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Werner Girsch, Rohit Arora, Eva-Maria Baur, Markus Gabl, Dietmar Hager, Thomas Hintringer, Lars-Peter Kamolz, Rupert Koller, Christian Krasny, Martin Leixnering, Walpurga Lick-Schiffer, Matthias Rab, Ingrid Schlenz, Gottfried Wechselberger, Gerlinde Weigel, Armin Zadra, Robert Zimmermann
Dupuytren's contracture (DC) or Dupuytren's disease (DD) is a progressive fibro-proliferative disease of palmoplantar connective tissue, resulting in characteristic nodal and/or cord formation from collagen disposition. When the disease progresses, the thickening and shortening of the cords eventually leads the affected fingers to being pulled into flexion, which may be associated with marked disability, especially with bilateral disease. DD is relatively common in Europe, with the highest prevalence in Nordic countries...
October 17, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Joshua L Kennedy, Richard C Kurten, Sandra McCullough, Reynold A Panettieri, Cynthia Koziol-White, Stacie M Jones, Katherine Caid, Pritmohinder S Gill, Dean Roberts, Hartmut Jaeschke, Mitchell R McGill, Laura James
INTRODUCTION: Epidemiologic studies have demonstrated an association between acetaminophen (APAP) use and the development of asthma symptoms. However, few studies have examined relationships between APAP-induced signaling pathways associated with the development of asthma symptoms. We tested the hypothesis that acute APAP exposure causes airway hyper-responsiveness (AHR) in human airways. METHODS: Precision cut lung slice (PCLS) airways from humans and mice were used to determine the effects of APAP on airway bronchoconstriction and bronchodilation and to assess APAP metabolism in lungs...
October 17, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
C Peters, A S P van Trotsenburg, N Schoenmakers
Congenital hypothyroidism (CH) may be primary, due to a defect affecting the thyroid gland itself, or central, due to impaired thyroid-stimulating hormone (TSH)-mediated stimulation of the thyroid gland as a result of hypothalamic or pituitary pathology. Primary CH is the most common neonatal endocrine disorder, traditionally subdivided into thyroid dysgenesis (TD), referring to a spectrum of thyroid developmental abnormalities, and dyshormonogenesis, where a defective molecular pathway for thyroid hormonogenesis results in failure of hormone production by a structurally intact gland...
September 24, 2018: European Journal of Endocrinology
Kuo-Tai Yang, Yi-Ling Lin, Yu-Xuen Lin, Sheng-Yao Wang, Yi-Hsieng Samuel Wu, Chung-Hsi Chou, Shih-Guei Fu, Yi-Chen Chen
BACKGROUND: Reactive oxygen species (ROS) overproduction is highly related to some human chronic diseases. There are approximately 400 metric tons of chalazae produced yearly after the processing of the liquid-egg production, which are disposed as waste. The objectives of this study were to look for the optimal production condition of antioxidant crude chalaza hydrolysates and evaluate the in vivo antioxidant capacity via a chronic alcohol-consumption mouse model. RESULTS: Antioxidant crude chalaza hydrolysates (CCH-As) could be produced by protease A at 1:100 ratio (w/w) and 0...
October 16, 2018: Journal of the Science of Food and Agriculture
Aaron Jamison, Paul Cauchi, David F Gilmour
Purpose: The aim of this study was to evaluate the safety and efficacy of photodynamic therapy (PDT) with verteporfin as a treatment for circumscribed choroidal haemangioma (CCH). Procedures: This is a retrospective cohort study of all treatment-naïve patients undergoing PDT with verteporfin for CCH in a single centre between April 1, 2007, and September 30, 2016. Best corrected visual acuity (BCVA; using ETDRS letter score), optical coherence tomography (OCT) measurements and a subjective measurement of visual function were recorded before treatment, at 3-month follow-up and at each annual follow-up...
September 2018: Ocular Oncology and Pathology
Rania Ben Saad, Anis Ben Hsouna, Walid Saibi, Karim Ben Hamed, Faical Brini, Thaura Ghneim-Herrera
Agricultural soil pollution by heavy metals is a severe global ecological problem. We recently showed that overexpression of LmSAP, a member of the stress-associated protein (SAP) gene family isolated from Lobularia maritima, in transgenic tobacco led to enhanced tolerance to abiotic stress. In this study, we characterised the response of LmSAP transgenic tobacco plants to metal stresses (cadmium (Cd), copper (Cu), manganese (Mn), and zinc (Zn)). In L. maritima, LmSAP expression increased after 12 h of treatment with these metals, suggesting its involvement in the plant response to heavy metal stress...
