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Peyronie’s disease

Nora M Haney, Taylor P Kohn, Paige E Nichols, Wayne Hellstrom
OBJECTIVE: To accurately characterize the effect of penile traction therapy (PTT) on stretched penile length (SPL) after primary treatment for men with PD. MATERIALS AND METHODS: A systematic search was performed for studies that evaluated the correction of PD using penile traction as secondary treatment published through January 2018. Studies were included if 1) a singular primary treatment of PD (injection or surgical treatment) was performed for all included men, 2) if there was a control group with no adjunct traction, and 3) if patients were required to wear the traction device for greater than 2 hours per day...
August 9, 2018: Urology
F Trimarchi, E A Jannini
No abstract text is available yet for this article.
August 9, 2018: Journal of Endocrinological Investigation
A Morgado, M R Morgado, N Tomada
BACKGROUND: Peyronie's Disease (PD) is an acquired connective tissue disorder that often leads to penile curvature (PC) and sexual dysfunction. Penile lengthening procedures (PLP) with four-layered porcine small intestinal submucosa graft (Surgisis® ES; Cook) have been widely used in patients with severe PC when erectile function is preserved. However, complications such as erectile dysfunction (ED) may limit treatment satisfaction. OBJECTIVES: Focusing on patients perspective, our study aims to evaluate longterm patient-reported outcomes, satisfaction, and dissatisfaction predictors after PLP...
August 3, 2018: Andrology
Faysal A Yafi, Linley Diao, Kenneth J DeLay, Ling DeYoung, Riad Talib, Laith Alzweri, Gerald Brock, Wayne J G Hellstrom, Georgios Hatzichristodoulou
OBJECTIVE: To compare in a prospective, non-randomized fashion the outcomes of Collagenase Clostridium Histolyticum (CCH) and surgical interventions (tunical plication [TP] and partial plaque excision and grafting [PEG]) in patients with PD. Intralesional injection of CCH is the only Food and Drug Administration-approved non-surgical intervention for Peyronie's disease (PD). MATERIALS AND METHODS: Between 6/2015 and 1/2017, 57 patients with PD and dorsal, dorsolateral and/or lateral penile curvatures 30-90 degrees were included in this study...
July 27, 2018: Urology
Mohamad Habous, Raanan Tal, Alaa Tealab, Mohammed Aziz, Hammoda Sherif, Saad Mahmoud, Osama Abdelwahab, Mohammed Nassar, Usama Kamil, Ziad Abdelrahman, Saleh Binsaleh, Simone Giona, David Ralph, Carlo Bettocchi, John P Mulhall
INTRODUCTION: Despite the high satisfaction with penile implant (PI) surgery reported in the literature, a significant proportion of patients remain dissatisfied. AIM: To evaluate satisfaction after PI surgery, using a single question and a scoring system. Furthermore, we attempted to define factors that predicted high patient satisfaction. METHODS: The study population consisted of all patients undergoing PI surgery between 2009 and 2015...
August 2018: Journal of Sexual Medicine
Shaan A Setia, Laurence A Levine
Penile traction therapy (PTT) is increasingly being recognized as a viable nonsurgical approach to Peyronie's disease (PD). The goal of this article is to review the current literature on PTT with attention to traction protocols, devices, and outcomes. Areas covered: Literature on the pathophysiology of PD, PTT as primary and adjunctive treatment for PD, perioperative use of PTT, and vacuum erection devices are all reviewed. Pertinent literature was obtained from the PubMed database. The key words 'penile traction,' 'mechanotransduction,' and 'Peyronie's disease' were searched and results were narrowed down based on relevance to the review...
July 26, 2018: Expert Review of Medical Devices
Georgios Hatzichristodoulou
Ventral penile curvature in Peyronie's disease (PD) is not very common but may lead to inability for sexual intercourse, especially in severe cases > 60°. Ventral curvatures are most often addressed surgically with plication owing to fear of urethral complications, as it requires the mobilisation of the urethra. In this study, the ventral sealing technique is introduced for correction of ventral curvatures in patients with PD. The surgical approach includes the mobilisation of the neurovascular bundle and the urethra...
July 5, 2018: International Journal of Impotence Research
Paolo Capogrosso, Francesco Montorsi, Andrea Salonia
The prevalence of sexual dysfunctions has increased over the last decades; despite a number of available treatments for erectile dysfunction (ED), premature ejaculation (PE), and Peyronie's disease (PD), still several unmet therapeutic needs deserve to be fulfilled. The aim of this review is to detail on phase I and II clinical trials investigating novel medical treatments for ED, PE, and PD. Areas covered: We conducted a systematic review of the literature including both published and ongoing phase I and II registered trials focused on medical treatment of ED, PE, and PD during the last 5 years...
July 2018: Expert Opinion on Investigational Drugs
Nora M Haney, Andrew Gabrielson, Taylor P Kohn, Wayne J G Hellstrom
INTRODUCTION: Stem cell therapy using stromal vascular fraction (SVF) is a promising treatment modality. SVF is comprised of a mixture of adipose-derived stem cells, endothelial precursor cells, and immune modulatory cells that act synergistically to facilitate angiogenesis and epithelial cell differentiation. This makes SVF an attractive option for men's sexual disorders that require reconstitution of vasculature and endothelial lining, namely erectile dysfunction (ED) and Peyronie's disease (PD)...
