases the susceptibility to cardiovascular diseases in adult age, including hypertension, a process known as fetal programming of hypertension (FPH). This study intends to investigate the interplay between vascular sympathetic nervous system (SNS) and RAS, namely the neuromodulatory role exerted by Angiotensin II (Ang II) receptor AT1 in FPH, and respective contribution for hypertension. METHODS: 6-month old Sprague-Dawley offspring from mothers fed ad-libitum (CONTROL) or with 50% intake during the second half of gestation (maternal undernutrition, MUN) were used...
October 13, 2018: Vascular Pharmacology
Sathish Kumar, Geoffrey H Gordon, David H Abbott, Jay S Mishra
Adequate maternal vascular adaptations and blood supply to the uterus and placenta are crucial for optimal oxygen and nutrient transport to growing fetuses of eutherian mammals, including humans. Multiple factors contribute to hemodynamics and structuring of placental vasculature essential for term pregnancy with minimal complications. In women, failure to achieve or sustain favorable pregnancy progression is, not surprisingly, associated with high incidence of antenatal complications, including preeclampsia, a hypertensive disorder of pregnancy...
October 16, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Eren Soyaltın, Demet Alaygut, Caner Alparslan, Tunç Özdemir, Seçil Arslansoyu- Çamlar, Fatma Mutlubaş, Belde Kasap-Demir, Önder Yavaşcan
Soyaltın E, Alaygut D, Alparslan C, Özdemir T, Arslansoyu-Çamlar S, Mutlubaş F, Kasap-Demir B, Yavaşcan Ö. A rare cause of neonatal hypertension: Congenital mesoblastic nephroma. Turk J Pediatr 2018; 60: 198-200. A rare cause of neonatal hypertension: Congenital Mesoblastic Nephroma (CMN) is a rare renal tumor in childhood and has been reported with palpable abdominal mass, hypertension, hematuria, polyuria and hypercalcemia. Histopathologically it has been classified into two histological types: classic and cellular...
2018: Turkish Journal of Pediatrics
Yamin Liu, Ting-Li Han, Xiaofang Luo, Yuxiang Bai, Xuehai Chen, Wei Peng, Xi Xiong, Philip N Baker, Chao Tong, Hongbo Qi
Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks' gestation and is a leading cause of maternal and neonatal morbidity and mortality. The pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental implantation. However, the exact underlying mechanisms remain unclear. Placental LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT-PCR, and the metabolic profile of trophoblasts overexpressing LncZBTB39-1:2 in vitro was analysed using gas chromatography-mass spectrometry (GC-MS)...
September 2018: Genes & Diseases
Nathalie J Farpour-Lambert, Louisa J Ells, Begoña Martinez de Tejada, Courtney Scott
Background: Maternal obesity, excessive gestational weight gain (GWG) and post-partum weight retention (PPWR) constitute new public health challenges, due to the association with negative short- and long-term maternal and neonatal outcomes. The aim of this evidence review was to identify effective lifestyle interventions to manage weight and improve maternal and infant outcomes during pregnancy and postpartum. Methods: A review of systematic reviews and meta-analyses investigating the effects of lifestyle interventions on GWG or PPWR was conducted (Jan 2009-2018) via electronic searches in the databases Medline, Pubmed, Web of Science and Cochrane Library using all keywords related to obesity/weight gain/loss, pregnancy or postpartum and lifestyle interventions;15 relevant reviews were selected...
2018: Frontiers in Endocrinology
Kelemu Tilahun Kibret, Catherine Chojenta, Ellie Gresham, Teketo K Tegegne, Deborah Loxton
OBJECTIVE: Epidemiological studies have indicated that dietary patterns during pregnancy are associated with adverse pregnancy and birth outcomes such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), preterm birth (PTB) and low birth weight (LBW). However, the results of these studies are varied and inconsistent. The present study aimed to assess the association between dietary patterns and the risk of adverse pregnancy and birth outcomes. DESIGN: Systematic review and meta-analysis...