September 29, 2018: Journal of Plant Physiology
Xiao-Li Niu, Xin Jiang, Guo-Dong Xu, Gui-Min Zheng, Zhi-Peng Tang, Nan Yin, Xiu-Qin Li, Yan-Yan Yang, Pei-Yuan Lv
BACKGROUND: DL-3-n-butylphthalide (NBP) has been approved to be effective in improving cognitive deficits. The aim of the current study was to determine whether NBP protects against cognitive deficits in a rat model of vascular dementia (VD) induced by chronic cerebral hypoperfusion (CCH) by regulating the sonic hedgehog (Shh)/patched1 (Ptch1) pathway and endoplasmic reticulum stress (ERS)-related markers. METHODS: Adult male Sprague-Dawley rats were subjected to permanent bilateral occlusion of the common carotid arteries (2VO) to established the model of VD...
October 10, 2018: Journal of Cellular Physiology
Mahima Yadav, Vinita Agrawal, Krushna Chandra Pani, Ritu Verma, Sushila Jaiswal, Anjali Mishra, Rakesh Pandey
Context: C-cell hyperplasia (CCH) is characterized by increased mass of C-cells and has been identified as a precursor condition for medullary thyroid carcinoma (MTC). Varying proportion of MTCs is associated with CCH in different studies. This could be due to the lack of uniformity of the definitions and techniques used to identify CCH in these studies. Aims: This study aims to study the occurrence, clinicopathological, and immunohistochemical features of CCH in MTC diagnosed during a 22-year period at a tertiary care center in North India and to review the available literature on CCH...
October 2018: Indian Journal of Pathology & Microbiology
Yu Izumisawa, Keiko Tanaka-Yamamoto, John Ciriello, Naoki Kitamura, Izumi Shibuya
Characteristics of subfornical organ (SFO) neurons were examined by measuring the cytosolic Ca2+ concentration ([Ca2+]i) in acutely dissociated neurons of the rat. SFO neurons, defined by the responsiveness to 50 mM K+ (n=67) responded to glutamate (86%), angiotensin II (AII) (50%), arginine vasopressin (AVP) (66%) and/or carbachol (CCh) (61%), at their maximal concentrations, with marked increases in [Ca2+]i. More than a half (174/307) of SFO neurons examined exhibited spontaneous Ca2+ oscillations, while the remainder showed a relatively stable baseline under unstimulated conditions...
October 5, 2018: Brain Research
Ling Zhang, Siqi Zhang, Hongdong Song, Bo Li
Osteoporosis is a common skeletal disorder in humans and gelatin hydrolysates from mammals have been reported to improve osteoporosis. In this study, 13-month-old mice were used to evaluate the effects of collagen hydrolysates (CHs) from silver carp skin on osteoporosis. No significant differences were observed in mice body weight, spleen or thymus indices after daily intake of antioxidant collagen hydrolysates (ACH; 200 mg/kg body weight (bw) (LACH), 400 mg/kg bw (MACH), 800 mg/kg bw (HACH)), collagenase hydrolyzed collagen hydrolysates (CCH) or proline (400 mg/kg body weight) for eight weeks, respectively...
October 4, 2018: Nutrients
Changhong Ren, Ning Li, Sijie Li, Rongrong Han, Qingjian Huang, Jiangnan Hu, Kunlin Jin, Xunming Ji
Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and Alzheimer's disease characterized by cognitive impairments. Our previous study demonstrated that limb remote ischemic conditioning (LRIC) improved cerebral perfusion in intracranial arterial stenosis patients. The current study aimed to test whether LRIC promotes angiogenesis and increases phosphorylated endothelial nitric oxide synthase (p-eNOS) activity in CCH rat model...
October 2018: Aging and Disease
Dan Loberman, Shahzad Shaefi, Rephael Mohr, Phillip Dombrowski, Richard B Zelman, Yifan Zheng, Paul A Pirundini, Tomer Ziv-Baran
Symptomatic aortic stenosis remains a surgical disease, with aortic valve replacement resulting in symptom reduction and improvement in survival. For patients who are deemed a higher surgical risk, Transcatheter aortic-valve replacement (TAVR) is a viable, less invasive and increasingly common alternative. The study compares early outcomes in patients treated within one year of the commencement of TAVR program in a community hospital against outcomes of TAVR patients from nationwide reported data (Society of Thoracic Surgeons/ American College of Cardiology TVT registry)...
2018: PloS One
Franck M Leclère, Sabine Kohl, Cédric Varonier, Frank Unglaub, Esther Vögelin
INTRODUCTION: In Switzerland, collagenase Clostridium histolyticum therapy (CCH) for Dupuytren's disease was introduced in 2011. This study analyzes possible differences between CCH and limited fasciectomy (LF) in terms of range of motion, patient satisfaction and postoperative rehabilitation. MATERIALS AND METHODS: This retrospective study included 52 patients with Dupuytren's disease stage 1-3 according to Tubiana, treated with CCH or LF between January 2012 and December 2013...
September 26, 2018: Archives of Orthopaedic and Trauma Surgery
Rafael Sanjuan-Cerveró, Francisco J Carrera-Hueso, Pedro Vazquez-Ferreiro
BACKGROUND: Collagenase clostridium histolyticum is now recognized as a viable treatment for Dupuytren disease. The high rate of adverse effects reported in patients continues to spark debate and raise questions about the true frequency of effects and their associated mechanisms of action. HYPOTHESIS: To investigate whether outcomes of CCH treatment are related to the number of adverse effects experienced. To evaluate short-term clinical outcomes in a series of patients...
