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Peyronie’s disease

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https://www.readbyqxmd.com/read/30552059/combined-plaque-incision-buccal-mucosa-grafting-and-additional-tunica-albuginea-plication-for-peyronie-s-disease
#1
Luigi Cormio, Vito Mancini, Paolo Massenio, Nicola d'Altilia, Oscar Selvaggio, Giuseppe Di Fino, Gennaro Selvaggi, Giuseppe Carrieri
INTRODUCTION: Surgery remains the gold standard for treatment in stable patients with penile deformity associated to Peyronie's disease (PD). AIM: To evaluate the long-term results of plaque incision and buccal mucosa grafting (BMG), with or without additional tunica albuginea plication (TAP), in the correction of severe penile curvatures secondary to PD. METHODS: 72 patients with severe curvature caused by PD, normal erections, and stable disease entered this prospective study...
December 11, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/30547361/low-serum-folic-acid-can-be-a-potential-independent-risk-factor-for-erectile-dysfunction-a-prospective-case-control-study
#2
Attia Abd Allah Attia, Mohamed Abd El Mawgood Amer, Mamdouh Hassan, Sameh Fayek GamalEl Din
PURPOSE: The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED. METHODS: Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie's disease, or decompensated systemic illnesses. ED was evaluated by the validated Arabic version of the abbreviated five-item form of the International Index Of Erectile Function and confirmed by penile duplex...
December 13, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30536599/simvastatin-and-the-rho-kinase-inhibitor-y-27632-prevent-myofibroblast-transformation-in-peyronie-s-disease-derived-fibroblasts-via-inhibition-of-yap-taz-nuclear-translocation
#3
U Milenkovic, M M Ilg, C Zuccato, Y Ramazani, D De Ridder, M Albersen
OBJECTIVES: To uncover the anti-myofibroblast (MFB) properties of Rho-kinase inhibitor (compound Y-27632) and simvastatin in an in vitro model of Peyronie's disease (PD). PD is a sexual debilitating disease caused by an irreversible fibrotic plaque in the penile tunica albuginea (TA). Treatment is limited to surgically restoring anatomical shape. Evidence for effective medical treatment is lacking. MATERIAL AND METHODS: Primary human fibroblasts were isolated from surgically obtained TA tissue from PD patients...
December 9, 2018: BJU International
https://www.readbyqxmd.com/read/30505731/what-about-the-partner-factors-associated-with-patient-perceived-partner-dyspareunia-in-men-with-peyronie-s-disease
#4
Yifan Meng, David Y Yang, Kevin M Hebert, Josh B Savage, Manaf Alom, Tobias S Kohler, Landon Trost
Background: Limited data are available on how partners of men with Peyronie's disease (PD) are affected by the disease. We sought to characterize PD patients whose curvatures result in pain for their partners during penetrative intercourse. Methods: We queried a database of all men undergoing initial evaluation for PD at a single clinic between March 2014 and June 2016. Patients were administered a questionnaire regarding sexual health concerns with domains including erectile dysfunction, ejaculatory dysfunction, libido, and penile curvature...
December 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/30503796/review-of-management-options-for-active-phase-peyronie-s-disease
#5
REVIEW
Scott C Brimley, Faysal A Yafi, Jacob Greenberg, Wayne J G Hellstrom, Hoang Minh Tue Nguyen, Georgios Hatzichristodoulou
INTRODUCTION: Peyronie's disease (PD) is a fibrotic disorder that leads to plaque formation in ∼3-9% of adult men. Connective tissue buildup results in plaque formation, penile curvature and shortening, and in some cases, pain. In the active phase of PD, penile pain is a common symptom, often accompanied by progression in curvature. Treatment options for PD include oral drugs, topical cream, intralesional injections, traction, and shock wave therapy. This article reviews the different treatment options for active-phase PD...
November 29, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/30503767/intratunical-injection-of-human-adipose-tissue-derived-stem-cells-restores-collagen-iii-i-ratio-in-a-rat-model-of-chronic-peyronie-s-disease
#6
Fabio Castiglione, Petter Hedlund, Emanuel Weyne, Lukman Hakim, Francesco Montorsi, Trinity J Bivalacqua, Dirk De Ridder, Uros Milenkovic, David Ralph, Giulio Garaffa, Asif Muneer, Steven Joniau, Maarten Albersen
INTRODUCTION: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis. AIM: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD. METHODS: 27 male, 12-week-old rats were divided into 3 equal groups: sham, PD without treatment, and PD treated with hADSCs 1 month after disease induction...
