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Vishwanatha K Rao, Gerardo Zavala, Abhijit Deb Roy, Richard E Mains, Betty A Eipper
The biosynthetic and endocytic pathways of secretory cells are characterized by progressive luminal acidification, a process which is crucial for posttranslational modifications and membrane trafficking. This progressive fall in luminal pH is mainly achieved by the vacuolar-type-H+ ATPase (V-ATPase). V-ATPases are large, evolutionarily ancient rotary proton pumps that consist of a peripheral V1 complex, which hydrolyzes ATP, and an integral membrane V0 complex, which transports protons from the cytosol into the lumen...
October 14, 2018: Journal of Cellular Physiology
M Dülle, H Özcoban, C S Leopold
This study focuses on the behavior of powder particles in a rotary tablet press with special focus on the feed frame system. To obtain a better knowledge of the continuous manufacturing of tablets, the experimental setup was carried out with a production scale rotary tablet press. The behavior of the powder particles at different flow rates through the tablet press, residual moisture contents, particle sizes, and amounts of tracer was investigated. The residence time distribution was evaluated using the tracer indigo carmine, which was sprayed onto microcrystalline cellulose particle as solution with fluidized bed spray granulator to obtain a tracer blend...
October 9, 2018: European Journal of Pharmaceutical Sciences
Ana Maria de Souza Santos Cheibub, Eduardo Silva Bahiense de Lyra, Annibal Duarte Pereira Netto
A highly sensitive analytical method was developed and validated, following international guidelines, for the determination of the residues of five macrocyclic lactones (MLs) (abamectin, doramectin, eprinomectin, ivermectin and moxidectin) in cheese. The extracts were concentrated by rotary-evaporation and derivatized; no clean-up was necessary. Despite matrix complexity, no significant matrix-effect was verified, and standards were prepared in solvents. Linear working ranges varied from 0.25 to 5.0 μg L-1 ...
January 30, 2019: Food Chemistry
Tarek-Fahed Alakabani, Vicente Faus-Llácer, Vicente Faus-Matoses
Background: When endodontic treatment fails, retreatment consists of the complete removal of the root canal filling material for thorough cleaning and reobturation. Various techniques are available for the filling removal procedure, which present varying degrees of efficacy, and take a varying length of time to perform. The aim of this study was to compare the time required to carry out reciprocating, rotary, and manual techniques with dental microscope and ultrasonic activation for removing filling material from root canals...
August 2018: Journal of Clinical and Experimental Dentistry
Celia Ruiz-Sánchez, Vicente Faus-Matoses, Teresa Alegre-Domingo, Ignacio Faus-Matoses, Vicente-José Faus-Llácer
Background: New designs and processing of Niquel-Titanium (NiTi) have been introduced to increase resistance to cyclic fatigue. The purpose of this study was to compare the cyclic fatigue resistance of 3 NiTi rotary instruments, ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), Profile Vortex Blue (PVB; Dentsply Tulsa Dental, Tulsa, OK, USA) and ProTaper Universal (PTU; Dentsply Maillefer, Ballaigues, Switzerland). Material and Methods: A cyclic fatigue test was conducted operating instruments from ProTaper Next X2, Profile Vortex Blue 25...
August 2018: Journal of Clinical and Experimental Dentistry
Joshua Cysyk, Joseph Brian Clark, Ray Newswanger, Choon-Sik Jhun, Jenelle Izer, Heidi Finicle, John Reibson, Bradley Doxtater, William Weiss, Gerson Rosenberg
An implantable rotary blood pump was developed to provide long-term mechanical right heart support for patients who have failing Fontan circulation. The objective of this study was to evaluate the pump in vivo in a 30 day sheep study. Pump speed was set at 3,900 rpm for the duration of the study, and pump power was between 4.3 and 4.6 W. The pump inlet pressures for the superior vena cava (SVC) and inferior vena cava (IVC) were 14 ± 15 and 11 ± 15 mm Hg, respectively, over the duration of the study. Hematocrit remained stable at 30% ± 4%...
October 3, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Robert P Thoerner, Jonathan D King, Marnie M Saunders
In terms of accurate and precise mechanical testing, machines run the continuum. Whereas commercial platforms offer excellent accuracy, they can be cost-prohibitive, often priced in the $100,000 - $200,000 price range. At the other extreme are stand-alone manual devices that often lack repeatability and accuracy (e.g., a manual crank device). However, if a single use is indicated, it is over-engineering to design and machine something overly elaborate. Nonetheless, there are occasions where machines are designed and built in-house to accomplish a motion not attainable with the existing machines in the laboratory...