October 15, 2018: Public Health Nutrition
Narongsak Nakwan, Suksham Jain, Kishore Kumar, Shigeharu Hosono, Majeda Hammoud, Yasser Yahia Elsayed, Shabina Ariff, Babar Hasan, Waqar Khowaja, Poom Woei Bing
OBJECTIVES: To explore the incidence, etiologies, diagnostic methods, treatment options and outcomes in neonates with persistent pulmonary hypertension of the newborn (PPHN) and to identify mortality risk factors in a study from six Asian countries. METHODS: A retrospective chart review of patients with documented PPHN from seven centers in six Asian countries (Japan, Kuwait, India, Pakistan, Singapore, and Thailand) between 1 January, 2014 and 31 December, 2016, was performed...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Ayesha Husain, Aliya Naseem, Sagheera Anjum, Sajida Imran, Muhammad Arifuzzaman, Syed Omair Adil
OBJECTIVE: To determine the relationship between the colour of liquor and the trace of cardiotocography to see whether it is reactive or non-reactive.. METHODS: This cross-sectional study was conducted at Obstetrics and Gynaecology department, Dar-ul-Sehat Hospital, Karachi from June 2015 to March 2016, and comprised women in labour who delivered singleton babies and had >37 weeks of gestation. Intrapartum monitoring by cardiotocography was conducted. The status of the amniotic membranes, colour and amount of liquor observed were recorded...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Amir Aviram, Ms Kristine Giltvedt, Christopher Sherman, John Kingdom, Arthur Zaltz, Jon Barrett, Nir Melamed
INTRODUCTION: In singletons, the pathogenesis of hypertensive disorders of pregnancy (HDP) is attributed to abnormal placentation, characterized by maternal vascular malperfusion (MVM) lesions. Whether MVM plays a similar role in twin pregnancies is unclear. The purpose of the study was to compared placental pathology findings between dichorionic-twin and singleton pregnancies complicated by HDP. METHODS: Retrospective cohort study of women with dichorionic-twin or singleton pregnancies complicated by HDP who gave birth in a single tertiary center between 2001 and 2015...
October 2018: Placenta
Su-A Kim, Jung-Dong Lee, Jeong Bae Park
We evaluated the relationship between blood pressure variability (BPV) and the development of hypertension during pregnancy. A total of 4163 pregnant women with normal blood pressure (BP) before 20 weeks of gestation were included in this study. The visit-to-visit blood pressure variability (VVV) was evaluated using the standard deviation (SD) of the systolic BP taken three times during pregnancy at approximately 10, 20, and 30 weeks of gestation. The VVV gradually decreased during pregnancy in normotensive subjects (SD: 7...
October 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Isaac Gibbs, Katherine Leavey, Samantha J Benton, David Grynspan, Shannon A Bainbridge, Brian J Cox
BACKGROUND: Infants born small-for-gestational-age (SGA) due to pathological placenta-mediated fetal growth restriction (FGR) can be difficult to distinguish from those who are constitutionally small. Additionally, even amongst FGR pregnancies with evident placental pathology, considerable heterogeneity in clinical outcomes and long-term consequences has been observed. Gene expression studies of FGR placentas also have limited consistency in their findings, which is likely due to the presence of different molecular subtypes of pathology...
October 9, 2018: American Journal of Obstetrics and Gynecology
Maria Vollsæter, Thomas Halvorsen, Trond Markestad, Knut Øymar, Per Magne Ueland, Klaus Meyer, Øivind Midttun, Anne-Lise Bjørke-Monsen
BACKGROUND: Preterm birth and low birth weight are associated with reduced nephron numbers and increased risk of hypertension and kidney disease in later life. AIMS: We tested the hypothesis that extremely preterm birth and intrauterine growth restriction is associated with decreased renal function in mid childhood. METHODS: At 11 years of age the following measures were obtained in a regional cohort of children born extremely premature (EP, i...
2018: PloS One
Marie Delnord, Jennifer Zeitlin
Late preterm (34-36 weeks of gestational age (GA)), and early term (37-38 weeks GA) birth rates among singleton live births vary from 3% to 6% and from 15% to 31%, respectively, across countries, although data from low- and middle-income countries are sparse. Countries with high preterm birth rates are more likely to have high early term birth rates; many risk factors are shared, including pregnancy complications (hypertension, diabetes), medical practices (provider-initiated delivery, assisted reproduction), maternal socio-demographic and lifestyle characteristics and environmental factors...
September 18, 2018: Seminars in Fetal & Neonatal Medicine
Luca Marozio, Giulia Chiarle, Claudia Filippini, Stephanie Challancin, Annalisa Tancredi, Elsa Viora, Chiara Benedetto
OBJECTIVE: We evaluated the possible correlation between pulse wave analysis (PWA) parameters measured during the first trimester of pregnancy in normotensive, low-risk women, and the development of hypertensive disorders later in pregnancy. Our hypothesis was that a still asymptomatic increase in arterial stiffness may potentially precede the onset of overt hypertension in pregnancy and that PWA could detect it. METHODS: The study population (n = 1648) was recruited at the time of prenatal screening for chromosomal abnormalities (11-12 weeks of gestation)...
October 10, 2018: Journal of Hypertension
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