November 29, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/30415815/impact-of-camera-deviation-on-penile-curvature-assessment-using-2d-pictures
#7
Bruno Nascimento, Ivan Cerqueira, Eduardo P Miranda, Jose Bessa, Renato F Ivanovic, Giuliano Guglielmetti, William C Nahas, Miguel Srougi, Giorgio A E Chiesa, Jose Cury
BACKGROUND: An accurate curvature assessment (CA) is required in the decision-making process for patients with Peyronie's disease. In-office CA following induced erection is the gold standard for CA, although penile photography is commonly used due to its convenience. Camera deviations during 2D image acquisition might affect CA accuracy. AIM: To investigate the impact of camera angle deviations on CA. METHODS: 2D pictures were taken from 5 models with a known uniplanar curvature (40°, 45°, 60°, 90°, and 120°)...
November 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30412970/re-a-worldwide-survey-on-peyronie-s-disease-surgical-practice-patterns-among-surgeons
#8
Allen F Morey
No abstract text is available yet for this article.
September 2018: Journal of Urology
https://www.readbyqxmd.com/read/30397330/nonsurgical-management-of-peyronie-s-disease
#9
REVIEW
Peter Tsambarlis, Laurence A Levine
Peyronie's disease is not a rare disorder, and it can be devastating to the affected man. Although the gold-standard treatment of Peyronie's disease is surgery in the stable phase, nonoperative management is preferred by some men and is the only treatment option in the acute phase of the disease, when surgery is contraindicated. No oral or topical therapy has been shown to be efficacious when administered alone, but some evidence supports their use as part of a combination therapy regimen. Intralesional therapies, particularly collagenase clostridium histolyticum (CCH), have shown promise...
November 5, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30370354/superficial-radiation-therapy-in-peyronie-s-disease-an-effective-and-well-tolerated-therapy
#10
Gunilla Pietsch, Tobias Anzeneder, Harald Bruckbauer, Michael Zirbs, Jan Gutermuth, Heidelore Hofmann, Knut Brockow, Tilo Biedermann, Johannes Ring, Bernadette Eberlein
Purpose: This study aimed to assess the safety, efficacy, and patient satisfaction of superficial radiation therapy in the treatment of Peyronie's disease (PD) in a retrospective analysis. Methods and materials: We performed a retrospective analysis of 83 patients who underwent radiation therapy between 1999 and 2008 with 8 fractions of 4 Gy over a period of 6 months. With a mean follow-up time of 52 months, patients responded to a comprehensive questionnaire that covered patient characteristics, disease duration before radiation therapy, course of disease, treatment response, side effects, and patient satisfaction...
October 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/30369422/primary-treatment-of-peyronie-s-disease-a-55-yr-old-male-with-45%C3%A2-dorsal-penile-curvature-and-good-erectile-function
#11
Ranjith Ramasamy
Peyronie's disease is an abnormal curvature of the penis that affects sexual intercourse. The treatment options include injection therapy into the scar or surgical correction of the curvature using plication or grafting.
April 2018: European Urology Focus
https://www.readbyqxmd.com/read/30367131/the-mechanisms-and-potential-of-stem-cell-therapy-for-penile-fibrosis
#12
REVIEW
Uros Milenkovic, Maarten Albersen, Fabio Castiglione
Fibrosis is often caused by chronic tissue injury leading to a persisting inflammatory response with excessive accumulation of extracellular connective tissue proteins. Peyronie's disease, urethral stricture and penile (corpora cavernosa) fibrosis are localized fibrotic disorders of the penile connective tissues that can substantially impair a patient's quality of life. Research over the past few decades has revealed the ability of stem cells to secrete a wide range of paracrine factors, a characteristic that could be exploited therapeutically to prevent and treat several inflammatory and fibrotic diseases...