September 19, 2018: Journal of Visualized Experiments: JoVE
Pritika Srivastava, Premalatha Shetty, Sameep Shetty
Background and Aim: One of the most commonly performed surgical procedures by oral and maxillofacial surgeons all over the world is the removal of impacted teeth. The most critical and important steps in third molar extraction are bone cutting or osteotomy. Many techniques are used for this purpose including chisels and mallet, rotary instruments, and ultrasonic-based bone cutting instruments. Piezotome is newer and innovative device for osteotomy based on piezoelectric vibrations. Piezotome is considered very efficient in performing osteotomy because of its selective cutting; being inert against soft tissues, including nerves and blood vessels...
September 2018: Contemporary Clinical Dentistry
Ekta Pansheriya, Manish Goel, Kapil Dev Gupta, Ravish Ahuja, Rupinder Deep Kaur, Vishal Garg
Background: Objective in root canal preparation is to develop a shape that tapers from apical to coronal, maintaining the original canal shape. With advent of instruments manufactured from nickel-titanium (NiTi) alloys, there was a significant improvement of quality of root canal shaping, with predictable results and less iatrogenic damage. Aim: The aim of the study was to evaluate the canal centric ability and apical transportation in apical region of newer NiTi file system in root canal using cone-beam computed tomography (CBCT) on extracted molars...
September 2018: Contemporary Clinical Dentistry
Alfredo Iandolo, Massimo Amato, Alberto Dagna, Claudio Poggio, Dina Abdellatif, Vittorio Franco, Giuseppe Pantaleo
Introduction: The aim of this study is to evaluate the surface of root canals dentine using scanning electron microscope (SEM) after instrumentation with rotary Nickel-Titanium systems and two different protocols of activation of sodium hypochlorite (NaOCl) (extracanal heating at 50°C and intracanal heating at 180°C), to assess the presence/absence of smear layer and also the presence/absence of open dentinal tubules along the walls at the coronal, middle, and apical third of each sample...
September 2018: Journal of Conservative Dentistry: JCD
Xiaojuan Pang, Chenwei Jiang, Yongnan Qi, Ling Yuan, Deping Hu, Xiuxing Zhang, Di Zhao, Dongdong Wang, Zhenggang Lan, Fuli Li
Unidirectional rotation represents a very important functional feature in photochemistry, such as in the design of light-driven molecular rotary motors. Great attention has recently been devoted to the unidirectional preference of the torsional motion of azobenzene and other molecules. Azoheteroarenes offer functional advantages over their more conventional azobenzene counterparts due to the introduction of heteroaromatic rings. In this paper, the Z-E photoisomerization dynamics of two azoheteroarenes, 1,2-bis(1-methyl-1H-imidazol-2-yl)diazene and 1,2-bis(1H-imidazol-2-yl)diazene, are investigated with trajectory surface-hopping molecular dynamics at the semi-empirical OM2/MRCI level...
October 5, 2018: Physical Chemistry Chemical Physics: PCCP
Ana Cl Marques, Bernardo A Aguiar, Luciana Ma Frota, Bruno M Guimarães, Nilton Vivacqua-Gomes, Rodrigo R Vivan, Marco Ah Duarte, Bruno C de Vasconcelos
AIM: The purpose of this study was to evaluate the influence of widening the apical root canal preparation (RCP) on the efficiency of different ethylenediaminetetraacetic acid (EDTA) agitation protocols on smear layer removal: EDTA; EDTA + Easy Clean in rotary movement (ECROT); EDTA + Easy Clean in reciprocating movement (ECREC); and EDTA + Passive ultrasonic irrigation (PUI). MATERIALS AND METHODS: A total of 80 mandibular premolars had their crowns sectioned and then were divided into two groups according to widening: size 25 or 40, 0...
September 1, 2018: Journal of Contemporary Dental Practice
Zhuwei Huang, Jingjing Quan, Jia Liu, Wen Zhang, Xiaolei Zhang, Xiaoli Hu
Objective To evaluate the shaping ability of three thermally-treated rotary nickel-titanium (NiTi) systems including ProTaper Next (PTN), HyFlex™ CM (HFCM) and HyFlex™ EDM (HFEDM) during root canal preparation in simulated root canals. Methods A total of 45 simulated root canals were divided into three groups ( n = 15) and prepared with PTN, HFCM or HFEDM files up to size 25. Microcomputed tomography (microCT) was used to scan the specimens before and after instrumentation. Volume and diameter changes, transportations and centring ratios at 11 levels of the simulated root canals were measured and compared...
