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Fernando Seijo-Fernandez, Antonio Saiz, Elena Santamarta, Lydia Nader, Marco Antonio Alvarez-Vega, Beatriz Lozano, Elisa Seijo, Juan A Barcia
BACKGROUND: Deep brain stimulation (DBS) and the proper target for chronic cluster headache (CCH) are still subjects of controversy. OBJECTIVES: We present our long-term results of analysis of the target and its structural connectivity. METHODS: Fifteen patients with drug-resistant CCH underwent DBS in coordinates 4 mm lateral to the III ventricular wall and 2 mm behind and 5 mm below the intercommissural point. The clinical parameters recorded were the number of weekly attacks, pain intensity, and duration of the headache...
July 31, 2018: Stereotactic and Functional Neurosurgery
Faysal A Yafi, Linley Diao, Kenneth J DeLay, Ling DeYoung, Riad Talib, Laith Alzweri, Gerald Brock, Wayne J G Hellstrom, Georgios Hatzichristodoulou
OBJECTIVE: To compare in a prospective, non-randomized fashion the outcomes of Collagenase Clostridium Histolyticum (CCH) and surgical interventions (tunical plication [TP] and partial plaque excision and grafting [PEG]) in patients with PD. Intralesional injection of CCH is the only Food and Drug Administration-approved non-surgical intervention for Peyronie's disease (PD). MATERIALS AND METHODS: Between 6/2015 and 1/2017, 57 patients with PD and dorsal, dorsolateral and/or lateral penile curvatures 30-90 degrees were included in this study...
July 27, 2018: Urology
Gary M Pess, Maj Sundbom, Koo Wilson, Daniel Lindqvist, Lars B Dahlin
This post hoc analysis from a multicenter study (NCT01674634) was designed to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) treatment in patients with different stages of Dupuytren contracture. Previously untreated patients who received two concurrent injections of CCH in two affected joints in the same finger were assessed by disease severity (Tubiana stage). The mean (SD) improvement in total fixed flexion contraction (FFC) 31 days post-CCH treatment in 181 patients was: 71.1 (36.5)% for Tubiana I, 77...
July 24, 2018: Journal of Plastic Surgery and Hand Surgery
Marie A Badalamente, Lawrence C Hurst
Proof-of-principle, basic-science studies, using a rat-tail tendon model and surgically removed Dupuytren cords, began collagenase Clostridium histolyticum (CCH) development. Clinical studies in humans were then conducted, where the primary endpoint was reduction in contracture to within 0° to 5° of extension. Phase 2 studies, which confirmed the optimal dose of collagenase as 0.58 mg, showed injectable CCH reduced contractures in MP and PIP joints to within 0° to 5° in many joints and was well tolerated...
August 2018: Hand Clinics
Yu Kakimoto, Masayuki Tanaka, Hideki Hayashi, Keiko Yokoyama, Motoki Osawa
Background: Cardiac hypertrophy is a well-known risk factor for heart failure and sudden cardiac death (SCD). On the other hand, physiological cardiac hypertrophy is often observed in young healthy men, and it is difficult to predict SCD in cardiac hypertrophy subjects who do not show symptoms of heart failure. MicroRNAs (miRNAs) widely regulate biological activity and play pivotal roles in heart failure progression. In this study, we investigated whether miRNA expression is altered in SCD with cardiac hypertrophy (SCH)...
June 2018: Heliyon
Ban Wang, Yuri Murakami, Maiki Ono, Saki Fujikawa, Hayato Matsuyama, Toshihiro Unno, Kiyotada Naitou, Yasuyuki Tanahashi
ATP-sensitive K+ (KATP ) channels are expressed in gastrointestinal smooth muscles, and their activity is regulated by muscarinic receptor stimulation. However, the physiological significance and mechanisms of muscarinic regulation of KATP channels are not fully understood. We examined the effects of the KATP channel opener cromakalim and the KATP channel blocker glibenclamide on electrical activity of single mouse ileal myocytes and on mechanical activity in ileal segment preparations. To explore muscarinic regulation of KATP channel activity and its underlying mechanisms, the effect of carbachol (CCh) on cromakalim-induced KATP channel currents (IKATP ) was studied in myocytes of M2 or M3 receptor-knockout (KO) and wild-type (WT) mice...
July 12, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Bin Liu, Shumin Li
As one of the most challenging tasks in sequence analysis, protein remote homology detection has been extensively studied. Methods based on discriminative models and ranking approaches have achieved the state-of-the-art performance, and these two kinds of methods are complementary. In this study, three LSTM models have been applied to construct the predictors for protein remote homology detection, including ULSTM, BLSTM, and CNN-BLSTM. They are able to automatically extract the local and global sequence order information...
