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https://www.readbyqxmd.com/read/30511683/association-of-persistent-minimal-residual-disease-with-poor-outcomes-of-patients-with-acute-myeloid-leukemia-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#1
Jing Liu, Xiao-Su Zhao, Yan-Rong Liu, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Wei Han, Yu-Qian Sun, Chen-Hua Yan, Fei-Fei Tang, Xiao-Dong Mo, Kai-Yan Liu, Qiao-Zhen Fan, Xiao-Jun Huang, Ying-Jun Chang
Background: Several studies have shown that detection of minimal residual disease (MRD) in acute myeloid leukemia (AML) is an independent prognostic factor. This study aimed to evaluate the significance of dynamic MRD pretransplantation on outcome of AML patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: We retrospectively analyzed 145 consecutive AML patients undergoing allo-HSCT in complete remission status between June 2013 and June 2016...
December 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/30504341/balancing-exercise-risk-and-benefits-lessons-learned-from-sickle-cell-trait-and-sickle-cell-anemia
#2
REVIEW
Robert I Liem
Development of exercise guidelines for individuals with sickle cell trait (SCT) and sickle cell anemia (SCA) is hampered by the need to weigh the benefits against risks of exercise in these populations. In SCT, concern for exercise collapse associated with sickle cell trait has resulted in controversial screening of student athletes for SCT. In SCA, there exists unsubstantiated concerns that high-intensity exercise may result in pain and other complications. In both, finding the "right dose" of exercise remains a challenge for patients and their providers...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30499895/stem-cells-and-platelet-rich-plasma-for-knee-osteoarthritis-prevalence-and-cost-in-south-florida
#3
Jose C Alcerro, Carlos J Lavernia
INTRODUCTION: The use of stem cell therapy (SCT) and platelet-rich plasma (PRP) injection for knee osteoarthritis (OA) is extremely controversial and at best experimental stage. These treatments are being offered across the nation for "cash-only payments." Our objectives were to determine (1) what proportion of board-certified orthopedic surgeons in Miami-Dade County offer SCT or PRP and (2) how much do practices charge for these services. METHODS: All board-certified orthopedic surgeons' offices in Miami-Dade County were identified by their American Academy of Orthopaedic Surgeons active membership...
November 28, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/30481598/a-4-or-5-deauville-score-assessed-by-18-f-fdg-pet-ct-early-post-allotransplant-is-highly-predictive-of-relapse-in-lymphoma-patients
#4
L Bouard, C Bodet-Milin, C Bailly, T Guillaume, P Peterlin, A Garnier, A Le Bourgeois, B Mahé, V Dubruille, N Blin, C Touzeau, T Gastinne, A Lok, A Bonnet, Marie C Béné, S Le Gouill, P Moreau, F Kraeber-Bodéré, P Chevallier
The impact of early Fluorine-18 Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET-CT) status on survival after allogeneic transplantation for lymphoma is poorly reported.This retrospective study included all adult Hodgkin (HL) or non-Hodgkin (NHL) lymphoma patients (>18 years old) who benefited from FDG PET-CT before (within 1 month) and/or early (+3 months and within +6-9 months) after Allo-SCT in our institution between 2005 and 2015 and who were still without documented progression nor relapse at the time of the FDG PET-CT...
November 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30481595/fluoroquinolone-prophylaxis-is-highly-effective-for-the-prevention-of-central-line-associated-bloodstream-infections-in-autologous-stem-cell-transplant-patients
#5
Matthew Ziegler, Daniel Landsburg, David Pegues, Warren Bilker, Cheryl Gilmar, Colleen Kucharczuk, Theresa Gorman, Kristen Bink, Amy Moore, Rebecca Fitzpatrick, Edward A Stadtmauer, Patricia Mangan, Kelly Kraus, Jennifer H Han
OBJECTIVES: Patients undergoing stem cell transplant (SCT) for the treatment of hematologic malignancy are at increased risk for central line-associated bloodstream infections (CLABSIs). The use of prophylactic antibiotics to prevent CLABSIs in the setting of autologous SCT is of unclear benefit. We aimed to evaluate the impact of levofloxacin prophylaxis on reducing CLABSIs in this high-risk population. METHODS: Patients undergoing autologous SCT at a tertiary-care hospital received levofloxacin prophylaxis from January 13, 2016 to January 12, 2017...