October 26, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30365247/penile-traction-therapy-with-the-new-device-penimaster-pro-is-effective-and-safe-in-the-stable-phase-of-peyronie-s-disease-a-controlled-multicenter-study
#13
Ignacio Moncada, Pramod Krishnappa, Javier Romero, Josep Torremade, Agustin Fraile, Juan Ignacio Martinez-Salamanca, Hartmut Porst, Lawrence Levine
OBJECTIVES: To evaluate the efficacy and safety of a new penile traction device (PTD) 'Penimaster PRO' in a group of patients with stable Peyronie's disease (PD) compared to a non-intervention group in a multicentre study trial. MATERIAL AND METHODS: 93 patients with chronic stable PD (without ED, no significant pain, and with a unidirectional curvature of at least 45 degrees being stable for more than 3 months) were recruited and followed for a 12-week period. 47 patients were randomly assigned to 'PeniMaster PRO' group (PG) and 46 assigned to the non-intervention group (NIG)...
October 26, 2018: BJU International
https://www.readbyqxmd.com/read/30360333/re-conservatively-managed-peyronie-s-disease-long-term-survey-results-from-patients-undergoing-nonsurgical-and-noninjection-therapies
#14
Allen F Morey
No abstract text is available yet for this article.
November 2018: Journal of Urology
https://www.readbyqxmd.com/read/30360313/re-patient-s-choice-of-health-information-and-treatment-modality-for-peyronie-s-disease-a-long-term-assessment
#15
Allen D Seftel
No abstract text is available yet for this article.
November 2018: Journal of Urology
https://www.readbyqxmd.com/read/30360312/re-plaque-calcification-an-important-predictor-of-collagenase-clostridium-histolyticum-treatment-outcomes-for-men-with-peyronie-s-disease
#16
Allen D Seftel
No abstract text is available yet for this article.
November 2018: Journal of Urology
https://www.readbyqxmd.com/read/30348999/comment-on-long-term-outcome-after-grafting-with-small-intestinal-submucosa-and-collagen-fleece-in-patients-with-peyronie-s-disease-a-matched-pair-analysis
#17
Faysal A Yafi
No abstract text is available yet for this article.
October 22, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30344087/antifibrotic-synergy-between-phosphodiesterase-type-5-inhibitors-and-selective-oestrogen-receptor-modulators-in-peyronie-s-disease-models
#18
Marcus M Ilg, Marta Mateus, William J Stebbeds, Uros Milenkovic, Nim Christopher, Asif Muneer, Maarten Albersen, David J Ralph, Selim Cellek
BACKGROUND: Peyronie's disease (PD) is a fibrotic disorder of the penile tunica albuginea, characterised by the formation of a localised fibrous plaque that can lead to deformity and erectile dysfunction. Nonsurgical therapeutic options for PD are limited in efficacy and safety. Myofibroblasts are key cells in the pathogenesis of PD, and inhibition of myofibroblast transformation has been suggested as a therapeutic option. OBJECTIVE: To identify potential drugs using a novel phenotypic assay and then to test them using in vitro and in vivo models of PD...
October 18, 2018: European Urology
https://www.readbyqxmd.com/read/30342867/beyond-curvature-prevalence-and-characteristics-of-penile-volume-loss-deformities-in-men-with-peyronie-s-disease
#19
Ezra J Margolin, Matthew J Pagano, Carrie M Aisen, Ifeanyi C Onyeji, Peter J Stahl
INTRODUCTION: Non-curvature penile deformities associated with loss of erect penile volume are often overlooked and have not been thoroughly investigated. AIM: To describe the prevalence and functional impact of penile volume-loss deformities in our cohort of men with Peyronie's disease (PD). METHODS: We retrospectively examined medical records of patients with PD consecutively evaluated by a specialized urologist from December 2012 to June 2016...
October 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/30337784/a-novel-technique-for-direct-visualization-of-reservoir-placement-for-penoscrotal-inflatable-penile-prostheses-using-a-single-incision
#20
Joshua D Roth, M Francesca Monn, Thomas M Shelton, Matthew J Mellon
Introduction: We aim to present a modified technique and outcomes of a novel method allowing for direct visualization of the reservoir placement during a penoscrotal inflatable penile prosthesis (IPP). Methods: Out of165 patients who underwent IPP placement from August 2012 to March 2015, 157 underwent a modified technique and comprised the cohort of this study. A Deaver's retractor was placed lateral to the penis and over the pubic bone to allow for direct visualization of the tissues overlying the lower abdomen...
October 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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