January 5, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Ibrahim Inan Harbiyeli, Elif Erdem, Seyda Erdogan, Yurdun Kuyucu, Sait Polat, Meltem Yagmur
PURPOSE: To investigate changes in conjunctival tissue of conjunctivochalasis (CCh) patients and to determine the relationship between pathological findings and localization of loose conjunctiva. METHODS: Our study included nineteen eyes of 19 patients who were referred to Cukurova University Ophthalmology Department based on ocular surface symptoms and CCh detected in ocular examination. Amniotic membrane was applied after conjunctival excision as surgical treatment...
July 10, 2018: International Ophthalmology
YoungJae Song, Francisco Sepulveda
Electromyography artifacts are a well-known problem in electroencephalography studies [brain-computer interfaces (BCIs), brain mapping, and clinical areas]. Blind source separation (BSS) techniques are commonly used to handle artifacts. However, these may remove not only the EMG artifacts but also some useful electroencephalography (EEG) sources. To reduce this useful information loss, we propose a new technique for statistically selecting EEG channels that are contaminated with class-dependent EMG (henceforth called EMG-CCh)...
July 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Yuanli Guo, Peiyan Yang, Liu Liu
BACKGROUND Several hyaluronan preparations are available that have different dosage forms, origins, and concentrations. The objective of the study was to compare the efficacy of intra-articular chemically cross-linked hyaluronan (CCH) and avian-derived hyaluronan (ADH) injections in knee osteoarthritis (KOA) patients. MATERIAL AND METHODS In total, 258 patients were randomized into 2 groups of 129 each: patients who received CCH injection (CCH group) and patients who received ADH injection (ADH group). Radiographic Kellgren-Lawrence score, visual analog scale (VAS) pain score, Lequesne index score, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, single-limb stance (SLS) test, and timed "Up-and-Go" (TUG) test were performed...
July 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jing-Yun Gan, Qing-Song Li, Huan-Ming Zhou, Wei Zhang, Ling-Zhi Lian, Zhang Yu, Zhen-Yong Zhang
AIM: To explore a feasible method on the establishment of an animal model of conjunctivochalasis (CCH). METHODS: Twelve clean-grade New Zealand white rabbits were divided into four groups ( n =3/group): the control group (one received no interventions, and the others underwent subconjunctival injection of sterile water), the matrix metalloproteinases (MMPs) group (administered subconjunctival injection of MMP-3), the aging group (administered subcutaneous injection of D-galactose), the tumor necrosis factor-α (TNF-α) solution group (administered eye drops of TNF-α)...
2018: International Journal of Ophthalmology
Joakim Strömberg, Allan Ibsen Sörensen, Jan Fridén
BACKGROUND: Local disruption of the cord that causes contracture of the finger in Dupuytren disease can be achieved either through mechanical division by percutaneous needle fasciotomy (PNF) or through enzymatic digestion by injectable collagenase Clostridium histolyticum (CCH). This study was designed to compare clinical and patient-reported outcomes between patients who had been treated with each method. METHODS: A prospective, randomized, single-blinded, controlled trial was designed and included 156 patients with a contracture of the metacarpophalangeal (MCP) joint of ≥20°...
July 5, 2018: Journal of Bone and Joint Surgery. American Volume
Shao-Hua Su, Yi-Fang Wu, Da-Peng Wang, Jian Hai
URB597 (URB) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuronal death. The present study investigated the protective effects of URB on autopahgy and mitophagy in a CCH model as well as the underlying mechanisms. The ultrastructural changes were examined by electron microscopy. The mitochondrial membrane potential was assessed by immunofluorescence. The expressions of autophagy-related proteins (beclin-1, p62, and LC3), lysosome-related proteins (CTSD and LAMP1), and mitophagy-related proteins (BNIP3, cyt C and parkin) were evaluated by western blotting, and the interaction of beclin-1 and Bcl-2 were determined by immunoprecipitation...
June 28, 2018: Cell Death & Disease
Amanda Santiago, Lígia Mendes Soares, Melissa Schepers, Humberto Milani, Tim Vanmierlo, Jos Prickaerts, Rúbia M Weffort de Oliveira
Chronic cerebral hypoperfusion (CCH) has been associated with aging-related vascular dementia, including Alzheimer's disease. It can be induced by the four-vessel occlusion/internal carotid artery (4VO/ICA) model in aged rats, resulting in persistent memory deficits, white matter injury, and significant neuronal loss in the hippocampus and cerebral cortex. The phosphodiesterase type 4 inhibitor (PDE4-I) roflumilast has been reported to have pro-cognitive effects in several behavioral paradigms. The present study evaluated the effects of repeated roflumilast treatment in aged rats that were subjected to CCH...