November 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30454873/allogeneic-stem-cell-transplantation-after-fanconi-anemia-conditioning-in-children-with-ataxia-telangiectasia-results-in-stable-t-cell-engraftment-and-lack-of-infections-despite-mixed-chimerism
#6
Marek Ussowicz, Elżbieta Wawrzyniak-Dzierżek, Monika Mielcarek-Siedziuk, Małgorzata Salamonowicz, Jowita Frączkiewicz, Blanka Rybka, Renata Ryczan-Krawczyk, Krzysztof Kałwak
Ataxia-telangiectasia (A-T) syndrome is an autosomal recessive chromosomal breakage syndrome caused by mutation of the ataxia-telangiectasia mutated gene manifested by progressive neurodegeneration, telangiectasias of sclera and skin, immune deficiency with sinopulmonary infections, and increased incidence of lymphoid malignancies and solid tumors. Three children with A-T underwent allogeneic stem cell transplantation (SCT) using protocols for Fanconi anemia. All 3 patients were engrafted with a mixed donor-recipient chimerism, but the full donor engraftment was observed in the T lymphocyte compartment...
November 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30450652/comparison-of-filgrastim-pegfilgrastim-and-lipegfilgrastim-added-to-chemotherapy-for-mobilization-of-cd34-cells-in-non-hodgkin-lymphoma-patients
#7
A Partanen, J Valtola, A Ropponen, H Kuitunen, O Kuittinen, K Vasala, L Ågren, K Penttilä, L Keskinen, M Pyörälä, T Nousiainen, T Selander, P Mäntymaa, J Pelkonen, V Varmavuo, E Jantunen
BACKGROUND: Data are limited on the long-acting granulocyte-colony stimulating factors (G-CSFs) pegfilgrastim (PEG) and lipegfilgrastim (LIPEG) compared with filgrastim (FIL) regarding the mobilization efficiency of CD34+ cells, graft cellular composition, and engraftment. STUDY DESIGN AND METHODS: In this prospective nonrandomized study, 36 patients with non-Hodgkin lymphoma received FIL, 67 received PEG, and 16 patients received LIPEG as a cytokine after chemotherapy...
November 19, 2018: Transfusion
https://www.readbyqxmd.com/read/30450212/storage-related-haematological-and-biochemical-changes-in-plasmodium-falciparum-infected-and-sickle-cell-trait-donor-blood
#8
Enoch Aninagyei, Emmanuel Tetteh Doku, Patrick Adu, Alexander Egyir-Yawson, Desmond Omane Acheampong
Background: In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties of SCT and asymptomatic malaria in donor blood have not been evaluated. This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units. Methods: Fifty-milliliters of sterile CPDA-1 anti-coagulated blood were drained into the sample pouch attached to the main blood bag...
2018: BMC Hematology
https://www.readbyqxmd.com/read/30408564/family-mismatched-allogeneic-stem-cell-transplantation-for-myelofibrosis-report-from-the-chronic-malignancies-working-party-of-european-society-for-blood-and-marrow-transplantation
#9
Kavita Raj, Diderik-Jan Eikema, Donal P McLornan, Eduardo Olavarria, Henric-Jan Blok, Stefania Bregante, Fabio Ciceri, Jakob Passweg, Per Ljungman, Nicolaas Schaap, Kristina Carlson, Tsila Zuckerman, Liesbeth C de Wreede, Liisa Volin, Yener Koc, J Diez-Martin, Peter Brossart, Dominik Wolf, Didier Blaise, Paolo Di Bartolomeo, Antonin Vitek, Marie Robin, I Yakoub-Agha, Yves Chalandon, Nicolaus Kroger
This analysis included 56 myelofibrosis (MF) patients transplanted from family mismatched donor between 2009 and 2015 enrolled in the European Society for Blood and Marrow Transplantation database. The median age was 57 years (range, 38 to 72); 75% had primary MF and 25% had secondary MF. JAK2 V617F was mutated in 61%. Donors were HLA mismatched at 2 or more loci. Stem cells were sourced from bone marrow in 66% and peripheral blood in 34%. The median CD34+ cell dose was 4.8 × 106 /kg (range, 1.7 to 22...