October 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Andrea Cocci, Gianmartin Cito, Daniele Urzì, Andrea Minervini, Fabrizio Di Maida, Francesco Sessa, Andrea Mari, Riccardo Campi, Marco Falcone, Marco Capece, Girolamo Morelli, Giovanni Cacciamani, Michele Rizzo, Chiara Polito, Bruno Giammusso, Giuseppe Morgia, Paolo Verze, Andrea Salonia, Tommaso Cai, Vincenzo Mirone, Nicola Mondaini, Giorgio Ivan Russo
INTRODUCTION: The effectiveness of phosphodiesterase type 5 (PDE5) inhibitors over the conservative management of Peyronie's disease (PD) has been widely questioned. AIM: To determine the role of sildenafil 25 mg film formulation twice a day (S25 b.i.d.) in the improvement of curvature after treatment of collagenase of Clostridium hystoliticum (CCH) in penile curvature owing to PD. METHODS: From April 2017 to April 2018, 161 consecutive patients were treated with S25 b...
September 20, 2018: Journal of Sexual Medicine
J Kaminetsky, M Gittelman, G J Kaufman, T M Smith, G H Jordan
Intralesional injection of collagenase clostridium histolyticum (CCH) improves Peyronie's disease (PD) symptoms; however, patient perspectives regarding PD and CCH treatment have not been fully elucidated. This cross-sectional qualitative study included heterosexual men with PD who received ≥1 injection of study medication and had ≥1 posttreatment Peyronie's Disease Questionnaire (PDQ) assessment during a prior phase 2b clinical trial. These patients were "responders" if they reported (as part of the Global Assessment of the PDQ) that overall symptoms and effects of PD had at least "improved in a small but important way" after CCH therapy...
September 20, 2018: International Journal of Impotence Research
Giorgio Ivan Russo, Uros Milenkovic, Wayne Hellstrom, Laurence A Levine, David Ralph, Maarten Albersen
CONTEXT: Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain. OBJECTIVE: To summarise the available evidence regarding injection and mechanical therapies for PD treatment. EVIDENCE ACQUISITION: An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up to 15 May 2018...
September 17, 2018: European Urology
Can Altınelataman, Olga Koroleva, Tatyana Fedorova, Anna Torkova, Ksenia Lisitskaya, Mikhail Tsentalovich, Aleksey Kononikhin, Igor Popov, Daria Vasina, Leonid Kovalyov, Ufuk Çelik
European seabass (Dicentrarchus labrax, Linnaeus, 1758) (L) and gilthead seabream (Sparus aurata, Linnaeus, 1758) (C) muscles were hydrolysated by Alcalase (Lalc , Calc ) and Chymotrypsin (Lch , Cch ) then hydrolysates were examined and their peptide profiles obtained. A total of 765, 794, 132 and 232 peptides were identified in Calc , Lalc , Cch and Lch , respectively. Although, Lch and Cch were expected to have more antioxidant capacity because of their peptide profiles, Alcalase hydrolysates observed in vitro, were slightly higher (TEAC assay for Calc : 848...
January 15, 2019: Food Chemistry
Qing-Guang Wang, Xiao Xue, Yang Yang, Peng-Yu Gong, Teng Jiang, Ying-Dong Zhang
INTRODUCTION: This study aimed to evaluate the influence of central angiotensin IV (Ang IV) infusion on chronic cerebral hypoperfusion (CCH)-related neuropathological changes including amyloid-β (Aβ), hyperphosphorylated tau (p-tau) and the inflammatory response. MATERIALS AND METHODS: Rats with CCH received central infusion of Ang IV, its receptor AT4 R antagonist divalinal-Ang IV or artificial cerebrospinal fluid for six weeks. During this procedure, the systolic blood pressure (SBP) was monitored, and the levels of Aβ42 , p-tau and pro-inflammatory cytokines in the brain were detected...
July 2018: Journal of the Renin-angiotensin-aldosterone System: JRAAS
Adam R Ford, Caitlin M Gibbons, Josefina Torres, Heather A Kornmehl, Sanminder Singh, Paulina M Young, Cindy J Chambers, Emanual Maverakis, Cory A Dunnick, April W Armstrong
BACKGROUND: Many patients with chronic skin diseases lack regular access to dermatologists in the United States and suffer poor clinical outcomes. INTRODUCTION: We performed a 12-month randomized controlled trial to evaluate the impact of an online, collaborative connected health (CCH) model for psoriasis management on access to specialty care. MATERIALS AND METHODS: The 300 enrolled patients were randomized to online or in-person care. We compared distance traveled as well as transportation and in-office waiting time between the two groups and obtained patient and provider perspectives on CCH...
September 14, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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