June 27, 2018: Sexual Medicine Reviews
Jared J Wallen, Enrique V Barrera, Liehui Ge, Alexander W Pastuszak, Rafael E Carrion, Paul E Perito, Tariq S Hakky
BACKGROUND: Throughout the last decade there has been a growing interest in the biomechanical differences between inflatable penile prostheses (IPPs) and their significance with regard to the patient experience. AIM: To present our findings assessing the biomechanical properties of IPPs with and without rear tip extenders (RTEs). METHODS: This is a biomechanical study of the 3 most commonly used IPPs (AMS CX, AMS LGX, and Coloplast Titan) as assessed by column compression, modified cantilever deflection, and 3-point bending methods...
July 2018: Journal of Sexual Medicine
Abdel Shakour Abdel Hafez Abdel Wahed, Mohamed Abdel Mawgood Amer, Nagah Mohamed Abou Mohamed, Mohamed Ismael Mobasher, Hassan Mamdouh, Sameh Fayek GamalEl Din, Mohammed Said ElSheemy
PURPOSE: The purpose of the study was to compare serum level of Arginase II in patients with vasculogenic erectile dysfunction (ED) versus healthy controls and to assess if its level is affected by severity of ED. METHODS: This is a prospective study that compared Arginase II in 40 patients with ED versus 40 healthy controls. Patients were excluded if they had any pelvic trauma or pelvic surgery, hormonal disorders, Peyronie's disease, smoking, drug addiction or systemic illnesses...
June 28, 2018: International Urology and Nephrology
Layth Al Attar, Wiliam Kilgore
Acute liver injury is an alarming condition, as it may lead to a devastating outcome. Of the many causes of acute liver injury, review of medications is crucial to identifying the cause of the injury. Some commonly used medications may unpredictably be the underlying cause of liver injury. We present a case of Peyronie's disease treated with potassium para-aminobenzoate that developed acute liver injury. After starting the new treatment, the patient complained of right upper quadrant pain. He was found to have elevated liver enzymes...
May 2018: Case Reports in Gastroenterology
Kevin Wymer, Matthew Ziegelmann, Joshua Savage, Tobias Kohler, Landon Trost
OBJECTIVE: To compare outcomes of men with or without calcified plaques undergoing collagenase clostridium histolyticum (CCH) injections for Peyronie's Disease (PD) and identify predictors of CCH success. MATERIAL AND METHODS: From March 2014 through January 2017, data were prospectively collected on 192 patients who underwent 1-4 cycles of CCH for the treatment of PD. Of these, 115 completed ≥2 CCH cycles and had data on curvature assessment. The primary outcome was the percentage of men with >20% improvement in composite curvature...
June 14, 2018: Urology
Marta Mateus, Marcus M Ilg, William J Stebbeds, Nim Christopher, Asif Muneer, David J Ralph, Selim Cellek
BACKGROUND: Peyronie's disease (PD) is a chronic fibrotic disease of the penis affecting a significant number of men worldwide without effective medical treatments. Myofibroblasts are pivotal in the pathogenesis of PD. Adenosine and adenosine receptors have been suggested to be involved in the pathophysiology of fibrosis. AIM: To understand the role of adenosine receptors in myofibroblast transformation in PD. METHODS: Fibroblasts were isolated from the non-PD tunica albuginea (TA) tissue and PD plaque tissue and were transformed into myofibroblasts using transforming growth factor (TGF)-β1...
July 2018: Journal of Sexual Medicine
Serkan Karakus, Biljana Musicki, Arthur L Burnett
OBJECTIVES: To clarify the molecular basis of penile erection at the human level and distinguish the mechanisms underlying vasculogenic and post-radical prostatectomy (RP) erectile dysfunction (ED) subtypes. PATIENTS AND METHODS: Erectile tissue was obtained from men without history of ED who underwent penile surgery for Peyronie's disease (control group, n = 5) and from men with ED who underwent penile prosthesis implantation (n = 17). ED was categorized into vasculogenic (n = 8) and post-RP (n = 9) subtypes...
June 11, 2018: BJU International
Georgios Hatzichristodoulou
No abstract text is available yet for this article.
June 8, 2018: International Journal of Impotence Research
Tom F Lue, Alan W Shindel
No abstract text is available yet for this article.
May 31, 2018: Journal of Sexual Medicine
Mirko Preto, Giulio Garaffa, Marco Falcone, Paolo Gontero, Luigi Rolle
No abstract text is available yet for this article.
July 2018: Journal of Sexual Medicine
Fawad Aslam, Jonathan A Flug, Yousif Yonan, Shelley S Noland
Polyfibromatosis is a rare disease characterized by fibrosis manifesting in different locations. It is commonly characterized by palmar fibromatosis (Dupuytren's contracture) in variable combinations with plantar fibromatosis (Ledderhose's disease), penile fibromatosis (Peyronie's disease), knuckle pads, and keloids. There are only three reported cases of polyfibromatosis and keloids with erosive arthritis. We report one such case and review the existing literature on this rare syndrome.
2018: Case Reports in Rheumatology
Jinhong Li, Shuzhen Wang, Feng Qin, Mengli Zhu, Xuanhe You, Changjing Wu, Fudong Fu, Jiuhong Yuan
Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea (TA). This study aimed to determine the therapeutic effects of a vacuum erection device (VED) in an animal model of PD and explore the possible mechanisms. Twenty-seven male Sprague-Dawley rats were used. The sham group (group A) (N = 9) received a 50-μl-saline vehicle injection into the TA, while the remaining 18 rats (groups B and C) received a TGF-β1 injection into the TA. The treatment group (group C) underwent VED therapy for 10 days after the TGF-β1 injection...
May 28, 2018: Andrologia
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