November 5, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30407701/reassessment-of-clinical-implication-of-pretransplant-surgical-procedures-for-pulmonary-invasive-fungal-lesions
#10
Naoki Shingai, Satoshi Kaito, Yuta Yamada, Tatsuya Konishi, Akihito Nagata, Shuhei Kurosawa, Kyoko Watakabe-Inamoto, Aiko Igarashi, Yuho Najima, Hideharu Muto, Takeshi Kobayashi, Noriko Doki, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
Dealing with the recent series of allogeneic hematopoietic stem cell transplantation (allo-SCT) performed this decade, we reassessed the clinical impact of pretransplant surgical procedures (SP) for pulmonary lesions of invasive fungal disease (IFD) on subsequent transplant outcome. We focused on the clinical outcomes of seven patients with pulmonary IFD who underwent segmentectomy (n = 4), lobectomy (n = 2) or abscess incision with drainage only (n = 1), and compared results to those of 21 patients carrying pulmonary IFD who never underwent invasive SP before allo-SCT...
November 8, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30397424/efficacy-and-safety-of-autologous-stem-cell-transplantation-for-decompensated-liver-cirrhosis-a-retrospective-cohort-study
#11
Ming-Fang Wang, You-Bing Li, Xiao-Juan Gao, Hao-Yang Zhang, Su Lin, Yue-Yong Zhu
AIM: To evaluate the long-term efficacy and safety of autologous stem cell transplantation (SCT) for decompensated liver cirrhosis. METHODS: Consecutive patients with decompensated liver cirrhosis were included and assigned into the SCT group and non-transplantation (non-SCT) group according to whether they received SCT treatment. Patients were followed up for ten years. The long-term survival rate and incidence of hepatocellular carcinoma (HCC) were compared between groups...
October 26, 2018: World Journal of Stem Cells
https://www.readbyqxmd.com/read/30386260/yi-nao-jie-yu-prescription-exerts-a-positive-effect-on-neurogenesis-by-regulating-notch-signals-in-the-hippocampus-of-post-stroke-depression-rats
#12
Huiling Tian, Xiaoli Li, Qisheng Tang, Wen Zhang, Qingmeng Li, Xinyue Sun, Ruizhen Zhao, Chongyang Ma, Haipeng Liu, Yushan Gao, Fei Han
Post-stroke depression (PSD) is one of the most frequent complications of stroke. The Yi-nao-jie-yu prescription (YNJYP) is an herbal prescription widely used as a therapeutic agent against PSD in traditional Chinese medicine. Disruption of adult neurogenesis has attracted attention as a potential cause of cognitive pathophysiology in neurological and psychiatric disorders. The Notch signaling pathway plays an important role in neurogenesis. This study investigated the effects of YNJYP on adult neurogenesis and explored its underlying molecular mechanism in a rat model of PSD that is established by middle cerebral artery occlusion and accompanied by chronic immobilization stress for 1 week...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30383109/clinical-outcomes-associated-with-sickle-cell-trait-a-systematic-review
#13
Rakhi P Naik, Kim Smith-Whitley, Kathryn L Hassell, Nkeiruka I Umeh, Mariane de Montalembert, Puneet Sahota, Carlton Haywood, Jean Jenkins, Michele A Lloyd-Puryear, Clinton H Joiner, Vence L Bonham, Gregory J Kato
Background: Although sickle cell trait (SCT) is largely a benign carrier state, it may increase risk for certain clinical outcomes. Purpose: To evaluate associations between SCT and clinical outcomes in children and adults. Data Sources: English-language searches of PubMed, CINAHL, the Cochrane Library, Current Contents Connect, Scopus, and Embase (1 January 1970 to 30 June 2018) and bibliographies of review articles. Study Selection: Observational controlled studies (published in English) in children or adults that examined an association between SCT and any of 24 clinical outcomes specified a priori in the following 6 categories: exertion-related injury; renal, vascular, pediatric, and surgery- or trauma-related outcomes; and overall mortality...