October 3, 2018: Journal of International Medical Research
Raidan A Ba-Hattab, Dieter Pahncke
Improvements in the thermomechanical processing procedures of NiTi wires have led to the development of new NiTi instruments that compose mainly of martensite crystals, making the wire stable at clinical condition. This study aimed at comparing the shaping ability of two rotary nickel-titanium systems manufactured from different NiTi wires. Twenty simulated root canals each with a curvature of 35° in resin blocks were divided into two groups of 10 canals each. Canals in the first group were prepared with superelastic F360 instruments (Gebr...
2018: International Journal of Dentistry
Xiaogang Zhang, Lei Zhang, Hua Chen, Bowang Dai
In alumina rotary kiln production, adjusting the coal feeding rate is the main way to maintain sintering temperature stability during the sintering process, which plays a critical role in improving production quality and reducing energy consumption. In this paper, a novel integrated method (termed PSR-PCA-HMM) is proposed to predict the coal feeding state for optimal control by integrating principal component analysis (PCA) and the hidden Markov model (HMM) based on phase space reconstruction (PSR). First, the thermal signals in rotary kilns are shown to have obvious chaotic characteristics...
September 21, 2018: ISA Transactions
Xian-Yue Hu, Hao Lou, Michael J Hageman
The objective of this study was to enhance solubility and dissolution of lapatinib (LB) ditosylate (DT) using solid dispersions (SD) prepared by solvent rotary evaporation (SRE) and hot melt extrusion (HME). A series of models based on solubility parameter, the solid-liquid equilibrium equation, and the Flory-Huggins equation were employed to provide insight to data and evaluate drug/polymer interactions. Experimentally, nine SD formulas were prepared and characterized by various analytical techniques including differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), solubility, and dissolution...
September 27, 2018: International Journal of Pharmaceutics
Min Woo Lee, Joon Woo Song, Woo Jae Kang, Hyeong Soo Nam, Tae Shik Kim, Sunwon Kim, Wang-Yuhl Oh, Jin Won Kim, Hongki Yoo
Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque's morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an atherosclerotic rabbit artery in vivo...
September 28, 2018: Scientific Reports
Sam Liao, Eric L Wu, Michael Neidlin, Zhiyong Li, Benjamin Simpson, Shaun D Gregory
Rotary left ventricular assist devices (LVADs) are commonly operated at a constant speed, attenuating blood flow pulsatility. Speed modulation of rotary LVADs has been demonstrated to improve vascular pulsatility and pump washout. The effect of LVAD speed modulation on intraventricular flow dynamics is not well understood, which may have an influence on thromboembolic events. This study aimed to numerically evaluate intraventricular flow characteristics with a speed modulated LVAD. A severely dilated anatomical left ventricle was supported by a HeartWare HVAD in a three-dimensional multiscale computational fluid dynamics model...
September 27, 2018: Artificial Organs
Marco Serafin, Matteo De Biasi, Vittorio Franco, Daniele Angerame
The aim of the present study was to evaluate the difference in cyclic fatigue resistance between OneCurve (OC) and OneShape (OS) endodontic single-file NiTi systems in a severely curved artificial canal. After sample size calculation (α = 0.01; β = 0.20; σ = 20.0; δ = 20.0), 25 OC and 25 OS files were used. An artificial canal with 60° angle and 5-mm radius of curvature was milled in a stainless-steel block reproducing the size and taper of the files used. The test device was electrically heated to maintain the environmental temperature at 37 °C...
September 25, 2018: Odontology
Eric G Keeler, Keith J Fritzsching, Ann E McDermott
We examine coherent evolution of spin-locked magnetization during magic-angle spinning (MAS), in the context of relaxation experiments designed to probe chemical exchange (rotating-frame relaxation (R1ρ )). Coherent evolution is expected in MAS based rotating-frame relaxation decay experiments if matching conditions are met (such as, ω1  = nωr ) and if the chemical shielding anisotropy (CSA) is substantial. We show here using numerical simulations and experiments that even when such matching requirements are avoided (e...
September 14, 2018: Journal of Magnetic Resonance
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