August 2018: Neuropharmacology
Baoguo He, Zhiqiang Qu, Zibin Tian, Kun Zhao, Liangzhou Wei, Li Ma
Although 7,8-dihydroxyflavone (7,8-DHF), a synthetic agonist specific for tyrosine kinase receptor B (TrkB), has been reported to promote intestinal dynamics, its effect on gastric dynamics has not been studied as yet. In this study, we explored how 7,8-DHF affected the carbachol (CCh)-induced contraction of rat gastric muscle by way of measuring the contractile tension of muscular strips. We found that although 7,8-DHF did not directly cause contraction of gastric muscle, it enhanced CCh-induced, instead of substance P- or high K+ -induced, contraction...
June 21, 2018: Clinical and Experimental Pharmacology & Physiology
Xianfang Jiang, Junting Liu, Qin Liu, Zhenhui Lu, Li Zheng, Jinmin Zhao, Xingdong Zhang
Correction for 'Therapy for cartilage defects: functional ectopic cartilage constructed by cartilage-simulating collagen, chondroitin sulfate and hyaluronic acid (CCH) hybrid hydrogel with allogeneic chondrocytes' by Xianfang Jiang et al., Biomater. Sci., 2018, 6, 1616-1626.
June 21, 2018: Biomaterials Science
Lasse Skibsbye, Anne K Bengaard, A M Uldum-Nielsen, Kim Boddum, Torsten Christ, Thomas Jespersen
Sympathetic and vagal activation is linked to atrial arrhythmogenesis. Here we investigated the small conductance Ca2+ -activated K+ (SK)-channel pore-blocker N -(pyridin-2-yl)-4-(pyridine-2-yl)thiazol-2-amine (ICA) on action potential (AP) and atrial fibrillation (AF) parameters in isolated rat atria during β-adrenergic [isoprenaline (ISO)] and muscarinic M2 [carbachol (CCh)] activation. Furthermore, antiarrhythmic efficacy of ICA was benchmarked toward the class-IC antiarrhythmic drug flecainide (Fleca)...
2018: Frontiers in Physiology
Ye Peng, Kai-Yuan Li, Yu-Fei Chen, Xiao-Jie Li, Shu Zhu, Zheng-Yu Zhang, Xiao Wang, Li-Na Duan, Zhuo-Jing Luo, Jun-Jie Du, Jian-Chang Wang
Longitudinally oriented microstructures are essential for a nerve scaffold to promote the significant regeneration of injured peripheral axons across nerve gaps. In the current study, we present a novel nerve-guiding collagen-chitosan (CCH) scaffold that facilitated the repair of 30 mm-long sciatic nerve defects in beagles. The CCH scaffolds were observed with a scanning electron microscope. Eighteen beagles were equally divided into CCH group, autograft group and non-graft group. The posture and gait of each dog was recorded at 12 and 24 weeks after surgery...
March 22, 2018: Injury
Thenmoly Damodaran, Byorn Wei Liang Tan, Ping Liao, Surash Ramanathan, Gin Keat Lim, Zurina Hassan
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea L. (CT), commonly known as Butterfly pea, is used in Indian Ayurvedic medicine to promote brain function and treat mental disorders. Root of CT has been proven to enhance memory, but its role in an animal model of chronic cerebral hypoperfusion (CCH), which has been considered as a major cause of brain disorders, has yet to be explored. AIM OF THE STUDY: To assess the motor and cognitive effects of acute oral administration of CT root methanolic extract and hippocampal long-term plasticity in the CA1 region of the CCH rat model...
June 18, 2018: Journal of Ethnopharmacology
Christian Lampl, Mirjam Rudolph, Elisabeth Bräutigam
BACKGROUND: Cluster headache (CH) is a clinically well-defined primary headache disorder, approximately 20% of cluster headache sufferers experience recurrent attacks without periods of significant remission. For the treatment of chronic cluster headache (CCH) only limited therapeutic options are available. METHODS: A potential refractory CCH patient group was identified according to the clinical definition of rCCH based on the consensus statement of the European Headache Federation (EHF)...
June 19, 2018: Journal of Headache and Pain
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