October 30, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30382485/cost-effectiveness-of-midostaurin-in-the-treatment-of-newly-diagnosed-flt3-mutated-acute-myeloid-leukemia-in-the-united-states
#14
Eytan Stein, Jipan Xie, Emilie Duchesneau, Subrata Bhattacharyya, Umakanth Vudumula, Briana Ndife, Gaetano Bonifacio, Annie Guerin, Nanxin Li, George Joseph
OBJECTIVES: The aim of this study was to assess the cost effectiveness of midostaurin + cytarabine + daunorubicin (midostaurin arm) versus placebo + cytarabine + daunorubicin (placebo arm) in the treatment of adult patients with newly diagnosed FLT3-mutated acute myeloid leukemia (AML) who are eligible for standard cytarabine + daunorubicin chemotherapy, from a US third-party payer perspective. METHODS: A lifetime partitioned survival model with four health states (active disease, complete remission [CR], relapse, and death) was constructed...
November 1, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/30355574/-salmonella-exploits-hla-b27-and-host-unfolded-protein-responses-to-promote-intracellular-replication
#15
Antony Nicodemus Antoniou, Izabela Lenart, Janos Kriston-Vizi, Takao Iwawaki, Mark Turmaine, Kirsty McHugh, Sadfer Ali, Neil Blake, Paul Bowness, Mona Bajaj-Elliott, Keith Gould, Darren Nesbeth, Simon J Powis
OBJECTIVE: Salmonella enterica infections can lead to Reactive Arthritis (ReA), which can exhibit an association with human leucocyte antigen (HLA)-B*27:05, a molecule prone to misfolding and initiation of the unfolded protein response (UPR). This study examined how HLA-B*27:05 expression and the UPR affect the Salmonella life-cycle within epithelial cells. METHODS: Isogenic epithelial cell lines expressing two copies of either HLA-B*27:05 and a control HLA-B*35:01 heavy chain (HC) were generated to determine the effect on the Salmonella infection life-cycle...
October 24, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30351488/brentuximab-vedotin-for-recurrent-hodgkin-lymphoma-after-allogeneic-hematopoietic-stem-cell-transplantation-a-report-from-the-ebmt-lymphoma-working-party
#16
Ali Bazarbachi, Ariane Boumendil, Hervé Finel, Mohamad Mohty, Luca Castagna, Didier Blaise, Karl S Peggs, Boris Afanasyev, J L Diez-Martin, Paolo Corradini, David Michonneau, Stephen Robinson, Gonzalo Gutiérrez García, Francesca Bonifazi, Ibrahim Yakoub-Agha, Zafer Gülbas, Adrian Bloor, Jeremy Delage, Albert Esquirol, Ram Malladi, Christof Scheid, Jean El-Cheikh, Hervé Ghesquières, Silvia Montoto, Peter Dreger, Anna Sureda
BACKGROUND: The treatment of patients with Hodgkin lymphoma (HL) who develop disease progression after undergoing allogeneic stem cell transplantation (allo-SCT) remains challenging. METHODS: The authors assessed outcomes in 184 adult patients with HL who developed disease recurrence or progression after a matched related or unrelated allo-SCT at European Society for Blood and Marrow Transplantation-participating centers between 2010 and 2014. RESULTS: Eighty patients who received brentuximab vedotin (BV) salvage therapy were compared with 104 patients who did not...
October 23, 2018: Cancer
https://www.readbyqxmd.com/read/30350912/long-term-outcome-of-renal-function-in-children-after-stem-cell-transplantation-measured-by-estimated-glomerular-filtration-rate
#17
Yukayo Ukeba-Terashita, Ryoji Kobayashi, Daiki Hori, Satoru Matsushima, Hirozumi Sano, Daisuke Suzuki, Masahide Nakajima, Masahiko Suzuki, Michihiko Ueno, Shoji Fujita, Kunihiko Kobayashi
BACKGROUND: Stem cell transplantation (SCT) outcomes have improved over the last three decades, with many patients being rescued with this treatment. However, improved outcomes have led to issues with long-term sequelae. One of these sequelae in children is renal dysfunction, an index of which is estimated using glomerular filtration rate (eGFR). PROCEDURE: We retrospectively analyzed eGFR in 83 pediatric patients who received SCT. Data from all patients extended up to 12 months or more post SCT...
October 23, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30340992/identifying-prognostic-factors-that-influence-outcome-of-childhood-acute-myeloid-leukemia-in-first-relapse-in-saudi-arabia-results-of-the-multicenter-saphos-study
#18
Wasil Jastaniah, Mohamed Bayoumy, Abdulrahman Alsultan, Saad Al Daama, Walid Ballourah, Faisal Al-Anzi, Omar Al Shareef, Reem Al Sudairy, Mohammed Burhan Abrar, Ibrahim Al Ghemlas
BACKGROUND: The outcome of childhood acute myeloid leukemia (AML) in first relapse (rAML) remains poor. Reported overall survival (OS) rates vary between high-income developed countries and those with fewer resources. The OS of rAML in high-income developing countries (HIDCs) has not been reported. PATIENTS AND MATERIALS: A multicenter study was performed in an HIDC. The outcome of patients with relapsed non-M3/non-Down syndrome AML was evaluated. Three-year OS was computed using the Kaplan-Meier method, and predictors of OS were analyzed using a Cox proportional hazards model...
September 12, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/30323896/clofarabine-based-reduced-intensity-conditioning-regimen-with-peripheral-blood-stem-cell-graft-and-post-transplant-cyclophosphamide-in-adults-with-myeloid-malignancies
#19
Patrice Chevallier, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Beatrice Mahé, Viviane Dubruille, Nicolas Blin, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Yannick Le Bris, Marie C Béné, Steven Le Gouill, Philippe Moreau, Thierry Guillaume
Background: The Baltimore reduced-intensity conditioning (RIC) regimen using high-dose post-transplant cyclophosphamide (PTCY) is considered as a standard of care for haploidentical allogeneic stem cell transplantation (allo-SCT). However, it is associated with relatively low survivals and high incidence of relapse, especially when considering myeloid malignancies. Results: This retrospective study included 36 adults (males n = 18; median age: 60.5 years old; haplodonors n = 27; matched donors n = 8) with myeloid malignancies transplanted between March 2014 and March 2017 at the University Hospital of Nantes...
September 11, 2018: Oncotarget
https://www.readbyqxmd.com/read/30323718/cost-effectiveness-analysis-for-midostaurin-versus-standard-of-care-in-acute-myeloid-leukemia-in-the-united-kingdom
#20
Gabriel Tremblay, Mike Dolph, Sachin Patel, Patricia Brandt, Anna Forsythe
Aims: Midostaurin (MIDO) has been proposed for the treatment of newly-diagnosed adult patients with FMS-like tyrosine kinase 3 mutation-positive (FLT3+) acute myeloid leukemia (AML) in combination with standard chemotherapy. The cost-effectiveness of MIDO and standard of care (SOC) followed by MIDO monotherapy was compared to SOC alone for newly-diagnosed FLT3+ AML in the UK. Methods: A partitioned survival model was developed from a UK public healthcare system perspective to compare the cost-effectiveness of MIDO plus SOC and SOC over a lifetime horizon...
2018: Cost Effectiveness and Resource Allocation: C/E
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